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MAVDWERRIDFDRLRTQRLTRALDALERSELGALLLFDMNNIRYTTATHIGNWARDKLFRMALLIRGQAP ILWDIGSAARLHQMQAPWLPQESWRAGLSTWRGAIDDEVGVQTGNAKKVADLLREHGLANDPVGVDVVEL PMLKALEAEGLTIVDGQGLMLDVRSIKTVDEIALLDHAAACVDAAYEELYKFLRVGVKENETVALVNKVL YELGSEEVEAVNAISGERCSPHPHVFSDRMIRPMDTAYFDIVHSYMGYRTCYYRTLNVAGATRAQRDAYK RAREYIDLAISEVKPGVLTSDIVKHFPAAQEFGFASEEEAFGLQYCHGVGLSVWEKPLMSRYHSFDHPVE IKEGMVFALETYWPTADGSSAARIEEEVEVTATGARVITRFPADELLVAGTRYWNGFDFPEIKAPIGRGV ASGVAATNGAGAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2167 | - | - | 100% (433) | aminopeptidase, putative |
| M. smegmatis MC2 155 | MSMEG_3881 | - | 2e-15 | 28.79% (264) | proline dipeptidase |
| M. smegmatis MC2 155 | MSMEG_4854 | - | 5e-12 | 25.00% (412) | peptidase, M24 family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2116c | pepE | 3e-15 | 27.70% (278) | dipeptidase PepE |
| M. gilvum PYR-GCK | Mflv_3098 | - | 3e-18 | 27.46% (386) | peptidase M24 |
| M. tuberculosis H37Rv | Rv2089c | pepE | 3e-15 | 27.70% (278) | dipeptidase PepE |
| M. leprae Br4923 | MLBr_00521 | pepQ | 2e-07 | 24.34% (267) | putative cytoplasmic peptidase |
| M. abscessus ATCC 19977 | MAB_2192 | - | 8e-14 | 25.85% (383) | dipeptidase PepE |
| M. marinum M | MMAR_3075 | pepE | 1e-13 | 26.72% (262) | dipeptidase PepE |
| M. avium 104 | MAV_2414 | - | 2e-14 | 27.86% (262) | proline dipeptidase |
| M. thermoresistible (build 8) | TH_0446 | - | 8e-15 | 29.17% (264) | proline dipeptidase |
| M. ulcerans Agy99 | MUL_2321 | pepE | 3e-14 | 26.72% (262) | dipeptidase PepE |
| M. vanbaalenii PYR-1 | Mvan_3437 | - | 7e-18 | 29.71% (276) | peptidase M24 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3098|M.gilvum_PYR-GCK ----MTDARFGTDVYAHRLRAAAEAAATAGLSGLVITPGYDLRYLTGSRA
Mvan_3437|M.vanbaalenii_PYR-1 ----MSQDRFDTEVYARRLRAAAAAAADAGLAGLVITPGYDLRYLVGSRA
TH_0446|M.thermoresistible__bu ----MSANRFSTDVYATRLRAAAAATAEAGLSGLVITPGYDLQYLTGSRA
Mb2116c|M.bovis_AF2122/97 ----MGSRRFDAEVYARRLALAAAATADAGLAGLVITPGYDLCYLIGSRA
Rv2089c|M.tuberculosis_H37Rv ----MGSRRFDAEVYARRLALAAAATADAGLAGLVITPGYDLCYLIGSRA
MMAR_3075|M.marinum_M ----MDSGRFDTAVYARRLAAAAAATEQAGLAGLVITPGYDLRYLIGSRA
MUL_2321|M.ulcerans_Agy99 ----MDSGRFDTAVYARRLAAAAAATEQAGLAGLVITPGYDLRYLIGSRA
MAV_2414|M.avium_104 ----MESHRFDADVYARRLAAAASATAAAGLVGLVITPGYDLRYLVGSRA
MAB_2192|M.abscessus_ATCC_1997 ----MAPQRFESDVYADRLRRAAQEAEKVGVTGLVVTPGYDLRYLTGSRA
MLBr_00521|M.leprae_Br4923 ------------MTHSQRRDNLKSQIATTGLDAMLVTCLINVRYLSGFTG
MSMEG_2167|M.smegmatis_MC2_155 MAVDWERRIDFDRLRTQRLTRALDALERSELGALLLFDMNNIRYTTATHI
: * : .::: :: * .
