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TPDSYDSIYAAKPFVSSMGSSTHDHIDVQGYDLAGELMGKVDFGSMFFVLLAGRLPSDAEAALFNAVLVA LADHGMTPSVLAARLTYTGAPEAVQGAVAAGVLGAGSTFLGVFEDSARFLVGLNAPTDADDSELDATART AAERYRRHDWRIPGFGHPVHKSGDPRTKALYRIAHEHNTVGVHFRLALHVEKYAQSRSGVPLPLNAGGAC GAILTDLGIPMTSLRGVAAVSRAAGIVGHLVEEARNPIGTALWHLAEERVQYVGRSSRKR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4035 | - | - | 100% (271) | citrate synthase |
| M. smegmatis MC2 155 | MSMEG_5676 | - | 4e-07 | 25.79% (221) | citrate synthase 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1162 | gltA1 | 2e-08 | 24.88% (205) | citrate synthase |
| M. gilvum PYR-GCK | Mflv_1726 | - | 2e-08 | 26.27% (217) | citrate synthase 2 |
| M. tuberculosis H37Rv | Rv1131 | gltA1 | 3e-08 | 24.88% (205) | citrate synthase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0932c | - | 4e-07 | 25.81% (217) | citrate synthase 2 |
| M. marinum M | MMAR_4643 | citA | 2e-07 | 26.27% (217) | citrate synthase II CitA |
| M. avium 104 | MAV_1016 | - | 4e-07 | 25.81% (217) | citrate synthase 2 |
| M. thermoresistible (build 8) | TH_3238 | - | 2e-06 | 25.35% (217) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_0259 | citA | 1e-07 | 26.27% (217) | citrate synthase 2 |
| M. vanbaalenii PYR-1 | Mvan_5025 | - | 4e-07 | 25.35% (217) | citrate synthase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1726|M.gilvum_PYR-GCK -------------------MTTSVPKDFVAGLAGVVAFETEIAEPDKDGG
Mvan_5025|M.vanbaalenii_PYR-1 --------------------MTAVSKDFVPGLAGVVAFETEIAEPDKDGG
MMAR_4643|M.marinum_M --------------------MTVVPEDFVPGLNGVVAFTTEIAEPDKDGG
MUL_0259|M.ulcerans_Agy99 --------------------------------------------------
MAV_1016|M.avium_104 --------------------MTVVPENFVPGLEGVVAFTTEIAEPDKDGG
TH_3238|M.thermoresistible__bu ----------------------LVPEDFVPGLEGVVAFTTEIAEPDKDGG
MAB_0932c|M.abscessus_ATCC_199 -----------------MTVAAPLPADFAPGLEGVTAFATEIAEPDKDGG
Mb1162|M.bovis_AF2122/97 MTGPLAAARSVAATKSMTAPTVDERPDIKKGLAGVVVDTTAISKVVPQTN
Rv1131|M.tuberculosis_H37Rv MTGPLAAARSVAATKSMTAPTVDERPDIKKGLAGVVVDTTAISKVVPQTN
MSMEG_4035|M.smegmatis_MC2_155 -----------------------MTPDSYDSIYAAKPFVSSMG--SSTHD
Mflv_1726|M.gilvum_PYR-GCK ALRYRGVDIEDLVAHRITFGDVWGLLVDGRFGDGLTPAEPFPLPIHSGDV
Mvan_5025|M.vanbaalenii_PYR-1 ALRYRGVDIQDLVSHRVTFGDVWGLLVDGRFGRGLPPAEPFPLPIHSGDV
MMAR_4643|M.marinum_M ALRYRGVDIEDLVSLRVTFGDVWALLVDGEFGRGLPPAEPFPLPIHTGDV
MUL_0259|M.ulcerans_Agy99 --------------------------------------------------
MAV_1016|M.avium_104 ALRYRGVDIEDLVSQQVTFGDVWALLVDGKFGHGLPPAEPFPLPIHTGDV
TH_3238|M.thermoresistible__bu ALRYRGVDIEDLVARRVTFADVWALLVDGRFGESLAPAEPFPLPIHSGDV
MAB_0932c|M.abscessus_ATCC_199 SLRYRGVDIEDLVAQRVTFGDVWALLVDGKFGQGLPPAEPFPIPVHTGDV
