For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LGRALSLVWRRSLQLRVVTLTLGLSLAVILVLGFVLTSQITDRILEVKVKAATEEVERARNTVSGIVGGE ESRSLESSLQLARNTLVDRKADVRADMAGAFDAVLVVPGDGPRAAAAAGPVAQIPEALRDFVKAGQVSYQ YATVQTEGFSGPALIVGSPTTSSVPNLELYLIFPLNNEESTIALVRGTMATGGVVLLGLLAAIALVVARQ IVQPVRSASRIAERFAEGHLTERMPVRGEDDMARLAVSFNDMAESLSRQIQQLEEFGNLQRRFTSDVSHE LRTPLTTVRMAADLIYDHSEDLDPALRRSTELMVNELDRFETLLADLLEISRHDAGVAELSVESLDLRST VRSALDNVGHLAADAGVELTLDMPEEDVIAEVDPRRVERILRNLIANAIDHAESKPVQIRMAADEDTVAV TVRDFGVGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISIEDARLHQGRLEAWGEPGKGACFRLTLP LVRGHKVTTSPLPLKPASEQRPARRRSNKDREAAEESV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1875 | - | - | 100% (528) | sensor histidine kinase MtrB |
| M. smegmatis MC2 155 | MSMEG_5870 | - | 3e-34 | 31.96% (341) | sensor histidine kinase PhoR |
| M. smegmatis MC2 155 | MSMEG_4989 | - | 7e-29 | 29.18% (401) | sensor histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3273c | mtrB | 0.0 | 83.23% (507) | two component sensory transduction histidine kinase MTRB |
| M. gilvum PYR-GCK | Mflv_4711 | - | 0.0 | 86.65% (532) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3245c | mtrB | 0.0 | 83.04% (507) | two component sensory transduction histidine kinase MTRB |
| M. leprae Br4923 | MLBr_00774 | mtrB | 0.0 | 80.70% (513) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_3590c | - | 0.0 | 76.60% (517) | sensor histidine kinase MtrB |
| M. marinum M | MMAR_1300 | mtrB | 0.0 | 82.64% (507) | two-component sensory transduction histidine kinase MtrB |
| M. avium 104 | MAV_4208 | - | 0.0 | 81.47% (518) | sensor histidine kinase MtrB |
| M. thermoresistible (build 8) | TH_0463 | mtrB | 0.0 | 86.28% (532) | TWO COMPONENT SENSORY TRANSDUCTION HISTIDINE KINASE MTRB |
| M. ulcerans Agy99 | MUL_2581 | mtrB | 0.0 | 81.66% (507) | two component sensory transduction histidine kinase MtrB |
| M. vanbaalenii PYR-1 | Mvan_1753 | - | 0.0 | 86.93% (528) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3273c|M.bovis_AF2122/97 --MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVALTLG
Rv3245c|M.tuberculosis_H37Rv --MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVALTLG
MMAR_1300|M.marinum_M --MIWGSRRRMRGRWGRSGPMTRGLSALSRAVGVAWRRSLQLRVVALTLG
MUL_2581|M.ulcerans_Agy99 --MIWGSRRRMRGRWGRSGPMTRGLSALSRAVGVAWRRSLQLRVVALTLG
MLBr_00774|M.leprae_Br4923 --MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFG
MAV_4208|M.avium_104 ------------------------MGAVSRAVGTAWRRSLQLRVVALTLG
MSMEG_1875|M.smegmatis_MC2_155 ---------------------------MGRALSLVWRRSLQLRVVTLTLG
TH_0463|M.thermoresistible__bu VAMIFSSRRRIRGR---SGPLLRGFGALGRALGHLWRRSLQLRVVALTLG
Mflv_4711|M.gilvum_PYR-GCK --MIFGSRRRIHRR---SAPLIRGLAALGRALSLAWRRSLQLRVVTLTLG
Mvan_1753|M.vanbaalenii_PYR-1 --MIFGSRRRIHRR---SAPLIRGLGALGRALSLAWRRSLQLRVVSLTLG
MAB_3590c|M.abscessus_ATCC_199 --MIFSSKRRIQRR---SAPLVRGLKALSRAVGFTWRRSLQVRVVVSNLA
: *.:. ******:*** .:.
