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EMDNERKQVGGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVR RPDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGLTQPGM TIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAGVTAKDIILALIAKIG TGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDETTYEFLRDRPHAPTGKQWDAAVAYW QQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGT PMRDIAVDAVFVGSCTNGRIEDLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQW RQPGCSMCLGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01685 | leuC | - | 100% (485) | isopropylmalate isomerase large subunit |
| M. leprae Br4923 | MLBr_01814 | acn | 2e-17 | 22.94% (401) | aconitate hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3012c | leuC | 0.0 | 88.54% (471) | isopropylmalate isomerase large subunit |
| M. gilvum PYR-GCK | Mflv_4227 | - | 0.0 | 84.75% (472) | isopropylmalate isomerase large subunit |
| M. tuberculosis H37Rv | Rv2988c | leuC | 0.0 | 88.75% (471) | isopropylmalate isomerase large subunit |
| M. abscessus ATCC 19977 | MAB_3294c | - | 0.0 | 82.59% (471) | 3-isopropylmalate dehydratase, large subunit (Leu2) |
| M. marinum M | MMAR_1726 | leuC | 0.0 | 88.56% (472) | 3-isopropylmalate dehydratase (large subunit) LeuC |
| M. avium 104 | MAV_3838 | leuC | 0.0 | 88.84% (475) | isopropylmalate isomerase large subunit |
| M. smegmatis MC2 155 | MSMEG_2387 | leuC | 0.0 | 85.11% (470) | isopropylmalate isomerase large subunit |
| M. thermoresistible (build 8) | TH_2043 | leuC | 0.0 | 85.99% (471) | PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (LARGE SUBUNIT) LEUC |
| M. ulcerans Agy99 | MUL_1968 | leuC | 0.0 | 87.71% (472) | isopropylmalate isomerase large subunit |
| M. vanbaalenii PYR-1 | Mvan_2135 | - | 0.0 | 85.53% (470) | isopropylmalate isomerase large subunit |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2387|M.smegmatis_MC2_155 MDQPTQTSV---------KPRTLAEKVWDDHVVARGEGEGTAKEPDLIYI
TH_2043|M.thermoresistible__bu -----VSTN---------RPRTLAEKVWDDHVVVRGSGTGAAREPDLIYI
Mflv_4227|M.gilvum_PYR-GCK ----MAVAN---------QPRTLAEKVWSDHVVVSGSGEGAAREPDLIYI
Mvan_2135|M.vanbaalenii_PYR-1 ----MAIVN---------QPRTLAEKVWSDHVVVAGTGEGAAREPDLIYI
MAB_3294c|M.abscessus_ATCC_199 ----MTSVQ---------QPRTLAEKVWDSHVVVRGTGEGEAREPDLIYI
Mb3012c|M.bovis_AF2122/97 ----MALQT--------GEPRTLAEKIWDDHIVVSGG----GCAPDLIYI
Rv2988c|M.tuberculosis_H37Rv ----MALQT--------GEPRTLAEKIWDDHIVVSGG----GCAPDLIYI
MMAR_1726|M.marinum_M ----MALQT--------REARTLAEKVWDDHVVVSGR----NEAPDLIYI
MUL_1968|M.ulcerans_Agy99 ----MALQT--------REARTLAEKVWDDHVVVSGR----NEAPDLIYI
MLBr_01685|M.leprae_Br4923 ----MEMDNERKQVGGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYI
MAV_3838|M.avium_104 ----MGIDAG-----TTATPRTLAEKVWDDHVVVSGG----ANEPDLIYI
.******:*..*:*. * ******
MSMEG_2387|M.smegmatis_MC2_155 DLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATEDHNVPTIDIDKPIADP
TH_2043|M.thermoresistible__bu DLHLVHEVTSPQAFDGLRLAGRKVRRPDLTIATEDHNVPTVDIDKPIADP
