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VMAQEYPKANALPAQDVGRLLLRCADRPGLVAAISGFLTAAGANIVSLDQHSTEQAGGTFIQRTIFHLPG LTAVRDELERSFREQVAGPFEMDFTLTEAAKPKRVALMASREDHCLLDLLWRNRRGELPMSVVMVIANHP DLAEQVRAFGVPFIYVPATKENRAEAEQRLLELLRGNVDLVVLARYMQILTPEFLDAVGCPLINIHHSFL PAFIGAAPYRRAKERGVKLVGATAHYVTEDLDEGPIIEQDVVRVDHRHTVEDLVRLGADVERLVLSRAVL WHCEDRVIRFGNQTVVF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2200 | purU | - | 100% (297) | formyltetrahydrofolate deformylase |
| M. smegmatis MC2 155 | MSMEG_5516 | purN | 7e-16 | 35.60% (191) | phosphoribosylglycinamide formyltransferase |
| M. smegmatis MC2 155 | MSMEG_3064 | fmt | 4e-08 | 26.71% (161) | methionyl-tRNA formyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2988 | purU | 1e-129 | 76.29% (291) | formyltetrahydrofolate deformylase |
| M. gilvum PYR-GCK | Mflv_5090 | purU | 1e-139 | 82.82% (291) | formyltetrahydrofolate deformylase |
| M. tuberculosis H37Rv | Rv2964 | purU | 1e-129 | 76.29% (291) | formyltetrahydrofolate deformylase |
| M. leprae Br4923 | MLBr_00160 | purN | 3e-12 | 35.26% (156) | phosphoribosylglycinamide formyltransferase |
| M. abscessus ATCC 19977 | MAB_1306 | purU | 1e-120 | 70.49% (288) | formyltetrahydrofolate deformylase |
| M. marinum M | MMAR_1753 | purU | 1e-128 | 74.16% (298) | formyltetrahydrofolate deformylase PurU |
| M. avium 104 | MAV_1080 | purN | 3e-13 | 33.92% (171) | phosphoribosylglycinamide formyltransferase |
| M. thermoresistible (build 8) | TH_1912 | purU | 1e-136 | 81.57% (293) | PROBABLE FORMYLTETRAHYDROFOLATE DEFORMYLASE PURU |
| M. ulcerans Agy99 | MUL_4713 | purN | 7e-12 | 29.35% (201) | phosphoribosylglycinamide formyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1265 | purU | 1e-138 | 82.82% (291) | formyltetrahydrofolate deformylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2988|M.bovis_AF2122/97 MGKGSMTAHATPNEPDYPPPPGGPPPPADIGRLLLRCHDRPGIIAAVSTF
Rv2964|M.tuberculosis_H37Rv MGKGSMTAHATPNEPDYPPPPGGPPPPADIGRLLLRCHDRPGIIAAVSTF
MMAR_1753|M.marinum_M MSQN------------FPPPPGGPPQPADIGRLLLRCHDHPGIIAAVSTF
MSMEG_2200|M.smegmatis_MC2_155 -----------MMAQEYPKAN--ALPAQDVGRLLLRCADRPGLVAAISGF
TH_1912|M.thermoresistible__bu ---------------VYPRSDHAELPVADVGRLLLRCPDRPGLVAAVSAF
Mflv_5090|M.gilvum_PYR-GCK ---------------MVEHTDADIHGPKDIGRLLLRCADRPGLIAAVSGF
Mvan_1265|M.vanbaalenii_PYR-1 ---------------MVEHTDADIHGPRDIGRLLLRCADRPGLIAAVSGF
MAB_1306|M.abscessus_ATCC_1997 ----------MFPQGMHPTGSSDAFHSKDIGRLLLQCPDRIGVVAAVSAF
MLBr_00160|M.leprae_Br4923 --------------------------------------------------
MAV_1080|M.avium_104 --------------------------------------------------
MUL_4713|M.ulcerans_Agy99 --------------------------------------------------
Mb2988|M.bovis_AF2122/97 LARAGANIISLDQHSTAPEGGTFLQRAIFHLPGLTAAVDELQRDFGSTVA
Rv2964|M.tuberculosis_H37Rv LARAGANIISLDQHSTAPEGGTFLQRAIFHLPGLTAAVDELQRDFGSTVA
MMAR_1753|M.marinum_M LTQAGANIISLDQHSTAPEGGTFLQRAIFHLPGLTAAIDELQREFGSAVA
MSMEG_2200|M.smegmatis_MC2_155 LTAAGANIVSLDQHSTEQAGGTFIQRTIFHLPGLTAVRDELERSFREQVA
TH_1912|M.thermoresistible__bu LAEAGANIISLDQHSTEQTGGIFMQRTIFHLPGLPAVRDTLEREFAERVA
Mflv_5090|M.gilvum_PYR-GCK LTQTGANIISLDQHSTEPVGGTFMQRTIFHLPGLTAARDGLEREFAEKVA
Mvan_1265|M.vanbaalenii_PYR-1 LTQTGANIISLDQHSTEPVGGTFMQRTIFHLPGLPAARDGLERDFAAQVA
MAB_1306|M.abscessus_ATCC_1997 LAEAGASIISLAQYSTEPQGGWFMQRTVFHRSGLAAARDAMEAKFAS-IA
MLBr_00160|M.leprae_Br4923 -----------------------MQEPLCVSP------------------
MAV_1080|M.avium_104 -----------------------MVEPLHVPP------------------
MUL_4713|M.ulcerans_Agy99 -----------------------MQEPVRVPP------------------
: ..: .
