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VDTRSMPVPEGLAGMRVDAGLSRLLGLSRTVVATLAEEGAVELDGAPAAKSDKLVAGAWLEVRLPEAPKP VENTPVDIEGMNILYSDADIVAVDKPPGVAAHATVGWHGPTVLGGLAAAGFRISTSGIHERQGIVHRLDV GTSGVMVVALSERAYTVLKRAFKQRTVEKRYHALVQGHPDPSSGTIDAPIGRHRGHDWKFAVVEGGRHSV THYDTLEMFQAASLLDIELETGRTHQIRVHFSALHHPCCGDLTYGADPTLAKRLGLERQWLHARSLAFAH PADGRRVEITSPYPDDLQNALDLLRRHAL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3175 | - | - | 100% (309) | ribosomal large subunit pseudouridine synthase D |
| M. smegmatis MC2 155 | MSMEG_1737 | - | 3e-11 | 29.09% (220) | RNA pseudouridine synthase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1567 | - | 1e-151 | 84.11% (302) | hypothetical protein Mb1567 |
| M. gilvum PYR-GCK | Mflv_3639 | - | 1e-166 | 92.13% (305) | RluA family pseudouridine synthase |
| M. tuberculosis H37Rv | Rv1540 | - | 1e-151 | 84.11% (302) | hypothetical protein Rv1540 |
| M. leprae Br4923 | MLBr_01200 | - | 1e-147 | 82.30% (305) | putative pseudouridine synthase |
| M. abscessus ATCC 19977 | MAB_2699c | - | 1e-142 | 80.53% (303) | pseudouridine synthase RluD |
| M. marinum M | MMAR_2362 | - | 1e-150 | 85.00% (300) | RluA family pseudouridine synthase |
| M. avium 104 | MAV_3230 | - | 1e-143 | 83.16% (291) | ribosomal large subunit pseudouridine synthase d |
| M. thermoresistible (build 8) | TH_1839 | - | 5e-08 | 30.08% (246) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1538 | - | 1e-151 | 83.99% (306) | RluA family pseudouridine synthase |
| M. vanbaalenii PYR-1 | Mvan_2774 | - | 1e-166 | 92.79% (305) | RluA family pseudouridine synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3639|M.gilvum_PYR-GCK -MTTRSMPVPDGLAGMRVDAGLARLLGLSRTAAAAIAEEGGVDIDGAPAA
Mvan_2774|M.vanbaalenii_PYR-1 -MTTRSMPVPEGLAGMRVDAGLARLLGLSRTAAAAIAEEGGVELDGARAA
MSMEG_3175|M.smegmatis_MC2_155 -MDTRSMPVPEGLAGMRVDAGLSRLLGLSRTVVATLAEEGAVELDGAPAA
MMAR_2362|M.marinum_M ------MPVPEGLAGMRVDAGLARLLGLSRSAVAVIAENGGVELDGVPAG
MUL_1538|M.ulcerans_Agy99 MTGDRSMPVPEGLAGMRVDAGLARLLGLSRSAVAVIAENGGVELDGVPAG
MAV_3230|M.avium_104 ---------------MRVDAGLARLLGLSRSAAAALAEDGGVELDGVPAG
Mb1567|M.bovis_AF2122/97 -MADRSMPVPDGLAGMRVDTGLARLLGLSRTAAAALAEEGAVELNGVPAG
Rv1540|M.tuberculosis_H37Rv -MADRSMPVPDGLAGMRVDTGLARLLGLSRTAAAALAEEGAVELNGVPAG
MLBr_01200|M.leprae_Br4923 -MTDRSMPIPEGLAGMRVDAGLARLLGLSRTAVAALAEDGGVELDGVQAG
MAB_2699c|M.abscessus_ATCC_199 -MTSRSLPVPDGLSGMRVDAGLARLLGLSRTAAAALAEEGAVLLDGVAVT
TH_1839|M.thermoresistible__bu -----------------VLVEFAERFG--EAAAAKVLRGEVFCADGTPVT
* . ::. :* .:..* : . . :*. .