Mb1162|M.bovis_AF2122/97 SLTYRGYPVQDLAAR-CSFEQVAFLLWRGELPTDAELALFSQRERASRRV
Rv1131|M.tuberculosis_H37Rv SLTYRGYPVQDLAAR-CSFEQVAFLLWRGELPTDAELALFSQRERASRRV
MSMEG_4035|M.smegmatis_MC2_155 HIDVQGYDLAGELMGKVDFGSMFFVLLAGRLPS-----------------
Mflv_1726|M.gilvum_PYR-GCK RVDVQAGLAMLAP----------IWGYRPLLDIDDQTARDQLARASVMAL
Mvan_5025|M.vanbaalenii_PYR-1 RVDVQAGLAMLAP----------IWGYPPILDIEDETARDQLARASVMAL
MMAR_4643|M.marinum_M RVDVQAGLAMLAP----------IWGYAPLLDIDDATAREQLARASVMAL
MUL_0259|M.ulcerans_Agy99 ---------MLAP----------IWGYAPLLDIDDATAREQLARASVMAL
MAV_1016|M.avium_104 RVDVQAGLAMLAP----------IWGYKPLLDTDDATARDQLARASVMAL
TH_3238|M.thermoresistible__bu RVDVQAGLAMLAP----------IWGYQPMLDIDDETAREQLARASVMAL
MAB_0932c|M.abscessus_ATCC_199 RVDVQAGLAMLAP----------IWGFEPLLDTEDSVARSQLARASVMAL
Mb1162|M.bovis_AF2122/97 DRSMLSLLAKLPDNCHPMDVVRTAISYLGAEDPDEDDAAANRAKAMRMMA
Rv1131|M.tuberculosis_H37Rv DRSMLSLLAKLPDNCHPMDVVRTAISYLGAEDPDEDDAAANRAKAMRMMA
MSMEG_4035|M.smegmatis_MC2_155 -----------------------------------------DAEAALFNA
*.* :
Mflv_1726|M.gilvum_PYR-GCK SYVAQSARGIY-RPAVPQRQVDECDTVTARFMTRWKGE-PDPRHVEAIDA
Mvan_5025|M.vanbaalenii_PYR-1 SYVAQSARGIY-QPAVPQRTVDECDTVTARFMTRWQGE-PDPRHIEAIDA
MMAR_4643|M.marinum_M SYVAQSARGIY-QPAVPQRVIDECSTVTARFMTRWQGE-PDPRHIEAIDA
MUL_0259|M.ulcerans_Agy99 SYVAQSARGIY-QPAVPQRVNDECSTVTARFMTRWQGE-PDPRHIEAIGA
MAV_1016|M.avium_104 SYVAQSARGIY-QPAVPQRVIDECETVTARFMTRWQGE-PDPRHIEAIDA
TH_3238|M.thermoresistible__bu SYVAQSARGIY-QPAVPQRLIDECSTVTERFMTRWKGE-PDPXHVEAIDA
MAB_0932c|M.abscessus_ATCC_199 SYVAQSARGNS-LPAVPQHIVDECSTVTSRFMTRWQGD-PDPKHVEAIDA
Mb1162|M.bovis_AF2122/97 VLPTIVAIDMRRRRGLPPIAPHSGLGYAQNFLHMCFGEVPETAVVSAFEQ
Rv1131|M.tuberculosis_H37Rv VLPTIVAIDMRRRRGLPPIAPHSGLGYAQNFLHMCFGEVPETAVVSAFEQ
MSMEG_4035|M.smegmatis_MC2_155 VLVALADHGMT------PSVLAARLTYTG---------------------
: . :
Mflv_1726|M.gilvum_PYR-GCK YWVSAAEHGMNASTFTARVIASTGADVAAALSGAVGAMSGPLHGGAPARV
Mvan_5025|M.vanbaalenii_PYR-1 YWVSAAEHGMNASTFTARVIASTGADVAAALSGAIGAMSGPLHGGAPARV
MMAR_4643|M.marinum_M YWVSAAEHGMNASTFTARVIASTGADVAAALSGAIGAMSGPLHGGAPARV
MUL_0259|M.ulcerans_Agy99 YWVSAAEHGMNASTFTARVIASTGADVAAALSGAIGAMSGPLHGGAPARV
MAV_1016|M.avium_104 YWVSAAEHGMNASTFTARVIASTGADVAAALSGAIGAMSGPLHGGAPARV
TH_3238|M.thermoresistible__bu YWVSAAEHGMNASTFTARVIASTGADVAAALSGAIGAMSGPLHGGAPARV
MAB_0932c|M.abscessus_ATCC_199 YWVSAAEHGMNASTFTARVIASTGADVAASLSGAVGAMSGPLHGGAPARV
Mb1162|M.bovis_AF2122/97 SMILYAEHGFNASTFAARVVTSTQSDIYSAVTGAIGALKGRLHGGANEAV
Rv1131|M.tuberculosis_H37Rv SMILYAEHGFNASTFAARVVTSTQSDIYSAVTGAIGALKGRLHGGANEAV
MSMEG_4035|M.smegmatis_MC2_155 --------------APEAVQGAVAAGVLGAGSTFLGVFEDSARFLVGLNA
. * :. :.: .: : :*.:.. : . .
