For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MEGTVARTASRRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARRYGARSAMPMHQ ARRLVGAPAVVLPPRGAVYGVASRRALDTVRSVVPVLEQLSFDEAFGEPSELAGAEAADVEAFCERLRAK VLEHTGLVASVGAGSGKQIAKIASGLAKPDGIRVVRREEEAVLLHGLPVRKLWGIGPVAEDRLHRIGIET IGAFAALTEAEAANVLGSTIGPALHRLARGIDDRPVAERAEAKQISAESTFPEDLTTLAQLQDAIVPIGE HAHRRLEKDGRGARTVTVKLKKSDMSTLTRSATLAYATTEASTLIGTARRLLLDPVEIGPIRLVGVGFSG LSDIRQESLFPDLEQPEEFPDAAPQVESVQTGPSSPTTQWRVGDDVAHTELGHGWVQGAGHGVMTVRFET RASGPGPARTFPEDSPEISRADPVDSLDWAEYLSSLADYQSTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3172 | - | - | 100% (463) | DNA polymerase IV |
| M. smegmatis MC2 155 | MSMEG_6443 | dinP | 1e-57 | 39.06% (361) | DNA polymerase IV |
| M. smegmatis MC2 155 | MSMEG_2294 | dinB | 1e-43 | 35.47% (344) | DNA polymerase IV |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1564 | dinX | 0.0 | 76.34% (448) | DNA polymerase IV |
| M. gilvum PYR-GCK | Mflv_3642 | - | 0.0 | 76.96% (447) | DNA polymerase IV |
| M. tuberculosis H37Rv | Rv1537 | dinX | 0.0 | 76.34% (448) | DNA polymerase IV |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2702c | - | 0.0 | 75.28% (441) | DNA polymerase IV |
| M. marinum M | MMAR_2359 | dinP_1 | 0.0 | 75.45% (448) | DNA polymerase IV, DinP_1 |
| M. avium 104 | MAV_3232 | - | 0.0 | 77.85% (456) | DNA polymerase IV |
| M. thermoresistible (build 8) | TH_0006 | dinP | 6e-45 | 37.61% (351) | POSSIBLE DNA-DAMAGE-INDUCIBLE PROTEIN P DINP (DNA POLYMERASE |
| M. ulcerans Agy99 | MUL_1535 | dinP_1 | 0.0 | 75.00% (448) | DNA polymerase IV |
| M. vanbaalenii PYR-1 | Mvan_2771 | - | 0.0 | 77.65% (452) | DNA polymerase IV |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3642|M.gilvum_PYR-GCK --------MAARWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGG----
Mvan_2771|M.vanbaalenii_PYR-1 --------MATRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGVGG----
MSMEG_3172|M.smegmatis_MC2_155 MEGTVARTASRRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGG----
Mb1564|M.bovis_AF2122/97 --------MESRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGG----
Rv1537|M.tuberculosis_H37Rv --------MESRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGG----
MMAR_2359|M.marinum_M --------MESRWVLHLDMDAFFASVEQLTRPTLMGRPVLVGGMGG----
MUL_1535|M.ulcerans_Agy99 -----MPVVESRWVLHLDMDAFFASVEQLTRPTLMGRPVLVGGMGG----
MAV_3232|M.avium_104 -------------MLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGG----
MAB_2702c|M.abscessus_ATCC_199 ------MCAAGRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGTGG----
TH_0006|M.thermoresistible__bu -------VPAMTWVLHVDLDQFLAAVELRRRPELAGTPVIVGGSGDPTEP
:**:*:* *:*:** ** * * **:*** *.
Mflv_3642|M.gilvum_PYR-GCK RGVVAGASYESRVFGARSAMPMHQARRLVGAGAVVLPPRGVVYGLASRRV
Mvan_2771|M.vanbaalenii_PYR-1 RGVVAGASYESRVFGARSAMPMLQAKRLVGAAAVVLPPRGVVYGTASRRV
MSMEG_3172|M.smegmatis_MC2_155 RGVVAGASYEARRYGARSAMPMHQARRLVGAPAVVLPPRGAVYGVASRRA
Mb1564|M.bovis_AF2122/97 RGVVAGASYEARAYGARSAMPMHQARRLIGVTAVVLPPRGVVYGIASRRV
Rv1537|M.tuberculosis_H37Rv RGVVAGASYEARAYGARSAMPMHQARRLIGVTAVVLPPRGVVYGIASRRV
MMAR_2359|M.marinum_M RGVVAGASYEARVFGARSAMPMHQARRLIGVTAVVLPPRGAVYGVASRRV
MUL_1535|M.ulcerans_Agy99 RGVVAGASYEARVFGARSAMPMHQARRLIGVTAVVLPPRGAVYGVASRRV
MAV_3232|M.avium_104 RGVVAGASYEARVFGARSAMPMHQAKRLVGVSAVVLPPRGVVYGVASRRV
MAB_2702c|M.abscessus_ATCC_199 RGVVAGASYEARVFGARSAMPMHQARRLVGINAVVLPPRGSVYGVASRRV
TH_0006|M.thermoresistible__bu RKVVTCASYEARRFGVHAGMPLRTAARKC-PDATFLPSDPQAYDAASEQV
* **: ****:* :*.::.**: * * *..**. .*. **.:.