Mflv_3639|M.gilvum_PYR-GCK KSDKLVAGAWLEVRLPPPPAPVENTPVDIEGMGILYSDDDIVAVDKPPGV
Mvan_2774|M.vanbaalenii_PYR-1 KSDKLTAGAWLEVRLPEAPAPVENTPVDIEGMGILYSDEDIVAVDKPPGV
MSMEG_3175|M.smegmatis_MC2_155 KSDKLVAGAWLEVRLPEAPKPVENTPVDIEGMNILYSDADIVAVDKPPGV
MMAR_2362|M.marinum_M KSDRLTAGAWLHVQLPEAPPPPENTPVEIEGMTILYSDDDIVAVDKPAAV
MUL_1538|M.ulcerans_Agy99 KSDRLTAGAWLHVQLPEAPPPPENTPVEIEGMTILYSDDDIVAVDKPAAV
MAV_3230|M.avium_104 KSDRLTGGAWLHVRLPEAPAPPQNTPVDIEGMTILYSDDDIVAVDKPAAV
Mb1567|M.bovis_AF2122/97 KSDRLVSGALLQVRLPEAPAPLQNTPIDIEGMTILYSDDDIVAVDKPAAV
Rv1540|M.tuberculosis_H37Rv KSDRLVSGALLQVRLPEAPAPLQNTPIDIEGMTILYSDDDIVAVDKPAAV
MLBr_01200|M.leprae_Br4923 KSDRLTSGAWLQVRLCEAPAPLENTPVDIEDMTILYSDDDIVAVDKPAAV
MAB_2699c|M.abscessus_ATCC_199 KSEKLTAGTWLEVTLPEPKAPPENRVEVIEGMKILYADDDLVAVDKPAGV
TH_1839|M.thermoresistible__bu ADTVLPPGSVVYLYR----ELPEEVPVPFD-IPILYRDENIVVVDKPHFL
. * *: : : :: :: : *** * ::*.**** :
Mflv_3639|M.gilvum_PYR-GCK AAHATVGWHGPTVLGGLAAAGFRISTSGIHERQGIVHRLDVGTSGVMVVA
Mvan_2774|M.vanbaalenii_PYR-1 AAHATVGWHGPTVLGGLAAAGFRISTSGIHERQGIVHRLDVGTSGVMVVA
MSMEG_3175|M.smegmatis_MC2_155 AAHATVGWHGPTVLGGLAAAGFRISTSGIHERQGIVHRLDVGTSGVMVVA
MMAR_2362|M.marinum_M AAHASVGWTGPTVLGGLAAAGYRISTSGVHERQGIVHRLDVGTSGVMVVA
MUL_1538|M.ulcerans_Agy99 AAHASVGWTGPTVLGGLAAAGYRISTSGVHERQGIVHRLDVGTSGVMVVA
MAV_3230|M.avium_104 AAHASVGWTGPTVLGGLAAAGYRITTSGVPERQGIVHRLDVGTSGVMVVA
Mb1567|M.bovis_AF2122/97 AAHASVGWTGPTVLGGLAAAGYRITTSGVHERQGIVHRLDVGTSGVMVVA
Rv1540|M.tuberculosis_H37Rv AAHASVGWTGPTVLGGLAAAGYRITTSGVHERQGIVHRLDVGTSGVMVVA
MLBr_01200|M.leprae_Br4923 AAHASVGWAGPTVLGGLAAAGYRITTSGVPERQGIVHRLDVGTSGVMLVA
MAB_2699c|M.abscessus_ATCC_199 AAHASVGWTGPTVLGGLAAAGFRMTTSGVPERKGIVHRLDVGTSGVMVVA
TH_1839|M.thermoresistible__bu ATTPRGRHVAQTAL-------VRLRRQLDLPELSPAHRLDRLTAGVLLFT
*: . . *.* *: . . . .**** *:**::.:
Mflv_3639|M.gilvum_PYR-GCK LSERAYTVLKRAFKQRTVEKRYHALVQGHPDPSSGTIDAPIGRHRGHDWK
Mvan_2774|M.vanbaalenii_PYR-1 LSERAYTALKRAFKQRTVEKRYHALVQGHPDPSSGTIDAPIGRHRGHDWK
MSMEG_3175|M.smegmatis_MC2_155 LSERAYTVLKRAFKQRTVEKRYHALVQGHPDPSSGTIDAPIGRHRGHDWK
MMAR_2362|M.marinum_M LSERAYTVLKRAFKQRTVDKRYHALVQGHPDPSSGTIDAPIGRHPGGEWK
MUL_1538|M.ulcerans_Agy99 LSERAYTVLKRAFKQRTVDKRYHALVQGHPDPSSGTIDAPIGRHPGGEWK
MAV_3230|M.avium_104 LSERAYTLLKRAFKQRTVDKRYHALVQGHPDPSSGTIDAPIGRHRGGEWK
Mb1567|M.bovis_AF2122/97 ISERAYTVLKRAFKYRTVDKRYHALVQGHPDPSSGTIDAPIGRHRGHEWK
Rv1540|M.tuberculosis_H37Rv ISERAYTVLKRAFKYRTVDKRYHALVQGHPDPSSGTIDAPIGRHRGHEWK
MLBr_01200|M.leprae_Br4923 ISERAYTVLKRAFKCRTVDKRYHALVQGHPDPSSGTIDAPIGRHRGHTWK
MAB_2699c|M.abscessus_ATCC_199 LSEKAYTELKRAFKYRRVEKRYHALVQGHPDPSSGTIDAPIGRHRGHDWK
TH_1839|M.thermoresistible__bu TRREVRGRYQRLFADEAVRKIYLAGAPVRPDLEFPRVVRSRIIKRRGSLQ