Mflv_1726|M.gilvum_PYR-GCK IPMIEEAEQTGDARAVVKGILDRNEKLMGFGHRVYRAEDPRARVLRATAE
Mvan_5025|M.vanbaalenii_PYR-1 IPMIEEAERTGDARSVVKGILDRNEKLMGFGHRVYRAEDPRARVLRATAE
MMAR_4643|M.marinum_M LPMIEQVERTGDARGLVKGILDRGEKLMGFGHRVYRAEDPRARVLRATAE
MUL_0259|M.ulcerans_Agy99 LPMIEQVELTGDARGLVKGILDRGEKLMGFGHRVYRAEDPRARVLRATAK
MAV_1016|M.avium_104 LPMIEEVERTGDARGLVKKILDSGDKLMGFGHRVYRAEDPRARVLRATAE
TH_3238|M.thermoresistible__bu LPMIEEVEKTGDARKVVTGILDRGEKLMGFGHRVYRAEDPRARVLRETAK
MAB_0932c|M.abscessus_ATCC_199 LPMIEQAEKTGDARGVIRGILDRREKLMGFGHRVYRAEDPRARVLRSTAK
Mb1162|M.bovis_AF2122/97 MHDMIEIGDPANAREWLRAKLARKEKIMGFGHRVYRHGDSRVPTMKRALE
Rv1131|M.tuberculosis_H37Rv MHDMIEIGDPANAREWLRAKLARKEKIMGFGHRVYRHGDSRVPTMKRALE
MSMEG_4035|M.smegmatis_MC2_155 PTDADDSELDATARTAAERYRRHDWRIPGFGHPVHKSGDPRTKALYRIAH
: . ** :: **** *:: *.*. .: .
Mflv_1726|M.gilvum_PYR-GCK RLAAPRFEVAAALEQAALAELRERRPDRAIETNVEFWAAVILDFAEVPPT
Mvan_5025|M.vanbaalenii_PYR-1 RLQAPRYEVAAALEQAALTELRERRPDRAIETNVEFWAAVILDFAQVPPK
MMAR_4643|M.marinum_M RLAAPRYEVAAALEQAALAELRERRPDRAIETNVEFWAAVILDFAGVPAN
MUL_0259|M.ulcerans_Agy99 RLAAPRYEVAAALEQAALAELRERRPDRAIETNVDFWAAVILDFAGVPAN
MAV_1016|M.avium_104 RLGAPRHEVAVALEQAALAELRERRPDRAIETNVEFWAAVILDFARVPAN
TH_3238|M.thermoresistible__bu RLGAPRYDVAAALEQAALTELRERRPDRAIETNVEFWAAVILDFAEVPPR
MAB_0932c|M.abscessus_ATCC_199 RLGAARYEVAAALEQAALAELRERRPDRVIETNVEFWAAVILDFAQVPTR
Mb1162|M.bovis_AF2122/97 RVGTVRDGQRWLDIYQVLAAEMASATG--ILPNLDFPTGPAYYLMGFDIA
Rv1131|M.tuberculosis_H37Rv RVGTVRDGQRWLDIYQVLAAEMASATG--ILPNLDFPTGPAYYLMGFDIA
MSMEG_4035|M.smegmatis_MC2_155 EHNTVGVHFRLALHVEKYAQS---RSGVPLPLNAGGACGAILTDLGIPMT
. : : .. : * . .
Mflv_1726|M.gilvum_PYR-GCK MMPAMFTCGRTAGWCAHILEQKR------LGKLVRPSAVYVGPAPRGPES
Mvan_5025|M.vanbaalenii_PYR-1 MMPAMFTCGRTAGWCAHILEQKR------LGKLVRPSAIYVGPEPRSPEA
MMAR_4643|M.marinum_M MMPAMFTCGRTAGWCAHILEQKR------LGKLVRPSAIYVGPAPRTPES
MUL_0259|M.ulcerans_Agy99 RMPAMFTCGRTVGWCAHILEQKR------LGKLVRPSAIYVGPAPRTPES
MAV_1016|M.avium_104 MMPAMFTCGRTAGWCAHILEQKR------LGKLVRPSAIYVGPGPRSPES
TH_3238|M.thermoresistible__bu MMPAMFTCGRTAGWCAHILEQKR------LGKLVRPSAVYVGPGPRSVES
MAB_0932c|M.abscessus_ATCC_199 MMPAMFTCARTAGWSAHIMEQKR------LGKLVRPAALYVGPGPRPIES
Mb1162|M.bovis_AF2122/97 SFTPIFVMSRITGWTAHIMEQAT------ANALIRPLSAYCGHEQRVLPG
Rv1131|M.tuberculosis_H37Rv SFTPIFVMSRITGWTAHIMEQAT------ANALIRPLSAYCGHEQRVLPG
MSMEG_4035|M.smegmatis_MC2_155 SLRGVAAVSRAAGIVGHLVEEARNPIGTALWHLAEERVQYVGRSSRKR--
: : . .* .* .*::*: * . * * *
Mflv_1726|M.gilvum_PYR-GCK VEGWD-SLTRR--
Mvan_5025|M.vanbaalenii_PYR-1 VEGWD-LLSH---
MMAR_4643|M.marinum_M VAGWDRVLTTA--
MUL_0259|M.ulcerans_Agy99 VAGWDRVLTTA--
MAV_1016|M.avium_104 VEGWDRSLTNA--
TH_3238|M.thermoresistible__bu VEGWETIARP---
MAB_0932c|M.abscessus_ATCC_199 VEGFGLLHSRVGA
Mb1162|M.bovis_AF2122/97 TF-----------
Rv1131|M.tuberculosis_H37Rv TF-----------
MSMEG_4035|M.smegmatis_MC2_155 -------------