Mflv_3642|M.gilvum_PYR-GCK FETVRARVPVLEQLSFDEAFG-------EPVALAGASAGEVADFCQALRA
Mvan_2771|M.vanbaalenii_PYR-1 FETVRTLVPVLEQLSFDEAFG-------EPTDLAGAAEPEVEAFCAELRS
MSMEG_3172|M.smegmatis_MC2_155 LDTVRSVVPVLEQLSFDEAFG-------EPSELAGAEAADVEAFCERLRA
Mb1564|M.bovis_AF2122/97 FDTVRGLVPVVEQLSFDEAFA-------EPPQLAGAVAEDVETFCERLRR
Rv1537|M.tuberculosis_H37Rv FDTVRGLVPVVEQLSFDEAFA-------EPPQLAGAVAEDVETFCERLRR
MMAR_2359|M.marinum_M FDTVRGLVPVVEQLSFDEAFG-------EPPQLGGAATAEVEQFCEDLRR
MUL_1535|M.ulcerans_Agy99 FDTVRGLVPVVEQLSFDEAFG-------EPPQLGGAATAEVEQFCEDLRR
MAV_3232|M.avium_104 FDTIRAVVPVVEQLSFDEGFG-------EPAQLAGAPAEDVEAFCEQLRR
MAB_2702c|M.abscessus_ATCC_199 FETVRSMIPILEQLSFDEAFG-------EPSELFGATTSAVADYIHELRS
TH_0006|M.thermoresistible__bu MDLLRDFGHPVEVLGWDEAFIGIGGGGTGEGVGGSAAATDPVALAEDIRA
:: :* :* *.:**.* .* :*
Mflv_3642|M.gilvum_PYR-GCK EVTAVTGLVASVGAGSGKQIAKIASGLAKPDGVTVIAHADERALLDDLPV
Mvan_2771|M.vanbaalenii_PYR-1 RVLAVTGLVASVGAGSGKQVAKIASGLAKPDGIRVIDRDEEATLLAGLPV
MSMEG_3172|M.smegmatis_MC2_155 KVLEHTGLVASVGAGSGKQIAKIASGLAKPDGIRVVRREEEAVLLHGLPV
Mb1564|M.bovis_AF2122/97 RVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVRHAEEQALLSGLPV
Rv1537|M.tuberculosis_H37Rv RVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVRHAEEQALLSGLPV
MMAR_2359|M.marinum_M RVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVARQEEQLLLGGLPV
MUL_1535|M.ulcerans_Agy99 RVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVARKEEQLLLGGLPV
MAV_3232|M.avium_104 RVREQTGLIASVGAGSGKQIAKIASGLAKPDGVRVVRRAEERELLGGLPV
MAB_2702c|M.abscessus_ATCC_199 RVLGETGLTASVGAGSGKQIAKIASGLAKPDGVRIIAPEEERTLLDELPV
TH_0006|M.thermoresistible__bu AVTAETGLSCSIGISDNKQRAKVATGFAKPAGIYRLTDANWMAVMGDRPV
* *** .*:* ...** **:*:*:*** *: : : :: **
Mflv_3642|M.gilvum_PYR-GCK RRLWGIGPVAEEKLHRLGIDTIGGFAALADTEVANILGPTVGPALHRLAR
Mvan_2771|M.vanbaalenii_PYR-1 RRLWGIGPVAEDRLHRLGIETIGALAALSEAEVANILGATVGPALHRLAR
MSMEG_3172|M.smegmatis_MC2_155 RKLWGIGPVAEDRLHRIGIETIGAFAALTEAEAANVLGSTIGPALHRLAR
Mb1564|M.bovis_AF2122/97 RRLWGIGPVAEEKLHRLGIETIGQLAALSDAEAANILGATIGPALHRLAR
Rv1537|M.tuberculosis_H37Rv RRLWGIGPVAEEKLHRLGIETIGQLAALSDAEAANILGATIGPALHRLAR
MMAR_2359|M.marinum_M RRLWGIGPVAEEKLHRLGIETVGQLAALADAEVANILGATVGPALHRLAR
MUL_1535|M.ulcerans_Agy99 RRLWGIGPVAEEKLHRLGIETVGQLAALADAEVANILGATVGPALHRLAR
MAV_3232|M.avium_104 RRLWGIGPVAEEKLHRLGIETIGELAALTDAEAANILGATIGPALHRLAR
MAB_2702c|M.abscessus_ATCC_199 RKLWGIGPVAEERLNRLGINTIGQFAALQTSEAASVLGGTIGPALHQLAR
TH_0006|M.thermoresistible__bu DALWGVGPKTAKRLATLGITTVADLEATDATVLTTTFGPSTGLWLLLLAK
***:** : .:* :** *:. : * : :. :* : * * **:
Mflv_3642|M.gilvum_PYR-GCK G-IDDRPVTENAPAKQISAESTFPEDLTTLRQLRDAAAPIGEHAHRRLLK
Mvan_2771|M.vanbaalenii_PYR-1 G-VDDRPVAENAPAKQISAESTFAQDLTTIAQLREAIGPIGDHAHKRLTK
MSMEG_3172|M.smegmatis_MC2_155 G-IDDRPVAERAEAKQISAESTFPEDLTTLAQLQDAIVPIGEHAHRRLEK
Mb1564|M.bovis_AF2122/97 G-IDDRPVVERAEAKQISAESTFAVDLTTMEQLHEAIDSIAEHAHQRLLR
Rv1537|M.tuberculosis_H37Rv G-IDDRPVVERAEAKQISAESTFAVDLTTMEQLHEAIDSIAEHAHQRLLR
MMAR_2359|M.marinum_M G-IDDRPVAERAEAKQISAESTFAIDLTTLDQLRDALDPIAEHAHQRLLR
MUL_1535|M.ulcerans_Agy99 G-IDDRPVAERAEAKQISAESTFAIDLTTLDQLRDALDPIAEHAHQRLLR
MAV_3232|M.avium_104 G-IDDRPVAERAEAKQISSESTFAADLTTLEQLREAIEPIAEHAHHRLLR
MAB_2702c|M.abscessus_ATCC_199 G-VDDRPVAERAETKQISAESTFPDDLTTLDQLRQAIEPIGVHAHRRLIK
TH_0006|M.thermoresistible__bu GGGDTEVSAEPWVPRSRSHVVTFPRDLTERAEMDAAVADLARRTVDEVVA
* * . .* .:. * **. *** :: * :. :: .:
Mflv_3642|M.gilvum_PYR-GCK DGRGARTVTVKLKKSDMSTLTRSATLPYATTDAGTLIATAHRLLLDPVDI
Mvan_2771|M.vanbaalenii_PYR-1 DGRGARTVTVKLKRSDMSTLTRSATLPYATTEATTLIGTARRLLLDPVEI
MSMEG_3172|M.smegmatis_MC2_155 DGRGARTVTVKLKKSDMSTLTRSATLAYATTEASTLIGTARRLLLDPVEI
Mb1564|M.bovis_AF2122/97 DGRGARTITVKLKKSDMSTLTRSATMPYPTTDAGALFTVARRLLPDPLQI
Rv1537|M.tuberculosis_H37Rv DGRGARTITVKLKKSDMSTLTRSATMPYPTTDAGALFTVARRLLPDPLQI
MMAR_2359|M.marinum_M DGRGSRTVTVKLKKADMSTLTRSATLPYATTDVGALLALARRLLLDPVQI
MUL_1535|M.ulcerans_Agy99 DGRGSRTVTVKLKKADMSTLTRSATLPYATTDVGALLALARRLLLDPAQI
MAV_3232|M.avium_104 DGRGARTVTVKLKKSDMSTLTRSATLPYATTEAAALVGVARRLLLDPREI
MAB_2702c|M.abscessus_ATCC_199 HGRGVRTVTVKLRRSDMSILTRSATLPYATTERAVLMSAARRLLLDPVEI
TH_0006|M.thermoresistible__bu AGRIVTRVAVTVRTDTFSTRTKIRKLPVPSTDPDLITATALAVMDLFDIE
** ::*.:: :* *: .:. .:*: : * ::
Mflv_3642|M.gilvum_PYR-GCK GPIRLVGIGFSGLSDIQQESLFPELESAT-TEELTSLGPLSSPLSSAASH
Mvan_2771|M.vanbaalenii_PYR-1 GPVRLVGVGFSGLSQVQQEPLFPDLE----TVEQTSDDAAPVTLADVAA-
