For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SMIIGIPRESQPGETRVAATPQTVGQILKLGYSVVVESGAGAAASFSDAAYADAGAQIGSADQVWSADVV MKVNAPSEGEIAALGDGATLVGLISPALRPDLVEQLAARPITVLAMDAVPRISRAQSLDVLSSMANIAGY RAVVEAAHRFGRFFTGQVTAAGKVPPAKVLVVGAGVAGLAAIGAAGSLGAIVRATDPRPEVADQVASLGG EYLAVDDSGEVAEVSKTGYAKEMGADYKAREAALYAEQCKDVDIIITTALIPGRPAPRIITAEMVASMKA GSVIVDMAAANGGNVEGTVKDQAIVTDNGVTIIGYTDLAGRLPAQSSQLYGTNLVNLLKLLTPEKDGKVV LDFDDVVQRSITVVRDGEITWPPPPVQVSAAPAAQPAAAAPGVKEEKQPMSTGRRLGVAFAAAAVLFALI ALSPAALQVHLVVFALAIVIGYYVIGNVHHALHTPLMSVTNAISGIIVVGALLQIGHHHTAITALAFVAI LLASINVFGGFAVTRRMLAMFSRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4109 | pntA | - | 100% (515) | NAD(P) transhydrogenase subunit alpha |
| M. smegmatis MC2 155 | MSMEG_0110 | pntA | 0.0 | 97.66% (513) | NAD(P) transhydrogenase subunit alpha |
| M. smegmatis MC2 155 | MSMEG_0152 | - | 1e-77 | 45.41% (370) | alanine dehydrogenase/pyridine nucleotide transhydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0160 | pntAa | 9e-75 | 44.20% (362) | NAD(P) transhydrogenase subunit alpha |
| M. gilvum PYR-GCK | Mflv_0726 | pntA | 0.0 | 85.49% (517) | NAD(P) transhydrogenase subunit alpha |
| M. tuberculosis H37Rv | Rv0155 | pntAa | 9e-75 | 44.20% (362) | NAD(P) transhydrogenase subunit alpha |
| M. leprae Br4923 | MLBr_02636 | pntAA | 3e-75 | 43.56% (365) | pyridine transhydrogenase subunit alpha1 |
| M. abscessus ATCC 19977 | MAB_4579c | - | 2e-77 | 44.11% (365) | NAD(P) transhydrogenase, alpha1 subunit PntAA |
| M. marinum M | MMAR_0377 | pntAa | 1e-76 | 45.33% (364) | NAD(P) transhydrogenase (subunit alpha) PntAa |
| M. avium 104 | MAV_5142 | - | 8e-78 | 45.21% (365) | alanine dehydrogenase/pyridine nucleotide transhydrogenase |
| M. thermoresistible (build 8) | TH_3398 | - | 2e-75 | 46.13% (349) | PUTATIVE NAD(P) transhydrogenase (subunit alpha) PntAa |
| M. ulcerans Agy99 | MUL_4735 | pntAa | 3e-76 | 45.33% (364) | NAD(P) transhydrogenase (subunit alpha) PntAa |
| M. vanbaalenii PYR-1 | Mvan_0120 | pntA | 0.0 | 87.94% (514) | NAD(P) transhydrogenase subunit alpha |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0377|M.marinum_M MTDPQTT---VGVVAESTPDERRVALVPKAVGSLVNSGVAVVVESGAGER
MUL_4735|M.ulcerans_Agy99 MTDPQTT---VGVVAESTPDERRVALVPKAVGSLVNSGVAVVVESGAGER
Mb0160|M.bovis_AF2122/97 MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVEAGAGER
Rv0155|M.tuberculosis_H37Rv MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVEAGAGER
MLBr_02636|M.leprae_Br4923 MTEAQTT---VGVVAESGSDERRVALVPKAVASLVNSGLAVVVESGAGEG
MAV_5142|M.avium_104 MTNAQANAVKVGVVAESGADERRVALVPKAVASLVGSGLAVVVESGAGER
TH_3398|M.thermoresistible__bu -----------------------VALVPKAVATLVKSGLSVVVESGAGER
MAB_4579c|M.abscessus_ATCC_199 MTDQPVT---IGVVRESGEDERRVALVPKAIAGLIGKGVNIVIESGAGER
Mflv_0726|M.gilvum_PYR-GCK --------MIIGIPRESMPGETRVAATPQTVGQLVKLGYQVAVETGAGAA
Mvan_0120|M.vanbaalenii_PYR-1 --------MIIGIPRESQPGETRVAATPQTVGQLIKLGYQVVVESGAGAA
MSMEG_4109|M.smegmatis_MC2_155 ------MSMIIGIPRESQPGETRVAATPQTVGQILKLGYSVVVESGAGAA
** .*:::. :: * :.:*:***
MMAR_0377|M.marinum_M ALLPDDLYTEAGATIG---DAWAADVVVKVAPPSADEVGKLRSGQTLIGF
MUL_4735|M.ulcerans_Agy99 ALLPDDLYTEAGATIG---DAWAADVVVKVAPPSADEVGKLRSGQTLIGF
Mb0160|M.bovis_AF2122/97 ALLPDELYTAVGASIG---DAWAADVVVKVAPPTAAEVGRLRGGQTLIGF
Rv0155|M.tuberculosis_H37Rv ALLPDELYTAVGASIG---DAWAADVVVKVAPPTAAEVGRLRGGQTLIGF
MLBr_02636|M.leprae_Br4923 ALLPEQLYTEAGARIG---DAWAADIVVKVAPPAAAEVGRLRRGQTLIGF
MAV_5142|M.avium_104 ALLPDALYTEAGADIG---DAWAADIVVKVAPPTADEVAKLHSGQTLIGF
TH_3398|M.thermoresistible__bu ALLPDALYTEAGATIG---DAWAADVVVKVAPPTAEEVKRLRSGQTLIGF
MAB_4579c|M.abscessus_ATCC_199 ALLPDELYTEAGATVG---DAWSADVVVKVAPPTAAEVARLRQGQTLIGF
Mflv_0726|M.gilvum_PYR-GCK SSFSDDAYTAAGATVGPNTEVLASDVVLKVNAPSEAEIAALRDGATLISL
Mvan_0120|M.vanbaalenii_PYR-1 ASFSDAAFAEAGAGIGSPDEVWSADVVLKVNAPTEAEIATLRDGATLIGL
MSMEG_4109|M.smegmatis_MC2_155 ASFSDAAYADAGAQIGSADQVWSADVVMKVNAPSEGEIAALGDGATLVGL
: :.: :: .** :* :. ::*:*:** .*: *: * * **:.:
MMAR_0377|M.marinum_M LAPRNADNSIGALKQAGVQAFALEAIPRISRAQVMDALSSQANVAGYKAV
MUL_4735|M.ulcerans_Agy99 LAPRNADYSIGALKQAGVQAFALEAIPRISRAQVMDALSSQANVAGYKAV
Mb0160|M.bovis_AF2122/97 LAPRNADNSIGALTQAGVQAFALEAIPRISRAQVMDALSSQANVSGYKAV
Rv0155|M.tuberculosis_H37Rv LAPRNADNSIGALTQAGVQAFALEAIPRISRAQVMDALSSQANVSGYKAV
MLBr_02636|M.leprae_Br4923 LASRNADNWIGELKRAGVQAFALEAIPRISRAQVMDALSSQANVTGYKAV
MAV_5142|M.avium_104 LAPRNADNSIGALKQAGVQAFALEAIPRISRAQAMDALSSQGNVAGYKAV
TH_3398|M.thermoresistible__bu LAPRNADNQIEALKSAGVQAFALEAIPRISRAQVMDALSSQANVAGYKAV
MAB_4579c|M.abscessus_ATCC_199 LAPRNAENSIGALRSAGVQAFAVEAIPRISRAQVMDALSSQANVAGYKSV
Mflv_0726|M.gilvum_PYR-GCK ISPALKPELVEQLATRPITVLAMDAVPRISRAQSLDVLSSMANIAGYRAV
