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M. smegmatis MC2 155 MSMEG_0746 (-)

annotation: carbon-monoxide dehydrogenase, large subunit
coordinates: 832120 - 834519
length: 799

MTTLENPVERPEDTAVNDAKPCGHGRMLRKEDPRFIRGRGNYVDDVKLPGMLHLAILRSPYAHATINSID
VTAAQAHPKVKAVVTGADLAAKGLAWMPTLSNDVQAVLATDKVRFQGQEVAFVVAEDRYSARDALELIDV
DYEPLDPVIDARHALDPGAPVIRTDLDGKTDNHCFDWETGDAAATDAVFAKADVVVKQEMVYPRVHPAPM
ETCGAVADLDPVTRKLTLWSTTQAPHAHRTLYALVAGLPEHKIRVISPDIGGGFGNKVPIYPGYVCAIVG
SLLLGKPVKWMEDRSENLTSTGFARDYIMVGEIAATRDGKILAIRSNVLADHGAFNGTAAPVKYPAGFFG
VFTGSYDIEAAYCHMTAVYTNKAPGGVAYACSFRITEAVYFVERLVDCLAYELKMDPAQLRLQNLLKAEQ
FPYTSKTGWVYDSGDYEKTMRLAMEMVDYEGLRAEQAEKRKRGELMGIGMSFFTEAVGAGPRKDMDILGL
GMADGCELRVHPTGKAVVRLSVQSQGQGHETTFAQIVAEELGIPPEDIDVVHGDTDQTPFGLGTYGSRST
PVSGAAAALVARKVRDKAKIIAAGMLEASIADLEWDKGSFHIKGDPSASVTIADIAMRAHGAGDLPEGLE
GGLDAQICYNPSNLTYPYGAYFCVVDIDPGTAVVKVRRFVAVDDCGTRINPMIIEGQIHGGLVDGIGMAL
MEMIAFDEDGNCLGGSLMDYLIPTAMEVPHFETGHTVTPSPHHPIGAKGIGESATVGSPPAVVNAVVDAL
APYGVRHADMPLTPSRVWEAMQGRATPPI
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_0746--100% (799)carbon-monoxide dehydrogenase, large subunit
M. smegmatis MC2 155MSMEG_5880-e-12937.45% (777) nicotine dehydrogenase
M. smegmatis MC2 155MSMEG_2462-5e-9832.63% (763) carbon-monoxide dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0380c-0.089.86% (799) carbon monoxyde dehydrogenase large subunit
M. gilvum PYR-GCKMflv_1573-1e-13237.77% (773) carbon-monoxide dehydrogenase (acceptor)
M. tuberculosis H37RvRv0373c-0.089.99% (799) carbon monoxyde dehydrogenase large subunit
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_2925c-4e-5528.37% (779) xanthine dehydrogenase family protein
M. marinum MMMAR_0657coxL0.091.36% (799) carbon monoxyde dehydrogenase (large chain), CoxL
M. avium 104-----
M. thermoresistible (build 8)TH_0176-0.090.88% (800) PROBABLE CARBON MONOXYDE DEHYDROGENASE (LARGE CHAIN)
M. ulcerans Agy99MUL_0115coxL0.090.24% (799) carbon monoxyde dehydrogenase (large chain), CoxL
M. vanbaalenii PYR-1Mvan_5183-1e-12936.62% (800) carbon-monoxide dehydrogenase (acceptor)

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1573|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_5183|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb0380c|M.bovis_AF2122/97           --------------------------------------------------
Rv0373c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_0657|M.marinum_M               --------------------------------------------------
MUL_0115|M.ulcerans_Agy99           --------------------------------------------------
MSMEG_0746|M.smegmatis_MC2_155      --------------------------------------------------
TH_0176|M.thermoresistible__bu      --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199      MKVNGKLIDASPRPGQCLRTFLREHGHVEVKKGCDAGDCGACTVLVDGAS
                                                                                      

