For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. smegmatis MC2 155 MSMEG_3599 (-)

RLGTTAFAIASATALGLGLTACGAGDPAANSDTTRIGVTVYDMSSFITAGKEGMDAYAKDNNIELIWNSA
NLDVSTQASQVDSMINQGVDAIIVVPVQADSLAPQVASAKAKGIPLVPVNAALDSKDIAGNVQPDDVAAG
AQEMQMMADRLGGKGNIVILQGPLGQSGELDRSKGIEQVLAKYPDIKVLAKDTANWKRDEAVNKMKNWIS
GFGPQIDGVVAQNDDMGLGALQALKESGRTGVPIVGIDGIEDGLNAVKSGDFIGTSLQNGTVELAAGLAV
ANRLAKGEPVNKEPVYIMPAITKDNVDVAIEHVVTERQQFLDGLTELINKNLETGDIAYEGIPGQKQP*

Operon Prediction Model: Genebank

Paralogs

species	id	gene	e-value	identity (len)	annotation
M. smegmatis MC2 155	MSMEG_3599	-	-	100% (349)	sugar-binding transcriptional regulator, LacI family protein
M. smegmatis MC2 155	MSMEG_3598	-	e-170	85.96% (349)	periplasmic sugar-binding proteins
M. smegmatis MC2 155	MSMEG_3095	-	1e-31	30.88% (285)	D-ribose-binding periplasmic protein

Closest Orthologs (e-value cutoff: 1e-4)

species	id	gene	e-value	identity (len)	annotation
M. bovis AF2122 / 97	-	-	-	-	-
M. gilvum PYR-GCK	Mflv_2605	-	2e-14	26.23% (324)	periplasmic binding protein/LacI transcriptional regulator
M. tuberculosis H37Rv	-	-	-	-	-
M. leprae Br4923	MLBr_00398	-	2e-08	24.69% (324)	putative D-ribose-binding protein
M. abscessus ATCC 19977	-	-	-	-	-
M. marinum M	-	-	-	-	-
M. avium 104	-	-	-	-	-
M. thermoresistible (build 8)	-	-	-	-	-
M. ulcerans Agy99	-	-	-	-	-
M. vanbaalenii PYR-1	Mvan_5293	-	8e-22	25.15% (330)	solute-binding protein

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_3599|M.smegmatis_MC2_155      ---------MRLGTTAFAIASATALGLGLTACGAGDPAANSDTT--RIGV
Mvan_5293|M.vanbaalenii_PYR-1       ---------MKR-TSSLLFTAVVGVGLTLTACGSNSDSGSTEARSGKVGV
Mflv_2605|M.gilvum_PYR-GCK          MTFKRLAAIAGAGVLAFGVVSCSSTGGAPRESGEGGGGGTVDTPRMTIAM
MLBr_00398|M.leprae_Br4923          ---------MSTGTSVPLRVASIMLILGLLPAILPACGFSESHHKLTIGV
                                                 .     .:          .     . . .     :.:

MSMEG_3599|M.smegmatis_MC2_155      TVYDMSS---FITAGKEGMDAYAKDNNIELIWNSANLDVSTQASQVDSMI
Mvan_5293|M.vanbaalenii_PYR-1       ILPDTKSSVRWETKDRPALAAAFQNAGVDYTIQNAEGSADTMATIADGMI
Mflv_2605|M.gilvum_PYR-GCK          ITHEVPGD-SFWDLVRKGAEAAAQKDNVELRYS-NDPEAPNQANLVQAAI
MLBr_00398|M.leprae_Br4923          SYPTANSP--FWNAYTRFIDEGSHQLGVYINAVSAEEDEQKQLSDVETLI
                                          .   :            :. .:       : .  .  . .:  *

MSMEG_3599|M.smegmatis_MC2_155      NQGVDAIIVVPVQADSLAPQVASAKAKGIPLVPVN---AALDSKDIAGNV
Mvan_5293|M.vanbaalenii_PYR-1       ADGVTVLAIVNLDSDSGASIQQKAASQGVKTIDYD---RLTLGGSADVYV
Mflv_2605|M.gilvum_PYR-GCK          DSNVDGIAVTLAKPDAMQAAVKAAEAKGIPVVAFN---AGMDSWKAMG-V
MLBr_00398|M.leprae_Br4923          NQGIDGLIVTPQSTSIAPTLLRIATQANIPVVVVDRYPGYAPGQNKNADY
                                     ..:  : :.  ...   .    *   .:  :  :       . .     