Mflv_3098|M.gilvum_PYR-GCK QTFE--RLTALVLPAAGEPTIVVPRLELAALKESAIPELG----------
Mvan_3437|M.vanbaalenii_PYR-1 QTFE--RLTALVLPATGDPTVVVPRLELASLKDSAVTELG----------
TH_0446|M.thermoresistible__bu QTFE--RLMALVVPASGEPTLVLPRLELAVLKDSAVPELG----------
Mb2116c|M.bovis_AF2122/97 ETFE--RLTALVLPAAGAPAVVLPRLELAALKQSAAAELG----------
Rv2089c|M.tuberculosis_H37Rv ETFE--RLTALVLPAAGAPAVVLPRLELAALKQSAAAELG----------
MMAR_3075|M.marinum_M DTFE--RLTALVLPASGVPTIVLPRLELASLKESAASDLG----------
MUL_2321|M.ulcerans_Agy99 DTFE--RLTALVLPASGVPTIVLPRLELASLKESAASDLG----------
MAV_2414|M.avium_104 QTLE--RFTALVLPASGEPTVVVPRLEVASLKGSAIAELG----------
MAB_2192|M.abscessus_ATCC_1997 QTFE--RLTALVVPATGQPTVVAPRMELAALRDSAIGDLN----------
MLBr_00521|M.leprae_Br4923 S------NGALLVFADERGAVLATDGRYRTQAAQQVPELE----------
MSMEG_2167|M.smegmatis_MC2_155 GNWARDKLFRMALLIRGQAPILWDIGSAARLHQMQAPWLPQESWRAGLST
: : .:: *
Mflv_3098|M.gilvum_PYR-GCK --VAVRDWVDGEN-PYQLVADALPGDGPQSVAVTDSMTALHLLPLADVLG
Mvan_3437|M.vanbaalenii_PYR-1 --VAVRDWVDGDD-PYRLVVEALPGDGPLAVAVTDSMPALHLLPLAEVLG
TH_0446|M.thermoresistible__bu --LTVRDWVDGDD-PYRLVAEALGAGPSGRPAVTDSMPALHLLPLTDLLG
Mb2116c|M.bovis_AF2122/97 --LRVCDWVDGDD-PYGLVSAVLGG-APVATAVTDSMPALHMLPLADALG
Rv2089c|M.tuberculosis_H37Rv --LRVCDWVDGDD-PYGLVSAVLGG-APVATAVTDSMPALHMLPLADALG
MMAR_3075|M.marinum_M --VCVRDWVDGDD-PYQLVAEALGG-APAATAVTDSMPALHLLPLADALG
MUL_2321|M.ulcerans_Agy99 --VCVRDWVDGDD-PYQLVAVALGG-APAATAVTDSMPALHLLPLADALG
MAV_2414|M.avium_104 --LPVRDWVDGEN-PYEMVAAALGG-APAATAVTDSIPALHLLPMAGVLG
MAB_2192|M.abscessus_ATCC_1997 --IPISDWVDGEN-PYELVRAALGT--AGTVAVTESMPALHLLPLAQLVG
MLBr_00521|M.leprae_Br4923 --VAIEQSCGRYL-AGRAADDGVCILGFESHVVTVDG-LDALTGELEGRH
MSMEG_2167|M.smegmatis_MC2_155 WRGAIDDEVGVQTGNAKKVADLLREHGLANDPVGVDVVELPMLKALEAEG
: : . . : * . :
Mflv_3098|M.gilvum_PYR-GCK TVPVLATDVLRTLRMIKDPAEIDALRKAGAAIDRVHARVPEF--LVPGRT
Mvan_3437|M.vanbaalenii_PYR-1 AVPVLATDVLRNLRMVKDPAEIDALRKAGAAIDRVHERVPQF--LRPGRT
TH_0446|M.thermoresistible__bu SVPVLATSVLRRLRMIKDPAEIDALRKAGAAIDRVHARVPEF--LVPGRT
Mb2116c|M.bovis_AF2122/97 VLPVLATDVLRRLRMVKEETEIDALRKAGAAIDRVHARVPEF--LVPGRT
Rv2089c|M.tuberculosis_H37Rv VLPVLATDVLRRLRMVKEETEIDALRKAGAAIDRVHARVPEF--LVPGRT
MMAR_3075|M.marinum_M VLPVLATDVLRQLRMVKEAAEVDALAKAGAAIDRVHARVPAF--LVPGRT
MUL_2321|M.ulcerans_Agy99 VLPVLATDVLRQLRMVKEAAEVDALAKAGAAIDRVHARVPAF--LVPGRT
MAV_2414|M.avium_104 VLPVLATDVLRGLRMVKEECEVDALRKAGAAIDRVHARVPSF--LVPGRT
MAB_2192|M.abscessus_ATCC_1997 TVPVLATGVLRRLRMVKDASEIDALRKAGAAIDRVHALVPEL--LIPGRT
MLBr_00521|M.leprae_Br4923 TELVRAPGTVEVLREVKDAGELALLRLAAEAADAALTELVARGGVRPGLT
MSMEG_2167|M.smegmatis_MC2_155 LTIVDGQGLMLDVRSIKTVDEIALLDHAAACVDAAYEELYKF--LRVGVK
* . . : :* :* *: * *. . * . : : * .