Mvan_0120|M.vanbaalenii_PYR-1 ISPALRPELVEQLATRRITVLAMDAVPRISRAQSLDVLSSMANIAGYRAV
MSMEG_4109|M.smegmatis_MC2_155 ISPALRPDLVEQLAARPITVLAMDAVPRISRAQSLDVLSSMANIAGYRAV
::. : * : .:*::*:******* :*.*** .*::**::*
MMAR_0377|M.marinum_M LLAASESTRFFPMLTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTT
MUL_4735|M.ulcerans_Agy99 LLAASESTRFFPMLTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTT
Mb0160|M.bovis_AF2122/97 LLAASESTRFFPMLTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTT
Rv0155|M.tuberculosis_H37Rv LLAASESTRFFPMLTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTT
MLBr_02636|M.leprae_Br4923 LLAASESTRFFPMLTTAAGTVKPAIVLVLGVGVAGLQALATAKRLGARTT
MAV_5142|M.avium_104 LLAASESTRFFPMLTTAAGTVKPASVLVLGVGVAGLQALATAKRLGARTS
TH_3398|M.thermoresistible__bu LLGAMELTRFFPMLTTAAGTVKPASVLVLGVGVAGLQALATAKRLGARTT
MAB_4579c|M.abscessus_ATCC_199 LVAASESTRFFPMLTTAAGTVKPALVLVLGVGVAGLQALATAKRLGARTT
Mflv_0726|M.gilvum_PYR-GCK IEAAHKFGRFFTGQVTAAGKVPPAKVLVVGAGVAGLAAIGAAGSLGAIVR
Mvan_0120|M.vanbaalenii_PYR-1 VEAAHRFGRFFTGQVTAAGKVPPAKVLVVGAGVAGLAAIGAAGSLGAIVR
MSMEG_4109|M.smegmatis_MC2_155 VEAAHRFGRFFTGQVTAAGKVPPAKVLVVGAGVAGLAAIGAAGSLGAIVR
: .* . ***. .****.* ** ***:*.***** *:.:* *** .
MMAR_0377|M.marinum_M GYDVRPEVADQVRSVGAQWLNIGID----AAGEGGYARELTDEERAQQQK
MUL_4735|M.ulcerans_Agy99 GYDVRPEVADQVRSVGAQWLNIGID----AAGEGGYARELTDEERAQQQK
Mb0160|M.bovis_AF2122/97 GYDVRPEVADQVRSVGAQWLDLGIS----ASGEGGYARELTDDERAQQQK
Rv0155|M.tuberculosis_H37Rv GYDVRPEVADQVRSVGAQWLDLGIS----ASGEGGYARELTDDERAQQQK
MLBr_02636|M.leprae_Br4923 GYDVRPEVAEQVRSVGAQWLDVGIE----ASGAGGYARELTADERAQQQK
MAV_5142|M.avium_104 GYDVRPEVADQVRSVGAQWLDLGID----AAGEGGYARELTEEERAQQQK
TH_3398|M.thermoresistible__bu GYDVRPEVADQVRSVGAQWLDLGIE----AAGEGGYARELTEEERAQQQR
MAB_4579c|M.abscessus_ATCC_199 GYDVRPEVADQVRSVGAQWLDLGID----AAGEGGYARELTDEERQKQQQ
Mflv_0726|M.gilvum_PYR-GCK ATDPRPEVADQVASLGGEYLAVDPA--AAEVSATGYAKEMGDDYKAREAA
Mvan_0120|M.vanbaalenii_PYR-1 ATDPRPEVADQVRSLGGEYLSIESP--EAEVSATGYAKEMGDDYKAREAQ
MSMEG_4109|M.smegmatis_MC2_155 ATDPRPEVADQVASLGGEYLAVDDSGEVAEVSKTGYAKEMGADYKAREAA
. * *****:** *:*.::* : . ***:*: : : ::
MMAR_0377|M.marinum_M ALETAISGFDVVITTALVPGRPAPRLVTAAAVEAMKPGSVVVDLAGETGG
MUL_4735|M.ulcerans_Agy99 ALEAAISGFDVVITTALVPGRPAPRLVTAAAVEAMKPGSVVVDLAGETGG
Mb0160|M.bovis_AF2122/97 ALEEAISGFDVVITTALVPGRPAPTLVTAAAVEAMKPGSVVVDLAGETGG
