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VTAPNHPPGRTRVAVVYGGRSSEHAISCVSAGSILRNLDPERFEVVAIGITPDGSWVLTDGRPETLAITD GKLPAVTEASGTELALPAAPNRSGQLLALGNGPGEILAAVDVVFPVLHGPYGEDGTIQGLLELAGVPYVG SGVLASAAGMDKEYTKKLLAAEGLPIGDQVVLRPGVETLDLEQRERLGLPVFVKPARGGSSIGVSRVTAW DELPAAVALARRHDPKVIVEAAVIGRELECGVLEFPDGRLEASTVGEIRVAGVRGREDGFYDFATKYLED AAELDVPAKVDDDVADEIRQLAVRAFTAIGCQGLARVDFFLTDDGPVINEINTMPGFTTISMYPRMWAAG GIDYPTLLAAMVDTAIARGTGLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2395 | ddl | - | 100% (373) | D-alanyl-alanine synthetase A |
| M. smegmatis MC2 155 | MSMEG_0334 | - | 1e-08 | 27.43% (237) | acetyl-/propionyl-coenzyme A carboxylase alpha chain |
| M. smegmatis MC2 155 | MSMEG_4716 | - | 2e-08 | 28.51% (221) | acetyl-/propionyl-coenzyme A carboxylase alpha chain |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3005c | ddl | 1e-168 | 79.89% (363) | D-alanyl-alanine synthetase A |
| M. gilvum PYR-GCK | Mflv_4219 | ddl | 1e-177 | 84.07% (364) | D-alanyl-alanine synthetase A |
| M. tuberculosis H37Rv | Rv2981c | ddl | 1e-168 | 78.23% (372) | D-alanyl-alanine synthetase A |
| M. leprae Br4923 | MLBr_01678 | ddl | 1e-160 | 75.07% (369) | D-alanyl-alanine synthetase A |
| M. abscessus ATCC 19977 | MAB_3286c | ddl | 1e-156 | 75.27% (368) | D-alanyl-alanine synthetase A |
| M. marinum M | MMAR_1733 | ddl | 1e-173 | 81.59% (364) | d-alanine--D-alanine ligase DdlA |
| M. avium 104 | MAV_3830 | ddl | 1e-172 | 81.04% (364) | D-alanyl-alanine synthetase A |
| M. thermoresistible (build 8) | TH_2049 | ddlA | 1e-169 | 77.75% (373) | PROBABLE D-ALANINE--D-ALANINE LIGASE DDLA (D-ALANYLALANINE |
| M. ulcerans Agy99 | MUL_1976 | ddl | 1e-172 | 81.04% (364) | D-alanyl-alanine synthetase A |
| M. vanbaalenii PYR-1 | Mvan_2143 | ddl | 1e-178 | 84.89% (364) | D-alanyl-alanine synthetase A |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4219|M.gilvum_PYR-GCK MNA-------------RIRVAVVYGGRSSEHAISCVSAGSILRNLDPDRF
Mvan_2143|M.vanbaalenii_PYR-1 MTA-------------RIRVAVVYGGRSSEHAISCVSAGSILRNLDPQRF
MSMEG_2395|M.smegmatis_MC2_155 MTAPNHPPG-------RTRVAVVYGGRSSEHAISCVSAGSILRNLDPERF
TH_2049|M.thermoresistible__bu VTARDRSEG-------RIRVAVVYGGRSNEHAISCVSAGSILRNLDPQRF
Mb3005c|M.bovis_AF2122/97 MSANDRR----------VRVAVVFGGRSNEHAISCVSAGSILRNLDSRRF
