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SSENTGKSSLNSFGARDTLTVGDQSYEIYRLNAVPGTEKLPYSLKVLAENLLRTEDGANITKDHIEAIAN WDPNAEPSIEIQFTPARVIMQDFTGVPCIVDLATMREAVAALGGDPNKVNPLAPAELVIDHSVILDVFGN ASAFERNVELEYERNAERYQFLRWGQGAFDDFKVVPPGTGIVHQVNIEYLARTVMVRDGVAYPDTCVGTD SHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLSGEIKPGVTATDVVLTVTDMLRRHGVVG KFVEFYGKGVAEVPLANRATLGNMSPEFGSTAAIFPIDEETINYLRLTGRTDEQLALVEAYAKAQGMWHD PEREPVFSEYLELDLSTVVPSISGPKRPQDRIELTDAKNAFRKDIHNYVEQNHPTPETKLDEAVEESFPA SDPVSLSFADDGAPDMRPSAANGATGRPTNPVLVHSEERGDFVLDHGAVVVAGITSCTNTSNPSVMLGAA LLAKKAVEKGLTTKPWVKTNMAPGSQVVTDYYNKAGLWPYLEKLGYYLGGYGCTTCIGNTGPLPEEISKA INDNDLAVTAVLSGNRNFEGRISPDVKMNYLASPPLVIAYGIAGTMDFDFESDPLGQDSEGNDVFLRDIW PSAAEIEETIASSINREMFTESYADVFKGDDRWRSLPTPEGDTFEWDPASTYVRKAPYFDGMPAEPEPVS DIKGARVLALLGDSVTTDHISPAGAIKPGTPAAQYLDANGVERKDYNSLGSRRGNHEVMIRGTFANIRLR NQLLDDVSGGYTRDFTQPGGPQAFIYDASENYKKAGIPLVVLGGKEYGSGSSRDWAAKGTVLLGVKAVIT ESFERIHRSNLIGMGVIPLQFPAGESAASLKLDGTETYDIEGIEELNSGKTPKTVHVTATKEDGSKVEFD AVVRIDTPGEADYYRNGGILQYVLRNMLKSSK*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_3143 | acnA | - | 100% (943) | aconitate hydratase 1 |
M. smegmatis MC2 155 | MSMEG_1112 | - | 2e-25 | 32.49% (237) | aconitate hydratase |
M. smegmatis MC2 155 | MSMEG_2387 | leuC | 4e-20 | 24.38% (402) | isopropylmalate isomerase large subunit |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1511c | acn | 0.0 | 81.77% (938) | aconitate hydratase |
M. gilvum PYR-GCK | Mflv_3665 | - | 0.0 | 84.36% (946) | aconitate hydratase |
M. tuberculosis H37Rv | Rv1475c | acn | 0.0 | 81.77% (938) | aconitate hydratase |
M. leprae Br4923 | MLBr_01814 | acn | 0.0 | 77.73% (943) | aconitate hydratase |
M. abscessus ATCC 19977 | MAB_2730 | - | 0.0 | 89.24% (939) | aconitate hydratase ACN |
M. marinum M | MMAR_2282 | acn | 0.0 | 81.67% (933) | aconitate hydratase Acn |
M. avium 104 | MAV_3303 | acnA | 0.0 | 81.82% (935) | aconitate hydratase |
M. thermoresistible (build 8) | TH_0252 | acn | 0.0 | 82.49% (948) | PROBABLE IRON-REGULATED ACONITATE HYDRATASE ACN (Citrate |
M. ulcerans Agy99 | MUL_1484 | acn | 0.0 | 81.66% (938) | aconitate hydratase |
M. vanbaalenii PYR-1 | Mvan_2745 | - | 0.0 | 90.28% (957) | aconitate hydratase 1 |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_2282|M.marinum_M ---------------------------------MNSFGARNTLEVGDKSY MUL_1484|M.ulcerans_Agy99 ---------------------------MTTKDSVNSFGARNTLEVGDKSY Mb1511c|M.bovis_AF2122/97 ----------------------------MTSKSVNSFGAHDTLKVGEKSY Rv1475c|M.tuberculosis_H37Rv ----------------------------MTSKSVNSFGAHDTLKVGEKSY