Mb3273c|M.bovis_AF2122/97 LSLAVILALGFVLTSQVTNRVLDIKVRAAIDQIERARTTVSGIVNGEETR
Rv3245c|M.tuberculosis_H37Rv LSLAVILALGFVLTSQVTNRVLDIKVRAAIDQIERARTTVSGIVNGEETR
MMAR_1300|M.marinum_M LSLAVVMALGFVLTSQVTNRVLDIKVKAAIDQIERARNTVSGIVNGEETR
MUL_2581|M.ulcerans_Agy99 LSLAVVMALGFVLTSQVTNRVFDIKVKATIDQIERARNTVSGIVNGEETR
MLBr_00774|M.leprae_Br4923 LSLAVILALGFVLTSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETR
MAV_4208|M.avium_104 LSLAVILALGFVLTSQVTNRVLDVKVKAAIEQIERARTTVGGIVNGEEAR
MSMEG_1875|M.smegmatis_MC2_155 LSLAVILVLGFVLTSQITDRILEVKVKAATEEVERARNTVSGIVGGEESR
TH_0463|M.thermoresistible__bu LSLAVIVVLGFVLTSQITDRILEVKVQAAIEEIERARNTVSGIVGGEETR
Mflv_4711|M.gilvum_PYR-GCK LSLAVILVLGFVLTSQITDRILEVKVGAATEEIERARTTVSGIVGGEETR
Mvan_1753|M.vanbaalenii_PYR-1 LSLAVILVLGFVLTSQITDRILEVKVGAAIEEIERARTTVSGIVGGEETR
MAB_3590c|M.abscessus_ATCC_199 LSSLVILILGFVLTSQVTDRILESKIRVATEEMERARVIVSDDVGGEETR
** *:: ********:*.*::: *: .: :::**** * . *.***:*
Mb3273c|M.bovis_AF2122/97 SLDSSLQLARNTLTSKTDPASGAGLAGAFDAVLMVPGDGPRAASTAGPVD
Rv3245c|M.tuberculosis_H37Rv SLDSSLQLARNTLTSKTDPASGAGLAGAFDAVLMVPGDGPRAASTAGPVD
MMAR_1300|M.marinum_M SLDSSLQLARNTLTSKTDPASGAGQAGAFDAVLMVPGDGPRAASAAGPVD
MUL_2581|M.ulcerans_Agy99 SLDSSLQLARNTLTSKTDPASGAGQAGAFDAVLMVPGDGPRAASAAGPVD
MLBr_00774|M.leprae_Br4923 SLDSSLQLARNTLTSKTDPTSGAGLVGAFDAVLIVPGDGPRTATTAGPVD
MAV_4208|M.avium_104 SLDSSLQLARNTLTSKTDSASGAGTAGTFDAVLMVPGDGPRAATTAGPVD
MSMEG_1875|M.smegmatis_MC2_155 SLESSLQLARNTLVDRKADV-RADMAGAFDAVLVVPGDGPRAAAAAGPVA
TH_0463|M.thermoresistible__bu SLDSSLQLARNTLIDRKADE-GSGLAGTFDAVLVVPGDGPRAATTAGPVQ