Mflv_4227|M.gilvum_PYR-GCK DLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATEDHNVPTVDIDKPIADP
Mvan_2135|M.vanbaalenii_PYR-1 DLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATEDHNVPTVDIDKPIADP
MAB_3294c|M.abscessus_ATCC_199 DLHLVHEVTSPQAFDGLRLAGRQVRRPDLTIATEDHNVPTIDIDKPIADP
Mb3012c|M.bovis_AF2122/97 DLHLVHEVTSPQAFDGLRLAGRRVRRPELTLATEDHNVPTVDIDQPIADP
Rv2988c|M.tuberculosis_H37Rv DLHLVHEVTSPQAFDGLRLAGRRVRRPELTLATEDHNVPTVDIDQPIADP
MMAR_1726|M.marinum_M DLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATEDHNVPTVDIDKPIADP
MUL_1968|M.ulcerans_Agy99 DLHQVHEVTSPQAFDGLRLAGRPVRRPDLTIATEDHNVPTVDIDKPIADP
MLBr_01685|M.leprae_Br4923 DLHLVHEVTSPQAFDGLRLAGRWVRRPDLTVATEDHNVPTVDIDKPIADP
MAV_3838|M.avium_104 DLHLVHEVTSPQAFDGLRLAGRPVRRPDLTLATEDHNVPTIDIDKPIADP
*** ****************** ****:**:*********:***:*****
MSMEG_2387|M.smegmatis_MC2_155 VSRTQVETLRRNCEEFGIRLHPMGDAEQGIVHIIGPQLGLTQPGMTVVCG
TH_2043|M.thermoresistible__bu ISRTQVETLRRNAAEFGIRLHPMGDAEQGIVHIIGPQLGLTQPGMTVVCG
Mflv_4227|M.gilvum_PYR-GCK VSRTQVETLRRNCEEFGIRLHPMGDVEQGIVHIIGPQLGLTQPGTTVVCG
Mvan_2135|M.vanbaalenii_PYR-1 VSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHIIGPQLGLTQPGMTVVCG
MAB_3294c|M.abscessus_ATCC_199 VSRTQVETLRKNCEEFGIRLHPMGDAEQGIVHVVGPQLGLTQPGTTVVCG
Mb3012c|M.bovis_AF2122/97 VSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQLGLTQPGMTIVCG
Rv2988c|M.tuberculosis_H37Rv VSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQLGLTQPGMTIVCG
MMAR_1726|M.marinum_M VSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQPGMTIVCG
MUL_1968|M.ulcerans_Agy99 VSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHVVGPQLGLTQPGMTIVCG
MLBr_01685|M.leprae_Br4923 VSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGLTQPGMTIVCG
MAV_3838|M.avium_104 VSRTQVETLRRNCAEFGVRLYPMGDAEQGIVHVVGPQLGLTQPGMTVVCG
:** ******:*. ***:**:.*** ******::********** *:***
MSMEG_2387|M.smegmatis_MC2_155 DSHTSTHGAFGAIAMGIGTSEVEHVMATQTLSLKPFKTMAVNVDGELPPG
TH_2043|M.thermoresistible__bu DSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGELPAG
Mflv_4227|M.gilvum_PYR-GCK DSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGELPPG
Mvan_2135|M.vanbaalenii_PYR-1 DSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGQLPPG
MAB_3294c|M.abscessus_ATCC_199 DSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFRTMAINIDGSLPTG
Mb3012c|M.bovis_AF2122/97 DSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPDG
Rv2988c|M.tuberculosis_H37Rv DSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPDG
MMAR_1726|M.marinum_M DSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPAG
MUL_1968|M.ulcerans_Agy99 DSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLWPFKTMAVNVDGQLPAG
MLBr_01685|M.leprae_Br4923 DSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAG
MAV_3838|M.avium_104 DSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGELPAG
************:********:***:*****.* **:***:.:** ** *
MSMEG_2387|M.smegmatis_MC2_155 VSAKDIILAVIAKIGTGGGQGHVIEYRGSAIRSLSMEGRMTICNMSIEAG
