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TDPQTTVGVVAESTPDERRVALVPKAVGSLVNSGVAVVVESGAGERALLPDDLYTEAGATIGDAWAADVV VKVAPPSADEVGKLRSGQTLIGFLAPRNADYSIGALKQAGVQAFALEAIPRISRAQVMDALSSQANVAGY KAVLLAASESTRFFPMLTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTTGYDVRPEVADQVRSVGA QWLNIGIDAAGEGGYARELTDEERAQQQKALEAAISGFDVVITTALVPGRPAPRLVTAAAVEAMKPGSVV VDLAGETGGNCELTEPGRVVVKHDVTIASPLNLPATMPEHASELYSKNITALLDLLLTDGKLAPDFDDEV IADSCVTRGDD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4735 | pntAa | - | 100% (362) | NAD(P) transhydrogenase (subunit alpha) PntAa |
| M. ulcerans Agy99 | MUL_2154 | ald | 1e-29 | 30.77% (364) | secreted L-alanine dehydrogenase Ald (40 kDa antigen) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0160 | pntAa | 0.0 | 90.96% (365) | NAD(P) transhydrogenase subunit alpha |
| M. gilvum PYR-GCK | Mflv_0726 | pntA | 4e-78 | 46.01% (363) | NAD(P) transhydrogenase subunit alpha |
| M. tuberculosis H37Rv | Rv0155 | pntAa | 0.0 | 90.96% (365) | NAD(P) transhydrogenase subunit alpha |
| M. leprae Br4923 | MLBr_02636 | pntAA | 1e-176 | 88.30% (359) | pyridine transhydrogenase subunit alpha1 |
| M. abscessus ATCC 19977 | MAB_4579c | - | 1e-173 | 84.96% (359) | NAD(P) transhydrogenase, alpha1 subunit PntAA |
| M. marinum M | MMAR_0377 | pntAa | 0.0 | 99.45% (362) | NAD(P) transhydrogenase (subunit alpha) PntAa |
| M. avium 104 | MAV_5142 | - | 1e-179 | 89.78% (362) | alanine dehydrogenase/pyridine nucleotide transhydrogenase |
| M. smegmatis MC2 155 | MSMEG_0152 | - | 1e-146 | 75.42% (354) | alanine dehydrogenase/pyridine nucleotide transhydrogenase |
| M. thermoresistible (build 8) | TH_3398 | - | 1e-169 | 88.89% (342) | PUTATIVE NAD(P) transhydrogenase (subunit alpha) PntAa |
| M. vanbaalenii PYR-1 | Mvan_0120 | pntA | 1e-78 | 46.94% (360) | NAD(P) transhydrogenase subunit alpha |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4735|M.ulcerans_Agy99 MTDPQTT---VGVVAESTPDERRVALVPKAVGSLVNSGVAVVVESGAGER
MMAR_0377|M.marinum_M MTDPQTT---VGVVAESTPDERRVALVPKAVGSLVNSGVAVVVESGAGER
Mb0160|M.bovis_AF2122/97 MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVEAGAGER
Rv0155|M.tuberculosis_H37Rv MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVEAGAGER
MLBr_02636|M.leprae_Br4923 MTEAQTT---VGVVAESGSDERRVALVPKAVASLVNSGLAVVVESGAGEG
MAV_5142|M.avium_104 MTNAQANAVKVGVVAESGADERRVALVPKAVASLVGSGLAVVVESGAGER
TH_3398|M.thermoresistible__bu -----------------------VALVPKAVATLVKSGLSVVVESGAGER
MAB_4579c|M.abscessus_ATCC_199 MTDQPVT---IGVVRESGEDERRVALVPKAIAGLIGKGVNIVIESGAGER
MSMEG_0152|M.smegmatis_MC2_155 MT-------LIGVPRESAEGERRVALVPKVVEKLSARGLEVVVESAAGAG
Mflv_0726|M.gilvum_PYR-GCK --------MIIGIPRESMPGETRVAATPQTVGQLVKLGYQVAVETGAGAA
Mvan_0120|M.vanbaalenii_PYR-1 --------MIIGIPRESQPGETRVAATPQTVGQLIKLGYQVVVESGAGAA