Mflv_4711|M.gilvum_PYR-GCK SLDSSLQLARNTLIDRKADA-GAGLAGTFDAVLVVAGDGPRAATAAGPAD
Mvan_1753|M.vanbaalenii_PYR-1 SLDSSLQLARNTLIDRKADA-GAGLAGTFDAVLVVPGDGPRAATAAGPVD
MAB_3590c|M.abscessus_ATCC_199 SLQSSLELARNQLLNGSKGS-EGGGAGAFDAVLLVPGDGPREATSAGPAT
**:***:**** * . . .. .*:*****:*.***** *::***.
Mb3273c|M.bovis_AF2122/97 QVPNALRGFVKAGQAAYQYATVQTEGFSGPALIIGTPT---LSRVANLEL
Rv3245c|M.tuberculosis_H37Rv QVPNALRGFVKAGQAAYQYATVQTEGFSGPALIIGTPT---LSRVANLEL
MMAR_1300|M.marinum_M QVPSALRGFVKAGQAAYQYATVHTDGFSGPALIVGTPT---SSRVANLEL
MUL_2581|M.ulcerans_Agy99 QVPSALRGFVKAGQAAYQYAIVHTDGFSGPALIVGTPT---SSRVANLEL
MLBr_00774|M.leprae_Br4923 QVPNSLRGFIKAGQAAYQYATVHTEGFSGPALIIGTPT---SSQVTNLEL
MAV_4208|M.avium_104 QVPASLRGFVKAGQASYQYATVHTDGFSGPALIVGSPA---SSQVANLEL
MSMEG_1875|M.smegmatis_MC2_155 QIPEALRDFVKAGQVSYQYATVQTEGFSGPALIVGSPT---TSSVPNLEL
TH_0463|M.thermoresistible__bu QIPTGLRDFVKAGQVSYQYATVHTDNFAGPALLVGSPTGSSTSSVTNLEL
Mflv_4711|M.gilvum_PYR-GCK QVPAALRDFVKAGQVSYQYATVHTDGFSGPALIVGSPT---SSPVTNLEL
Mvan_1753|M.vanbaalenii_PYR-1 QIPAALRDFVKAGQVSYQYATVHTDGFSGPALIIGSPT---SSPVTNLEL
MAB_3590c|M.abscessus_ATCC_199 QIPGPLREFVKAGQVSYQYSTVHTESFSGKALVIGSPT---TSKVTALEL
*:* ** *:****.:***: *:*:.*:* **::*:*: * *. ***
Mb3273c|M.bovis_AF2122/97 YLIFPLASEQATITLVRGTMATGGLVLLVLLAGIALLVSRQVVVPVRSAS
Rv3245c|M.tuberculosis_H37Rv YLIFPLASEQATITLVRGTMATGGLVLLVLLAGIALLVSRQVVVPVRSAS
MMAR_1300|M.marinum_M YLIFPLANEQATITLVRGTMATGSLVLLVLLAGIALLVSRQVVVPVRSAS
MUL_2581|M.ulcerans_Agy99 YLIFPLANEQATITLVRGTMATGSLVLLVLLAGIALLISRQVVVPVRSAS
MLBr_00774|M.leprae_Br4923 YLIFPLKNEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVPVRSAS
MAV_4208|M.avium_104 YLIFPLKNEQATIQLVRGTMITGGAVLLVLLAGIALLVSRQVVVPVRSAS
MSMEG_1875|M.smegmatis_MC2_155 YLIFPLNNEESTIALVRGTMATGGVVLLGLLAAIALVVARQIVQPVRSAS
TH_0463|M.thermoresistible__bu YLIFPLNNEESTIALVRGTIATGGLVLLGLLAAISLLVARQVVLPVRSAS