MLBr_01814|M.leprae_Br4923 --------------------------MISSKDSVNSFSARDTLKIGDNSY MAV_3303|M.avium_104 -----------------------------MTDSVNSFGARNTLKVGDKSY TH_0252|M.thermoresistible__bu -----------------------VSKGNTKGSSLNSFDARGTLTVGDRKF MSMEG_3143|M.smegmatis_MC2_155 -----------------------MSSENTGKSSLNSFGARDTLTVGDQSY MAB_2730|M.abscessus_ATCC_1997 MVAPPEPRLAQPAGGWPSSFGADVTSSPNKTESVNSFGARGTLQVGDESY Mvan_2745|M.vanbaalenii_PYR-1 -----------------------MSS---KNSSLNSYGAKDTLKVGDNSY Mflv_3665|M.gilvum_PYR-GCK -----------------------MSS---KNSSLNSFGAKDTLKVGDNSY :**:.*:.** :*:..: MMAR_2282|M.marinum_M QIYRLDAVPNTKKLPYSLKVLAENLLRNEDGSNITKDHIEAIANWDPQAE MUL_1484|M.ulcerans_Agy99 QIYRLDAVPNTKKLPYSLKVLAENLLRNEDGSNITKDHIEAIANWDPQAE Mb1511c|M.bovis_AF2122/97 QIYRLDAVPNTAKLPYSLKVLAENLLRNEDGSNITKDHIEAIANWDPKAE Rv1475c|M.tuberculosis_H37Rv QIYRLDAVPNTAKLPYSLKVLAENLLRNEDGSNITKDHIEAIANWDPKAE MLBr_01814|M.leprae_Br4923 QIYRLDAVSNTKRLPYSLKVLAENLLRNEDGKNITKDHIEAIANWDRQAE MAV_3303|M.avium_104 QIYRLDAVPNTEKLPYSLKVLAENLLRNEDGSNITKDHIEAIANWDPKAE TH_0252|M.thermoresistible__bu DIYRLSAVPGTDKLPYSLKVLAENLLRTEDGANITKEHIEALANWDPNAE MSMEG_3143|M.smegmatis_MC2_155 EIYRLNAVPGTEKLPYSLKVLAENLLRTEDGANITKDHIEAIANWDPNAE MAB_2730|M.abscessus_ATCC_1997 EIFRLNAVPGTEKLPYSLKVLAENLLRTEDGANITKDHVLALANWDPSAE Mvan_2745|M.vanbaalenii_PYR-1 EIYRLDAVPGTEKLPYSLKVLAENLLRTEDGANITKDHIEAIANWDPEAE Mflv_3665|M.gilvum_PYR-GCK EIYRLDAVPGTEKLPYSLKVLAENLLRTEDGANITKDHIEAIAKWDPSAD :*:**.**..* :**************.*** ****:*: *:*:** .*: MMAR_2282|M.marinum_M PSIEIQYTPARVVMQDFTGVPCIVDLATMREAIGDLGGQPDKVNPLAPAD MUL_1484|M.ulcerans_Agy99 PSIEIQYTPARVVMQDFTGVPCIVDLATMREAIGDLGGQPDKVNPLAPAD Mb1511c|M.bovis_AF2122/97 PSIEIQYTPARVVMQDFTGVPCIVDLATMREAIADLGGNPDKVNPLAPAD Rv1475c|M.tuberculosis_H37Rv PSIEIQYTPARVVMQDFTGVPCIVDLATMREAIADLGGNPDKVNPLAPAD MLBr_01814|M.leprae_Br4923 PSIEIQYTPARIVMQDFTGVPCIVDLATMREAIGDLGGNPEKVNPLARVD MAV_3303|M.avium_104 PSIEIQYTPARVVMQDFTGVPCIVDLATMREAIADLGGNPEKVNPLAPAD TH_0252|M.thermoresistible__bu PSVEIQFTPARVVMQDFTGVPCIVDLATMREAIAELGGDPEKVNPLAPAD MSMEG_3143|M.smegmatis_MC2_155 PSIEIQFTPARVIMQDFTGVPCIVDLATMREAVAALGGDPNKVNPLAPAE MAB_2730|M.abscessus_ATCC_1997 PSVEIQFTPARVVMQDFTGVPCVVDLATMREAVAALGGDPDKVNPLSPAE Mvan_2745|M.vanbaalenii_PYR-1 PSIEIQFTPARVLMQDFTGVPCIVDLATMREAVAALGGDPAKVNPLSPAE Mflv_3665|M.gilvum_PYR-GCK PSVEIQFTPARVIMQDFTGVPCIVDLATMREAVGELGGDPQQVNPLAPAD **:***:****::*********:*********:. ***:* :****: .: MMAR_2282|M.marinum_M LVIDHSVIADLFGRADAFERNVEIEYQRNGERYQFLRWGQGAFDDFKVVP MUL_1484|M.ulcerans_Agy99 LVIDHSVIADLFGRADAFERNVEIEYQRNGERYQFLRWGQGAFDDFKVVP Mb1511c|M.bovis_AF2122/97 