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MSAERRLSLNTMTTKRLTLREAVEATAAAGLESIGLWRDRVAEAGVDTAAKLMHDNGLRVSSLCRGGFLT GFEEDHALADNRRAIEEAVTLGTRELVMVVGGIPDRDLAAARGRVAQRLETLVPYAVDHGVRLALEPLHP VFCADRAVISTLGQALALAAPYPAEAVGVVVDTFHVWWDPELADGIAAAGAQHRISSYQVCDWLVPMAAD PLVSRGMMGDGVIDFGAVTAMVRAAGYDGDVEVEIFNEDIWATDAAVVIDTMKQRYRDLVAPALTAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2640 | - | - | 100% (277) | 3-dehydroshikimate dehydratase |
| M. smegmatis MC2 155 | MSMEG_2005 | - | 8e-09 | 24.11% (253) | sugar phosphate isomerase/epimerase |
| M. smegmatis MC2 155 | MSMEG_4653 | - | 7e-05 | 26.47% (204) | AP endonuclease, family protein 2 superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2495 | - | 3e-13 | 27.42% (248) | xylose isomerase domain-containing protein |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2510 | - | 6e-06 | 28.74% (167) | sugar phosphate isomerase/epimerase |
| M. avium 104 | MAV_0064 | - | 7e-07 | 26.51% (166) | AP endonuclease, family protein 2 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1694 | - | 2e-06 | 28.74% (167) | sugar phosphate isomerases/epimerases |
| M. vanbaalenii PYR-1 | Mvan_2673 | - | 1e-05 | 27.84% (273) | xylose isomerase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2510|M.marinum_M -MHVGYNTNSLADHPIAEALALIAEEGYSAVALTVGYPHVRPMDSDLGAQ
MUL_1694|M.ulcerans_Agy99 -MHVGYNTNSLADHPIAEALALISEEGYSAVALTVGYPHVRPMDSDLGAQ
Mflv_2495|M.gilvum_PYR-GCK -------MAEISGAAERISVHSVTFHGAPLDELRRVWESLG------VSR
MAV_0064|M.avium_104 ----------MTGAHKRLSVHNVTFYGAPPAALQAHWAALG------VSR
MSMEG_2640|M.smegmatis_MC2_155 -----------MSAERRLSLNTMTTKRLTLREAVEATAAAG------LES
Mvan_2673|M.vanbaalenii_PYR-1 MRLTRRRAAEDIGGTRPVTLAPLTVLELSPPELVACAAEAG------YDG
. :: :: .
MMAR_2510|M.marinum_M LDALGCLLDTYGLTVAIETGARYLLDPHNKHKPSLV-DVAAQPRIEFLQR
MUL_1694|M.ulcerans_Agy99 LDALGCLLDTYGLTVAIETDARYLLDPHNKHKPSPV-DVAAQPRIEFLQR
Mflv_2495|M.gilvum_PYR-GCK LSLIDAQLRQPGLTEAIASDNYSVESVFHLFE-----SSD------ALRG
MAV_0064|M.avium_104 LSILDNQLLDPQLPMLLGRNDYTVEAVYHLFAGGRL-TSDPGAAREALIA
MSMEG_2640|M.smegmatis_MC2_155 IGLWRDRVAEAGVDTAAKLMHDNGLRVSSLCRGGFLTGFEEDHALADNRR
Mvan_2673|M.vanbaalenii_PYR-1 VGLRLIRATDEEPVRATIGQTPVIRETRRRLDDTGLFVLDVEVLRLRPDT
:.