TH_2043|M.thermoresistible__bu VSAKDIILAVIAKIGTGGGQGHVIEYRGSTIESLSMEGRMTICNMSIEAG
Mflv_4227|M.gilvum_PYR-GCK VSAKDVILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAG
Mvan_2135|M.vanbaalenii_PYR-1 VSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAG
MAB_3294c|M.abscessus_ATCC_199 VTSKDVILAVIAKIGTGGGQGYVLEYRGQAVEEMSMEARMTMCNMSIEAG
Mb3012c|M.bovis_AF2122/97 VSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAG
Rv2988c|M.tuberculosis_H37Rv VSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAG
MMAR_1726|M.marinum_M VSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAG
MUL_1968|M.ulcerans_Agy99 VSAKDIILALIAKIGTGGGQGHVIEYQGSAIESLSMEGRMTICNMSIEAG
MLBr_01685|M.leprae_Br4923 VTAKDIILALIAKIGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAG
MAV_3838|M.avium_104 VTAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAG
*::**:***:***********:*:**:*..:..:***.***:********
MSMEG_2387|M.smegmatis_MC2_155 ARAGMVAPDETTFEFLKGRPHAPKGADWDAAVAAWSRLRTDEGAEFDTEV
TH_2043|M.thermoresistible__bu ARAGMIAPDETTFEYLRGRPHAPKGADWDAAVAAWRQLRTDEGAEFDVEV
Mflv_4227|M.gilvum_PYR-GCK ARAGMIAPDETTFEFLKGRPHAPQGADWDAAVEAWKLLRTDEGAQFDTEV
Mvan_2135|M.vanbaalenii_PYR-1 ARAGMIAPDETTFEFLRGRPHAPKGAEWDAAVAVWRQLRTDEGAQFDTEI
MAB_3294c|M.abscessus_ATCC_199 ARAGMVAPDETTYAYLKDRPHAPKGQLWDAAVAEWDSLRTDEGAQFDAEV
Mb3012c|M.bovis_AF2122/97 ARAGMVAPDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEV
Rv2988c|M.tuberculosis_H37Rv ARAGMVAPDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEV
MMAR_1726|M.marinum_M ARAGMVAPDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEV
MUL_1968|M.ulcerans_Agy99 ARAGMVAPDETTYEYLRNRPHAPTGAQWDAALGYWQQLRTDPGAVFDTEV
MLBr_01685|M.leprae_Br4923 ARAGMVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEV
MAV_3838|M.avium_104 ARAGMIAPDDTTYEFLRDRPHAPKGAQWDAAMRYWQQLRTDPGAVFDTEV
*****:***:**: :*:.***** * **:*: * **** .* **.*:
MSMEG_2387|M.smegmatis_MC2_155 YIDASTLSPFVTWGTNPGQGVPLSEAVPDPELIVDEGARQAAEKALAYMD
TH_2043|M.thermoresistible__bu YIDATELSPFVTWGTNPGQGVPLSGSVPDPELMTDEADRLAAEKALAYMD
Mflv_4227|M.gilvum_PYR-GCK YIDAASLSPFVTWGTNPGQGVPLSDSVPDPEMIFDEGERSAVEKALAYMD
Mvan_2135|M.vanbaalenii_PYR-1 YIDASTLSPFVTWGTNPGQGVPLSDPVPDPELMFDEAERQAAEKALAYMD
MAB_3294c|M.abscessus_ATCC_199 HIDASTLTPFVTWGTNPGQGVPLGADVPDPELMADEEERLAAEKALTYMD
Mb3012c|M.bovis_AF2122/97 YLDAASLSPFVTWGTNPGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMD
Rv2988c|M.tuberculosis_H37Rv YLDAASLSPFVTWGTNPGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMD
MMAR_1726|M.marinum_M HLDAAELSPFVTWGTNPGQGVPLCATVPDPELIGDDGERQAAEKALAYMD
MUL_1968|M.ulcerans_Agy99 HLDAAELSPFVTWGTNPGQGVPLCATVPDPELIGDDGERQAAEKALAYMD
MLBr_01685|M.leprae_Br4923 YLDATSLSPFVTWGTNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMD
MAV_3838|M.avium_104 YLDAASLSPFVTWGTNPGQGVPLAAAVPDPELMTDDAERQAAEKALAYMD
::**: *:*************** ****::: *: * *.****:***
MSMEG_2387|M.smegmatis_MC2_155 LRPGTPMRDIAVDTVFVGSCTNGRIEDLRVVADVLRGRKVADGVRMLIVP