LVIDHSVIADLFGRADAFERNVEIEYQRNGERYQFLRWGQGAFDDFKVVP Rv1475c|M.tuberculosis_H37Rv LVIDHSVIADLFGRADAFERNVEIEYQRNGERYQFLRWGQGAFDDFKVVP MLBr_01814|M.leprae_Br4923 LVIDHSVIADLFGRADAFERNVEIEYQRNGERYQFLRWGQGAFNDFKVVP MAV_3303|M.avium_104 LVIDHSVIADLFGTADAFERNVEIEYQRNGERYQFLRWGQGAFSDFKVVP TH_0252|M.thermoresistible__bu LVIDHSVIADLFGRPDAFERNVEIEYQRNGERYQFLRWGQGAFNDFKVVP MSMEG_3143|M.smegmatis_MC2_155 LVIDHSVILDVFGNASAFERNVELEYERNAERYQFLRWGQGAFDDFKVVP MAB_2730|M.abscessus_ATCC_1997 MVIDHSVILDVFGTADAFERNVELEYERNAERYQFLRWGQGAFDDFKVVP Mvan_2745|M.vanbaalenii_PYR-1 MVIDHSVILDVFGRADAFERNVELEYERNGERYQFLRWGQGAFDDFKVVP Mflv_3665|M.gilvum_PYR-GCK LVIDHSVIADLFGRADAFERNVEIEYERNGERYQFLRWGQGAFDDFKVVP :******* *:** ..*******:**:**.*************.****** MMAR_2282|M.marinum_M PGTGIVHQVNIEYLASVVMDRDG-----------VAYPDTCVGTDSHTTM MUL_1484|M.ulcerans_Agy99 PGTGIVHQVNIEYLASVVMDRDG-----------VAYPDTCVGTDSHTTM Mb1511c|M.bovis_AF2122/97 PGTGIVHQVNIEYLASVVMTRDG-----------VAYPDTCVGTDSHTTM Rv1475c|M.tuberculosis_H37Rv PGTGIVHQVNIEYLASVVMTRDG-----------VAYPDTCVGTDSHTTM MLBr_01814|M.leprae_Br4923 PGTGIVHQVNIEYLASVVMTQENTQG------TVVAYPDTCVGTDSHTTM MAV_3303|M.avium_104 PGTGIVHQVNIEYLARVVMERDG-----------VAYPDTCVGTDSHTTM TH_0252|M.thermoresistible__bu PGTGIVHQVNIEYLASVVMDRDG-----------VAYPDTCVGTDSHTTM MSMEG_3143|M.smegmatis_MC2_155 PGTGIVHQVNIEYLARTVMVRD-----------GVAYPDTCVGTDSHTTM MAB_2730|M.abscessus_ATCC_1997 PGTGIVHQVNIEYLARTVMVRN-----------GQAYPDTCVGTDSHTTM Mvan_2745|M.vanbaalenii_PYR-1 PGTGIVHQVNIEYLARVVMVRDRAGEAGEGDSISVAYPDTCVGTDSHTTM Mflv_3665|M.gilvum_PYR-GCK PGTGIVHQVNIEYLASVVMARSDAEG------NTVAYPDTCVGTDSHTTM *************** .** :. *************** MMAR_2282|M.marinum_M VNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLTGEIQPGVTATDV MUL_1484|M.ulcerans_Agy99 VNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLTGEIQPGVTATDV Mb1511c|M.bovis_AF2122/97 VNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFRLTGEIQPGVTATDV Rv1475c|M.tuberculosis_H37Rv VNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFRLTGEIQPGVTATDV MLBr_01814|M.leprae_Br4923 VNGLGVLGWGVGGIEAEAAMLGQPVSMLIPWVVGFKLSGEIQPGVTATDV MAV_3303|M.avium_104 VNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLTGEIQPGVTATDV TH_0252|M.thermoresistible__bu VNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLTGERQPGVTATDI MSMEG_3143|M.smegmatis_MC2_155 VNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLSGEIKPGVTATDV MAB_2730|M.abscessus_ATCC_1997 VNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLTGEIQPGVTATDV Mvan_2745|M.vanbaalenii_PYR-1 ENGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLTGEIKPGVTATDV Mflv_3665|M.gilvum_PYR-GCK ENGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKITGERRPGVTATDV ***************************** ****:::** :*******: MMAR_2282|M.marinum_M VLTVTEMLRKHGVVGKFVEFYGEGVAEVPLANRATLGNMSPEFGSTAAIF MUL_1484|M.ulcerans_Agy99 VLTVTEMLRKHGVVGKFVEFYGEGVAEVPLANRATLGNMSPEFGSTAAIF Mb1511c|M.bovis_AF2122/97 VLTVTEMLRQHGVVGKFVEFYGEGVAEVPLANRATLGNMSPEFGSTAAIF Rv1475c|M.tuberculosis_H37Rv VLTVTEMLRQHGVVGKFVEFYGEGVAEVPLANRATLGNMSPEFGSTAAIF MLBr_01814|M.leprae_Br4923 VLTVTEMLRRHGVVGKFVEFYGEGVAEVPLANRATLGNMSPEFGSTAAIF MAV_3303|M.avium_104 VLTVTEMLRKHGVVGKFVEFYGEGVAEVPLANRATLGNMSPEFGSTAAIF TH_0252|M.thermoresistible__bu VLTVTEMLREHGVVGKFVEFYGEGVAAVPLANRATLGNMSPEFGSTAAIF MSMEG_3143|M.smegmatis_MC2_155 VLTVTDMLRRHGVVGKFVEFYGKGVAEVPLANRATLGNMSPEFGSTAAIF MAB_2730|M.abscessus_ATCC_1997 VLTVTDMLRKHGVVGKFVEFYGKGVAEVPLANRATLGNMSPEFGSTAAIF Mvan_2745|M.vanbaalenii_PYR-1 VLTVTDMLRKHGVVGKFVEFYGNGVAEVPLANRATLGNMSPEFGSTAAMF Mflv_3665|M.gilvum_PYR-GCK VLTVTEMLRQHGVVGKFVEFYGDGVDEVPLANRATLGNMSPEFGSTAAIF *****:***.************.** *********************:* MMAR_2282|M.marinum_M PIDEETIKYLELTGRSAEQVALVAAYAKEQGMWHDPKHEPVLSEYLELNL MUL_1484|M.ulcerans_Agy99 PIDEETIKYLELTGRSAEQVALVAAYAKEQGMWHDPKHEPVFSEYLELNL Mb1511c|M.bovis_AF2122/97 PIDEETIKYLRFTGRTPEQVALVEAYAKAQGMWHDPKHEPEFSEYLELNL Rv1475c|M.tuberculosis_H37Rv PIDEETIKYLRFTGRTPEQVALVEAYAKAQGMWHDPKHEPEFSEYLELNL MLBr_01814|M.leprae_Br4923 PIDEETINYLRFTGRTPEQVALVEGYAKEQGMWHDPKNEPTFSEYLELNL MAV_3303|M.avium_104 PIDQETIDYLKFTGRNAEQVALVETYAKEQGLWHDPAHEPAFSEYLELDL TH_0252|M.thermoresistible__bu PIDEETISYLRFTGRSEEQLALVEAYAKEQGLWHDPQRQPQYSEYLELDL MSMEG_3143|M.smegmatis_MC2_155 PIDEETINYLRLTGRTDEQLALVEAYAKAQGMWHDPEREPVFSEYLELDL MAB_2730|M.abscessus_ATCC_1997 PIDDETINYLRLTGRDEAQLALVEAYAREQGMWHDADHEPAFSEYLELDL Mvan_2745|M.vanbaalenii_PYR-1 PIDEETINYLRLTGRTDEQLALVEAYAKEQGMWHDPAKEPVFSEYLELDL Mflv_3665|M.gilvum_PYR-GCK PIDDVTIEYLRLTGRSEEQLALVEAYAKEQGMWHDPSREPKFSEYLELDL ***: **.**.:*** *:*** **: **:***. .:* ******:* MMAR_2282|M.marinum_M SDVVPSIAGPKRPQDRIVLSEAKGTFREQITHYVSDDS--SAHDQHSKLD MUL_1484|M.ulcerans_Agy99 SDVVPSIAGPKRPQDRIVLAEAKGTFREQITHYVSDDS--SAHDQHSKLD Mb1511c|M.bovis_AF2122/97 SDVVPSIAGPKRPQDRIALAQAKSTFREQIYHYVGNGSPDSPHDPHSKLD Rv1475c|M.tuberculosis_H37Rv SDVVPSIAGPKRPQDRIALAQAKSTFREQIYHYVGNGSPDSPHDPHSKLD MLBr_01814|M.leprae_Br4923 SDVVPSISGPKRPQDRICLAQAKSTFRAQIPKYVDGSS---LHNQHSKLD MAV_3303|M.avium_104 SQVVPSIAGPKRPQDRIALSQAKSVFREQIPSYVGDGD---GQQGYSKLD TH_0252|M.thermoresistible__bu STVVPSIAGPKRPQDRISLNEAKSAFRRDLADYVDDGE---HSTEYTKLD MSMEG_3143|M.smegmatis_MC2_155 STVVPSISGPKRPQDRIELTDAKNAFRKDIHNYVEQNH----PTPETKLD MAB_2730|M.abscessus_ATCC_1997 STVVPSISGPKRPQDRIELSDAKNAFRKDIHNYVEENH----PAPHTNLD Mvan_2745|M.vanbaalenii_PYR-1 STVVPSIAGPKRPQDRIELTDAKNAFRKDIHNYVEENH----PTPETKLD Mflv_3665|M.gilvum_PYR-GCK ADVVPSIAGPKRPQDRIALDDAKNAFRKDIHNYVENNH----PAPETKLD : *****:********* * :**..