Rv2981c|M.tuberculosis_H37Rv MSANDRRDR-------RVRVAVVFGGRSNEHAISCVSAGSILRNLDSRRF
MLBr_01678|M.leprae_Br4923 MNVYQRPLMPWLPSGGRVRVAVVFGGRSNEHAVSCLSAGSILRNLDRQRF
MMAR_1733|M.marinum_M MSGSSRRGE-------RLRVAVVFGGRSNEHAISCVSAGSILRNLDPRRF
MUL_1976|M.ulcerans_Agy99 MSGSSRRGE-------RLRVAVVFGGRSNEHAISCVSAGSILRNLDPRRF
MAV_3830|M.avium_104 MNASQR-----------VRVAVVFGGRSNEHAISCVSAGSILRNLDPRRF
MAB_3286c|M.abscessus_ATCC_199 MNDSVGRSR---ADQQRIKVALVFGGRSSEHAISCVSAGSILRNLDQAVY
:. :**:*:****.***:**:********** :
Mflv_4219|M.gilvum_PYR-GCK EVTAVGITPEGSWVLTEGRPETLAITDGKLPGVTGDSGTALTLTADPARR
Mvan_2143|M.vanbaalenii_PYR-1 EVVPVGITPEGSWVLTDGRPETLAITDGALPGVSGSSGTELALAADPGRR
MSMEG_2395|M.smegmatis_MC2_155 EVVAIGITPDGSWVLTDGRPETLAITDGKLPAVTEASGTELALPAAPNRS
TH_2049|M.thermoresistible__bu EAIPIGITPGGTWLLTGAHPDSLTIVDGRLPEVDESAGSELILAADPRRK
Mb3005c|M.bovis_AF2122/97 DVIAVGITPAGSWVLTDANPDALTITNRELPQVKSGSGTELALPADPRRG
Rv2981c|M.tuberculosis_H37Rv DVIAVGITPAGSWVLTDANPDALTITNRELPQVKSGSGTELALPADPRRG
MLBr_01678|M.leprae_Br4923 DVVAVGITPEGTWMLTDPNPDALAIANRQLPAVSCESGIELTLPADPRRS
MMAR_1733|M.marinum_M EVIAIGITPQGSWVLTDGNPDALAITDRRLPEVSSQSGTELALPADPRWG
MUL_1976|M.ulcerans_Agy99 EVIAIGITPQGSWVLTDGNPDALAITDRRLPEVSSQSGTELALPADPRWG
MAV_3830|M.avium_104 EVVAIGITPQGSWVLTDGDPAALAISDRQLPEVTSASGTELALPADPGRS
MAB_3286c|M.abscessus_ATCC_199 EVVAVGVTPEGGWVLTDGDPAQLAISDRTLPQVTDASGTELLLATDPRRA
:. .:*:** * *:** * *:* : ** * :* * *.: *
Mflv_4219|M.gilvum_PYR-GCK GQLVSLGE----AAGEVLASADVVFPVLHGPYGEDGTIQGLLELAGVPYV
Mvan_2143|M.vanbaalenii_PYR-1 GQLLSLGD----AAGDVLAAVDVVFPVLHGPYGEDGTIQGLLELAGVPYV
MSMEG_2395|M.smegmatis_MC2_155 GQLLALGN----GPGEILAAVDVVFPVLHGPYGEDGTIQGLLELAGVPYV
TH_2049|M.thermoresistible__bu GQLLSMGP----GVREVLATIDVVFPVLHGPYGEDGTIQGLLELAGVPYV
Mb3005c|M.bovis_AF2122/97 GQLVSLPP----GAGEVLESVDVVFPVLHGPYGEDGTIQGLLELAGVPYV
Rv2981c|M.tuberculosis_H37Rv GQLVSLPP----GAGEVLESVDVVFPVLHGPYGEDGTIQGLLELAGVPYV
MLBr_01678|M.leprae_Br4923 GQLVSLSHGAGLGAGEVLTSVDVVFPVLHGPYGEDGTIQGLLELARVPYV
MMAR_1733|M.marinum_M GQLVSLPP----GAGEVLASVDVVFPVLHGPYGEDGTIQGLLELAGVPYV
MUL_1976|M.ulcerans_Agy99 GQLVSLPP----GAGEVLASVDVVFPVLHGPYGEDGTIQGLLELAGVPYV
MAV_3830|M.avium_104 GQLVSLPP----GASEVLASVDVVFPVLHGPYGEDGTIQGLLELAGVPYV
