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GSTVIEQLLGRASEHPAPKPGDTVVVDVDLTVLIDLQFQHDRLHHVLQVHDPDKIAVVMDHAVPAPSIRD ASGGERAREFARSHGVSKFYDVGRHGIVHQVIAEQALALPGQNLACTDSHTCAAGALNVAARGLGPAEVL QIVCTGKTWHMVPPTIRYDLVGQKPDHINGKDIFLHIAGTYGEATDHAIEYGGPGLSSVPMSDRRTMAAQ GAEVGADFSVFPADEVCLESLGDRARDAHPCNGDDDARYAVRRSVDLSALKPMVSKPGTVINNSLPVSEL EDKPIHQAFIGSCANGQLDDLRVAATILDGKKVKSGVRLIVTPASQQVYLDAVAAGYVTSIVSAGGVVTN PTCGACFGYHMGVLGPGEVCVTASTRNFKGRMGSPDAEIYMASPATVATSAIAGHITAPGGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2505 | - | - | 100% (413) | 3-isopropylmalate dehydratase large subunit |
| M. smegmatis MC2 155 | MSMEG_6854 | - | e-148 | 61.86% (409) | 3-isopropylmalate dehydratase large subunit |
| M. smegmatis MC2 155 | MSMEG_1112 | - | 5e-45 | 30.28% (426) | aconitate hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3012c | leuC | 1e-37 | 28.30% (417) | isopropylmalate isomerase large subunit |
| M. gilvum PYR-GCK | Mflv_4227 | - | 9e-40 | 27.95% (415) | isopropylmalate isomerase large subunit |
| M. tuberculosis H37Rv | Rv2988c | leuC | 4e-38 | 28.37% (416) | isopropylmalate isomerase large subunit |
| M. leprae Br4923 | MLBr_01685 | leuC | 4e-41 | 29.88% (415) | isopropylmalate isomerase large subunit |
| M. abscessus ATCC 19977 | MAB_3294c | - | 2e-37 | 27.16% (416) | 3-isopropylmalate dehydratase, large subunit (Leu2) |
| M. marinum M | MMAR_1726 | leuC | 2e-38 | 29.64% (415) | 3-isopropylmalate dehydratase (large subunit) LeuC |
| M. avium 104 | MAV_1740 | - | 1e-143 | 61.31% (411) | 3-isopropylmalate dehydratase large subunit |
| M. thermoresistible (build 8) | TH_2043 | leuC | 9e-43 | 28.85% (461) | PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (LARGE SUBUNIT) LEUC |
| M. ulcerans Agy99 | MUL_1968 | leuC | 5e-39 | 29.88% (415) | isopropylmalate isomerase large subunit |
| M. vanbaalenii PYR-1 | Mvan_2135 | - | 2e-41 | 29.98% (417) | isopropylmalate isomerase large subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3012c|M.bovis_AF2122/97 MALQT--------GEPRTLAEKIWDDHIVVSGG----GCAPDLIYIDLHL
Rv2988c|M.tuberculosis_H37Rv MALQT--------GEPRTLAEKIWDDHIVVSGG----GCAPDLIYIDLHL
MMAR_1726|M.marinum_M MALQT--------REARTLAEKVWDDHVVVSGR----NEAPDLIYIDLHL
MUL_1968|M.ulcerans_Agy99 MALQT--------REARTLAEKVWDDHVVVSGR----NEAPDLIYIDLHQ
MLBr_01685|M.leprae_Br4923 MEMDNERKQVGGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHL
Mflv_4227|M.gilvum_PYR-GCK MAVAN---------QPRTLAEKVWSDHVVVSGSGEGAAREPDLIYIDLHL
Mvan_2135|M.vanbaalenii_PYR-1 MAIVN---------QPRTLAEKVWSDHVVVAGTGEGAAREPDLIYIDLHL
TH_2043|M.thermoresistible__bu -VSTN---------RPRTLAEKVWDDHVVVRGSGTGAAREPDLIYIDLHL
MAB_3294c|M.abscessus_ATCC_199 MTSVQ---------QPRTLAEKVWDSHVVVRGTGEGEAREPDLIYIDLHL
MSMEG_2505|M.smegmatis_MC2_155 --------------MGSTVIEQLLGRASEHPAP-----KPGDTVVVDVDL
MAV_1740|M.avium_104 ----------------MTVIEKILARKAGLDSV-----SSGDTVVVDVDM
*: *:: . * : :*:.