Mflv_1573|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_5183|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb0380c|M.bovis_AF2122/97           --------------------------------------------------
Rv0373c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_0657|M.marinum_M               --------------------------------------------------
MUL_0115|M.ulcerans_Agy99           --------------------------------------------------
MSMEG_0746|M.smegmatis_MC2_155      --------------------------------------------------
TH_0176|M.thermoresistible__bu      --------------------------------------------------
MAB_2925c|M.abscessus_ATCC_199      QHSCIVPAHRVTDAEIHTVRSLAGEHDLHPMQRGFIDHAGFQCGFCTAGM
                                                                                      

Mflv_1573|M.gilvum_PYR-GCK          ---MTDADVQ-------AVDAVSPRYAGQR---------------VPRVE
Mvan_5183|M.vanbaalenii_PYR-1       ---MTDT----------ATNAVTARYAGQR---------------VPRVE
Mb0380c|M.bovis_AF2122/97           ---MTTIESRPPS-PEDLADNAQQPCGHGR---------------MMRKE
Rv0373c|M.tuberculosis_H37Rv        ---MTTIESRPPS-PEDLADNAQQPCGHGR---------------MMRKE
MMAR_0657|M.marinum_M               ---MTTIESRP----EDLADNDQKPCGHGR---------------MLRKE
MUL_0115|M.ulcerans_Agy99           ---MTTIESRP----EDLADNDQKPCGHGR---------------MLRKE
MSMEG_0746|M.smegmatis_MC2_155      ---MTTLENPVER-PEDTAVNDAKPCGHGR---------------MLRKE
TH_0176|M.thermoresistible__bu      ---MTTLESNPAARPDDFENNDQKPCGHGR---------------MLRKE
MAB_2925c|M.abscessus_ATCC_199      VLTAATLTGDQTEDLGNALKGNLCRCTGYRPIRDAVCGVVPPRGSVSAPA
                                        :                        *               :    

Mflv_1573|M.gilvum_PYR-GCK          DSRLLTGQGRFVDDISRPGMLHACFVRSPFARATIRGIDTSAALALPGVH
Mvan_5183|M.vanbaalenii_PYR-1       DSRLLTGHGRFVDDISRPGMLHACFVRSPFAHATINGVDASAALALPGVH
Mb0380c|M.bovis_AF2122/97           DPRFIRGRGTYVDDVALPGMLHLAILRSPYAHARIVRIDVTAAQAHPKVK
Rv0373c|M.tuberculosis_H37Rv        DPRFIRGRGTYVDDVALPGMLHLAILRSPYAHARIVRIDVTAAQAHPKVK
MMAR_0657|M.marinum_M               DPRFIRGRGNYVDDVALPGMLHLAILRSPYAHARIVSIDVTAALAHPKVK
MUL_0115|M.ulcerans_Agy99           DPRFIRGRGNYVDDVALPGMLHLAIFRSPYAHARIVSIDVTAALAHPKVK
MSMEG_0746|M.smegmatis_MC2_155      DPRFIRGRGNYVDDVKLPGMLHLAILRSPYAHATINSIDVTAAQAHPKVK
TH_0176|M.thermoresistible__bu      DPRFIRGRGRYVDDVQLPGMLHLAILRSPYAHARIAGIDTSAAQAHPKVK
MAB_2925c|M.abscessus_ATCC_199      AARVVTGTEPYTMDELPAGVGHVAVLGSPHPSARITRIDTDRARLLPGVR
                                     .*.: *   :. *   .*: * ... **.. * *  :*.  *   * *:

Mflv_1573|M.gilvum_PYR-GCK          AVFTASDLNPDVREAWHAVAGKDVPDTPRPPLAEGEVKFVGDPVALVVAD
Mvan_5183|M.vanbaalenii_PYR-1       AVFTAADLNPDVKEAWHAVAGKDVPDTPRPPLAEGEVKFVGDPVALVVAD
Mb0380c|M.bovis_AF2122/97           AVVTGADLAAKG-LAWMPTLANDVQAV----LATDKTRFQGQEVASVVAE
Rv0373c|M.tuberculosis_H37Rv        AVVTGADLAAKG-LAWMPTLANDVQAV----LATDKTRFQGQEVAFVVAE
MMAR_0657|M.marinum_M               AVVTGADLAEKG-LAWMPTLSNDVQAV----LATDKVRFQGQEVAFVVAE
MUL_0115|M.ulcerans_Agy99           AVVTGADLAEKG-LAWMPTLSNDVQAV----LATDKVHFQGQEVVFVVAE
MSMEG_0746|M.smegmatis_MC2_155      AVVTGADLAAKG-LAWMPTLSNDVQAV----LATDKVRFQGQEVAFVVAE
TH_0176|M.thermoresistible__bu      AVVTGADLAEKG-LAWMPTLSNDVQAV----LATDKVRFQGQEVAFVVAE
MAB_2925c|M.abscessus_ATCC_199      AVLCYRDDPGVPFSTARHHERTDDPDD--TLVFDRVLRFAGQRVAAVVAD
                                    **.   *       :      .*        :     :* *: *. ***:

Mflv_1573|M.gilvum_PYR-GCK          SRYLAEDAVDLVEVDYEPLPAVADFRKAVGGASAGVP--------VVHEA
Mvan_5183|M.vanbaalenii_PYR-1       SRYLAEDAVDLVEVDYDPLPAVADFRKAVGGAEAGVP--------VVHAA
Mb0380c|M.bovis_AF2122/97           DRYSARDACELVDVDYEPRDPVVDARTALDPSAPVIR--------TDLEG
Rv0373c|M.tuberculosis_H37Rv        DRYSARDACELVDVDYEPRDPVVDARTALDPSAPVIR--------TDLEG
MMAR_0657|M.marinum_M               DRYSARDALELIDVEYDPLDPVVDVRKALDPSAPVIR--------TDLDG
MUL_0115|M.ulcerans_Agy99           DRYSARDALELIDVEYDPLDPVVDVRKALHPSAPVIR--------TDLDG
MSMEG_0746|M.smegmatis_MC2_155      DRYSARDALELIDVDYEPLDPVIDARHALDPGAPVIR--------TDLDG
TH_0176|M.thermoresistible__bu      DHYSARDALELIDVDYDPLDPVVDVRRALEPDAPVIR--------TDLDG
MAB_2925c|M.abscessus_ATCC_199      TPAIAHRALEHIDVEYEVLPAVFDPEMAQLPGAHLVHGDKGLGARIADPA
                                        *. * : ::*:*:   .* * . *       :             .

Mflv_1573|M.gilvum_PYR-GCK          YPDN--VAGGMGGMPPDEELFATAPHVVEQHIYQQMYVPVPMETRGMVVE
Mvan_5183|M.vanbaalenii_PYR-1       YPDN--VAGGMGGMPPDEEIFATAAHVVEEHIYQQMYVPVPMETRGMVVE
Mb0380c|M.bovis_AF2122/97           KSDNHIFDWETGDAAATEAVFAKADVVVQQEIVYPRVHPAPMETCGAVAD
Rv0373c|M.tuberculosis_H37Rv        KSDNHIFDWETGDAAATEAVFAKADVVVQQEIVYPRVHPAPMETCGAVAD
MMAR_0657|M.marinum_M               KQDNHIFDWETGDAAATDAVFAKADVVIKQEMVYPRVHPAPMETCGAVAD
MUL_0115|M.ulcerans_Agy99           KQDNHIFDWETGDAAATDAVFAKADVVIKQEMVYPRVHPAPMETCGAVAD
MSMEG_0746|M.smegmatis_MC2_155      KTDNHCFDWETGDAAATDAVFAKADVVVKQEMVYPRVHPAPMETCGAVAD
TH_0176|M.thermoresistible__bu      KTDNHCFDWETGDPAATEAAFAKADVVVEQEIVYPRVHPAPMETCGAVAD
MAB_2925c|M.abscessus_ATCC_199      RNLVAEVHGEVGDVAAALARARESGAVVTGSWQTARVQHVHLETHGSVG-
                                          .    *. ..       :  *:           . :** * *  

