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NPTLAVLGAGAKAVAVAAKASVLRDMGVDVPDVIAVERIGVGANWQASGGWTDGAHRLGTSPEKDVGFPY RSALVPRRNAELDERMTRYSWQSYLIATASFAEWIDRGRPAPTHRRWSQYLAWVADHIGLKVIHGEVERL AVTGDRWALCTHETTVQADALMITGPGQAEKSLLPGNPRVLSIAQFWDRAAGHDRINAERVAVIGGGETA ASMLNELFRHRVSTITVISPQVTLFTRGEGFFENSLFSDPTDWAALTFDERRDALARTDRGVFSATVQEA LLADDRIHHLRGRVAHAVGRQGQIRLTLSTNRGSENFETVHGFDLVIDGSGADPLWFTSLFSQHTLDLLE LGLGGPLTADRLQEAIGYDLAVTDVTPKLFLPTLSGLTQGPGFPNLSCLGLLSDRVLGAGIFTPTKHNDT RRSGEHQSFR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2378c | mbtG | - | 100% (431) | LYSINE-N-OXYGENASE MBTG (L-LYSINE 6-MONOOXYGENASE) (LYSINE N6-HYDROXYLASE) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2399c | mbtG | 0.0 | 100.00% (431) | lysine-N-oxygenase MBTG (L-lysine 6-monooxygenase) (lysine |
| M. gilvum PYR-GCK | Mflv_2698 | - | 0.0 | 76.10% (431) | FAD dependent oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2249 | - | 1e-173 | 71.67% (406) | lysine-N-oxygenase MbtG |
| M. marinum M | MMAR_3697 | mbtG | 1e-167 | 67.21% (433) | lysine-N-oxygenase MbtG |
| M. avium 104 | MAV_2015 | - | 0.0 | 88.71% (425) | MbtG protein |
| M. smegmatis MC2 155 | MSMEG_4509 | - | 0.0 | 75.41% (431) | MbtG protein |
| M. thermoresistible (build 8) | TH_1927 | mbtG | 0.0 | 74.25% (435) | LYSINE-N-OXYGENASE MBTG (L-LYSINE 6-MONOOXYGENASE) (LYSINE |
| M. ulcerans Agy99 | MUL_3640 | mbtG | 1e-166 | 66.97% (433) | lysine-N-oxygenase MbtG |
| M. vanbaalenii PYR-1 | Mvan_3843 | - | 0.0 | 75.76% (429) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2378c|M.tuberculosis_H37Rv -----------------------------------MNPTLAVLGAGAKAV
Mb2399c|M.bovis_AF2122/97 -----------------------------------MNPTLAVLGAGAKAV
MAV_2015|M.avium_104 -----------------------------------MS-TLAILGAGAKAV
MSMEG_4509|M.smegmatis_MC2_155 --------------------------------MSETTPRLAVIGAGPKGI
Mvan_3843|M.vanbaalenii_PYR-1 -------------------------------MTTRPTPTLAVVGAGPKAI
Mflv_2698|M.gilvum_PYR-GCK -----------------------------------MNPTLTVIGAGAKGV
TH_1927|M.thermoresistible__bu -----------------------------------MTGTLAVLGAGPKAI
MAB_2249|M.abscessus_ATCC_1997 -----------------------------------MTSTLAVIGAGAKAV
MMAR_3697|M.marinum_M MAGGRRHPRRDAGELEMAALLPNVLPRPCAIAGRRMSATLAIVGAGAKAA
MUL_3640|M.ulcerans_Agy99 -----------------------------------MSATLAIVGAGAKAA
. *:::***.*.
Rv2378c|M.tuberculosis_H37Rv AVAAKASVLRDMGVDVPDVIAVERIGVGANWQASGGWTDGAHRLGTSPEK
Mb2399c|M.bovis_AF2122/97 AVAAKASVLRDMGVDVPDVIAVERIGVGANWQASGGWTDGAHRLGTSPEK
MAV_2015|M.avium_104 AVAAKASVLRDMGVEVPDVVAVERIGVAANWQASGGWTDGAHRLGTSPEK
MSMEG_4509|M.smegmatis_MC2_155 AVAAKAAELRAMGAAAPEVVVIDRAGVAANWQAVGGWTDGQHRLGTSPEK
Mvan_3843|M.vanbaalenii_PYR-1 AVAAKAAELRGMGVDVPDVVAIERSVVGANWQAVGGWTDGQHRLGTSPEK
Mflv_2698|M.gilvum_PYR-GCK AVAAKAAVLRDMGVDAPDVVVVERAEVGANWDAMGGWTDGQHRLGTNPEK
TH_1927|M.thermoresistible__bu AVAAKAAELRDMGVDTPEIVVVERTGIAANWTAAGGWTDGEHRLGTSPEK
MAB_2249|M.abscessus_ATCC_1997 AVAAKAAVLRECGVDVPDVVAIERQQVGANWQACGGWTDGQHRLGTSPEK
MMAR_3697|M.marinum_M AVAAKAAVLREMGVEVPDLVAIESTGVAANWRAGGGWTDGRQRLGTSPEK
MUL_3640|M.ulcerans_Agy99 AVAAKAAVLREMGVEVPDLVAIESTGVAANWRAGGGWTDGRQRLGTSPEK
******: ** *. .*:::.:: :.*** * ****** :****.***
Rv2378c|M.tuberculosis_H37Rv DVGFPYRSALVPRRNAELDERMTRYSWQSYLIATASFAEWIDRGRPAPTH
Mb2399c|M.bovis_AF2122/97 DVGFPYRSALVPRRNAELDERMTRYSWQSYLIATASFAEWIDRGRPAPTH
MAV_2015|M.avium_104 DVGFPYRSALVPRRNAELDERMTRYSWQSYLIATASFAEWIDRGRPAPTH
MSMEG_4509|M.smegmatis_MC2_155 DVGFPYRSSLVPRRNAELDERMMRHSWQSYLVDIGQFAEWIDRGRPAPTH
Mvan_3843|M.vanbaalenii_PYR-1 DVGFPYRSSLVPRRNAELDERMMRHSWQSYLVASAQFADWVDRGRPAPTH
Mflv_2698|M.gilvum_PYR-GCK DVGFPYRSALVRRRNAELDERMTRYSWQSYLIATGGFAEWIDRGRPAPPH
TH_1927|M.thermoresistible__bu DVGFPYRSTLVPRRNAELDERMTRHSWQAYLIDTAQFAEWVDRGRPAPTH
MAB_2249|M.abscessus_ATCC_1997 DVGFPYRSAILPGRNAEIDARMMRLSWQSYLVATGQFAEWVDRDKPAPTH
MMAR_3697|M.marinum_M DVGFPYRSALWPGRNAEIDERMIRFSWQSFLVDTDQFVGWVDRGRPSPAH
MUL_3640|M.ulcerans_Agy99 DVGFPYRSALWPGRNAEIDERMIRFSWQSFLVDTDQFVGWVDRGRPSPAH
********:: ****:* ** * ***::*: *. *:**.:*:*.*
Rv2378c|M.tuberculosis_H37Rv RRWSQYLAWVADHIGLKVIHGEVERLAV--TGDRWALCTHET------TV
Mb2399c|M.bovis_AF2122/97 RRWSQYLAWVADHIGLKVIHGEVERLAV--TGDRWALCTHET------TV
MAV_2015|M.avium_104 RRWSQYLSWVADHVGMTVVHGEVEQLAV--TGDRWALHTHET------TV
MSMEG_4509|M.smegmatis_MC2_155 RRWSQYLNWVADNIGMSLITGEVTRIGLGDDQNSWTLHTHED------TV
Mvan_3843|M.vanbaalenii_PYR-1 LGWSRYLRWVADNIGMSVITGEVQRIST--DGRRWELVTPRQ------IV
Mflv_2698|M.gilvum_PYR-GCK HRWARYLRWVAEQIDMTVVSGDVQRISV--DGERWALHTHDT------VL
TH_1927|M.thermoresistible__bu RKWAAYLRWVADRIGLNVHHGEVTRISVG--GPGWQLHTADTTVSADATV
MAB_2249|M.abscessus_ATCC_1997 KRWADYLTWVANTVDMKVVHGEVTGLSID--DDRWVVGTKDC------AI
MMAR_3697|M.marinum_M DTWAQYLRWVADRAGLEVVGGEVVQLSVD--ESRWVVHTADS------SL
MUL_3640|M.ulcerans_Agy99 DTWAQYLRWVADRAGLEVVGGEVVQLSVD--ESRWVVHTADS------SL
*: ** ***: .: : *:* :. * : * :
Rv2378c|M.tuberculosis_H37Rv QADALMITGPGQAEKSLLPGNPRVLSIAQFWDRAAGHDRINAERVAVIGG
Mb2399c|M.bovis_AF2122/97 QADALMITGPGQAEKSLLPGNPRVLSIAQFWDRAAGHDRINAERVAVIGG
MAV_2015|M.avium_104 HADALMITGPGQAEKSLLPGNPRMLSIAQFWDRAANHDRISAERVAVIGG
MSMEG_4509|M.smegmatis_MC2_155 AADAVMITGPGQAERSILPGNPRVLSIAQFWHRAAANELISAERVAVIGG
Mvan_3843|M.vanbaalenii_PYR-1 HADGVMITGPGQAQRSILPNDPRVLSIAQFWERAARPDLIVAERVAVIGG
Mflv_2698|M.gilvum_PYR-GCK HSDGVMITGPGQAERSILPGHPRVLSIAQFWHRAAEHERIAAERVAVIGG
TH_1927|M.thermoresistible__bu SADAVMITGPGQAERTLLPGDPRVMSIAEFWRRAAAHELIVAERVAMIGG
MAB_2249|M.abscessus_ATCC_1997 AADAVMVTGPGQPERSVLPEHPNVLSIAEFWRRCAGPMRLTAERVAVIGG
MMAR_3697|M.marinum_M TADMVMFTGPGQPERSILAHDPRVLSIAQFWHRAAQHERIVAERVAVIGG
MUL_3640|M.ulcerans_Agy99 TADMVMFTGPGQPERSILAHDPRVLSIAQFWHRAAQHERIVAERVAVIGG
:* :*.*****.::::*. .*.::***:** *.* : *****:***
Rv2378c|M.tuberculosis_H37Rv GETAASMLNELFRHRVSTITVISPQVTLFTRGEGFFENSLFSDPTDWAAL
Mb2399c|M.bovis_AF2122/97 GETAASMLNELFRHRVSTITVISPQVTLFTRGEGFFENSLFSDPTDWAAL
MAV_2015|M.avium_104 GETAAAMLNELFRHRVSSITVISPQATLFTRGEGYFENSLFSDPTNWPAL
MSMEG_4509|M.smegmatis_MC2_155 GETAATMLNELFRHRVSAITVISPQVTLFTRGESFFENTLYSDPTHWAGL
Mvan_3843|M.vanbaalenii_PYR-1 GETAASMLNELFRHRVSTITVISPQVTLFTRGESFFENTLFSDPTDWASL
Mflv_2698|M.gilvum_PYR-GCK GETAASMLNELFRHRVSTITVISPSVTLFTRGESFFENTLFSDPTGWTGL
TH_1927|M.thermoresistible__bu GETAASMLNELFRHRVSTITVISPQVTLFTRGEGFFENSLFSDPTGWTSL
MAB_2249|M.abscessus_ATCC_1997 GETAASVLNELFGHRVSTVTVISPGVTLFTRGEGYFENALFSDPTGWLHH
MMAR_3697|M.marinum_M GETAASILNELFHHRVSAITAFSPQATLFTRGEGFFENSLFSDPAGWRNL
MUL_3640|M.ulcerans_Agy99 GETAASILNELFHHRVSAITAFSPQATLFTRGEGFFENSLFSDPAGWRNL
*****::***** ****::*.:** .*******.:***:*:***: *
Rv2378c|M.tuberculosis_H37Rv TFDERRDALARTDRGVFSATVQEALLADDRIHHLRGRVAHAVGRQGQIRL
Mb2399c|M.bovis_AF2122/97 TFDERRDALARTDRGVFSATVQEALLADDRIHHLRGRVAHAVGRQGQIRL
MAV_2015|M.avium_104 TLAERRDALARTDRGVFSSSVQEALLADDRIHHLRGRVAHAVGVQGQIRL
MSMEG_4509|M.smegmatis_MC2_155 TLDERRDAMNRTDRGVFSARVQESLLADDRIRHLRGRVAHAVARDEKIRL
Mvan_3843|M.vanbaalenii_PYR-1 TMAERRDALGRTDRGVFSARVQDALLADDRIRHLRGRVAHAVARDERIRL
Mflv_2698|M.gilvum_PYR-GCK TPAERRDAMARTDRGVFSARVQDALLADDRIRHLRGRVAHAVPRDGRIRL
TH_1927|M.thermoresistible__bu TLAERQDAITRTDRGVFSARVQEALLADDRIRHLRGRVAHAVPKDGRIRL
MAB_2249|M.abscessus_ATCC_1997 TMEERRDALNRTDRGVFSARVQDSLLADDRIRHLRGRVAHAVALDDRIRL
MMAR_3697|M.marinum_M ALSERRDCIARTDRGVFSARVQESLLTDERIRHMRGRVARAVNRDNRIWL
MUL_3640|M.ulcerans_Agy99 VLSERRDCIARTDRGVFSARVQESLLTDERIRHMRGRVARAVNRDNRIWL
. **:*.: ********: **::**:*:**:*:*****:** : :* *
Rv2378c|M.tuberculosis_H37Rv TLSTNR-GSENFETVHGFDLVIDGSGADPLWFTSLFSQHTLDLLELGLGG
Mb2399c|M.bovis_AF2122/97 TLSTNR-GSENFETVHGFDLVIDGSGADPLWFTSLFSQHTLDLLELGLGG
MAV_2015|M.avium_104 TLSTNR-GSENLETVHGFDLVIDGSGADSLWFAPLFSQEALDLLELGLGG
MSMEG_4509|M.smegmatis_MC2_155 TLQTNS-GSERLETVHGFDLVIDGSGADALWFVPLLAQDALDKLELGLGR
Mvan_3843|M.vanbaalenii_PYR-1 TLSSNR-GGEALETVHGFDLVIDGSGADSMWFEPLFSQDARDLIELALRA
Mflv_2698|M.gilvum_PYR-GCK TLNSDR-GGERLETVHGFDLVIDGSGADALWFLPLLGQDARDLIELGLGG
TH_1927|M.thermoresistible__bu TLHTDQAGGERIETVHGFDLVIDGQGADSTWFMNLLGQDARDLLELALGG
MAB_2249|M.abscessus_ATCC_1997 TLRSDR-AGEPSETVHGFDLVIDGAGADALWFLPLFDQSALDLMELKLGA
MMAR_3697|M.marinum_M TLSTDC-CGEPRETLHDFDLVIDGSGADPLWFLSLLSQDAVDLLELGLQA
MUL_3640|M.ulcerans_Agy99 TLSTDC-CGEPRETLHDFDLVIDGSGADPLWFLSLLSQDAVDLLELGLQA
** :: .* **:*.******* ***. ** *: * : * :** *
Rv2378c|M.tuberculosis_H37Rv PLTADRLQEAIGYDLAVTDVTPKLFLPTLSGLTQGPGFPNLSCLGLLSDR
Mb2399c|M.bovis_AF2122/97 PLTADRLQEAIGYDLAVTDVTPKLFLPTLSGLTQGPGFPNLSCLGLLSDR
MAV_2015|M.avium_104 PLSSERLQEAIGYDLAVTDVTPKLFLPNLSGLTQGPGFPNLSCLGLLSDR
MSMEG_4509|M.smegmatis_MC2_155 PLTGDTLQESIGYDLAVTGVTPKLFLPGLAGLNQGPGFPNLSCLGLLSDR
Mvan_3843|M.vanbaalenii_PYR-1 PLSGDALQESIGHDLSVAALTPKLFLPGLSGLTQGPGFPNLSCLGLLSDR
Mflv_2698|M.gilvum_PYR-GCK TLTGDALCESIGYDLAVSNVSPKLFLPGLSGLTQGPGFPNLSCLGLLSDR
TH_1927|M.thermoresistible__bu PLTADLLQQSIGHDLAVAGVTPKLFLPNLAGLNQGPGFPNLSCLGLLSDR
MAB_2249|M.abscessus_ATCC_1997 PVDGNVLQESLGHDLSVNGLTPKLILPTLSGLTQGPGFPNLSCLGLLSDR
MMAR_3697|M.marinum_M PLTCQRLEESIGADLAVSGVAPKLFLPNLAGLNEGPGFPNLSCLGLLSDR
MUL_3640|M.ulcerans_Agy99 PLTCQRLEESIGADLAVSGVAPKMFLPNLAGLNEGPGFPNLSCLGLLSDR
.: : * :::* **:* ::**::** *:**.:****************
Rv2378c|M.tuberculosis_H37Rv VLGAGIFT----PTKHNDTRRSGEHQSFR
Mb2399c|M.bovis_AF2122/97 VLGAGIFT----PTKHNDTRRSGEHQSFR
MAV_2015|M.avium_104 VLGS-TLG----PTKYPARRRHDERQPL-
MSMEG_4509|M.smegmatis_MC2_155 VLGAEMS-----VTTDRTIRRTDEHQSVR
Mvan_3843|M.vanbaalenii_PYR-1 VLGARYPD----VAPHPSTRRTDEHQPVR
Mflv_2698|M.gilvum_PYR-GCK VLGAELG-----AAPQRSVRSSDEHQPVR
TH_1927|M.thermoresistible__bu ILGADIV-----TSADRTKWRSDEHQPI-
MAB_2249|M.abscessus_ATCC_1997 VLGGHSG-----TDSVRRERKIVEYQPI-
MMAR_3697|M.marinum_M ILSAELGLAPAPVGTSRSKGRSDEYQSV-
MUL_3640|M.ulcerans_Agy99 ILSAELGLAPAPVGTNRSKGRSDEYQSV-
:*.. * *..