Mb3012c|M.bovis_AF2122/97 VHEVTSPQAFDGLRLAGRRVRRPELTLATEDHNVPTVDIDQPIADPVSRT
Rv2988c|M.tuberculosis_H37Rv VHEVTSPQAFDGLRLAGRRVRRPELTLATEDHNVPTVDIDQPIADPVSRT
MMAR_1726|M.marinum_M VHEVTSPQAFDGLRLAGRPVRRPDLTIATEDHNVPTVDIDKPIADPVSRT
MUL_1968|M.ulcerans_Agy99 VHEVTSPQAFDGLRLAGRPVRRPDLTIATEDHNVPTVDIDKPIADPVSRT
MLBr_01685|M.leprae_Br4923 VHEVTSPQAFDGLRLAGRWVRRPDLTVATEDHNVPTVDIDKPIADPVSRI
Mflv_4227|M.gilvum_PYR-GCK VHEVTSPQAFDGLRLAGRPVRRPDLTIATEDHNVPTVDIDKPIADPVSRT
Mvan_2135|M.vanbaalenii_PYR-1 VHEVTSPQAFDGLRLAGRPVRRPDLTIATEDHNVPTVDIDKPIADPVSRT
TH_2043|M.thermoresistible__bu VHEVTSPQAFDGLRLAGRKVRRPDLTIATEDHNVPTVDIDKPIADPISRT
MAB_3294c|M.abscessus_ATCC_199 VHEVTSPQAFDGLRLAGRQVRRPDLTIATEDHNVPTIDIDKPIADPVSRT
MSMEG_2505|M.smegmatis_MC2_155 TVLIDLQFQHDRLHHVLQVHD-PDKIAVVMDHAVPAPSIRDASGGERARE
MAV_1740|M.avium_104 TVLIDLQFATMWIS-PTRIHD-PDRLAVIMDHAVPAPTIKDADGGRQARR
. : : : *: . ** **: * .. .. :*
Mb3012c|M.bovis_AF2122/97 QVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQLGLTQPGMTIVCGDSHT
Rv2988c|M.tuberculosis_H37Rv QVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQLGLTQPGMTIVCGDSHT
MMAR_1726|M.marinum_M QVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQPGMTIVCGDSHT
MUL_1968|M.ulcerans_Agy99 QVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQPGMTIVCGDSHT
MLBr_01685|M.leprae_Br4923 QVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGLTQPGMTIVCGDSHT
Mflv_4227|M.gilvum_PYR-GCK QVETLRRNCEEFGIRLHPMGDVEQGIVHIIGPQLGLTQPGTTVVCGDSHT
Mvan_2135|M.vanbaalenii_PYR-1 QVETLRRNCAEFGIRLHPMGDVEQGIVHIIGPQLGLTQPGMTVVCGDSHT
TH_2043|M.thermoresistible__bu QVETLRRNAAEFGIRLHPMGDAEQGIVHIIGPQLGLTQPGMTVVCGDSHT
MAB_3294c|M.abscessus_ATCC_199 QVETLRKNCEEFGIRLHPMGDAEQGIVHVVGPQLGLTQPGTTVVCGDSHT
MSMEG_2505|M.smegmatis_MC2_155 FARSHG------VSKFYDVG--RHGIVHQVIAEQALALPGQNLACTDSHT
MAV_1740|M.avium_104 FVADFG------IERFYDVG--RHGICHQVIAENGLARPGEVLACTDSHT
. ::: :* .:** * : .: .*: ** :.* ****
Mb3012c|M.bovis_AF2122/97 STHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPDGVSAK
Rv2988c|M.tuberculosis_H37Rv STHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPDGVSAK
MMAR_1726|M.marinum_M STHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAGVSAK
MUL_1968|M.ulcerans_Agy99 STHGAFGALAMGIGTSEVEHVLATQTLPLWPFKTMAVNVDGQLPAGVSAK
MLBr_01685|M.leprae_Br4923 STHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAGVTAK
Mflv_4227|M.gilvum_PYR-GCK STHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGELPPGVSAK
Mvan_2135|M.vanbaalenii_PYR-1 STHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGQLPPGVSAK
TH_2043|M.thermoresistible__bu STHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGELPAGVSAK
MAB_3294c|M.abscessus_ATCC_199 STHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAINIDGSLPTGVTSK
MSMEG_2505|M.smegmatis_MC2_155 CAAGALNVAARGLGPAEVLQIVCTGKTWHMVPPTIRYDLVGQKPDHINGK
MAV_1740|M.avium_104 CAAGAYNNAARGLGPAEIYSIMCTGTTWFQVAPTIRYEFHGAKPEVVSGK