Mflv_1573|M.gilvum_PYR-GCK          WTSSTDELTIWASTQTPHELRAFAARLLGIPAQGVRVIMRDTGGAFGQKV
Mvan_5183|M.vanbaalenii_PYR-1       WTSTTNELTVWASTQTPHELRAFAARLLGIPAQGVRVIMRDTGGAFGQKV
Mb0380c|M.bovis_AF2122/97           LDPVTGKLTLWTTSQAPHAHRTLYALVAGLPEHKIRVISPDIGGGFGNKV
Rv0373c|M.tuberculosis_H37Rv        LDPVTGKLTLWTTSQAPHAHRTLYALVAGLPEHKIRVISPDIGGGFGNKV
MMAR_0657|M.marinum_M               LDPVTGKLTLWTTSQAPHAHRTLYALVAGLPEHKIRVISPDIGGGFGNKV
MUL_0115|M.ulcerans_Agy99           LDPVTGKLTLWTTSQAPHAHRTLYALVAGLPEHKIRVISPDIGGGFGNKV
MSMEG_0746|M.smegmatis_MC2_155      LDPVTRKLTLWSTTQAPHAHRTLYALVAGLPEHKIRVISPDIGGGFGNKV
TH_0176|M.thermoresistible__bu      LDPVTGKLTLWSTSQAPHAHRTLYALVAGLPEHKIRVIAPDIGGGFGNKV
MAB_2925c|M.abscessus_ATCC_199      WQDERGRYVLRTSSQVPFLVRDELCHVFGLAREQVRVFAPRVGGGFGAKQ
                                          . .: :::*.*.  *   . : *:. . :**:    **.** * 

Mflv_1573|M.gilvum_PYR-GCK          VPMREDMCILLAARRVP---------AALKWIEDRRENLMSAGQSRHVDG
Mvan_5183|M.vanbaalenii_PYR-1       VPMREDMCILLAARKMPTATSNAQSGVAVKWIEDRRENLMSAGQSRHVDG
Mb0380c|M.bovis_AF2122/97           PIYPGYVCAIVASLLLD---------KPVKWMEDRSENLTSTGFARDYIM
Rv0373c|M.tuberculosis_H37Rv        PIYPGYVCAIVASLLLD---------KPVKWMEDRSENLTSTGFARDYIM
MMAR_0657|M.marinum_M               PIYPGYVCAIVGSLVLG---------KPVKWMEDRSENLTSTSFARDYIM
MUL_0115|M.ulcerans_Agy99           PIYPGYVCAIVGSSVLG---------KPVKWMEDRSENLTSTSFARDYIM
MSMEG_0746|M.smegmatis_MC2_155      PIYPGYVCAIVGSLLLG---------KPVKWMEDRSENLTSTGFARDYIM
TH_0176|M.thermoresistible__bu      PIYPGYVCAIVGSLLLG---------KPVKWVEDRSENLTSTGFARDYIM
MAB_2925c|M.abscessus_ATCC_199      EMLTEDLVLLAVRVTGA----------PVVYEFTRSDQFTIAPCRHPMRV
                                          :  :                 .: :   * :::  :   :    