Mflv_3098|M.gilvum_PYR-GCK EADVAADIAQAIVAEGHSEVAFI-IVGSGPHGADPHHECSDRELQAGDIV
Mvan_3437|M.vanbaalenii_PYR-1 EADVAADIAEAIVAEGHSEVAFI-IVGSGPHGADPHHECSDRELRAGDIV
TH_0446|M.thermoresistible__bu EADVAADIAEAIVAEGHSDVAFI-IVGSGPHGADPHHECSDRTLQVGDIV
Mb2116c|M.bovis_AF2122/97 EADVAADIAEAIVAEGHSEVAFV-IVGSGPHGADPHHGYSDRELREGDIV
Rv2089c|M.tuberculosis_H37Rv EADVAADIAEAIVAEGHSEVAFV-IVGSGPHGADPHHGYSDRELREGDIV
MMAR_3075|M.marinum_M EAQVAADIAEAIVAEGHSGVAFV-IVGSGPHGADPHHGYSDRKLQVGDIV
MUL_2321|M.ulcerans_Agy99 EAQVAADIAEAIVAEGHSAVAFV-IVGSGPHGADPHHGYSDRKLQVGDIV
MAV_2414|M.avium_104 EADVAADIAEAIVAEGHSEVAFI-IVGSGPHGADPHHGYSDRELQVGDIV
MAB_2192|M.abscessus_ATCC_1997 EAQVAADIAEAIVAEGHSEVAFI-IVGSGPHGADPHHECSDRELRTGDIV
MLBr_00521|M.leprae_Br4923 EREVGRELEGLMLDHGADALSFETIVAAGPNSAIPHHRPTDTVLAAGDFV
MSMEG_2167|M.smegmatis_MC2_155 ENETVALVNKVLYELGSEEVEAVNAISGERCSPHP-HVFSDRMIRPMDTA
* :. : : * . : :.. .. * * :* : * .
Mflv_3098|M.gilvum_PYR-GCK VVDIGGPYDPGYNSDSTRTYSIGEPDPEVARRYAVLQRAQRAAVDAVRPG
Mvan_3437|M.vanbaalenii_PYR-1 VVDIGGPYDPGYNSDSTRTYSIGEPDPEVARRYAVLQRAQRVAVDMVRPG
TH_0446|M.thermoresistible__bu VVDIGGPYAPGYHSDCTRTYSIGEPDPEIARRYAVLQRAQRAAVDAVRPG
Mb2116c|M.bovis_AF2122/97 VVDIGGTYGPGYHSDSTRTYSIGEPDSDVAQSYSMLQRAQRAAFEAIRPG
Rv2089c|M.tuberculosis_H37Rv VVDIGGTYGPGYHSDSTRTYSIGEPDSDVAQSYSMLQRAQRAAFEAIRPG
MMAR_3075|M.marinum_M VVDIGGTYEPGYYSDSTRTYSIGDPSPDVAQQYSALQRAQRAAVDAVRPG
MUL_2321|M.ulcerans_Agy99 VVDIGGTYEPGYYSDSTRTYSIGDPSPDVAQQYSALQRAQRAAVDAVRPG
MAV_2414|M.avium_104 VVDIGGSYEPGYHSDSTRTYSIGEPSHEVAQQYSILQRAQRAACDAVRPG
MAB_2192|M.abscessus_ATCC_1997 VVDIGGSYEPGYNSDSTRTYSIGEPDPDVAQRISVLERAQQAAVHAARPG
MLBr_00521|M.leprae_Br4923 KIDFG-ALVAGYHSDMTRTFVLGPAADWQLEIYQLVADAQRAGRKALRPG
MSMEG_2167|M.smegmatis_MC2_155 YFDIVHSYMG-YRTCYYRTLNVAGATRAQRDAYKRAREYIDLAISEVKPG
.*: . * : ** :. . . :**
Mflv_3098|M.gilvum_PYR-GCK VTAEQVD--AAARDVLADEGLADAFVHRTGHGIGLSVHEEPYIVA----G
Mvan_3437|M.vanbaalenii_PYR-1 VTAEQVD--AAARDVLAAEGLAEAFVHRTGHGIGLSVHEEPYIVA----G
TH_0446|M.thermoresistible__bu VTAEQID--AAARDVLAAEGLAEAFVHRTGHGIGLSVHEEPYIVA----G
Mb2116c|M.bovis_AF2122/97 VTAEQVD--AAARDVLAEAGLAEYFVHRTGHGIGLCVHEEPYIVA----G
Rv2089c|M.tuberculosis_H37Rv VTAEQVD--AAARDVLAEAGLAEYFVHRTGHGIGLCVHEEPYIVA----G
