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VDVPKPESALPHLADVVPSVLAAMGVAAFETVAGIDLPSPIRGACVLLVDGLGAELLDAHAAEAPVMAGL RHRTLQVGFPATTAAGLAAIGTGCRSGEHGMVGYSFRVPGAGVINALRWRPHPWGEDLRSTVVPETVQPF PTTFERAAGAGVAVRVVSGAEFAHSGLTRAVLRGGDYVGVHAIGDLGAAVADTVAGGGFCWGYHSELDLV GHLHGPGSTAWLMQLRQVDRLVESIVETLPRDGLLAVVADHGMVTADPASVVDIDAHAPLLDGVDAIGGE PRARHVYTSDGAADAVLAAWRDSLADTAWVLSRDEAIEAGWFGGRVRDDVRGRIGDVVAAARDSAVLVRR AVEPMESSLVGHHGSLTPAEQRIPLLLATGLASE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3492 | - | - | 100% (384) | phosphodiesterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_3271 | - | 1e-154 | 71.96% (378) | type I phosphodiesterase/nucleotide pyrophosphatase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | MLBr_01572 | - | 4e-09 | 33.33% (102) | hypothetical protein MLBr_01572 |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_1855 | - | 6e-61 | 40.53% (375) | hypothetical protein MMAR_1855 |
| M. avium 104 | MAV_3712 | - | 2e-63 | 40.26% (380) | type I phosphodiesterase / nucleotide pyrophosphatase |
| M. thermoresistible (build 8) | TH_1346 | - | 1e-163 | 72.89% (380) | phosphodiesterase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2990 | - | 1e-156 | 72.49% (378) | type I phosphodiesterase/nucleotide pyrophosphatase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3271|M.gilvum_PYR-GCK MKLPRPDPAQPHLADVAPSVLAAMGVPGFE--PRIDLPFDIGG------A
Mvan_2990|M.vanbaalenii_PYR-1 MELPRPDPAAPHLADVTPSVLAAMGVTGFP--PRIPLPYDVAG------A
MSMEG_3492|M.smegmatis_MC2_155 MDVPKPESALPHLADVVPSVLAAMGVAAFETVAGIDLPSPIRG------A
TH_1346|M.thermoresistible__bu MDLPRPDPGLAHLADVVPAVLAAMGVAGFD--SRIPLRHGLAG------A
MMAR_1855|M.marinum_M --MPG------SICDVLPAAGALLGVPGTEDRLG---LIDRVG--HLDRV
MAV_3712|M.avium_104 --MPG------SLRDVLPAAAALLGVADAGHEPGGSAVTDWVGAERVDRV
MLBr_01572|M.leprae_Br4923 --------------------------------------------------
Mflv_3271|M.gilvum_PYR-GCK CVLLVDGLGAELLDRYADDAPVLAGMRG------ATLNVGFPSTTAAGLA
Mvan_2990|M.vanbaalenii_PYR-1 CVLLIDGLGAELLDAHAQDAPVLAGLRG------MTLQVGFPATTAAGLA
MSMEG_3492|M.smegmatis_MC2_155 CVLLVDGLGAELLDAHAAEAPVMAGLRH------RTLQVGFPATTAAGLA
TH_1346|M.thermoresistible__bu CVLLIDGLGAELLDTHADDAPVLAGLRG------ETLQVGFPSTTAAGLA
MMAR_1855|M.marinum_M LVVLVDGLGWHLLPELAADGALLASVLAGDAGRVSQLSCTFPSTTPTSLV
MAV_3712|M.avium_104 LVLLVDGLGWQLLAQLAGDAPLLAAVRAGEVGRLTRLDCTFPSTTPTSLV
MLBr_01572|M.leprae_Br4923 --------------------------------------------------
Mflv_3271|M.gilvum_PYR-GCK AVGTGCRSGEHGMVGMTFRLPDVG-VVNALRWRPHPWGDDLRDRVTPETV
Mvan_2990|M.vanbaalenii_PYR-1 AVGTGCRSGEHGMVGMSFRLPDVG-VINALRWRPHPWGDDLRETAVPEVV
MSMEG_3492|M.smegmatis_MC2_155 AIGTGCRSGEHGMVGYSFRVPGAG-VINALRWRPHPWGEDLRSTVVPETV
TH_1346|M.thermoresistible__bu ALGTGCHSGEHGFVGYSFRVPAAG-VINALRWRPHPWGEDLRAELPPEQV
MMAR_1855|M.marinum_M SLGTGAMPGEHGILGFTVNVPGTDRVLNHIRWRDDPP---------QGQW
MAV_3712|M.avium_104 SLATGAAPGQHGILGFTLRVPGTDRVLNHVRWRDDPA---------PDAW