MSMEG_3599|M.smegmatis_MC2_155      QPDDVAAGAQEMQMMADRLGGK-GNIVILQGPLGQSGELDRSKGIEQVLA
Mvan_5293|M.vanbaalenii_PYR-1       SFDNNVVGELQGQGLVDCLGGRPANVVFLNGSPTDNNATLFSSGAHSVVD
Mflv_2605|M.gilvum_PYR-GCK          KEYFGQDGRIAGQGVGDRLRAEGATKAVCIVQ--EQGHVDLEARCAGVRE
MLBr_00398|M.leprae_Br4923          VAFLGPNNEKAGSGIAEALMAGGGSKFLALGGMPGNSVAQGRKAGLESAL
                                           .    . : : * .  ..  .       ..             

MSMEG_3599|M.smegmatis_MC2_155      KYPDIKVLAKDTA-NWKRDEAVNKMKNWISGFGPQIDGVVAQNDDMGLGA
Mvan_5293|M.vanbaalenii_PYR-1       ATPSITIVGEQAVPDWDNDKAVTIFEQLYTAADGRVDGVYAANDGLAGSV
Mflv_2605|M.gilvum_PYR-GCK          TFPATEVLNVNGK----DMPSVESTITAKLQQDPSIDYLVALGAPFALTA
MLBr_00398|M.leprae_Br4923          TAVGHRLVQFQYAGDSEDKGLAAAENMLQAHPAGDANAIWCFNDKLCQGA
                                          ::  :          .              : : . .  :   .

MSMEG_3599|M.smegmatis_MC2_155      LQALKESGRTG-VPIVGIDGIEDGLNAVKSGDFIGTSLQNGTVELAAGLA
Mvan_5293|M.vanbaalenii_PYR-1       ISILEKNKRAGQVPVTGQDATVEGLQNILAGTQCMTVYKSATEEANALAE
Mflv_2605|M.gilvum_PYR-GCK          VQSAKNAGSTA--KIGTFDTNAALVSAIQAGDVQWAVDQQPYLQGYLAVD
MLBr_00398|M.leprae_Br4923          IKAVYNANREKEFIFGGMDLTPQAIAAIENG-LYTVSLGAHWLEGGFGLA
                                    :.   :        .   *     :  :  *    .       :      

MSMEG_3599|M.smegmatis_MC2_155      VANRLAKGEPVNKEPVYIMPAITKDNVDVAIEHVVTERQQFLDGLTELIN
Mvan_5293|M.vanbaalenii_PYR-1       VAIALANGE----QPQTTSTSRDDTGGRDVPSVLLTPKSITKDNINVVFD
Mflv_2605|M.gilvum_PYR-GCK          S------------LWLYLSNGNVIGGGQPTLTGPAFIDQSNIDAVAEYAK
MLBr_00398|M.leprae_Br4923          ILYRKIHGQ------DPAERMVKLDLLKVDKSNVAKFKARYIDNTPHYNW
                                                                              *       

MSMEG_3599|M.smegmatis_MC2_155      KNLETGDIAYEGIPGQKQP----
Mvan_5293|M.vanbaalenii_PYR-1       DGGQSKDEVCSGQFAEACSAAGV
Mflv_2605|M.gilvum_PYR-GCK          AGTR-------------------
MLBr_00398|M.leprae_Br4923          KSTTPFDMTITLN----------
                                     .