** :: ** . ::** MMAR_2282|M.marinum_M EVVEETFPASDPGQLTFANDDVA---AVHSAAAHADGRVSKPVRVRSDEL MUL_1484|M.ulcerans_Agy99 EVVEETFPASDPGQLTFANDDVA---AVHSAAAHADGRVSKPVRVRSDEL Mb1511c|M.bovis_AF2122/97 EVVEETFPASDPGQLTFANDDVATDETVHSAAAHADGRVSNPVRVKSDEL Rv1475c|M.tuberculosis_H37Rv EVVEETFPASDPGQLTFANDDVATDETVHSAAAHADGRVSNPVRVKSDEL MLBr_01814|M.leprae_Br4923 EVVEETCPASDPGKLSFTNNDEV---VMQSAAAHANGRVSNPVRIKTQEL MAV_3303|M.avium_104 EVVDETFPASDPGAPSNGHADDLP--AVQSAAAHANGRPSNPVTVRSDEL TH_0252|M.thermoresistible__bu EAVDETFPASDPVRNTEFADNGTP-AHVHSAAVEPTGRPTKRVRVKSDEL MSMEG_3143|M.smegmatis_MC2_155 EAVEESFPASDPVSLSFADDGAPD--MRPSAANGATGRPTNPVLVHSEER MAB_2730|M.abscessus_ATCC_1997 EAVEESFPASDSAVLSFAEDDA----VIPSAANGGEGRPSKPVKVTSAER Mvan_2745|M.vanbaalenii_PYR-1 EAVEESFPASDSVSLSFADDGAVD--ARPSAANGATGRPSKPVTVKSAER Mflv_3665|M.gilvum_PYR-GCK DTIDDTFPASDPATLQFADDGAV---NMHSAANGADGRPTKPVTVKSDEH :.:::: ****. . *** ** :: * : : * MMAR_2282|M.marinum_M GEFVLDHGAVVIAAITSCTNTSNPEVMLGAALLARNAVDKGLTSKPWVKT MUL_1484|M.ulcerans_Agy99 GEFVLDHGAVVIAAITSCTNTSNPEVMLGAALLARNAVDKGLTSKPWVKT Mb1511c|M.bovis_AF2122/97 GEFVLDHGAVVIAAITSCTNTSNPEVMLGAALLARNAVEKGLTSKPWVKT Rv1475c|M.tuberculosis_H37Rv GEFVLDHGAVVIAAITSCTNTSNPEVMLGAALLARNAVEKGLTSKPWVKT MLBr_01814|M.leprae_Br4923 GEFVLDHGAVVIAAITSCTNTSNPEVMLCAALLARNAVEKGLASKPWVKT MAV_3303|M.avium_104 GEFVLDHGAVVIAAVTSCTNTSNPEVMLGAALLARNAVEKGLASKPWVKT TH_0252|M.thermoresistible__bu GEFELDHGAVVIAAITSCTNTSNPEVMLGAALLAKNAVDKGLATKPWVKT MSMEG_3143|M.smegmatis_MC2_155 GDFVLDHGAVVVAGITSCTNTSNPSVMLGAALLAKKAVEKGLTTKPWVKT MAB_2730|M.abscessus_ATCC_1997 GNFVLDHGAVVVAGITSCTNTSNPSVMLGAALLAKKAVEKGLTTKPWVKT Mvan_2745|M.vanbaalenii_PYR-1 GEFVLDHGAVVVAGITSCTNTSNPSVMLGAALLAKKAVEKGLSTKPWVKT Mflv_3665|M.gilvum_PYR-GCK GEFVLDHGAVVIAAITSCTNTSNPEVMIGAALLAKNAVDKGLARKPWVKT *:* *******:*.:*********.**: *****::**:***: ****** MMAR_2282|M.marinum_M TMAPGSQVVNDYYDKAGLWPYLEKLGFYLVGYGCTTCIGNSGPLPEDISK MUL_1484|M.ulcerans_Agy99 TMAPGSQVVNDYYDKAGLWPYLEKLGFFLVGYGCTTCIGNSGPLPEEISK Mb1511c|M.bovis_AF2122/97 TIAPGSQVVNDYYDRSGLWPYLEKLGFYLVGYGCTTCIGNSGPLPEEISK Rv1475c|M.tuberculosis_H37Rv TIAPGSQVVNDYYDRSGLWPYLEKLGFYLVGYGCTTCIGNSGPLPEEISK MLBr_01814|M.leprae_Br4923 TMAPGSQVVNDYYDRSGLWPYLEKLGFYLVGYGCTTCIGNSGPLPEEISK MAV_3303|M.avium_104 