MLBr_01572|M.leprae_Br4923 --------------------------------------------------
Mflv_3271|M.gilvum_PYR-GCK QPRPTLFERAAATGVAVSVISGAQFAGSGLTRAVLRGGAYVGVHTMGDLA
Mvan_2990|M.vanbaalenii_PYR-1 QPRATIFERAVSAGVAVSVISGAQFAGSGLTRAVLRGGDYVGVHALGDLA
MSMEG_3492|M.smegmatis_MC2_155 QPFPTTFERAAGAGVAVRVVSGAEFAHSGLTRAVLRGGDYVGVHAIGDLG
TH_1346|M.thermoresistible__bu QPLPTTFERAAAAGVAVSVISGAQFTGSGLTRAVLRGGRYVGVHALGDLA
MMAR_1855|M.marinum_M QPLPTWFERLTWAGISTRAVLPEWFIGSGLTAAAYRGAQFHPTRASDDYA
MAV_3712|M.avium_104 QPLPTWFERLAAAGVRARAVLPSSFLGSGLTEAAYRGARLVPAEPADDYP
MLBr_01572|M.leprae_Br4923 -----------------------------MTYAAYRDVRFVLTNMTEDYT
:* *. *. .. *
Mflv_3271|M.gilvum_PYR-GCK ATIRSVLADR--GFCYGYHADLDLVGHLHGPGSEAWRLQLRQVDRLVESI
Mvan_2990|M.vanbaalenii_PYR-1 ATIGATIAGG--GFCYGYHADLDLVGHLHGPGSQAWRLQLRQVDRMVESI
MSMEG_3492|M.smegmatis_MC2_155 AAVADTVAGG--GFCWGYHSELDLVGHLHGPGSTAWLMQLRQVDRLVESI
TH_1346|M.thermoresistible__bu ATVRQTIADG--GFCYGYHSDVDLLGHLHGPGSPAWRMQLRQVDRLVESV
MMAR_1855|M.marinum_M QLVIDEVRGAP-GLVYAYTSDLDTAAHLFGIGSSQWHEAGRSVDSLLTRL
MAV_3712|M.avium_104 RLVGDELRAGP-GLVYGYTAELDTAAHLFGIGSPQWHTAAAAVDALLSGL
MLBr_01572|M.leprae_Br4923 QQLADEVSRRDGSGLWLYITELDTAAHAFGIGSYQWHDAAAHVNGLLTHL
: : . : * :::* .* .* ** * *: :: :
Mflv_3271|M.gilvum_PYR-GCK VEGLPRGGLLAVVADHGMIALD-DNAVDLDVSAALLAGTEAIGGEVRARH
Mvan_2990|M.vanbaalenii_PYR-1 VEGLPSGGLLAVVADHGMVAVD-GDVIDIDAIGALRDGTEAIGGEVRARH
MSMEG_3492|M.smegmatis_MC2_155 VETLPRDGLLAVVADHGMVTADPASVVDIDAHAPLLDGVDAIGGEPRARH
TH_1346|M.thermoresistible__bu LDDLPSGGLLAVVADHGMVGVTDDHVIDLDAHVTLWDGVDAVAGEPRARH
MMAR_1855|M.marinum_M VEALPPDAALLVTADHGGLNVAADARVDLDTDPRLSAGIRVVAGEPRVRY
MAV_3712|M.avium_104 LEALPPNAALLVTADHGGLNVPPEARVDLDSDPRLAAGIRVVAGEPRVRY
MLBr_01572|M.leprae_Br4923 TEVLPRNAVLLVTANHGVLNVPNDSSIDVNADP--TSARRNTGGRRRAAN
: ** .. * *.*:** : :*:: . .*. *.
Mflv_3271|M.gilvum_PYR-GCK VYTHPGAVDDVLAAWQSTLGDRAWVVSRDEAIASGWFGERVADDVRSRIG
Mvan_2990|M.vanbaalenii_PYR-1 IYTRPGAASDVLAVWREILGERAWTVSGEEAVAAGWFGEHVADEVRPRIG
MSMEG_3492|M.smegmatis_MC2_155 VYTSDGAADAVLAAWRDSLADTAWVLSRDEAIEAGWFGGRVRDDVRGRIG
TH_1346|M.thermoresistible__bu VYAADGAADDVLATWRDTLGEQAWVLSREEAVTAGWFGHRVTDEVRYRIG
MMAR_1855|M.marinum_M LHTVPGATTDVLDTWRELLGTRADVRTRDDAIATGIFGS-VAPEHRLRIG
MAV_3712|M.avium_104 LHTEPGAAPDVQAAWSELLDGRAAVYSRAQAVATGMFGP-VADRHLPRLG
MLBr_01572|M.leprae_Br4923 ALPTHSTPAPQST-------------------------------------
. .:
Mflv_3271|M.gilvum_PYR-GCK DVVAAARGCAGMLRRATEPVESS-LVGQHGSLTAAEQTVPLLLAHR----
Mvan_2990|M.vanbaalenii_PYR-1 DVVAAARGSTGLLRRTTEPVESS-LVGQHGSLTDAEQRIPLLLAHR----
MSMEG_3492|M.smegmatis_MC2_155 DVVAAARDSAVLVRRAVEPMESS-LVGHHGSLTPAEQRIPLLLATGLASE
TH_1346|M.thermoresistible__bu DVVAAARGTAALVRRSAEPLESA-LIGHHGSLTTAEQRVPLLLAYG----
MMAR_1855|M.marinum_M DVVVTCADDAAVLATAHEPPETARLIGFHGAATAAEMAIPLISF------
MAV_3712|M.avium_104 DVVVVCSADTAVLASAHEPPETARLVGFHGAATPAETAIPLILFRR----
MLBr_01572|M.leprae_Br4923 --------------------------------------------------