** .*:.: * * :.:*:.**
MUL_4735|M.ulcerans_Agy99 ALLPDDLYTEAGATIG---DAWAADVVVKVAPPSADEVGKLRSGQTLIGF
MMAR_0377|M.marinum_M ALLPDDLYTEAGATIG---DAWAADVVVKVAPPSADEVGKLRSGQTLIGF
Mb0160|M.bovis_AF2122/97 ALLPDELYTAVGASIG---DAWAADVVVKVAPPTAAEVGRLRGGQTLIGF
Rv0155|M.tuberculosis_H37Rv ALLPDELYTAVGASIG---DAWAADVVVKVAPPTAAEVGRLRGGQTLIGF
MLBr_02636|M.leprae_Br4923 ALLPEQLYTEAGARIG---DAWAADIVVKVAPPAAAEVGRLRRGQTLIGF
MAV_5142|M.avium_104 ALLPDALYTEAGADIG---DAWAADIVVKVAPPTADEVAKLHSGQTLIGF
TH_3398|M.thermoresistible__bu ALLPDALYTEAGATIG---DAWAADVVVKVAPPTAEEVKRLRSGQTLIGF
MAB_4579c|M.abscessus_ATCC_199 ALLPDELYTEAGATVG---DAWSADVVVKVAPPTAAEVARLRQGQTLIGF
MSMEG_0152|M.smegmatis_MC2_155 ALFSDADYERAGATIG---DPWPADVVVKVNPPTSDEISQLKPGSVLIGF
Mflv_0726|M.gilvum_PYR-GCK SSFSDDAYTAAGATVGPNTEVLASDVVLKVNAPSEAEIAALRDGATLISL
Mvan_0120|M.vanbaalenii_PYR-1 ASFSDAAFAEAGAGIGSPDEVWSADVVLKVNAPTEAEIATLRDGATLIGL
: :.: : .** :* : .:*:*:** .*: *: *: * .**.:
MUL_4735|M.ulcerans_Agy99 LAPRNADYSIGALKQAGVQAFALEAIPRISRAQVMDALSSQANVAGYKAV
MMAR_0377|M.marinum_M LAPRNADNSIGALKQAGVQAFALEAIPRISRAQVMDALSSQANVAGYKAV
Mb0160|M.bovis_AF2122/97 LAPRNADNSIGALTQAGVQAFALEAIPRISRAQVMDALSSQANVSGYKAV
Rv0155|M.tuberculosis_H37Rv LAPRNADNSIGALTQAGVQAFALEAIPRISRAQVMDALSSQANVSGYKAV
MLBr_02636|M.leprae_Br4923 LASRNADNWIGELKRAGVQAFALEAIPRISRAQVMDALSSQANVTGYKAV
MAV_5142|M.avium_104 LAPRNADNSIGALKQAGVQAFALEAIPRISRAQAMDALSSQGNVAGYKAV
TH_3398|M.thermoresistible__bu LAPRNADNQIEALKSAGVQAFALEAIPRISRAQVMDALSSQANVAGYKAV
MAB_4579c|M.abscessus_ATCC_199 LAPRNAENSIGALRSAGVQAFAVEAIPRISRAQVMDALSSQANVAGYKSV
MSMEG_0152|M.smegmatis_MC2_155 LAPRTQPELASRLRIADVTAFAMESIPRISRAQTMDALSSQANVAGYKAV
Mflv_0726|M.gilvum_PYR-GCK ISPALKPELVEQLATRPITVLAMDAVPRISRAQSLDVLSSMANIAGYRAV
Mvan_0120|M.vanbaalenii_PYR-1 ISPALRPELVEQLATRRITVLAMDAVPRISRAQSLDVLSSMANIAGYRAV
::. * : .:*::::******* :*.*** .*::**::*
MUL_4735|M.ulcerans_Agy99 LLAASESTRFFPMLTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTT
MMAR_0377|M.marinum_M LLAASESTRFFPMLTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTT
Mb0160|M.bovis_AF2122/97 LLAASESTRFFPMLTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTT
Rv0155|M.tuberculosis_H37Rv LLAASESTRFFPMLTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTT
MLBr_02636|M.leprae_Br4923 LLAASESTRFFPMLTTAAGTVKPAIVLVLGVGVAGLQALATAKRLGARTT
MAV_5142|M.avium_104 LLAASESTRFFPMLTTAAGTVKPASVLVLGVGVAGLQALATAKRLGARTS
TH_3398|M.thermoresistible__bu LLGAMELTRFFPMLTTAAGTVKPASVLVLGVGVAGLQALATAKRLGARTT
MAB_4579c|M.abscessus_ATCC_199 LVAASESTRFFPMLTTAAGTVKPALVLVLGVGVAGLQALATAKRLGARTT
MSMEG_0152|M.smegmatis_MC2_155 LLGASLSTRFVPMLTTAAGTVKPASALVLGVGVAGLQALATAKRLGAKTT
Mflv_0726|M.gilvum_PYR-GCK IEAAHKFGRFFTGQVTAAGKVPPAKVLVVGAGVAGLAAIGAAGSLGAIVR
Mvan_0120|M.vanbaalenii_PYR-1 VEAAHRFGRFFTGQVTAAGKVPPAKVLVVGAGVAGLAAIGAAGSLGAIVR
: .* **.. .****.* ** .**:*.***** *:.:* *** .
MUL_4735|M.ulcerans_Agy99 GYDVRPEVADQVRSVGAQWLNIG--IDAAGEGGYARELTDEERAQQQKAL
MMAR_0377|M.marinum_M GYDVRPEVADQVRSVGAQWLNIG--IDAAGEGGYARELTDEERAQQQKAL
Mb0160|M.bovis_AF2122/97 GYDVRPEVADQVRSVGAQWLDLG--ISASGEGGYARELTDDERAQQQKAL
Rv0155|M.tuberculosis_H37Rv GYDVRPEVADQVRSVGAQWLDLG--ISASGEGGYARELTDDERAQQQKAL
MLBr_02636|M.leprae_Br4923 GYDVRPEVAEQVRSVGAQWLDVG--IEASGAGGYARELTADERAQQQKAL
MAV_5142|M.avium_104 GYDVRPEVADQVRSVGAQWLDLG--IDAAGEGGYARELTEEERAQQQKAL
TH_3398|M.thermoresistible__bu GYDVRPEVADQVRSVGAQWLDLG--IEAAGEGGYARELTEEERAQQQRAL
MAB_4579c|M.abscessus_ATCC_199 GYDVRPEVADQVRSVGAQWLDLG--IDAAGEGGYARELTDEERQKQQQAL
MSMEG_0152|M.smegmatis_MC2_155 GYDVRPEVAEQVRSVGAQWLDLG--IDAAGEGGYARELSEAERAQQQQAL
Mflv_0726|M.gilvum_PYR-GCK ATDPRPEVADQVASLGGEYLAVDPAAAEVSATGYAKEMGDDYKAREAALY
Mvan_0120|M.vanbaalenii_PYR-1 ATDPRPEVADQVRSLGGEYLSIESPEAEVSATGYAKEMGDDYKAREAQLY
. * *****:** *:*.::* : . ***:*: : ::
MUL_4735|M.ulcerans_Agy99 EAAISGFDVVITTALVPGRPAPRLVTAAAVEAMKPGSVVVDLAGETGGNC
MMAR_0377|M.marinum_M ETAISGFDVVITTALVPGRPAPRLVTAAAVEAMKPGSVVVDLAGETGGNC
Mb0160|M.bovis_AF2122/97 EEAISGFDVVITTALVPGRPAPTLVTAAAVEAMKPGSVVVDLAGETGGNC
Rv0155|M.tuberculosis_H37Rv EEAISGFDVVITTALVPGRPAPTLVTAAAVEAMKPGSVVVDLAGETGGNC
MLBr_02636|M.leprae_Br4923 EKAISGFDVVITTALVPGKPAPRLVTAAAVEAMKPGSVVVDLAGETGGNC
MAV_5142|M.avium_104 EEAIAGFDVVITTALVPGRPAPRLVTAAAVESMKPGSVVVDLAGETGGNC
TH_3398|M.thermoresistible__bu EEAIKGFDVVITTALVPGRPAPRLVTADAVRGMKPGSVVVDLAGETGGNC
MAB_4579c|M.abscessus_ATCC_199 EDAIKGFDVVITTALVPGRPAPRLVTAAAVQGMKPGSVVVDLAGETGGNC
MSMEG_0152|M.smegmatis_MC2_155 EDAITKFDIVITTALVPGRPAPRLVTAAAATGMQPGSVVVDLAGETGGNC
Mflv_0726|M.gilvum_PYR-GCK AEQCKDVDIIITTALIPGRPAPRIITAEMVASMKPGSVIVDMAAANGGNV
Mvan_0120|M.vanbaalenii_PYR-1 AQQSEDVDIIITTALIPGRPAPRIITADMVASMKSGSVIVDMAAANGGNV
.*::*****:**:*** ::** . .*:.***:**:*. .***
MUL_4735|M.ulcerans_Agy99 ELTEPGRVVVKHD-VTIASPLNLPATMPEHASELYSKNITALLDLLLT--
MMAR_0377|M.marinum_M ELTEPGRVVVKHD-VTIASPLNLPATMPEHASELYSKNITALLDLLLT--
Mb0160|M.bovis_AF2122/97 ELTEPGRTVVKHD-VTIAAPLNLPATMPEHASELYSKNITALLDLLIK--
Rv0155|M.tuberculosis_H37Rv ELTEPGRTVVKHD-VTIAAPLNLPATMPEHASELYSKNITALLDLLIK--
MLBr_02636|M.leprae_Br4923 ELTEPGQTVIKHD-VTIAAPLNLPATMPEHASELYSKNIKALLDLLIK--
MAV_5142|M.avium_104 ELTEPGKTVVKHD-VTIAAPLNLPATMPEHASELYSKNITALLDLLIK--
TH_3398|M.thermoresistible__bu ELTEPGQTVVKHG-VTIASPLNLPATMPEHASELYSKNITALLDLLIT--
MAB_4579c|M.abscessus_ATCC_199 ELTEPGQTVVKHG-VTIASPLNLPATMPEHASELYAKNITSVLELLIK--
MSMEG_0152|M.smegmatis_MC2_155 ELTEPGRTIVHHG-VTITSPLNLPATMPEHASELYAKNVTALLDLLLT--
Mflv_0726|M.gilvum_PYR-GCK EGTVKDEAVVTANGVTIIGYTDLAGRLPAQSSQLYGTNLVNLLKLLTPEK
Mvan_0120|M.vanbaalenii_PYR-1 EGTVKDQAVVTDNGVTIIGYTDLAGRLPTQASQLYGTNLVNLLKLLTPEK
* * ...:: . *** . :*.. :* ::*:**..*: :*.**
MUL_4735|M.ulcerans_Agy99 DGKLAPDFDDEVIADSCVTRGDD---------------------------
MMAR_0377|M.marinum_M DGKLAPDFDDEVIADSCVTRGDD---------------------------
Mb0160|M.bovis_AF2122/97 DGRLAPDFDDEVIAQSCVTRGKDS--------------------------
Rv0155|M.tuberculosis_H37Rv DGRLAPDFDDEVIAQSCVTRGKDS--------------------------
MLBr_02636|M.leprae_Br4923 DGKFAPDFDDEVVAESCVTRDREDSIDV----------------------
MAV_5142|M.avium_104 DGKLAPDFDDEVVAAACVTRESA---------------------------
TH_3398|M.thermoresistible__bu DGALAPDFTDEVVAEACVTRGKDA--------------------------
MAB_4579c|M.abscessus_ATCC_199 DGALAPDFDDEIVAGSCVTREVS---------------------------
MSMEG_0152|M.smegmatis_MC2_155 DDGVAPDFTDEIVAASCITRTEGDI-------------------------
Mflv_0726|M.gilvum_PYR-GCK DGQLTLDWDDVVQRSVTVVRGGEITWPPPPVQVSAAPAAAVAATPVEPKP
Mvan_0120|M.vanbaalenii_PYR-1 DGQLTVDFDDVVQRSVTVVRDGEITWPPPPVQVSAAPVAAAAA-PVEQKP
*. .: *: * : :.*
MUL_4735|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0377|M.marinum_M --------------------------------------------------
Mb0160|M.bovis_AF2122/97 --------------------------------------------------
Rv0155|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02636|M.leprae_Br4923 --------------------------------------------------
MAV_5142|M.avium_104 --------------------------------------------------
TH_3398|M.thermoresistible__bu --------------------------------------------------
MAB_4579c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0152|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0726|M.gilvum_PYR-GCK AKKPMTTARRLGVTFGVAAALLLLIALSPAALQVHLTVFALAIVIGYYVI
Mvan_0120|M.vanbaalenii_PYR-1 AKKPMTTGRRLGVTFAVAAALFVLIALSPAALQVHLTVFALAIVIGYYVI
MUL_4735|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0377|M.marinum_M --------------------------------------------------
Mb0160|M.bovis_AF2122/97 --------------------------------------------------
Rv0155|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02636|M.leprae_Br4923 --------------------------------------------------
MAV_5142|M.avium_104 --------------------------------------------------
TH_3398|M.thermoresistible__bu --------------------------------------------------
MAB_4579c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0152|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0726|M.gilvum_PYR-GCK GNVHHALHTPLMSVTNAISGIIVVGALLQIGHDLDSGGALITGLAFVAIL
Mvan_0120|M.vanbaalenii_PYR-1 GNVHHALHTPLMSVTNAISGIIVVGALLQIGH----GNIAITALAFAAIL
MUL_4735|M.ulcerans_Agy99 -----------------------
MMAR_0377|M.marinum_M -----------------------
Mb0160|M.bovis_AF2122/97 -----------------------
Rv0155|M.tuberculosis_H37Rv -----------------------
MLBr_02636|M.leprae_Br4923 -----------------------
MAV_5142|M.avium_104 -----------------------
TH_3398|M.thermoresistible__bu -----------------------
MAB_4579c|M.abscessus_ATCC_199 -----------------------
MSMEG_0152|M.smegmatis_MC2_155 -----------------------
Mflv_0726|M.gilvum_PYR-GCK LASINIFGGFAVTRRMLAMFSRS
Mvan_0120|M.vanbaalenii_PYR-1 LASINIFGGFAVTRRMLAMFSRS