TMAPGSQVVHDYYDKAGLWPYLEKLGFYLVGYGCTTCIGNSGPLPEEISK TH_0252|M.thermoresistible__bu TMAPGSQVVSDYYEKAGLWPYLEKLGFYLVGYGCTTCIGNSGPLPDEISK MSMEG_3143|M.smegmatis_MC2_155 NMAPGSQVVTDYYNKAGLWPYLEKLGYYLGGYGCTTCIGNTGPLPEEISK MAB_2730|M.abscessus_ATCC_1997 NMAPGSQVVTDYYNKAGLWPYLEKLGYYLGGYGCTTCIGNTGPLPDEISK Mvan_2745|M.vanbaalenii_PYR-1 NMAPGSQVVTDYYNKAGLWPYLEKLGYYLGGYGCTTCIGNTGPLPDEISA Mflv_3665|M.gilvum_PYR-GCK TMAPGSQVVTDYYNKAGLWPYLEKLGFFLVGYGCTTCIGNSGPLPEEVSK .:******* ***:::**********::* **********:****:::* MMAR_2282|M.marinum_M AVNDNDLSVAAVLSGNRNFEGRINPDVKMNYLASPPLVVAYALAGTMDFD MUL_1484|M.ulcerans_Agy99 AVNDNDLSVAAVLSGNRNFEGRINPDVKMNYLASPPLVVAYALAGTMDFD Mb1511c|M.bovis_AF2122/97 AVNDNDLSVTAVLSGNRNFEGRINPDVKMNYLASPPLVIAYALAGTMDFD Rv1475c|M.tuberculosis_H37Rv AVNDNDLSVTAVLSGNRNFEGRINPDVKMNYLASPPLVIAYALAGTMDFD MLBr_01814|M.leprae_Br4923 AINYNNLSVTAVLSGNRNFEGRINPDVKMNYLASPPLVIAYALAGTMDFD MAV_3303|M.avium_104 AINDNDLSVTAVLSGNRNFEGRINPDVKMNYLASPPLVVAYALAGTMDFD TH_0252|M.thermoresistible__bu AINDNDLSVAAVLSGNRNFEGRINPDTKMNYLASPPLVIAYALAGTMDFD MSMEG_3143|M.smegmatis_MC2_155 AINDNDLAVTAVLSGNRNFEGRISPDVKMNYLASPPLVIAYGIAGTMDFD MAB_2730|M.abscessus_ATCC_1997 AINDNDLSVTAVLSGNRNFEGRISPDVKMNYLASPPLVIAYGIAGTMDFD Mvan_2745|M.vanbaalenii_PYR-1 AINDNDLSVTAVLSGNRNFEGRISPDVKMNYLASPPLVIAYGLAGTMDFD Mflv_3665|M.gilvum_PYR-GCK AINDNDLSVTAVLSGNRNFEGRINPDVKMNYLASPPLVIAYALAGSMDFD *:* *:*:*:*************.**.***********:**.:**:**** MMAR_2282|M.marinum_M FENQPLGTDKEGKDVFLRDIWPSQQDVADTIASAINQEMFTKNYADVFKG MUL_1484|M.ulcerans_Agy99 FENQPLGTDKEGKDVFLRDIWPSQQDVADTIASAINQEMFTKNYADVFKG Mb1511c|M.bovis_AF2122/97 FQTQPLGQDKDGKNVFLRDIWPSQQDVSDTIAAAINQEMFTRNYADVFKG Rv1475c|M.tuberculosis_H37Rv FQTQPLGQDKDGKNVFLRDIWPSQQDVSDTIAAAINQEMFTRNYADVFKG MLBr_01814|M.leprae_Br4923 FESQPLDTDKNGKAVYLKDIWPSQKDVTDTIASAINQEMFTKNYADVFKG MAV_3303|M.avium_104 FEKQPLGKDKDGNDVYLKDIWPSQKDVSDTIASAINSEMFTKNYADVFKG TH_0252|M.thermoresistible__bu FESQPLGKDSDGNDVFLRDIWPSQQEIEDTIRSAISQEMFTKNYADVFKG MSMEG_3143|M.smegmatis_MC2_155 FESDPLGQDSEGNDVFLRDIWPSAAEIEETIASSINREMFTESYADVFKG MAB_2730|M.abscessus_ATCC_1997 FETDPLGKDHDGNDVFLKDIWPSASEIEETIASSINREMFTSSYADVFKG Mvan_2745|M.vanbaalenii_PYR-1 FEADPLGQDGDGNDVFLKDIWPSAAEIQETITSSINREMFADSYADVFKG Mflv_3665|M.gilvum_PYR-GCK FESDSLGNDSDGNPVFLKDIWPSQKDISDTIAEAISQEMFTKNYADVFKG *: :.*. * :*: *:*:***** :: :** :*. ***: .