Mflv_4711|M.gilvum_PYR-GCK YLIFPLNSEDSTIALVRGTMATGGVVLLGLLAAIALLVARQIVLPVRSAS
Mvan_1753|M.vanbaalenii_PYR-1 YLIFPLNNEDSTIALVRGTMATGGVVLLGLLAAIALLVARQIVLPVRSAS
MAB_3590c|M.abscessus_ATCC_199 YLVFPLSNEESTISLVRGTIVTGGVVLLVLLAAAALLVARQVVLPVRSAS
**:*** .*::*: *****: **. *** **:. :*:::**:* ******
Mb3273c|M.bovis_AF2122/97 RIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQIAQLEEFGNL
Rv3245c|M.tuberculosis_H37Rv RIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQIAQLEEFGNL
MMAR_1300|M.marinum_M RIAERFAEGHLSERMPVRGEDDMARLALSFNDMAESLSRQITQLEEFGNL
MUL_2581|M.ulcerans_Agy99 RIAERFAEGHLSERMPVRGEDDMARLALSFNDMAESLSRQITQLEEFGNL
MLBr_00774|M.leprae_Br4923 RIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQITQLEEFGNL
MAV_4208|M.avium_104 RIAERFAEGHLSERMPVRGEDDMARLAMSFNDMAESLSRQITQLEEFGNL
MSMEG_1875|M.smegmatis_MC2_155 RIAERFAEGHLTERMPVRGEDDMARLAVSFNDMAESLSRQIQQLEEFGNL
TH_0463|M.thermoresistible__bu RIAERFAEGHLTERMPVRGEDDMARLAMSFNDMAESLSRQITQLEEFGNL
Mflv_4711|M.gilvum_PYR-GCK RIAERFAEGHLTERMPVRGEDDMARLAVSFNDMAESLHRQITQLEEFGNL
Mvan_1753|M.vanbaalenii_PYR-1 RIAERFAEGHLTERMPVRGEDDMARLAVSFNDMAESLHRQITQLEEFGNL
MAB_3590c|M.abscessus_ATCC_199 RIAERFAEGHLSERMPVRGVDDMARLAVSFNDMAESLSREITQLEEFGNL
***********:******* *******:********* *:* ********
Mb3273c|M.bovis_AF2122/97 QRRFTSDVSHELRTPLTTVRMAADLIYDHSAD----LDPTLRRSTELMVS
Rv3245c|M.tuberculosis_H37Rv QRRFTSDVSHELRTPLTTVRMAADLIYDHSAD----LDPTLRRSTELMVS
MMAR_1300|M.marinum_M QRRFTSDVSHELRTPLTTVRMAADLIYDHSAD----LDPTLRRSTELMVN
MUL_2581|M.ulcerans_Agy99 QRRFTSDVSHELRTPLTTVRMAADLIYDHSAD----LDPTLRRSTELMVN
MLBr_00774|M.leprae_Br4923 QRRFTSDVSHELRTPLTTVRMAADLIYDHSSD----LDPTLRRSTELMVS
MAV_4208|M.avium_104 QRRFTSDVSHELRTPLTTVRMAADLIYDHSAD----LDPTLARSTELMVN
MSMEG_1875|M.smegmatis_MC2_155 QRRFTSDVSHELRTPLTTVRMAADLIYDHSED----LDPALRRSTELMVN
TH_0463|M.thermoresistible__bu QRRFTSDVSHELRTPLTTVRMAADLIHDNSAD----LDPALRRSIELMVS