MMAR_2510|M.marinum_M AIDIAAELGATCVSLWSGYSVSYSDAATTRDLLLSRLSRLVEYADRKSVI
MUL_1694|M.ulcerans_Agy99 AIDIAAELGATCVSLWSGYSVSYSDAATTRDLLLSRLSRLVEYADRKSVM
Mflv_2495|M.gilvum_PYR-GCK VIDAAAGVGARVVYMLTGGRGDR-TWEQAAGRFCDAVQPCLDAARQAGVA
MAV_0064|M.avium_104 VIDAAASVGAHTVYLLTGGRAGL-TWPQAAERFAAMVAPCAARAKAAGVV
MSMEG_2640|M.smegmatis_MC2_155 AIEEAVTLGTRELVMVVGGIPDR-DLAAARGRVAQRLETLVPYAVDHGVR
Mvan_2673|M.vanbaalenii_PYR-1 DVRRDFGGVLETAAYLGATQALVTGNDREHSRLADNLAELADIAAEFGIR
: . . : * .:
MMAR_2510|M.marinum_M LGFEPE-PGMFVET-VQQALGLCSELGDP---ARLGITLDVGHCVMTEPA
MUL_1694|M.ulcerans_Agy99 LGFEPE-PGMFVET-VQQALGLCSELGDP---ARLGITLDVGHCVMTEPA
Mflv_2495|M.gilvum_PYR-GCK LAIENA-SGLYADIHIAHTLSDTIELAES---AGVGICIDLFHCWTEA--
MAV_0064|M.avium_104 LAIENA-SSLYADIHIAHTLRDTVALAEM---SDLGICIDLFHCWAEG--
MSMEG_2640|M.smegmatis_MC2_155 LALEPLHPVFCADRAVISTLGQALALAAPYPAEAVGVVVDTFHVWWDP--
Mvan_2673|M.vanbaalenii_PYR-1 PNLEPM------PWTEVRNLAEATAILQR-CQDGAGVLVDALHYDREL--
:* * : *: :* *
MMAR_2510|M.marinum_M GAEAAIAELGDKLVNVHLDDMTPLKHEHLEFGYGALDLGAVMDALQVAGF
MUL_1694|M.ulcerans_Agy99 GAEAAIAELGDKLVNVHLDDMTPLKHEHLEFGYGALDLGAVMDALQVAGF
Mflv_2495|M.gilvum_PYR-GCK ----------------------------------------RLGTLLDRAL
MAV_0064|M.avium_104 ----------------------------------------DFEAQLPRAL
MSMEG_2640|M.smegmatis_MC2_155 --------------------------------------ELADGIAAAGAQ
Mvan_2673|M.vanbaalenii_PYR-1 ---------------------------------------ATPDDLHALPS
MMAR_2510|M.marinum_M AGVASVELPRHAHDAPKVARRSMNSIKLAQLPLQVRTWIAEAAAVLRRDP
MUL_1694|M.ulcerans_Agy99 AGVASVELPRHAHDAPKVARRSMNSIKLPQLPLQVRTWIAEAAAVLRRDP
Mflv_2495|M.gilvum_PYR-GCK PRTELIQLSDYVLGDRSLPARAVP--------------------------
MAV_0064|M.avium_104 PRTALIQLSDYVLGDRALPGRAVP--------------------------
MSMEG_2640|M.smegmatis_MC2_155 HRISSYQVCDWLVPMAADPLVSRG--------------------------
Mvan_2673|M.vanbaalenii_PYR-1 EWISYVQICDGLSPRPTAVDELRYQGRNAR--------------------
::
MMAR_2510|M.marinum_M EKVLELFSGAQRQMPASSDEATVLARGRLVATLVAETPDVTAGPLIDKLY
MUL_1694|M.ulcerans_Agy99 EKVLELFSGAQCQMPASSDEATVLARGRLVATLVAETPDVTAGPLIDKLY
Mflv_2495|M.gilvum_PYR-GCK ---------GDGAIPLEAIVAQALSAG----------------------Y
MAV_0064|M.avium_104 ---------GDGAIPIEAFVAQALAVG----------------------Y
MSMEG_2640|M.smegmatis_MC2_155 -------MMGDGVIDFGAVTAMVRAAG----------------------Y
Mvan_2673|M.vanbaalenii_PYR-1 ------LFPGEGGIDLTGMLRALPDVP-----------------------
.: : .
MMAR_2510|M.marinum_M RWGDSDERLGVFCGLETAASEETLGPDATRVGVGLAEDALRCNDPRLVAA
MUL_1694|M.ulcerans_Agy99 RWGDSDERLGVFCGLETAASEETLGPDATRVGVGLAEDALRCNDPRLVAA
Mflv_2495|M.gilvum_PYR-GCK QHG---------------FDLELIGPRIAEEGP--LPAARRART--YVAE
MAV_0064|M.avium_104 AHG---------------FDLELIGPRIEREGR--LESARRACD--VVGA
MSMEG_2640|M.smegmatis_MC2_155 DGD---------------VEVEIFNEDIWATDAAVVIDTMKQRYRDLVAP
Mvan_2673|M.vanbaalenii_PYR-1 ----------------VSIEAPVQWPAPAGVRARAALRAARTVVGRADAS
. : : .
MMAR_2510|M.marinum_M ALGGFGARFLAQHRWRDGVMKLVFMGVPLRGVSGLRSRADTELGRMATDY
MUL_1694|M.ulcerans_Agy99 ALGGFGARFLAQHRWRDGVMKLVFMGVPLRGVSSLCSRADTELGRMATDY
Mflv_2495|M.gilvum_PYR-GCK LLTRIGTS------------------------------------------
MAV_0064|M.avium_104 MLDKLGG-------------------------------------------
MSMEG_2640|M.smegmatis_MC2_155 ALTAG---------------------------------------------
Mvan_2673|M.vanbaalenii_PYR-1 RLPLSA--------------------------------------------
*
MMAR_2510|M.marinum_M ASERAAAGRMIPADAQLLQRLCATEAEALK
MUL_1694|M.ulcerans_Agy99 ASERAAAGRMIPADAQLLQRLCATEAEALK
Mflv_2495|M.gilvum_PYR-GCK ------------------------------
MAV_0064|M.avium_104 ------------------------------
MSMEG_2640|M.smegmatis_MC2_155 ------------------------------
Mvan_2673|M.vanbaalenii_PYR-1 ------------------------------