MSMEG_3172|M.smegmatis_MC2_155 GPIRLVGVGFSGLSDIRQESLFPDLEQ---PEEFPDAAPQVESVQTGPSS
Mb1564|M.bovis_AF2122/97 GPIRLLGVGFSGLSDIRQESLFADSDLTQETAAAHYVETPG--AVVPAAH
Rv1537|M.tuberculosis_H37Rv GPIRLLGVGFSGLSDIRQESLFADSDLTQETAAAHYVETPG--AVVPAAH
MMAR_2359|M.marinum_M GPIRLLGVGFSGLSEVRQESLFPDLDLAAETSEEAHQDFHPSHGALSSTP
MUL_1535|M.ulcerans_Agy99 GPIRLLGVGFSGLSELRQESLFPDLDLAAETSEEAHKDFHPSHGALSSTP
MAV_3232|M.avium_104 GPIRLLGVGFSGLSEVRQESLFPDLEMPAPQSDSQSVETAA--EAMFGPG
MAB_2702c|M.abscessus_ATCC_199 GPIRLVGVGFSGFSDVQQTSLFPDLDQAEPVAESDEVPSTA-----EPTH
TH_0006|M.thermoresistible__bu RPVRLLGVRLELAMESGAQAGQAGR-------------------------
*:**:*: :. : . .
Mflv_3642|M.gilvum_PYR-GCK VEPAWRVGDDVSHTEFGHGWVQGAGHGVMTVRFETRGTGPGPARTFREDD
Mvan_2771|M.vanbaalenii_PYR-1 TAPAWRVGDDVAHTDHGHGWVQGAGHGVMTVRFETRGTGPGPARTFRADD
MSMEG_3172|M.smegmatis_MC2_155 PTTQWRVGDDVAHTELGHGWVQGAGHGVMTVRFETRASGPGPARTFPEDS
Mb1564|M.bovis_AF2122/97 DATMWRVGDDVAHPELGHGWVQGAGHGVVTVRFETRGSGPGSARTFPVDT
Rv1537|M.tuberculosis_H37Rv DATMWRVGDDVAHPELGHGWVQGAGHGVVTVRFETRGSGPGSARTFPVDT
MMAR_2359|M.marinum_M AGAVWRIGDDVTHRELGHGWVQGAGHGVVTVRFETRGSGPGPARTFPIET
MUL_1535|M.ulcerans_Agy99 AGAVWRIGDDVTHRELGHGWVQGAGHGVVTVRFETRDSGPGPARTFPIET
MAV_3232|M.avium_104 HDAGWRVGDDVAHPDLGHGWVQGAGHGVVTARFETRTSGPGPARTFPADS
MAB_2702c|M.abscessus_ATCC_199 STAGWGVGDDVDHAEFGHGWIQGTGHGVMTVRFETRSSGPGIARTFAVDD
TH_0006|M.thermoresistible__bu --------------------------------------------------
Mflv_3642|M.gilvum_PYR-GCK PALSRANPVDSLDWPDYVA----EMTRSDT----------
Mvan_2771|M.vanbaalenii_PYR-1 PALTRANPVDSLDWPDFVE----EMARHQNTP--------
MSMEG_3172|M.smegmatis_MC2_155 PEISRADPVDSLDWAEYLS----SLADYQSTP--------
Mb1564|M.bovis_AF2122/97 GDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVDDVGDR
Rv1537|M.tuberculosis_H37Rv GDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVDDVGDR
MMAR_2359|M.marinum_M SDITAANPVDSLDWPDFVGQLRVENAADTSTPAVDDLDDG
MUL_1535|M.ulcerans_Agy99 SDITAANPVDSLDWPDFVGQLRVENAADTSTPAVDDLDDG
MAV_3232|M.avium_104 AELVRANPVDSLDWPDYV-----EGLQESSAPPAENVGGR
MAB_2702c|M.abscessus_ATCC_199 PGIARADPVASLDWPGESAEPVDDGDEIGTGG--------
TH_0006|M.thermoresistible__bu ----------------------------------------