MMAR_3075|M.marinum_M VTAAQVD--AAARDVLADAGLAEYFVHRTGHGIGLCVHEEPYIVA----G
MUL_2321|M.ulcerans_Agy99 VTAAQVD--AAARDVLADAGLAEYFVHRTGHGIGLCVHEEPYIVA----G
MAV_2414|M.avium_104 VTAEQVD--AAARDVLAAAGLAEYFVHRTGHGIGLSVHEEPYIVA----G
MAB_2192|M.abscessus_ATCC_1997 VTAESVD--AAARRVLTEAGMGEAFVHRTGHGIGLSVHEEPYIVE----G
MLBr_00521|M.leprae_Br4923 ANLRDVD--AAARQLIVDAGYGQQFSHGLGHGVGLEIHEAPGIGT----T
MSMEG_2167|M.smegmatis_MC2_155 VLTSDIVKHFPAAQEFGFASEEEAFGLQYCHGVGLSVWEKPLMSRYHSFD
. .: .* : . : * **:** : * * :
Mflv_3098|M.gilvum_PYR-GCK NALPLQEGMAFSVEPGIYFP-GQWGARIEDIVVVTADG--ALAVNNRPHD
Mvan_3437|M.vanbaalenii_PYR-1 NSLPLQEGMAFSVEPGIYFP-GQWGARIEDIVIVTGDG--AEPVNHRPHE
TH_0446|M.thermoresistible__bu NNVPLEAGMAFSVEPGIYFP-GQWGARIEDIVIVTADG--AEPVNHRPHE
Mb2116c|M.bovis_AF2122/97 NDLVLVPGMAFSIEPGIYFP-GRWGARIEDIVIVTEDG--AVSVNNCPHE
Rv2089c|M.tuberculosis_H37Rv NDLVLVPGMAFSIEPGIYFP-GRWGARIEDIVIVTEDG--AVSVNNCPHE
MMAR_3075|M.marinum_M NELPLVAGMAFSVEPGIYFP-GRWGARIEDIVVVTEDG--ALSVNNRPHE
MUL_2321|M.ulcerans_Agy99 NELPLVAGMAFSIEPGIYFP-GRWGARIEDIVVVTENG--ALSVNNRPHE
MAV_2414|M.avium_104 NDLPLAAGMAFSIEPGIYFP-GRWGARIEDIVVVTDDG--ALAVNNRPHE
MAB_2192|M.abscessus_ATCC_1997 NELVLEPGMAFSIEPGVYFP-GQWGARIEDIVVITENG--CESVNSRPHG
MLBr_00521|M.leprae_Br4923 SAGTLLAGSVVTVEPGVYLS-GRGGVRIEDTLVVAAKGTSETPITSRPTG
MSMEG_2167|M.smegmatis_MC2_155 HPVEIKEGMVFALETYWPTADGSSAARIEEEVEVTATG--ARVITRFPAD
: * ..::*. . * ..***: : :: * :. *
Mflv_3098|M.gilvum_PYR-GCK LVVVPVP--------------------------------
Mvan_3437|M.vanbaalenii_PYR-1 LVVVPVP--------------------------------
TH_0446|M.thermoresistible__bu LVVVVPV--------------------------------
Mb2116c|M.bovis_AF2122/97 LIVVPVS--------------------------------
Rv2089c|M.tuberculosis_H37Rv LIVVPVS--------------------------------
MMAR_3075|M.marinum_M LMVVPVS--------------------------------
MUL_2321|M.ulcerans_Agy99 LMVVPVS--------------------------------
MAV_2414|M.avium_104 LIVVPVP--------------------------------
MAB_2192|M.abscessus_ATCC_1997 LTVVPTR--------------------------------
MLBr_00521|M.leprae_Br4923 FIPELLTRFPKELAIL-----------------------
MSMEG_2167|M.smegmatis_MC2_155 ELLVAGTRYWNGFDFPEIKAPIGRGVASGVAATNGAGAS