MAB_3286c|M.abscessus_ATCC_199 GQLVNVDSS---AAGQVLASVDVVFPVLHGPYGEDGTIQGLLELAGVPYV
***: : . ::* : ************************ ****
Mflv_4219|M.gilvum_PYR-GCK GAGVLASAAGMDKEFTKKLLASAGLPVGDHVVLRARDSTLSLQDRERLGL
Mvan_2143|M.vanbaalenii_PYR-1 GAGVLASAAGMDKEFTKKLLTAAGLPVGDHVVLRPREATVSLEDRERLGL
MSMEG_2395|M.smegmatis_MC2_155 GSGVLASAAGMDKEYTKKLLAAEGLPIGDQVVLRPGVETLDLEQRERLGL
TH_2049|M.thermoresistible__bu GAGVFASAAGMDKEFTKKLLTVAGLPIGDHVVLRAGRADLDRGERDRLGL
Mb3005c|M.bovis_AF2122/97 GAGVLASAVGMDKEFTKKLLAADGLPVGAYAVLRPPRSTLHRQECERLGL
Rv2981c|M.tuberculosis_H37Rv GAGVLASAVGMDKEFTKKLLAADGLPVGAYAVLRPPRSTLHRQECERLGL
MLBr_01678|M.leprae_Br4923 GAGVLASAAGMDKEFTKKLFAAEGLPLSAYTVLRPLRPTLHRQECERLSL
MMAR_1733|M.marinum_M GAGVLASAAGMDKEFTKKLWSAAGLPIGPHAVLRPSRQSLDREELQRLGL
MUL_1976|M.ulcerans_Agy99 GAGVLASAAGMDKEFTKKLWSAAGLPIGPHAVLRPSRQSLDREELQRLGL
MAV_3830|M.avium_104 GAGVFASAAGMDKEFTKKLFAAEGLPIGDYAVLRPSQSTLSLQDRERLGL
MAB_3286c|M.abscessus_ATCC_199 GAGVLASAAGMDKEFTKKLLAAEGLPIGKYAVIRPRDTTLTLDQREDLGL
*:**:***.*****:**** : ***:. .*:*. : : : *.*
Mflv_4219|M.gilvum_PYR-GCK PVFVKPSRGGSSIGVSRVTAWDELPAAIELARRHDPKVIIEAAVPGRELE
Mvan_2143|M.vanbaalenii_PYR-1 PVFVKPSRGGSSIGVSRVTAWDALPAAIELARRHDPKVIVEAAIPGRELE
MSMEG_2395|M.smegmatis_MC2_155 PVFVKPARGGSSIGVSRVTAWDELPAAVALARRHDPKVIVEAAVIGRELE
TH_2049|M.thermoresistible__bu PVFVKPARGGSSIGVTRVTDWSALPGAVAEARRHDPKVIVEAAIEGRELE
Mb3005c|M.bovis_AF2122/97 PVFVKPARGGSSIGVSRVSSWDQLPAAVARARRHDPKVIVEAAISGRELE
Rv2981c|M.tuberculosis_H37Rv PVFVKPARGGSSIGVSRVSSWDQLPAAVARARRHDPKVIVEAAISGRELE
MLBr_01678|M.leprae_Br4923 PVFVKPARGGSSIGISRVSSWGQLPSAIAYARRHDPKVIVEAAVNGRELE
MMAR_1733|M.marinum_M PAYVKPARGGSSIGVSRVSSFDELPAAIAAARRHDPKVIVEAAINGRELE
MUL_1976|M.ulcerans_Agy99 PAYVKPARGGSSIGVSRVSSFDELPAAIAAARRHDPKVIVEAAINGRELE
MAV_3830|M.avium_104 PVFVKPARGGSSIGVSRVSSWDELDAAVAAARDHDPKVIVEAAIAGRELE
MAB_3286c|M.abscessus_ATCC_199 PVFVKPARAGSSFGVSRVTAWEELPAAIAHARQYDPKVIVEAAIVGRELE
*.:***:*.***:*::**: : * .*: ** :*****:***: *****
Mflv_4219|M.gilvum_PYR-GCK CGVLEFPDGHLEASTLGEIRVEGVRG---REDGFYDFETKYLDDGAELDV
Mvan_2143|M.vanbaalenii_PYR-1 CGVLEFPDGHLEASTVGEIRVAGVRG---REDGFYDFETKYLDDGAELDV
MSMEG_2395|M.smegmatis_MC2_155 CGVLEFPDGRLEASTVGEIRVAGVRG---REDGFYDFATKYLEDAAELDV
TH_2049|M.thermoresistible__bu CAVLEFPDGRVRSSTVGEIRVAGVRG---REDGFYDFTTKYLADDAELDV
Mb3005c|M.bovis_AF2122/97 CGVLEMPDGTLEASTLGEIRVAGVRG---REDSFYDFATKYLDDAAELDV
Rv2981c|M.tuberculosis_H37Rv CGVLEMPDGTLEASTLGEIRVAGVRG---REDSFYDFATKYLDDAAELDV
MLBr_01678|M.leprae_Br4923 CGVLEMPDGTVAASAVGEIRVAGVSG---SEDSFYDFTTKYLDDAAELDV
MMAR_1733|M.marinum_M CGVLEFPDGRLEASTLGEIRVAGVRG---REDGFYDFETKYLDDAAELDV
MUL_1976|M.ulcerans_Agy99 CGVLEFPDGRLEASTLGEIRVAGVRG---REDGFYDFETKYLDDAAELDV
MAV_3830|M.avium_104 CGVLEMPDGTVQASTVGEIRVAGVRG---REDSFYDFATKYLDDTAELDV
MAB_3286c|M.abscessus_ATCC_199 CGVLEFPDGDTRASVLGEIRVEGVNRDQTAAGAFYDFETKYLDDTAELDV
*.***:*** :*.:***** ** ..**** **** * *****
Mflv_4219|M.gilvum_PYR-GCK PAKVDDDVAEAIRALSLRAFTAIDCQGLARVDFFLTDDGPVINEINTMPG
Mvan_2143|M.vanbaalenii_PYR-1 PAKVDDAIAEAVRGLAIRAFDAIDCQGLARVDFFLTDAGPVINEINTMPG
MSMEG_2395|M.smegmatis_MC2_155 PAKVDDDVADEIRQLAVRAFTAIGCQGLARVDFFLTDDGPVINEINTMPG
TH_2049|M.thermoresistible__bu PAKIDDAVADEVRELAIKAFHAIDCQGLARVDFFLTDDGPVVNEINTMPG
Mb3005c|M.bovis_AF2122/97 PAKVDDQVAEAIRQLAIRAFAAIDCRGLARVDFFLTDDGPVINEINTMPG
Rv2981c|M.tuberculosis_H37Rv PAKVDDQVAEAIRQLAIRAFAAIDCRGLARVDFFLTDDGPVINEINTMPG
MLBr_01678|M.leprae_Br4923 PAKVDDDVADEVRQLAIQAFRAIDCQGLARVDFFLTDDGPVINEINTMPG
MMAR_1733|M.marinum_M PAKVEDDVADAVRQLAIRAFEAIDCQGLARVDFFLTDDGPVINEINTMPG
MUL_1976|M.ulcerans_Agy99 PAKVEDDVADAVRQLAIRAFEAIDCQGLARVDFFLTDDGPVINELNTMPG
MAV_3830|M.avium_104 PAKVDDEIADAVRELAIRAFKAVDCQGLARVDFFLTETGPVLNEINTMPG
MAB_3286c|M.abscessus_ATCC_199 PAKVDDDVSDQIRELAVAAFRAIDCQGLARVDFFLAEDGPLINEINTMPG
***::* ::: :* *:: ** *:.*:*********:: **::**:*****
Mflv_4219|M.gilvum_PYR-GCK FTTISMYPRMWAASGVDYPTLLATMVETALARGTGLR
Mvan_2143|M.vanbaalenii_PYR-1 FTTISMYPRMWAASGIDYPTLLATMVETAIARGTGLR
MSMEG_2395|M.smegmatis_MC2_155 FTTISMYPRMWAAGGIDYPTLLAAMVDTAIARGTGLR
TH_2049|M.thermoresistible__bu FTMISMYPRMWAASGVDYPTLLAAMVDTALARGTGLR
Mb3005c|M.bovis_AF2122/97 FTTISMYPRMWAASGVDYPTLLATMIETALARGVGLH
Rv2981c|M.tuberculosis_H37Rv FTTISMYPRMWAASGVDYPTLLATMIETTLARGVGLH
MLBr_01678|M.leprae_Br4923 FTMTSMYPKLWAVSSVDYPTLLATMVDTALARGVGMR
MMAR_1733|M.marinum_M FTTISMYPRMWAASGVDYPTLLATMVETALSRGIGLR
MUL_1976|M.ulcerans_Agy99 FTTISMYPRMWVASGVDYPTLLATMVETALSRGIGLR
MAV_3830|M.avium_104 FTTISMYPRMWAASGVDYPSLLATMVETALTRGVGLR
MAB_3286c|M.abscessus_ATCC_199 FTTISMYPRMWDATGVDYPTLLDAMVRTALARGTGLR
** ****::* . .:***:** :*: *:::** *::