Mb2988|M.bovis_AF2122/97 DKFGIDYRFAEAAKPKRVAIMASTEDHCLLDLLWRNRRGELEMSVVMVIA
Rv2964|M.tuberculosis_H37Rv DKFGIDYRFAEAAKPKRVAIMASTEDHCLLDLLWRNRRGELEMSVVMVIA
MMAR_1753|M.marinum_M DKFDIDYRFTEAAKPKRVAIMASKEDHCLLDLLWRNRRGELEMSVAMVIA
MSMEG_2200|M.smegmatis_MC2_155 GPFEMDFTLTEAAKPKRVALMASREDHCLLDLLWRNRRGELPMSVVMVIA
TH_1912|M.thermoresistible__bu GRFGMDFKLTEAARPKRVAIMASREDHCLLDLLWRNRRGELNMTVVMVIA
Mflv_5090|M.gilvum_PYR-GCK EPFGIDFRLTEAAKPKRVAIMASREDHCLLDLLWRNRRGELDMSVVMVIA
Mvan_1265|M.vanbaalenii_PYR-1 DPFGMDFRLTEAAKPKRVAIMASREDHCLLDLLWRNRRGELDMSVVMVIA
MAB_1306|M.abscessus_ATCC_1997 EEFDIQYRFSEAAKPKRVAIMVSRTDHCLLDLLWRNRRGELDMSIAMVIS
MLBr_00160|M.leprae_Br4923 ------------SAPSRVVVLASG-TGSLLGSLIDASVGNYPARVVAVGV
MAV_1080|M.avium_104 ------------NAPARVVVLASG-TGSLLSSLIDAAVGDYPARVVAVGA
MUL_4713|M.ulcerans_Agy99 ------------SAPARLVVLASG-TGSLLNSLLDAAVADYPARIVAVGV
* *:.::.* .**. * .: :. *
Mb2988|M.bovis_AF2122/97 NHPDLAAHVRPFG-VPFIHIPATRDTRTEAEQRQLQLLSG--NVDLVVLA
Rv2964|M.tuberculosis_H37Rv NHPDLAAHVRPFG-VPFIHIPATRDTRTEAEQRQLQLLSG--NVDLVVLA
MMAR_1753|M.marinum_M NHADLADHVRPFG-VPFIHIPVTRDTRADAEQRQLQLLSG--NVDLVILA
MSMEG_2200|M.smegmatis_MC2_155 NHPDLAEQVRAFG-VPFIYVPATKENRAEAEQRLLELLRG--NVDLVVLA
TH_1912|M.thermoresistible__bu NHPELADQVRPFD-VPFIHVPASKEIREQAEQRQLELLRG--NVDLVVLA
Mflv_5090|M.gilvum_PYR-GCK NHPDLADAVRPFG-VPFIHVPARTEIRDEAEQRQLDLLRG--NVDLVVLA
Mvan_1265|M.vanbaalenii_PYR-1 NHPDLADAVRPFG-VPFIHVPARTEIRDEAEQRQLDLLRG--NVDLVVLA
MAB_1306|M.abscessus_ATCC_1997 NHPDLADQVRSFG-LPFVHIPATRENRADAERKQLELLQG--NVDLVVLA
MLBr_00160|M.leprae_Br4923 DRDCGATKIAKAASVPTFTVRLADPPGRDAWDAKITEAVASYKPDLVVLA
MAV_1080|M.avium_104 DRDCLATQIAAAASLPSFTVRLGDHPDRAAWDAAITEATAAHSPDLVVSA
MUL_4713|M.ulcerans_Agy99 DRDCRATEVAAQASVPAFTVRVSDHPSRDAWNAAITAATAAHSPDLVVSA
:: * : :* . : * : . . ***: *
Mb2988|M.bovis_AF2122/97 RYMQILSPGFLEAIGCPLINIHHSFLPAFTGAAPYQRARERGVKLIGATA
Rv2964|M.tuberculosis_H37Rv RYMQILSPGFLEAIGCPLINIHHSFLPAFTGAAPYQRARERGVKLIGATA
MMAR_1753|M.marinum_M RYMQILSPAFLDAIGCPLINIHHSFLPAFTGASPYKRARERGVKLIGATA
MSMEG_2200|M.smegmatis_MC2_155 RYMQILTPEFLDAVGCPLINIHHSFLPAFIGAAPYRRAKERGVKLVGATA
TH_1912|M.thermoresistible__bu RYMQILTPRFLDEVGVPLINIHHSFLPAFIGAAPYQQAKDRGVKLIGATA
Mflv_5090|M.gilvum_PYR-GCK RYMQILTPGFIEQVGCPLINIHHSFLPAFIGASPYRRAKERGVKLVGATA
Mvan_1265|M.vanbaalenii_PYR-1 RYMQILTPSFIEQVGCPLINIHHSFLPAFIGASPYRRAKERGVKLVGATA
MAB_1306|M.abscessus_ATCC_1997 RYMQILSPEFLNEIDCPLINIHHSFLPAFTGAMPYRRARERGVKMIGATA
MLBr_00160|M.leprae_Br4923 GFMRILGPQFLARFFGRIVNTHPALLPAFPGTHGVADALAYGVKVTGATV
MAV_1080|M.avium_104 GFMKILGPQFLSRFYGRVINTHPALLPAFPGAHGVAEALAYGVKVTGCTV
MUL_4713|M.ulcerans_Agy99 GFMRILGPQFLSKFHQRILNTHPALLPAFPGAHGVADALAYGVKVTGCTV
:*:** * *: . ::* * ::**** *: * ***: *.*.
Mb2988|M.bovis_AF2122/97 HYVTEVLDEGPIIEQDVVRVDHTHTVDDLVRVGADVERAVLSRAVLWHCQ
Rv2964|M.tuberculosis_H37Rv HYVTEVLDEGPIIEQDVVRVDHTHTVDDLVRVGADVERAVLSRAVLWHCQ
MMAR_1753|M.marinum_M HYVTEALDEGPIIEQDVVRVDHNDTVHDLVRVGADVERAVLSRAVLWHCQ
MSMEG_2200|M.smegmatis_MC2_155 HYVTEDLDEGPIIEQDVVRVDHRHTVEDLVRLGADVERLVLSRAVLWHCE
TH_1912|M.thermoresistible__bu HYVTEELDEGPIIEQDVVRVDHRDTVDDLRRMGADVERVVLSRAVRWHCE
Mflv_5090|M.gilvum_PYR-GCK HYVTDDLDEGPIIEQDVVRVDHRHSVDDLVRLGADVERAVLSRAVLWHCE
Mvan_1265|M.vanbaalenii_PYR-1 HYVTDDLDEGPIIEQDVVRVDHRHSVDDLVRLGADVERAVLSRAVLWHCE
MAB_1306|M.abscessus_ATCC_1997 HYVTAELDEGPIIEQDVIRVDHTHTVEDLVRLGSDVERLVLSRAVAWHCE
MLBr_00160|M.leprae_Br4923 HLVDAGTDTGPILAQQSVPVLDGDDTAALHERIKVIERRLLVDVVAVIAT
MAV_1080|M.avium_104 HLVDAGTDTGPILAQQSVPVLDGDDEQTLHERIKVTERKLLVDVVAAIAT
MUL_4713|M.ulcerans_Agy99 HLVDAGMDTGPILAQQAIAVLDGDDEATLHERIKVVERKLLVDVVAGIAA
* * * ***: *: : * . . * . ** :* .* .
Mb2988|M.bovis_AF2122/97 DRVIVHHNQTIVF------
Rv2964|M.tuberculosis_H37Rv DRVIVHHNQTIVF------
MMAR_1753|M.marinum_M DRVIVHHNQTIVF------
MSMEG_2200|M.smegmatis_MC2_155 DRVIRFGNQTVVF------
TH_1912|M.thermoresistible__bu DRVIRYGNQTVVL------
Mflv_5090|M.gilvum_PYR-GCK DRVIRHGNQTICL------
Mvan_1265|M.vanbaalenii_PYR-1 DRVIRHGNQTICL------
MAB_1306|M.abscessus_ATCC_1997 DRVMRHGNVTAIL------
MLBr_00160|M.leprae_Br4923 GGVTLVGRKATIGRKATIE
MAV_1080|M.avium_104 GGLTLVGRKATIG------
MUL_4713|M.ulcerans_Agy99 GGVTVIGRKAMIGRKATIG
. : . :