Mflv_1573|M.gilvum_PYR-GCK          KVRMAFDDDGKILAADIDFIQDVGSYP-TPYPVLTTAAIGMFFPGPYRVP
Mvan_5183|M.vanbaalenii_PYR-1       KVRMAFDSDGKILAADIDFVQDVGSYP-TPYPVLTTAAIGMFFPGPYRVP
Mb0380c|M.bovis_AF2122/97           VGEIAANRDGKILAIRSNVLADHGAFNAQAAPAKYPAGFFGVFTGSYDIE
Rv0373c|M.tuberculosis_H37Rv        VGEIAANRDGKILAIRSNVLADHGAFNAQAAPAKYPAGFFGVFTGSYDIE
MMAR_0657|M.marinum_M               VGEIAATNEGKILALRSHVLADHGAFNGQAAPTKYPAGFYGVFTGSYDLE
MUL_0115|M.ulcerans_Agy99           VGEIAATNEGKILALRSHVLADHGAFNGQAAPTKYPAGFYGVFTGSYDLE
MSMEG_0746|M.smegmatis_MC2_155      VGEIAATRDGKILAIRSNVLADHGAFNGTAAPVKYPAGFFGVFTGSYDIE
TH_0176|M.thermoresistible__bu      VGEIAATRDGRILAIRSHVLADHGAFNGTAAPVKYPAGFFGVFTGSYDLE
MAB_2925c|M.abscessus_ATCC_199      NVTAAADGDGVLTALAVDVLSDAGAYGNHSVGVMFHG--CNESMAQYRCA
                                        *   :* : *   ..: * *::   .  .   .       . *   

Mflv_1573|M.gilvum_PYR-GCK          KASFNYKTVFSNTPG---LHAYRGPWQYETLTREMLLDCAARKIGMDPVE
Mvan_5183|M.vanbaalenii_PYR-1       KASFNYKTVFSNTPG---LHAYRGPWQYETLTREMLLDSAARKIGMDPVE
Mb0380c|M.bovis_AF2122/97           AAYCHMTAVYTNKAPGGVAYACSFRITEAVYFVERLVDCLAFELKMDPAE
Rv0373c|M.tuberculosis_H37Rv        AAYCHMTAVYTNKAPGGVAYACSFRITEAVYFVERLVDCLAFELKMDPAE
MMAR_0657|M.marinum_M               AAYCHMTAVYTNKAPGGVAYACSFRITEAVYFVERLVDCLAFELKMDPAE
MUL_0115|M.ulcerans_Agy99           AAYCHMTAVYTNKAPGGVAYACSFRITEAVYFVERLVDCLAFELKMGPAE
MSMEG_0746|M.smegmatis_MC2_155      AAYCHMTAVYTNKAPGGVAYACSFRITEAVYFVERLVDCLAYELKMDPAQ
TH_0176|M.thermoresistible__bu      AAYCHMTAVYTNKAPGGVAYACSFRITEAVYLVERLVDCLAHELEMDPAE
MAB_2925c|M.abscessus_ATCC_199      NKRVDAQAVYTNNIPSGAFRGYG--LGQVLFGIESALDELARNLGIDPFE
                                        .  :*::*.       .            *  :*  * :: :.* :

Mflv_1573|M.gilvum_PYR-GCK          LRRINILRGDEMPFFNPNGMPYDNCAPADTFEQAVKILDHEGFRKEQAEA
Mvan_5183|M.vanbaalenii_PYR-1       LRRINILRGDEMPFFNPNGMPYDNCAPADTFEQAVKILDHEGFRKEQADA
Mb0380c|M.bovis_AF2122/97           LRLRNLLRPNQFPYQSKTGWVYDSGDYETTMRKAMNMIGYEALRAEQKQR
Rv0373c|M.tuberculosis_H37Rv        LRLRNLLRPNQFPYQSKTGWVYDSGDYETTMRKAMNMIGYEALRAEQKQR
MMAR_0657|M.marinum_M               VRLRNLLKPEQFPYTTKTGWVYDSGDYESTMRQAMDMIGYDALRAEQKEK
MUL_0115|M.ulcerans_Agy99           LRLRNLLKPEQFPYTTKTGWVYDSGDYESTMRQAMDMIGGDALRAEQKEK
MSMEG_0746|M.smegmatis_MC2_155      LRLQNLLKAEQFPYTSKTGWVYDSGDYEKTMRLAMEMVDYEGLRAEQAEK
TH_0176|M.thermoresistible__bu      LRLRNLLKPDQFPYTSKTGWVYDSGDYETTMRKAMAMVGYDELRAEQAER
MAB_2925c|M.abscessus_ATCC_199      FRRRNVIVPGDS-FVSWEVEEDDLAFGSYGLDQCLDLAQDALARGAADPA
                                    .*  *::   :  : .      *       :  .: :      *      