Mflv_4711|M.gilvum_PYR-GCK QRRFTSDVSHELRTPLTTVRMAADLIHDHIHDSPDDLDPALRRSTELMVN
Mvan_1753|M.vanbaalenii_PYR-1 QRRFTSDVSHELRTPLTTVRMAADLIHDHAED----LDPALRRSTELMVN
MAB_3590c|M.abscessus_ATCC_199 QRRFTSDVSHELRTPLTTVRMAADLIYDNREE----LDPALQRSAELMVN
**************************:*: : ***:* ** ****.
Mb3273c|M.bovis_AF2122/97 ELDRFETLLNDLLEISRHDAGVAELSVEAVDLRTTVNNALGNVGHLAEEA
Rv3245c|M.tuberculosis_H37Rv ELDRFETLLNDLLEISRHDAGVAELSVEAVDLRTTVNNALGNVGHLAEEA
MMAR_1300|M.marinum_M ELDRFESLLNDLLEISRHDAGVAELSVEAVDLRTTVNSALGNVGHLAEEA
MUL_2581|M.ulcerans_Agy99 ELDRFESLLNDLLEISRHDAGVAELSVEAVDLRTTVNSALGNVGHLAEEA
MLBr_00774|M.leprae_Br4923 ELDRFETLLNDLLEISRHDAGVAELSVEAVDLRVMVNNALGNVGHLAEEA
MAV_4208|M.avium_104 ELDRFESLLNDLLEISRHDAGVAELSVEAVDLRSTVQSALSNVGHLAEDA
MSMEG_1875|M.smegmatis_MC2_155 ELDRFETLLADLLEISRHDAGVAELSVESLDLRSTVRSALDNVGHLAADA
TH_0463|M.thermoresistible__bu ELDRFESLLNDLLEISRHDAGVAELSVESVDLRSTVRSALDNVGHLADDA
Mflv_4711|M.gilvum_PYR-GCK ELDRFESLLNDLLEISRHDAGVAELAVEAVDLRSIVQRALDNVGHLAEGA
Mvan_1753|M.vanbaalenii_PYR-1 ELDRFESLLNDLLEISRHDAGVAELAVDAVDLRSIVQRALDNVGHLAEEA
MAB_3590c|M.abscessus_ATCC_199 ELDRFETLLADLLEISRHDAGVAELAVEQVDLRDTVKAVVASVQHLADEL
******:** ***************:*: :*** *. .: .* ***
Mb3273c|M.bovis_AF2122/97 GIELLVDLPAEQVIAEVDARRVERILRNLIANAIDHAEHKPVRIRMAADE
Rv3245c|M.tuberculosis_H37Rv GIELLVDLPAEQVIAEVDARRVERILRNLIANAIDHAEHKPVRIRMAADE
MMAR_1300|M.marinum_M GIELLVEMPDSEVIAEVDARRVERILRNLIANAIDHAEHKPVRIRMGADE
MUL_2581|M.ulcerans_Agy99 GIELLVEMPDSEVIAEVDARRVERILRNLIANAIDHAEHRPVRIRMGADE
MLBr_00774|M.leprae_Br4923 GIELLVDMPVDEVIAEVDARRVERILRNLIANAIDHSEHKPVRIRMAADE
MAV_4208|M.avium_104 GIELQVELPAEEVIAEVDTRRVERILRNLIANAIDHAEHKPVKIRMAADE
MSMEG_1875|M.smegmatis_MC2_155 GVELTLDMPEEDVIAEVDPRRVERILRNLIANAIDHAESKPVQIRMAADE
TH_0463|M.thermoresistible__bu GIELLMDLPEHEVIAEVDSRRVERILRNLIANAIDHAERKPVRIRMAADE
Mflv_4711|M.gilvum_PYR-GCK DVEMDVEMPPDDVIAEVDPRRVERILRNLIANAIDHAEHKPVQIRMAADV
Mvan_1753|M.vanbaalenii_PYR-1 GVELIVDLPADEVIAEVDARRVERILRNLIANAIDHAEHKPVRIRMAADV
MAB_3590c|M.abscessus_ATCC_199 DTSVELDMPDKEIIAEVDPRRVERILRNLVANAIDHSEHKPVTIRMAADI
. .: :::* ::*****.**********:******:* :** ***.**
Mb3273c|M.bovis_AF2122/97 DTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISVED
Rv3245c|M.tuberculosis_H37Rv DTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISVED
MMAR_1300|M.marinum_M DTVAVTVRDYGVGLRPGEEKLVFSRFWRADPSRVRRSGGTGLGLAISVED
MUL_2581|M.ulcerans_Agy99 DTVAVTVRDYGVGLRPGEEKLVFSRFWRADPSRVRRSGGTGLGLAISVED