Rv0155|M.tuberculosis_H37Rv ALEEAISGFDVVITTALVPGRPAPTLVTAAAVEAMKPGSVVVDLAGETGG
MLBr_02636|M.leprae_Br4923 ALEKAISGFDVVITTALVPGKPAPRLVTAAAVEAMKPGSVVVDLAGETGG
MAV_5142|M.avium_104 ALEEAIAGFDVVITTALVPGRPAPRLVTAAAVESMKPGSVVVDLAGETGG
TH_3398|M.thermoresistible__bu ALEEAIKGFDVVITTALVPGRPAPRLVTADAVRGMKPGSVVVDLAGETGG
MAB_4579c|M.abscessus_ATCC_199 ALEDAIKGFDVVITTALVPGRPAPRLVTAAAVQGMKPGSVVVDLAGETGG
Mflv_0726|M.gilvum_PYR-GCK LYAEQCKDVDIIITTALIPGRPAPRIITAEMVASMKPGSVIVDMAAANGG
Mvan_0120|M.vanbaalenii_PYR-1 LYAQQSEDVDIIITTALIPGRPAPRIITADMVASMKSGSVIVDMAAANGG
MSMEG_4109|M.smegmatis_MC2_155 LYAEQCKDVDIIITTALIPGRPAPRIITAEMVASMKAGSVIVDMAAANGG
..*::*****:**:*** ::** * .**.***:**:*. .**
MMAR_0377|M.marinum_M NCELTEPGRVVVKHD-VTIASPLNLPATMPEHASELYSKNITALLDLLLT
MUL_4735|M.ulcerans_Agy99 NCELTEPGRVVVKHD-VTIASPLNLPATMPEHASELYSKNITALLDLLLT
Mb0160|M.bovis_AF2122/97 NCELTEPGRTVVKHD-VTIAAPLNLPATMPEHASELYSKNITALLDLLIK
Rv0155|M.tuberculosis_H37Rv NCELTEPGRTVVKHD-VTIAAPLNLPATMPEHASELYSKNITALLDLLIK
MLBr_02636|M.leprae_Br4923 NCELTEPGQTVIKHD-VTIAAPLNLPATMPEHASELYSKNIKALLDLLIK
MAV_5142|M.avium_104 NCELTEPGKTVVKHD-VTIAAPLNLPATMPEHASELYSKNITALLDLLIK
TH_3398|M.thermoresistible__bu NCELTEPGQTVVKHG-VTIASPLNLPATMPEHASELYSKNITALLDLLIT
MAB_4579c|M.abscessus_ATCC_199 NCELTEPGQTVVKHG-VTIASPLNLPATMPEHASELYAKNITSVLELLIK
Mflv_0726|M.gilvum_PYR-GCK NVEGTVKDEAVVTANGVTIIGYTDLAGRLPAQSSQLYGTNLVNLLKLLTP
Mvan_0120|M.vanbaalenii_PYR-1 NVEGTVKDQAVVTDNGVTIIGYTDLAGRLPTQASQLYGTNLVNLLKLLTP
MSMEG_4109|M.smegmatis_MC2_155 NVEGTVKDQAIVTDNGVTIIGYTDLAGRLPAQSSQLYGTNLVNLLKLLTP
* * * ...::. . *** . :*.. :* ::*:**..*: :*.**
MMAR_0377|M.marinum_M --DGKLAPDFDDEVIADSCVTRGDD-------------------------
MUL_4735|M.ulcerans_Agy99 --DGKLAPDFDDEVIADSCVTRGDD-------------------------
Mb0160|M.bovis_AF2122/97 --DGRLAPDFDDEVIAQSCVTRGKDS------------------------
Rv0155|M.tuberculosis_H37Rv --DGRLAPDFDDEVIAQSCVTRGKDS------------------------
MLBr_02636|M.leprae_Br4923 --DGKFAPDFDDEVVAESCVTRDREDSIDV--------------------
MAV_5142|M.avium_104 --DGKLAPDFDDEVVAAACVTRESA-------------------------
TH_3398|M.thermoresistible__bu --DGALAPDFTDEVVAEACVTRGKDA------------------------
MAB_4579c|M.abscessus_ATCC_199 --DGALAPDFDDEIVAGSCVTREVS-------------------------
Mflv_0726|M.gilvum_PYR-GCK EKDGQLTLDWDDVVQRSVTVVRGGEITWPPPPVQVSAAPAAAVAATPVEP
Mvan_0120|M.vanbaalenii_PYR-1 EKDGQLTVDFDDVVQRSVTVVRDGEITWPPPPVQVSAAPVAAAAA-PVEQ