Mflv_1573|M.gilvum_PYR-GCK          LAEGRYIGLGFSAYIEPTGAATGN-------LATEGATVRMESTGKINVY
Mvan_5183|M.vanbaalenii_PYR-1       LAEGRYIGLGFSAYIEPTGAATGN-------LATEGATIRMESTGKINVY
Mb0380c|M.bovis_AF2122/97           RARGELMGIGMSFFTEAVGAGPRKDMDILGLGMADGCELRVHPTGKAVLR
Rv0373c|M.tuberculosis_H37Rv        RARGELMGIGMSFFTEAVGAGPRKDMDILGLGMADGCELRVHPTGKAVLR
MMAR_0657|M.marinum_M               RDRGELMGIGISFFTEAVGAGPRKDMDILGLGMADGCELRVHPTGKAVVR
MUL_0115|M.ulcerans_Agy99           RDRGELMGIGISFFTEAVGAGPRKDMDILGLGMADGCELRVHPTGKAVVR
MSMEG_0746|M.smegmatis_MC2_155      RKRGELMGIGMSFFTEAVGAGPRKDMDILGLGMADGCELRVHPTGKAVVR
TH_0176|M.thermoresistible__bu      RRRGELMGIGMSFFTEAVGAGPRKDMDILGLGMADGCELRVHPTGKAVVR
MAB_2925c|M.abscessus_ATCC_199      RNGSDLP----AGWKVGEGMAIAMIATVPPRGHVADARAELDARGRYRIS
                                       .       : :    * .            . ..  .:.. *:  : 

Mflv_1573|M.gilvum_PYR-GCK          VNGGSAGNSIETTVVQLTADALGANIDDVATIQGDTAVTPYGAGTQGSRS
Mvan_5183|M.vanbaalenii_PYR-1       VNGGSAGNSIETTVVQLTADALGANIEDVATIQGDTAVTPYGAGTQGSRS
Mb0380c|M.bovis_AF2122/97           LSVQTQGQGHETTFAQIVAEELGIAPDDIEVVHGDTDQTPFGLGTYGSRS
Rv0373c|M.tuberculosis_H37Rv        LSVQTQGQGHETTFAQIVAEELGIAPDDIEVVHGDTDQTPFGLGTYGSRS
MMAR_0657|M.marinum_M               LSVQTQGQGHETTFAQIVAEELGIPPDDIDVVHGDTDQTPFGLGTYGSRS
MUL_0115|M.ulcerans_Agy99           LSVQTQGQGHETTFAQIVAEELGIPTDDIDVAHGDTDQTPFGLGTYGSRS
MSMEG_0746|M.smegmatis_MC2_155      LSVQSQGQGHETTFAQIVAEELGIPPEDIDVVHGDTDQTPFGLGTYGSRS
TH_0176|M.thermoresistible__bu      LSVQTQGQGHETTFAQIVAEELGIPPDDIEVVHGDTDQTPFGLGTYGSRS
MAB_2925c|M.abscessus_ATCC_199      VGSAEFGNGTTTVHAQLAAGVLGCAPDQVYIHQADTDAVSHDTGAFGSAG
                                    :.    *:.  *. .*:.*  **   :::   :.**  .... *: ** .