******* MMAR_2282|M.marinum_M DERWRNLPTPSGNTFDWDQSSTYVRKPPYFEGMAAAPTPVSDITGARVLA MUL_1484|M.ulcerans_Agy99 DERWRNLPTPSGNTFDWDQSSTYVRKPPYFEGMAAAPAPVSDITGARVLA Mb1511c|M.bovis_AF2122/97 DDRWRNLPTPSGNTFEWDPNSTYVRKPPYFEGMTAKPEPVGNISGARVLA Rv1475c|M.tuberculosis_H37Rv DDRWRNLPTPSGNTFEWDPNSTYVRKPPYFEGMTAKPEPVGNISGARVLA MLBr_01814|M.leprae_Br4923 DERWRNLPTPSGNTFDWEQNSTYVRKPPYFEGMSVEPKPVRNITGARVLA MAV_3303|M.avium_104 DERWRNLPTPSGNTFEWSPDSTYVRKPPYFEGMPAEPEPVADISGARVLA TH_0252|M.thermoresistible__bu DERWRSLPTPSGSTFQWDPESTYVRKPPYFEGMSAEPAPVSDITGARVLA MSMEG_3143|M.smegmatis_MC2_155 DDRWRSLPTPEGDTFEWDPASTYVRKAPYFDGMPAEPEPVSDIKGARVLA MAB_2730|M.abscessus_ATCC_1997 DERWRGLPTPEGNTFAWSDDSTYVRKAPYFDGMPLEPTPVTDIKGARVLA Mvan_2745|M.vanbaalenii_PYR-1 DERWRSLPTPEGNTFEWDEDSTYVRKAPYFDGMPAEPEPVKDIKGARVLA Mflv_3665|M.gilvum_PYR-GCK DERWRNLPTPSGNTFEWDQDSTYVRKPPYFEGMPAEPQPVTDISGARVLA *:***.****.*.** *. ******.***:**. * ** :*.****** MMAR_2282|M.marinum_M LLGDSVTTDHISPAGAIKPGTPAAQYLDEHGVARKDYNSFGSRRGNHEVM MUL_1484|M.ulcerans_Agy99 LLGDSVTTDHISPAGAIKPGTPAAQYLDEHGVARKDYNSFGSRRGNHEVM Mb1511c|M.bovis_AF2122/97 LLGDSVTTDHISPAGAIKPGTPAARYLDEHGVDRKDYNSFGSRRGNHEVM Rv1475c|M.tuberculosis_H37Rv LLGDSVTTDHISPAGAIKPGTPAARYLDEHGVDRKDYNSFGSRRGNHEVM MLBr_01814|M.leprae_Br4923 LLDDSVTTDHISPASTIKPGTPAAQYLDTHGVDRKDYNSFGSRRGNHEVM MAV_3303|M.avium_104 LLGDSVTTDHISPAGSIKPGTPAAQYLDEHGVDRKDYNSFGSRRGNHEVM TH_0252|M.thermoresistible__bu LLGDSVTTDHISPAGTIQPGTPAAQYLESHGVQRKDYNSYGSRRGNHEVM MSMEG_3143|M.smegmatis_MC2_155 LLGDSVTTDHISPAGAIKPGTPAAQYLDANGVERKDYNSLGSRRGNHEVM MAB_2730|M.abscessus_ATCC_1997 LLGDSVTTDHISPAGSIKSGTPAAQYLDEHGVERKDYNSLGSRRGNHEVM Mvan_2745|M.vanbaalenii_PYR-1 LLGDSVTTDHISPAGSIKKGTPAAQYLEEHGVEPKDFNSLGSRRGNHEVM Mflv_3665|M.gilvum_PYR-GCK LLGDSVTTDHISPAGAIKPGTPAAEYLESHGVERKDYNSYGSRRGNHEVM **.***********.:*: *****.**: :** **:** ********** MMAR_2282|M.marinum_M IRGTFANIRLRNQLLD-----DVSGGYTRDFTQDGAPQAFIYDAAQNYAA MUL_1484|M.ulcerans_Agy99 IRGTFANIRLRNQLLD-----DVSGGYTRDFTQDGAPQAFIYDAAQNYAA Mb1511c|M.bovis_AF2122/97 IRGTFANIRLRNQLLD-----DVSGGYTRDFTQPGGPQAFIYDAAQNYAA Rv1475c|M.tuberculosis_H37Rv IRGTFANIRLRNQLLD-----DVSGGYTRDFTQPGGPQAFIYDAAQNYAA MLBr_01814|M.leprae_Br4923 IRGTFANIRLRNMLLN-----GVAGGYTRDFTKPGAPQAFIYDAAQNYAA MAV_3303|M.avium_104 IRGTFANIRLRNLLLD-----DVAGGYTRDFTQDGGPQAFIYDAAQNYAA TH_0252|M.thermoresistible__bu IRGTFANIRLRNRLLDAIVEGGVSGGYTRDFTK-GGEQAFIYDAAQNYAA MSMEG_3143|M.smegmatis_MC2_155 IRGTFANIRLRNQLLD-----DVSGGYTRDFTQPGGPQAFIYDASENYKK MAB_2730|M.abscessus_ATCC_1997 VRGTFANIRLRNQLLD-----DVSGGYTRDFTQDGGPQSFIYDASVNYQK Mvan_2745|M.vanbaalenii_PYR-1 IRGTFANIRLRNQLLD-----DVSGGYTRDFTQDGGPQAFIYDAAQNYAK Mflv_3665|M.gilvum_PYR-GCK IRGTFANIRLKNQLLD-----DVSGGYTRDFTKEG-EQAFIYDAAQNYAE :*********:* **: .