TH_2043|M.thermoresistible__bu LRPGTPMRDIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVADGVRMLIVP
Mflv_4227|M.gilvum_PYR-GCK LRPGTPMREIPVDAVFVGSCTNGRIEDLRVVADVLRGRTVADDVRMLVVP
Mvan_2135|M.vanbaalenii_PYR-1 LRAGTPMRQIPVDTVFVGSCTNGRIEDLRVVADILRGRRVADNVRMLVVP
MAB_3294c|M.abscessus_ATCC_199 LTPGTPMREIPVDTVFVGSCTNGRIEDLRAVADVLRDRKVAAGVTMLIVP
Mb3012c|M.bovis_AF2122/97 LRPGTAMREIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVADGVRMLIVP
Rv2988c|M.tuberculosis_H37Rv LRPGTAMRDIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVADGVRMLIVP
MMAR_1726|M.marinum_M LEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVAPGVRMLIVP
MUL_1968|M.ulcerans_Agy99 LEPGKAMRDIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVAPGVRMLIVP
MLBr_01685|M.leprae_Br4923 LRPGTPMRDIAVDAVFVGSCTNGRIEDLRLVADVLRGHKVADGVRMLIVP
MAV_3838|M.avium_104 LRPGTPMRDIAVDAVFVGSCTNGRIEDLRVVADVLRGRKVAPGVRMLVVP
* .*..**:*.**:*************** **::**.: ** .* **:**
MSMEG_2387|M.smegmatis_MC2_155 GSMRVRAQAESEGLDQIFTAAGAQWRQAGCSMCLGMNPDQLSPGERCAST
TH_2043|M.thermoresistible__bu GSMRVRAQAESEGLHEIFLAAGAEWRQAGCSMCLGMNPDQLAPGERCAST
Mflv_4227|M.gilvum_PYR-GCK GSMRVRAQAEAEGLGEIFTAAGAEWRQAGCSMCLGMNPDQLAPGERCAST
Mvan_2135|M.vanbaalenii_PYR-1 GSMRVRAQAESEGLGEIFTAAGAEWRQAGCSMCLGMNPDQLAPGERCAST
MAB_3294c|M.abscessus_ATCC_199 GSMRVRAQAESEGLGEIFAAAGAQWRQAGCSMCLGMNPDQLSPGQRCAST
Mb3012c|M.bovis_AF2122/97 GSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNPDQLASGERCAAT
Rv2988c|M.tuberculosis_H37Rv GSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNPDQLASGERCAAT
MMAR_1726|M.marinum_M GSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAPGERCAAT
MUL_1968|M.ulcerans_Agy99 GSMRVRAQAEKEGLGEVFTVAGAEWRQAGCSMCLGMNPDQLAPGERCAAT
MLBr_01685|M.leprae_Br4923 GSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQLAPGERCAAT
MAV_3838|M.avium_104 GSMRVRAQAEAEGLGEVFTAAGAEWRQAGCSMCLGMNPDQLAPGERCAAT
********** *** ::* ***:***.*************:.*:***:*
MSMEG_2387|M.smegmatis_MC2_155 SNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLPAAAR-
TH_2043|M.thermoresistible__bu SNRNFEGRQGKGGRTHLVSPAVAAATAVAGKLASPADLSA----
Mflv_4227|M.gilvum_PYR-GCK SNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLTAEPTR
Mvan_2135|M.vanbaalenii_PYR-1 SNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLAAEPTH
MAB_3294c|M.abscessus_ATCC_199 SNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLSSPADLAKSVK-
Mb3012c|M.bovis_AF2122/97 SNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN-----
Rv2988c|M.tuberculosis_H37Rv SNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN-----
MMAR_1726|M.marinum_M SNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN-----
MUL_1968|M.ulcerans_Agy99 SNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN-----
MLBr_01685|M.leprae_Br4923 SNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN-----
MAV_3838|M.avium_104 SNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLD-----
********** ***************** *.:::****