.: ** . * *:*.:*: ::.* . *: . * * :..*
Mb3012c|M.bovis_AF2122/97 DIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAG
Rv2988c|M.tuberculosis_H37Rv DIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAG
MMAR_1726|M.marinum_M DIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAG
MUL_1968|M.ulcerans_Agy99 DIILALIAKIGTGGGQGHVIEYQGSAIESLSMEGRMTICNMSIEAGARAG
MLBr_01685|M.leprae_Br4923 DIILALIAKIGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAG
Mflv_4227|M.gilvum_PYR-GCK DVILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAG
Mvan_2135|M.vanbaalenii_PYR-1 DIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAGARAG
TH_2043|M.thermoresistible__bu DIILAVIAKIGTGGGQGHVIEYRGSTIESLSMEGRMTICNMSIEAGARAG
MAB_3294c|M.abscessus_ATCC_199 DVILAVIAKIGTGGGQGYVLEYRGQAVEEMSMEARMTMCNMSIEAGARAG
MSMEG_2505|M.smegmatis_MC2_155 DIFLHIAGTYGEATD--HAIEYGGPGLSSVPMSDRRTMAAQGAEVGADFS
MAV_1740|M.avium_104 DIFLHIADEYGDAPN--RNLEFGGPGLAGIPMHDRRTIATQGAEVSADFS
*::* : * . . :*: * : :.* * *:. . *..* .
Mb3012c|M.bovis_AF2122/97 MVAPDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDA
Rv2988c|M.tuberculosis_H37Rv MVAPDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDA
MMAR_1726|M.marinum_M MVAPDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDA
MUL_1968|M.ulcerans_Agy99 MVAPDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEVHLDA
MLBr_01685|M.leprae_Br4923 MVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDA
Mflv_4227|M.gilvum_PYR-GCK MIAPDETTFEFLKGRPHAPQGADWDAAVEAWKLLRTDEGAQFDTEVYIDA
Mvan_2135|M.vanbaalenii_PYR-1 MIAPDETTFEFLRGRPHAPKGAEWDAAVAVWRQLRTDEGAQFDTEIYIDA
TH_2043|M.thermoresistible__bu MIAPDETTFEYLRGRPHAPKGADWDAAVAAWRQLRTDEGAEFDVEVYIDA
MAB_3294c|M.abscessus_ATCC_199 MVAPDETTYAYLKDRPHAPKGQLWDAAVAEWDSLRTDEGAQFDAEVHIDA
MSMEG_2505|M.smegmatis_MC2_155 VFPADEVCLESLGDR------------ARDAHPCNGDDDARYAVRRSVDL
MAV_1740|M.avium_104 TFEPDDVLTSFLAERG-----------VVEYEAVTPDSDAAYHDVRRVDL
. .*:. * * * .* : :*
Mb3012c|M.bovis_AF2122/97 ASLSPFVTWGTNPGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPG
Rv2988c|M.tuberculosis_H37Rv ASLSPFVTWGTNPGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPG
MMAR_1726|M.marinum_M AELSPFVTWGTNPGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPG
MUL_1968|M.ulcerans_Agy99 AELSPFVTWGTNPGQGVPLCATVPDPELIGDDGERQAAEKALAYMDLEPG
MLBr_01685|M.leprae_Br4923 TSLSPFVTWGTNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPG
Mflv_4227|M.gilvum_PYR-GCK ASLSPFVTWGTNPGQGVPLSDSVPDPEMIFDEGERSAVEKALAYMDLRPG
Mvan_2135|M.vanbaalenii_PYR-1 STLSPFVTWGTNPGQGVPLSDPVPDPELMFDEAERQAAEKALAYMDLRAG
TH_2043|M.thermoresistible__bu TELSPFVTWGTNPGQGVPLSGSVPDPELMTDEADRLAAEKALAYMDLRPG
MAB_3294c|M.abscessus_ATCC_199 STLTPFVTWGTNPGQGVPLGADVPDPELMADEEERLAAEKALTYMDLTPG
MSMEG_2505|M.smegmatis_MC2_155 SALKPMVSK------------------------------PGTVINNSLPV
MAV_1740|M.avium_104 ATLEPYVAR------------------------------PGTVSRNGSPV
: * * *: . . : .