Mflv_1573|M.gilvum_PYR-GCK          APMTAGAVNEAGAILRTQIIAIAAQILGVEAAEIELANSRASVRSDPEKS
Mvan_5183|M.vanbaalenii_PYR-1       APMTAGAVNEAGAILRRQIIAIGAQILGVEESEIELANSRAGVRNDPERS
Mb0380c|M.bovis_AF2122/97           TPVSGGAAALVARKVRDKAKIIASGMLEVSVADLQWEKGKFHVKGDPSAA
Rv0373c|M.tuberculosis_H37Rv        TPVSGGAAALVARKVRDKAKIIASGMLEVSVADLQWEKGKFHVKGDPSAA
MMAR_0657|M.marinum_M               TPVSGAAAALVARKVRDKAKIIASGMLEVSVADLEWEKGSFHVKGDPSAS
MUL_0115|M.ulcerans_Agy99           TPVSGAAAALVARKVRDKAKIIASGMLEVSVADLEWEKGSFHVKGDPSAS
MSMEG_0746|M.smegmatis_MC2_155      TPVSGAAAALVARKVRDKAKIIAAGMLEASIADLEWDKGSFHIKGDPSAS
TH_0176|M.thermoresistible__bu      TPVSGAAAALVARKVRDKAKIIASGMLEASIADLEWEKGSFRVKGDPSAS
MAB_2925c|M.abscessus_ATCC_199      TTVAGLAVYRAAELLRDQIIRFAATKLAVPQSRCVLEPDGVRAGADLLGL
                                    :.::. *.  ..  :* :   :.:  * .  :      .      *    

Mflv_1573|M.gilvum_PYR-GCK          VSFADIAYRSYYDPGQLGGVSPTLEATARFNSQAMIHWANATHVCTCEVD
Mvan_5183|M.vanbaalenii_PYR-1       VSFADIAYRSYYDPAQLGGVSPTLEATARFNSQAMIHWANATHVCTCEVD
Mb0380c|M.bovis_AF2122/97           VTIADIAMRAHGAGDLPEGIEGGLDAEVCYN-PSNLTYPYGAYFCVVDID
Rv0373c|M.tuberculosis_H37Rv        VTIADIAMRAHGAGDLPEGIEGGLDAEVCYN-PSNLTYPYGAYFCVVDID
MMAR_0657|M.marinum_M               VTIADIAMRAHGAGDLPEGIEGGLDAEVCYN-PSNLTYPYGAYFCVVDVD
MUL_0115|M.ulcerans_Agy99           VTIADIAMRAHGAGDLPEGIEGGLDAEVCYN-PSNLTYPYGAYFCVVDVD
MSMEG_0746|M.smegmatis_MC2_155      VTIADIAMRAHGAGDLPEGLEGGLDAQICYN-PSNLTYPYGAYFCVVDID
TH_0176|M.thermoresistible__bu      VTIQDIAMRAHGAGDLPDGIEGGLDAQICYN-PSNLTYPYGAYFCVVDVD
MAB_2925c|M.abscessus_ATCC_199      TEIAASAPEPLSAVGHHEGTPRSVAFN--------------VQAFRVAVR
                                    . :   * ..        *    :                 .      : 

Mflv_1573|M.gilvum_PYR-GCK          VETGHVTLTRYIVSEDVGPMINPNIVEGQVAGGTVQGIGGALLEKLAYDD
Mvan_5183|M.vanbaalenii_PYR-1       VETGQVTLTRYIVSEDVGPMINPNIVEGQVAGGTVQGIGGALLEKLAYDD
Mb0380c|M.bovis_AF2122/97           PGTAVVKVRRFLAVDDCGTRINPMIIEGQVHGGIVDGIGMALMEMIAFDE
Rv0373c|M.tuberculosis_H37Rv        PGTAVVKVRRFLAVDDCGTRINPMIIEGQVHGGIVDGIGMALMEMIAFDE
MMAR_0657|M.marinum_M               PGTGVVKVRRFLAVDDCGTRINPMIIEGQVHGGIVDGIGMALMEMIAFDE
MUL_0115|M.ulcerans_Agy99           PGTGVVKVRRFLAVDDAGTRINPMIIEGQVHGGIVDGIGMALMEMIAFDE
MSMEG_0746|M.smegmatis_MC2_155      PGTAVVKVRRFVAVDDCGTRINPMIIEGQIHGGLVDGIGMALMEMIAFDE
TH_0176|M.thermoresistible__bu      PGTAVVKVRRFLAVDDCGTRINPMIIEGQVHGGIVDGIGMALMQMIGFDE
MAB_2925c|M.abscessus_ATCC_199      PQTGTVRILQSVQTADAGVVVNPQQCRGQVEGGVAQAIGSALYEEILVHD
                                      *. * : : :   * *  :**   .**: ** .:.** ** : :  .:

Mflv_1573|M.gilvum_PYR-GCK          DGNPVASTFVDYLLPTATEVPPIEFGHVEIPGPG-VGGYKGAGEGGAIGS
Mvan_5183|M.vanbaalenii_PYR-1       AGNPVASTFVDYLLPTATEVPPIEFGHVEIPGPG-VGGYKGAGEGGAIGS
Mb0380c|M.bovis_AF2122/97           DGNCLGGSLMDYLIPTALEVPHLETGHTVTPSPHHPIGAKGIGESATVGS
Rv0373c|M.tuberculosis_H37Rv        DGNCLGGSLMDYLIPTALEVPHLETGHTVTPSPHHPIGAKGIGESATVGS
MMAR_0657|M.marinum_M               DGNCLGGSLMDYLIPTALEVPHLETGHTVTPSPHHPIGAKGIGESATVGS
MUL_0115|M.ulcerans_Agy99           DGNCLGGSLMDYLIPTALEVPHLETGHTVTPSPHHPIGAKGIGESATVGS
MSMEG_0746|M.smegmatis_MC2_155      DGNCLGGSLMDYLIPTAMEVPHFETGHTVTPSPHHPIGAKGIGESATVGS
TH_0176|M.thermoresistible__bu      DGNCLGGSLMDYLIPTAMEVPTLETGFTVTPSPHHPIGAKGIGESATVGS
MAB_2925c|M.abscessus_ATCC_199      -GFVSTTALRNYHIPRLVDVPDTEVYFADTYDTFGPLGAKSMSESPYNPV
                                     *     :: :* :*   :**  *  ..   ..    * *. .*.     

Mflv_1573|M.gilvum_PYR-GCK          PPAVINAVNDALAPLGVTLTQLPATPATIVELIDAASRKDH-
Mvan_5183|M.vanbaalenii_PYR-1       PPAVINAINDALAPLGVTLTQLPATPATIVELIERAG-KDH-
Mb0380c|M.bovis_AF2122/97           PPAVVNAVVDALAPFGVRHADMPLTPSRVWEAMQGRATPPI-
Rv0373c|M.tuberculosis_H37Rv        PPAVVNAVVDALAPFGVRHADMPLTPSRVWEAMQGRATPPI-
MMAR_0657|M.marinum_M               PPAVVNAVVDALAPYGVRHADMPLTPSRVWEAMQGRATPPI-
MUL_0115|M.ulcerans_Agy99           PPAVVNAVVDALAPYGVRHADMPLTPSRVWEAMQGRATPPI-
MSMEG_0746|M.smegmatis_MC2_155      PPAVVNAVVDALAPYGVRHADMPLTPSRVWEAMQGRATPPI-
TH_0176|M.thermoresistible__bu      PPAVVNAVVDALAPFGVRHVDMPLTPSRVWEAMQGRAQPSI-
MAB_2925c|M.abscessus_ATCC_199      APALANAIRDAVG---VRVYRLPMNAARVWRVINDSGGGESS
                                    .**: **: **:.   *    :* ..: : . ::  .