MLBr_00774|M.leprae_Br4923 DTVAVTVRDYGIGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISIED
MAV_4208|M.avium_104 DTVAVTVRDYGVGLRPGEEKLVFSRFWRADPSRVRRSGGTGLGLAISIED
MSMEG_1875|M.smegmatis_MC2_155 DTVAVTVRDFGVGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISIED
TH_0463|M.thermoresistible__bu DTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISVED
Mflv_4711|M.gilvum_PYR-GCK DTVAVTVRDFGVGLRPGEEKLVFSRFWRADPSRVRRSGGTGLGLAISIED
Mvan_1753|M.vanbaalenii_PYR-1 DTVAVTVRDYGVGLRPGEEKLVFSRFWRADPSRVRRSGGTGLGLAISIED
MAB_3590c|M.abscessus_ATCC_199 DSVAVTVRDRGVGLRPGEEKLVFNRFWRADPSRKRHSGGTGLGLAISVED
*:******* *:***********.****:**** *:***********:**
Mb3273c|M.bovis_AF2122/97 ARLHQGRLEAWGEPGEGACFRLTLPLVRGHKVTTSPLPMKPIPQPV----
Rv3245c|M.tuberculosis_H37Rv ARLHQGRLEAWGEPGEGACFRLTLPMVRGHKVTTSPLPMKPIPQPV----
MMAR_1300|M.marinum_M ARLHQGRLEAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKPIPQ------
MUL_2581|M.ulcerans_Agy99 ARLHQGRLEAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKPIPQ------
MLBr_00774|M.leprae_Br4923 ARLHQGRLEAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKPILQ------
MAV_4208|M.avium_104 ARLHQGRLEAWGEPGVGSCFRLTLPLVRGHKVTTSPLPMKPIPQP-----
MSMEG_1875|M.smegmatis_MC2_155 ARLHQGRLEAWGEPGKGACFRLTLPLVRGHKVTTSPLPLKPASE------
TH_0463|M.thermoresistible__bu ARLHQGRLEAWGEPGKGACFRLTLPLVRGHKVTTSPLPLKPMDE------
Mflv_4711|M.gilvum_PYR-GCK ARLHQGRLEAWGEPGKGACFRLTLPLVRGHKVTSSPLPVKPIET------
Mvan_1753|M.vanbaalenii_PYR-1 ARLHQGRLEAWGEPGKGACFRLTLPLVRGHKVTSSPLPVKPIDV------
MAB_3590c|M.abscessus_ATCC_199 ARLHQGRLEAWGEPGNGALFRLTVPLVRGHKVTTSPLPLNPTSRPSSAVR
*************** *: ****:*:*******:****::*
Mb3273c|M.bovis_AF2122/97 -----LQPVAQPNPQPMPPEYKERQRPREHAEWSG----
Rv3245c|M.tuberculosis_H37Rv -----LQPVAQPNPQPMPPEYKERQRPREHAEWSG----
MMAR_1300|M.marinum_M -------PAAQPN----ALEHTDRLRPREHAEWSG----
MUL_2581|M.ulcerans_Agy99 -------PAAQPN----ALEHTDRLRPREHAEWSG----
MLBr_00774|M.leprae_Br4923 -------PSPQASTAG-QQHGTQRQRLREHAERSR----
MAV_4208|M.avium_104 ------SPSGGQSPSTGPQHAKDRARQREHAERSL----
MSMEG_1875|M.smegmatis_MC2_155 ---------------QRP-ARRRSNKDREAAEESV----
TH_0463|M.thermoresistible__bu ---------------SGARAAQRANRHREPAGEGV----
Mflv_4711|M.gilvum_PYR-GCK ---------------AAG----AGRRVREPAGESV----
Mvan_1753|M.vanbaalenii_PYR-1 ---------------SGA----PSRRVRETAGESV----
MAB_3590c|M.abscessus_ATCC_199 RAASRGAHPGEQETTPMRASGAKIERPRESAGGRAEDAS
: ** *