Mb3012c|M.bovis_AF2122/97 TAMREIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVADGVRMLIVPGSMR
Rv2988c|M.tuberculosis_H37Rv TAMRDIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVADGVRMLIVPGSMR
MMAR_1726|M.marinum_M KAMRDIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVAPGVRMLIVPGSMR
MUL_1968|M.ulcerans_Agy99 KAMRDIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVAPGVRMLIVPGSMR
MLBr_01685|M.leprae_Br4923 TPMRDIAVDAVFVGSCTNGRIEDLRLVADVLRGHKVADGVRMLIVPGSMR
Mflv_4227|M.gilvum_PYR-GCK TPMREIPVDAVFVGSCTNGRIEDLRVVADVLRGRTVADDVRMLVVPGSMR
Mvan_2135|M.vanbaalenii_PYR-1 TPMRQIPVDTVFVGSCTNGRIEDLRVVADILRGRRVADNVRMLVVPGSMR
TH_2043|M.thermoresistible__bu TPMRDIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVADGVRMLIVPGSMR
MAB_3294c|M.abscessus_ATCC_199 TPMREIPVDTVFVGSCTNGRIEDLRAVADVLRDRKVAAGVTMLIVPGSMR
MSMEG_2505|M.smegmatis_MC2_155 SELEDKPIHQAFIGSCANGQLDDLRVAATILDGKKVKSGVRLIVTPASQQ
MAV_1740|M.avium_104 SRLGRQKIDQAFIGSCANGQLEDLRIAAEVLRGKTVAPGVRLLITPASQA
. : :. .*:***:**:::*** .* :* .: * .* :::.*.*
Mb3012c|M.bovis_AF2122/97 VRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNPDQLASGERCAATSNRN
Rv2988c|M.tuberculosis_H37Rv VRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNPDQLASGERCAATSNRN
MMAR_1726|M.marinum_M VRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAPGERCAATSNRN
MUL_1968|M.ulcerans_Agy99 VRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAPGERCAATSNRN
MLBr_01685|M.leprae_Br4923 VRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQLAPGERCAATSNRN
Mflv_4227|M.gilvum_PYR-GCK VRAQAEAEGLGEIFTAAGAEWRQAGCSMCLGMNPDQLAPGERCASTSNRN
Mvan_2135|M.vanbaalenii_PYR-1 VRAQAESEGLGEIFTAAGAEWRQAGCSMCLGMNPDQLAPGERCASTSNRN
TH_2043|M.thermoresistible__bu VRAQAESEGLHEIFLAAGAEWRQAGCSMCLGMNPDQLAPGERCASTSNRN
MAB_3294c|M.abscessus_ATCC_199 VRAQAESEGLGEIFAAAGAQWRQAGCSMCLGMNPDQLSPGQRCASTSNRN
MSMEG_2505|M.smegmatis_MC2_155 VYLDAVAAGYVTSIVSAGGVVTNPTCGACFGYHMGVLGPGEVCVTASTRN
MAV_1740|M.avium_104 VYREALRRGYLQDLADAGAVVTNSTCGACFGYHMGLLGAGEVCITASTRN
* :* * : **. :. *. *:* : . *..*: * ::*.**
Mb3012c|M.bovis_AF2122/97 FEGRQGA-GGRTHLVSPAVAAATAVRGTLSSPADLN-----
Rv2988c|M.tuberculosis_H37Rv FEGRQGA-GGRTHLVSPAVAAATAVRGTLSSPADLN-----
MMAR_1726|M.marinum_M FEGRQGK-GGRTHLVSPAVAAATAVRGTLSAPADLN-----
MUL_1968|M.ulcerans_Agy99 FEGRQGK-GGRTHLVSPAVAAATAVRGTLSAPADLN-----
MLBr_01685|M.leprae_Br4923 FEGRQGK-GGRTHLVSPAVAAATAVRGTFSAPADLN-----
Mflv_4227|M.gilvum_PYR-GCK FEGRQGK-GGRTHLVSPAVAAATAVRGTLSSPADLTAEPTR
Mvan_2135|M.vanbaalenii_PYR-1 FEGRQGK-GGRTHLVSPAVAAATAVRGTLSSPADLAAEPTH
TH_2043|M.thermoresistible__bu FEGRQGK-GGRTHLVSPAVAAATAVAGKLASPADLSA----
MAB_3294c|M.abscessus_ATCC_199 FEGRQGK-GGRTHLVSPAVAAATAVRGKLSSPADLAKSVK-
MSMEG_2505|M.smegmatis_MC2_155 FKGRMGSPDAEIYMASPATVATSAIAGHITAPGGV------
MAV_1740|M.avium_104 FTGRMGSTEAEIFMASPATVAASAVAGYITDPRSVTA----
* ** * .. .:.***..*::*: * :: * .: