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QQRLTMWSATGLIFGHALCMNTCRTMVVPRGKPLCIERVPPLPCQPKMGESTMPSGGIADPELALVDRTL SVVGVGFGVTGLALAAALHEAEMTEDALFLESRPKFGWHDDMLIEGSSMQVSFLKDIVTMRNPTSRFSFI SYLHAMGRLTNFINHGVLTPSRREFADYLRWVARQLDHLVRYDVHVTDVRPVYEGATVSALDIVAGENAV VRTRNLVLGTGLRPRMPQGVIPNRRVWHSSELLSRLAECGDYLARQIVVVGAGQSAAEIALYLLDRYPDS QVCPVFARYGYSAVDASPFANRIFDPSGVDDFYAASPSVKASLLRYHGNTNYSVVSSDVLGALYRRQYEQ SVIGDPRLRIFHASRLHLVSFNDDSVVADIEFLPTGEVTRLDTDLVVIYATGYESRDPKHLLTSLAGYLR TDELGALRLDRRYRVKTVEGFRCGIFVQGATESTHGIASTLLSVAAVRAGEISQSLMETSQARPPAGSVT HRH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3780 | - | - | 100% (494) | monooxygenase |
| M. marinum M | MMAR_3697 | mbtG | 8e-05 | 25.34% (221) | lysine-N-oxygenase MbtG |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2399c | mbtG | 4e-05 | 24.09% (220) | lysine-N-oxygenase MBTG (L-lysine 6-monooxygenase) (lysine |
| M. gilvum PYR-GCK | Mflv_2698 | - | 6e-09 | 27.69% (260) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv2378c | mbtG | 4e-05 | 24.09% (220) | lysine-N-oxygenase MBTG (L-lysine 6-monooxygenase) (lysine |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1937 | - | 2e-93 | 44.98% (418) | putative peptide monooxygenase |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_0022 | - | 1e-87 | 45.39% (412) | L-ornithine 5-monooxygenase |
| M. thermoresistible (build 8) | TH_1927 | mbtG | 2e-05 | 24.14% (261) | LYSINE-N-OXYGENASE MBTG (L-LYSINE 6-MONOOXYGENASE) (LYSINE |
| M. ulcerans Agy99 | MUL_3640 | mbtG | 5e-05 | 25.34% (221) | lysine-N-oxygenase MbtG |
| M. vanbaalenii PYR-1 | Mvan_3843 | - | 6e-05 | 24.07% (324) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2399c|M.bovis_AF2122/97 -------------------------------------------------M
Rv2378c|M.tuberculosis_H37Rv -------------------------------------------------M
Mflv_2698|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_3843|M.vanbaalenii_PYR-1 ---------------------------------------------MTTRP
TH_1927|M.thermoresistible__bu -------------------------------------------------M
MUL_3640|M.ulcerans_Agy99 -------------------------------------------------M
MAB_1937|M.abscessus_ATCC_1997 ------------------------------------------------ML
MSMEG_0022|M.smegmatis_MC2_155 ------------------------------------------------MQ
MMAR_3780|M.marinum_M MQQRLTMWSATGLIFGHALCMNTCRTMVVPRGKPLCIERVPPLPCQPKMG
Mb2399c|M.bovis_AF2122/97 NPTLAVLGAGAKAVAVAAKASVLRDMGVDVPDVIAVERIGVG---ANWQA
Rv2378c|M.tuberculosis_H37Rv NPTLAVLGAGAKAVAVAAKASVLRDMGVDVPDVIAVERIGVG---ANWQA
Mflv_2698|M.gilvum_PYR-GCK NPTLTVIGAGAKGVAVAAKAAVLRDMGVDAPDVVVVERAEVG---ANWDA
Mvan_3843|M.vanbaalenii_PYR-1 TPTLAVVGAGPKAIAVAAKAAELRGMGVDVPDVVAIERSVVG---ANWQA
TH_1927|M.thermoresistible__bu TGTLAVLGAGPKAIAVAAKAAELRDMGVDTPEIVVVERTGIA---ANWTA
MUL_3640|M.ulcerans_Agy99 SATLAIVGAGAKAAAVAAKAAVLREMGVEVPDLVAIESTGVA---ANWRA
MAB_1937|M.abscessus_ATCC_1997 SDSHAS--------------HDVLGIGFGPSNLALAIALSEH----PHRL
MSMEG_0022|M.smegmatis_MC2_155 SIDHLNGRNGD------SPVLDVVGVGFGPSNLALAIAIREYNETHAEAI
MMAR_3780|M.marinum_M ESTMPSGGIADPELALVDRTLSVVGVGFGVTGLALAAALHEA----EMTE
: :*. . :
Mb2399c|M.bovis_AF2122/97 SGGWTDGAHRLGTSPEKDVGFPYRSALVPRRNAELDERMTRYSWQSYLIA
Rv2378c|M.tuberculosis_H37Rv SGGWTDGAHRLGTSPEKDVGFPYRSALVPRRNAELDERMTRYSWQSYLIA
Mflv_2698|M.gilvum_PYR-GCK MGGWTDGQHRLGTNPEKDVGFPYRSALVRRRNAELDERMTRYSWQSYLIA
Mvan_3843|M.vanbaalenii_PYR-1 VGGWTDGQHRLGTSPEKDVGFPYRSSLVPRRNAELDERMMRHSWQSYLVA
TH_1927|M.thermoresistible__bu AGGWTDGEHRLGTSPEKDVGFPYRSTLVPRRNAELDERMTRHSWQAYLID
MUL_3640|M.ulcerans_Agy99 GGGWTDGRQRLGTSPEKDVGFPYRSALWPGRNAEIDERMIRFSWQSFLVD
MAB_1937|M.abscessus_ATCC_1997 SAQFVDAQSRFGWHRGMLIPGARMQVSFLKDLVTLRNPKSHYTFVNYLTE
MSMEG_0022|M.smegmatis_MC2_155 NAEFVEVKPEFGWHTGMLIPGATMQVSFLKDLATQRNPTSEFTFLNYLTE
MMAR_3780|M.marinum_M DALFLESRPKFGWHDDMLIEGSSMQVSFLKDIVTMRNPTSRFSFISYLHA
. : : .:* : . . . : ..:: :*
Mb2399c|M.bovis_AF2122/97 TASFAEWIDRGRPAPTHRRWSQYLAWVADHIGLKVIHG-EVERLAVTGDR
Rv2378c|M.tuberculosis_H37Rv TASFAEWIDRGRPAPTHRRWSQYLAWVADHIGLKVIHG-EVERLAVTGDR
Mflv_2698|M.gilvum_PYR-GCK TGGFAEWIDRGRPAPPHHRWARYLRWVAEQIDMTVVSG-DVQRISVDGER
Mvan_3843|M.vanbaalenii_PYR-1 SAQFADWVDRGRPAPTHLGWSRYLRWVADNIGMSVITG-EVQRISTDGRR
TH_1927|M.thermoresistible__bu TAQFAEWVDRGRPAPTHRKWAAYLRWVADRIGLNVHHG-EVTRISVGGPG
MUL_3640|M.ulcerans_Agy99 TDQFVGWVDRGRPSPAHDTWAQYLRWVADRAGLEVVGG-EVVQLSVDESR
MAB_1937|M.abscessus_ATCC_1997 RGRLPDFINQQSFFPTRQEFHDYLDWAQEALEPDVSYSSRMTGIEATSDG
MSMEG_0022|M.smegmatis_MC2_155 RRRLTEFINFKTFFPTRLEFHDYLSWAADKVGATVHYGSRVVSVRDTDGA
MMAR_3780|M.marinum_M MGRLTNFINHGVLTPSRREFADYLRWVARQLDHLVRYDVHVTDVRPVYEG
: ::: *.: : ** *. * . : :
Mb2399c|M.bovis_AF2122/97 WALCTHETTVQADA------LMITGPGQAEKSLLPGNP--RVLSIAQFWD
Rv2378c|M.tuberculosis_H37Rv WALCTHETTVQADA------LMITGPGQAEKSLLPGNP--RVLSIAQFWD
Mflv_2698|M.gilvum_PYR-GCK WALHTHDTVLHSDG------VMITGPGQAERSILPGHP--RVLSIAQFWH
Mvan_3843|M.vanbaalenii_PYR-1 WELVTPRQIVHADG------VMITGPGQAQRSILPNDP--RVLSIAQFWE
TH_1927|M.thermoresistible__bu WQLHTADTTVSADATVSADAVMITGPGQAERTLLPGDP--RVMSIAEFWR
MUL_3640|M.ulcerans_Agy99 WVVHTADSSLTADM------VMFTGPGQPERSILAHDP--RVLSIAQFWH
MAB_1937|M.abscessus_ATCC_1997 FEVRLQDTMGSRPDRLMRARALVLGCGTFPAMPSGINPTARQWHSSQLLH
MSMEG_0022|M.smegmatis_MC2_155 FDVTVTGAT----EGILRARNVVVAGGLQPLLPPGVQRTRRQIHNHGLLH
MMAR_3780|M.marinum_M ATVSALDIVAG-ENAVVRTRNLVLGTGLRPRMPQGVIPNRRVWHSSELLS
: :. . * * :
Mb2399c|M.bovis_AF2122/97 RAAGHDRINAERVAVIGGGETAASMLNELFRHR-VSTITVISPQVTLFTR
Rv2378c|M.tuberculosis_H37Rv RAAGHDRINAERVAVIGGGETAASMLNELFRHR-VSTITVISPQVTLFTR
Mflv_2698|M.gilvum_PYR-GCK RAAEHERIAAERVAVIGGGETAASMLNELFRHR-VSTITVISPSVTLFTR
Mvan_3843|M.vanbaalenii_PYR-1 RAARPDLIVAERVAVIGGGETAASMLNELFRHR-VSTITVISPQVTLFTR
TH_1927|M.thermoresistible__bu RAAAHELIVAERVAMIGGGETAASMLNELFRHR-VSTITVISPQVTLFTR
MUL_3640|M.ulcerans_Agy99 RAAQHERIVAERVAVIGGGETAASILNELFHHR-VSAITAFSPQATLFTR
MAB_1937|M.abscessus_ATCC_1997 RLEALDVP-PARVAVVGAGQSAAEAVAYLHSQYPGAQVHAIFARYGYSPA
MSMEG_0022|M.smegmatis_MC2_155 DLAAMPDPRHNRYVVVGAGQSAAEVCAYLHDLSPDNEVHGVFAKYGYSPA
MMAR_3780|M.marinum_M RLAECGDYLARQIVVVGAGQSAAEIALYLLDRYPDSQVCPVFARYGYSAV
: .::*.*::**. * : . . .
Mb2399c|M.bovis_AF2122/97 GEGFFENSLFSDP--TDWAALTFDERR---DALARTDRGVFSATVQEALL
Rv2378c|M.tuberculosis_H37Rv GEGFFENSLFSDP--TDWAALTFDERR---DALARTDRGVFSATVQEALL
Mflv_2698|M.gilvum_PYR-GCK GESFFENTLFSDP--TGWTGLTPAERR---DAMARTDRGVFSARVQDALL
Mvan_3843|M.vanbaalenii_PYR-1 GESFFENTLFSDP--TDWASLTMAERR---DALGRTDRGVFSARVQDALL
TH_1927|M.thermoresistible__bu GEGFFENSLFSDP--TGWTSLTLAERQ---DAITRTDRGVFSARVQEALL
MUL_3640|M.ulcerans_Agy99 GEGFFENSLFSDP--AGWRNLVLSERR---DCIARTDRGVFSARVQESLL
MAB_1937|M.abscessus_ATCC_1997 DDSPYANRIFDPAAVDDFYGAPAEVRRQLVDYHRDTNYAAVDSPLIADLY
MSMEG_0022|M.smegmatis_MC2_155 DDSPFANRVFDPDAVDDFFVADPAVRRRLINYHRSTNYSAVDLELIEELY
MMAR_3780|M.marinum_M DASPFANRIFDPSGVDDFYAASPSVKASLLRYHGNTNYSVVSSDVLGALY
. . : * :*. .: : *: .... : *
Mb2399c|M.bovis_AF2122/97 ADDRIHHLRGRVAHAVGRQGQIRLTLSTNR-GSENFETVHGFDLVIDGSG
Rv2378c|M.tuberculosis_H37Rv ADDRIHHLRGRVAHAVGRQGQIRLTLSTNR-GSENFETVHGFDLVIDGSG
Mflv_2698|M.gilvum_PYR-GCK ADDRIRHLRGRVAHAVPRDGRIRLTLNSDR-GGERLETVHGFDLVIDGSG
Mvan_3843|M.vanbaalenii_PYR-1 ADDRIRHLRGRVAHAVARDERIRLTLSSNR-GGEALETVHGFDLVIDGSG
TH_1927|M.thermoresistible__bu ADDRIRHLRGRVAHAVPKDGRIRLTLHTDQAGGERIETVHGFDLVIDGQG
MUL_3640|M.ulcerans_Agy99 TDERIRHMRGRVARAVNRDNRIWLTLSTDC-CGEPRETLHDFDLVIDGSG
MAB_1937|M.abscessus_ATCC_1997 DREYRERVSGERRLWMHNASRIAAVDETPDRVRLAITHLPTSSTELLDCD
MSMEG_0022|M.smegmatis_MC2_155 AREYAERVAGRRRLFVRGASSVQHTDEDDAGVRVHIRHHPSGTVEELDCD
MMAR_3780|M.marinum_M RRQYEQSVIGDPRLRIFHASRLHLVSFNDDSVVADIEFLPTGEVTRLDTD
: . : * : : . . .
Mb2399c|M.bovis_AF2122/97 ADPLWFTSLFSQHTLDLLELGLGGPLTADRLQEAIGYDLAVTDVTP---K
Rv2378c|M.tuberculosis_H37Rv ADPLWFTSLFSQHTLDLLELGLGGPLTADRLQEAIGYDLAVTDVTP---K
Mflv_2698|M.gilvum_PYR-GCK ADALWFLPLLGQDARDLIELGLGGTLTGDALCESIGYDLAVSNVSP---K
Mvan_3843|M.vanbaalenii_PYR-1 ADSMWFEPLFSQDARDLIELALRAPLSGDALQESIGHDLSVAALTP---K
TH_1927|M.thermoresistible__bu ADSTWFMNLLGQDARDLLELALGGPLTADLLQQSIGHDLAVAGVTP---K
MUL_3640|M.ulcerans_Agy99 ADPLWFLSLLSQDAVDLLELGLQAPLTCQRLEESIGADLAVSGVAP---K
MAB_1937|M.abscessus_ATCC_1997 -AVVYATGYRPLDVRAFLGALASCYEFDEEGRPVVERDYRLRPRADAPGE
MSMEG_0022|M.smegmatis_MC2_155 -AVIYATGFMPARLDGILGDLYHDLVLED-GNPVVSRDYRLATVPPTAGG
MMAR_3780|M.marinum_M LVVIYATGYESRDPKHLLTSLAGYLRTDELGALRLDRRYRVKTVEGFRCG
: :: : : :
Mb2399c|M.bovis_AF2122/97 LFLPTLSGLTQGPGFPNLSCLGLLSDRVLGAGIFTPTKHNDTRRS----G
Rv2378c|M.tuberculosis_H37Rv LFLPTLSGLTQGPGFPNLSCLGLLSDRVLGAGIFTPTKHNDTRRS----G
Mflv_2698|M.gilvum_PYR-GCK LFLPGLSGLTQGPGFPNLSCLGLLSDRVLGAELG-AAPQRSVRSS----D
Mvan_3843|M.vanbaalenii_PYR-1 LFLPGLSGLTQGPGFPNLSCLGLLSDRVLGARYPDVAPHPSTRRT----D
TH_1927|M.thermoresistible__bu LFLPNLAGLNQGPGFPNLSCLGLLSDRILGADIVTSADR-TKWRS----D
MUL_3640|M.ulcerans_Agy99 MFLPNLAGLNEGPGFPNLSCLGLLSDRILSAELGLAPAPVGTNRSKGRSD
MAB_1937|M.abscessus_ATCC_1997 IYLNGSVEHSHGLSSSLLSNVAVRAGEIVDSLVAEAET-REAVAS-----
MSMEG_0022|M.smegmatis_MC2_155 LYIQGNTEHTHGLTSSLLSNIAVRSGEILESVITHTRTGTHRLSP-----
MMAR_3780|M.marinum_M IFVQGATESTHGIASTLLSVAAVRAGEISQSLMETSQARPPAGSV-----
::: ..* . ** .: :..: :
Mb2399c|M.bovis_AF2122/97 EHQSFR
Rv2378c|M.tuberculosis_H37Rv EHQSFR
Mflv_2698|M.gilvum_PYR-GCK EHQPVR
Mvan_3843|M.vanbaalenii_PYR-1 EHQPVR
TH_1927|M.thermoresistible__bu EHQPI-
MUL_3640|M.ulcerans_Agy99 EYQSV-
MAB_1937|M.abscessus_ATCC_1997 FKTG--
MSMEG_0022|M.smegmatis_MC2_155 VGSDA-
MMAR_3780|M.marinum_M THRH--