... :* * . * * * * . :** . : . : :
Mflv_3639|M.gilvum_PYR-GCK FAVVEDGRHSITHYDTLEAHQAASLLDIELETGRTHQIRVHFAALHHPCC
Mvan_2774|M.vanbaalenii_PYR-1 FAVVEGGRHSVTHYDTLEAHQAASLLDIELETGRTHQIRVHFAALHHPCC
MSMEG_3175|M.smegmatis_MC2_155 FAVVEGGRHSVTHYDTLEMFQAASLLDIELETGRTHQIRVHFSALHHPCC
MMAR_2362|M.marinum_M FAVTKNGRHSLTHYDTVEAFVAASLLDVHLETGRTHQIRVHFAALHHPCC
MUL_1538|M.ulcerans_Agy99 FAVTKNGRHSLTHYDTVEAFVAASLLDVHLETGRTHQIRVHFAALHHPCC
MAV_3230|M.avium_104 FAVTKDGRHSLTHYDTVEAFVAASLLDVHLETGRTHQIRVHFSALHHPCC
Mb1567|M.bovis_AF2122/97 FAITKNGRHSLTHYDTLEAFVAASLLDVHLETGRTHQIRVHFAALHHPCC
Rv1540|M.tuberculosis_H37Rv FAITKNGRHSLTHYDTLEAFVAASLLDVHLETGRTHQIRVHFAALHHPCC
MLBr_01200|M.leprae_Br4923 FAVTKDGRHSITHYDTLEAFVAASLLDVHLETGRTHQIRAHFAELHRPCC
MAB_2699c|M.abscessus_ATCC_199 FAVVEDGRHSITHYDTLEAFVAASLLDIHLETGRTHQIRVHFSAIKHPCC
TH_1839|M.thermoresistible__bu AVEEPGEPNAETLVELLDASAGR--YRLTPRTGRTHQLRVHMAVLGVPIV
. . :: * : :: . : .******:*.*:: : *
Mflv_3639|M.gilvum_PYR-GCK GDLTYGADPTLAKKLGLERQWLHARSLAFAHPADGRRVEFTSPYPADLQH
Mvan_2774|M.vanbaalenii_PYR-1 GDLTYGADPTLAKKLGLERQWLHARSLAFVHPADGRRIEITSPYPADLQH
MSMEG_3175|M.smegmatis_MC2_155 GDLTYGADPTLAKRLGLERQWLHARSLAFAHPADGRRVEITSPYPDDLQN
MMAR_2362|M.marinum_M GDLVYGADPKLAKRLGLQRQWLHARSLAFAHPADGRRVEIVSPYPPDLQH
MUL_1538|M.ulcerans_Agy99 GDLVYGADPKLAKRLGLQRQWLHARSLAFAHPADGRRVEIVSPYPPDLQH
MAV_3230|M.avium_104 GDLVYGADPKLAKKLGLQRQWLHARSLSFAHPADGRRMEIVSPYPPDLQH
Mb1567|M.bovis_AF2122/97 GDLVYGADPKLAKRLGLDRQWLHARSLAFAHPADGRRVEIVSPYPADLQH
Rv1540|M.tuberculosis_H37Rv GDLVYGADPKLAKRLGLDRQWLHARSLAFAHPADGRRVEIVSPYPADLQH
MLBr_01200|M.leprae_Br4923 GDLVYGADPKLAKRLGLERQWLHARSLSFAHPADGRRVEIVSSYPPDLQH
MAB_2699c|M.abscessus_ATCC_199 GDLTYGADPTLAAKLGLERQWLHAKSLAFAHPGDGRWIEITSEYPEDLAH
TH_1839|M.thermoresistible__bu NDPLYPEVVDVAPDDFSSPLQLLAHSVEFTDPLTGRTHRFVSARSIGGQ-
.* * :* . * *:*: *..* ** .:.* . .
Mflv_3639|M.gilvum_PYR-GCK ALDVLRRHDR-----------------------------------
Mvan_2774|M.vanbaalenii_PYR-1 ALDVLRQHDR-----------------------------------
MSMEG_3175|M.smegmatis_MC2_155 ALDLLRRHAL-----------------------------------
MMAR_2362|M.marinum_M ALDVLRDEG------------------------------------
MUL_1538|M.ulcerans_Agy99 ALDVLPRRGVSDAHSVGFRASTNTRVGWVTKRPSTWMRSCNSTSR
MAV_3230|M.avium_104 ALDVLRDEG------------------------------------
Mb1567|M.bovis_AF2122/97 ALKILRGEG------------------------------------
Rv1540|M.tuberculosis_H37Rv ALKILRGEG------------------------------------
MLBr_01200|M.leprae_Br4923 ALDVLRAES------------------------------------
MAB_2699c|M.abscessus_ATCC_199 ALDVLR---------------------------------------
TH_1839|M.thermoresistible__bu ---------------------------------------------