MSMEG_4109|M.smegmatis_MC2_155 EKDGKVVLDFDDVVQRSITVVRDGEITWPPPPVQVSAAPAAQPAAAAPGV
** .. *: * : *.*
MMAR_0377|M.marinum_M --------------------------------------------------
MUL_4735|M.ulcerans_Agy99 --------------------------------------------------
Mb0160|M.bovis_AF2122/97 --------------------------------------------------
Rv0155|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02636|M.leprae_Br4923 --------------------------------------------------
MAV_5142|M.avium_104 --------------------------------------------------
TH_3398|M.thermoresistible__bu --------------------------------------------------
MAB_4579c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0726|M.gilvum_PYR-GCK KPAKKPMTTARRLGVTFGVAAALLLLIALSPAALQVHLTVFALAIVIGYY
Mvan_0120|M.vanbaalenii_PYR-1 KPAKKPMTTGRRLGVTFAVAAALFVLIALSPAALQVHLTVFALAIVIGYY
MSMEG_4109|M.smegmatis_MC2_155 KEEKQPMSTGRRLGVAFAAAAVLFALIALSPAALQVHLVVFALAIVIGYY
MMAR_0377|M.marinum_M --------------------------------------------------
MUL_4735|M.ulcerans_Agy99 --------------------------------------------------
Mb0160|M.bovis_AF2122/97 --------------------------------------------------
Rv0155|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02636|M.leprae_Br4923 --------------------------------------------------
MAV_5142|M.avium_104 --------------------------------------------------
TH_3398|M.thermoresistible__bu --------------------------------------------------
MAB_4579c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0726|M.gilvum_PYR-GCK VIGNVHHALHTPLMSVTNAISGIIVVGALLQIGHDLDSGGALITGLAFVA
Mvan_0120|M.vanbaalenii_PYR-1 VIGNVHHALHTPLMSVTNAISGIIVVGALLQIGH----GNIAITALAFAA
MSMEG_4109|M.smegmatis_MC2_155 VIGNVHHALHTPLMSVTNAISGIIVVGALLQIGH----HHTAITALAFVA
MMAR_0377|M.marinum_M -------------------------
MUL_4735|M.ulcerans_Agy99 -------------------------
Mb0160|M.bovis_AF2122/97 -------------------------
Rv0155|M.tuberculosis_H37Rv -------------------------
MLBr_02636|M.leprae_Br4923 -------------------------
MAV_5142|M.avium_104 -------------------------
TH_3398|M.thermoresistible__bu -------------------------
MAB_4579c|M.abscessus_ATCC_199 -------------------------
Mflv_0726|M.gilvum_PYR-GCK ILLASINIFGGFAVTRRMLAMFSRS
Mvan_0120|M.vanbaalenii_PYR-1 ILLASINIFGGFAVTRRMLAMFSRS
MSMEG_4109|M.smegmatis_MC2_155 ILLASINVFGGFAVTRRMLAMFSRS