*:********: * *:*****: ** MMAR_2282|M.marinum_M QNIPLVVLGGKEYGSGSSRDWAAKGTLLLGVRVVIAESFERIHRSNLIGM MUL_1484|M.ulcerans_Agy99 QNIPLVVLGGKEYGSGSSRDWAAKGTLLLGVRVVIAESFERIHRSNLIGM Mb1511c|M.bovis_AF2122/97 QHIPLVVFGGKEYGSGSSRDWAAKGTLLLGVRAVIAESFERIHRSNLIGM Rv1475c|M.tuberculosis_H37Rv QHIPLVVFGGKEYGSGSSRDWAAKGTLLLGVRAVIAESFERIHRSNLIGM MLBr_01814|M.leprae_Br4923 ENIPLVVLSGKEYGSGSSRDWAAKGTLLLGVRAVIAESFERIHRSNLIGM MAV_3303|M.avium_104 QNIPLVVLGGKEYGSGSSRDWAAKGTRLLGVRAVIAESFERIHRSNLIGM TH_0252|M.thermoresistible__bu QNIPLVVLGGKEYGSGSSRDWAAKGTALLGVKAVITESFERIHRSNLIGM MSMEG_3143|M.smegmatis_MC2_155 AGIPLVVLGGKEYGSGSSRDWAAKGTVLLGVKAVITESFERIHRSNLIGM MAB_2730|M.abscessus_ATCC_1997 AGIPLVVLGGKEYGSGSSRDWAAKGTRLLGVKAVITESFERIHRSNLIGM Mvan_2745|M.vanbaalenii_PYR-1 EGIPLVVLGGKEYGSGSSRDWAAKGTTLLGVRAVITESFERIHRSNLIGM Mflv_3665|M.gilvum_PYR-GCK QNIPLVVLGGKEYGSGSSRDWAAKGTSLLGVRAVITESFERIHRSNLIGM *****:.***************** ****:.**:************** MMAR_2282|M.marinum_M GVIPLQFPKGQSASSLGLDGTETFDVTGIEELNSGKTPKTVHVKATK--D MUL_1484|M.ulcerans_Agy99 GVIPLQFPTGQSASSLGLDGTETFDVTGIEELNSGKTPKTVHVKATK--D Mb1511c|M.bovis_AF2122/97 GVIPLQFPEGKSASSLGLDGTEVFDITGIDVLNDGKTPKTVCVQATK--G Rv1475c|M.tuberculosis_H37Rv GVIPLQFPEGKSASSLGLDGTEVFDITGIDVLNDGKTPKTVCVQATK--G MLBr_01814|M.leprae_Br4923 GVIPLQFPQGESASSLGLDGTEVFEINGIDVFNNGKTPKTVHVKASK--A MAV_3303|M.avium_104 GVIPLQFPDGKSAKDLGLDGTEVFDITGIEELNKGKTPKTVHVKASK--N TH_0252|M.thermoresistible__bu GVLPLQFPQGQSAASLGLDGTETFDITGIEALNEGRTPKTVKVTATK--E MSMEG_3143|M.smegmatis_MC2_155 GVIPLQFPAGESAASLKLDGTETYDIEGIEELNSGKTPKTVHVTATK--E MAB_2730|M.abscessus_ATCC_1997 GVVPLQFPAGESAASLKLDGTETYDISGIEKLNEGSTPKTVQVTATR--E Mvan_2745|M.vanbaalenii_PYR-1 GVIPLQFPKGESAASLKLDGTETFDIEGIEALNEGKTPKTVKVTAKKIAE Mflv_3665|M.gilvum_PYR-GCK GVIPLQFPEGESAASLKLDGTETFDITGIEELNNGKTPKTVKVTATK--P **:***** *:** .* *****.::: **: :*.* ***** * *.: MMAR_2282|M.marinum_M GA---DPIEFDAVVRIDTPGEADYYRNGGILQYVLRNMLKSG- MUL_1484|M.ulcerans_Agy99 GA---DPIEFDAVVRIDTPGEADYYRNGGILQYVLRNMLKSG- Mb1511c|M.bovis_AF2122/97 DG---ATIEFDAVVRIDTPGEADYYRNGGILQYVLRNILKSG- Rv1475c|M.tuberculosis_H37Rv DG---ATIEFDAVVRIDTPGEADYYRNGGILQYVLRNILKSG- MLBr_01814|M.leprae_Br4923 SG---TTVTFDALVRIDTPGEADYYRNGGILHYVLRNILKSN- MAV_3303|M.avium_104 GS---DAVEFDAVVRIDTPGEADYYRNGGILQYVLRNMLKSG- TH_0252|M.thermoresistible__bu DG---SKVEFDAVVRIDTPGEADYYRNGGILHYVLRNMLESK- MSMEG_3143|M.smegmatis_MC2_155 DG---SKVEFDAVVRIDTPGEADYYRNGGILQYVLRNMLKSSK MAB_2730|M.abscessus_ATCC_1997 NG---ETVQFDAVVRIDTPGEADYYRNGGILQYVLRNMLAG-- Mvan_2745|M.vanbaalenii_PYR-1 DGTVSSAVEFDAVVRIDTPGEADYYRNGGILQYVLRNMLKS-- Mflv_3665|M.gilvum_PYR-GCK DG---GKVEFDAVVRIDTPGEADYYRNGGILQYVLRNMLKS-- .. : ***:******************:*****:* .