For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
EPDVIPAKNLVFGSGPECPTELLCLPLLRARYGLTFKEFRVTDAGGPRTVDALEAGEIQVGVLFTTDPRL LAGDFVLLEDDRHAQPAESVTPILRDELRAAHGEHLAASIDALSAELTTARLAELNRRVLLGASAAAVAA EFLTKRRHGLTPRTPRRNQPAIVVGSANFAESVTVAELYAHALAGAGFLVERHLGIGNRDTYFPLLRDGT VGLVPEYVGSLLAYLDGSRGSISDPPQAHAVLAQALQGTGLGALQPAPAQNKNGIVVTASTAAHYGLTKI SDLGRAIGEPDGNG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3575 | - | - | 100% (295) | hypothetical protein MMAR_3575 |
| M. marinum M | MMAR_5302 | proX | 1e-20 | 44.72% (123) | osmoprotectant (glycine betaine/carnitine/choline/L-proline) |
| M. marinum M | MMAR_0032 | - | 4e-07 | 32.80% (125) | hypothetical protein MMAR_0032 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3785c | proX | 2e-21 | 43.90% (123) | osmoprotectant (glycine betaine/carnitine/choline/L-proline) |
| M. gilvum PYR-GCK | Mflv_1207 | - | 2e-22 | 43.44% (122) | substrate-binding region of ABC-type glycine betaine transport |
| M. tuberculosis H37Rv | Rv3759c | proX | 3e-20 | 43.09% (123) | osmoprotectant (glycine betaine/carnitine/choline/L-proline) |
| M. leprae Br4923 | MLBr_01093 | - | 4e-06 | 31.07% (103) | lipoprotein |
| M. abscessus ATCC 19977 | MAB_0261 | - | 7e-21 | 42.06% (126) | amino acid ABC transporter substrate-binding protein |
| M. avium 104 | MAV_0317 | - | 4e-19 | 38.06% (134) | ABC transporter, quaternary amine uptake transporter (QAT) |
| M. smegmatis MC2 155 | MSMEG_6334 | - | 1e-10 | 33.33% (120) | ABC transporter, quaternary amine uptake transporter (QAT) |
| M. thermoresistible (build 8) | TH_0699 | - | 7e-07 | 29.03% (124) | permease binding-protein component |
| M. ulcerans Agy99 | MUL_4377 | proX | 2e-21 | 44.72% (123) | osmoprotectant (glycine betaine/carnitine/choline/L-proline) |
| M. vanbaalenii PYR-1 | Mvan_5601 | - | 8e-23 | 43.90% (123) | substrate-binding region of ABC-type glycine betaine transport |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3785c|M.bovis_AF2122/97 MRMLRRLRRATVAAAVWLATVCLVASCANADPLG--SATGSVKS------
Rv3759c|M.tuberculosis_H37Rv MRMLRRLRRATVAAAVWLATVCLVASCANADPLG--SATGSVKS------
MUL_4377|M.ulcerans_Agy99 MGTLRRMCRATLAAALCVVMVCSVAACGSSDPFG--TTSCDINS------
MAV_0317|M.avium_104 -------------MAVLLTTMFVVAACSNSDPLG--AQVRSPDS------
Mflv_1207|M.gilvum_PYR-GCK -MTVTRRTGAAYIPVVLALIAVLLAACGSSNPLGGGEISGDLKT------
MSMEG_6334|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5601|M.vanbaalenii_PYR-1 -MICSRRTRRAAVAVAIALLAAVLSACGSSNPLGGGEISGDLKS------
MAB_0261|M.abscessus_ATCC_1997 -------MRRAAQLLVAVMAAIFFSGCGSANPLGGGPLSGNLNT------
TH_0699|M.thermoresistible__bu -------MVRGIALLCTVLLAAVTAGCGLQSSSGAVLKADPGSIGYYESL
MLBr_01093|M.leprae_Br4923 -------------MRVGRLAALLLAGVGVFVAGGCATDRGDRHP------
MMAR_3575|M.marinum_M ------------MEPDVIPAKNLVFGSGPECPTELLCLPLLRAR------
Mb3785c|M.bovis_AF2122/97 ----IVVGSGDFPESQVIAEIYAQVLQANGFDVGRRLGIGSRETYIPALK
Rv3759c|M.tuberculosis_H37Rv ----IVVGSGDFPESQVIAEIYAQVLQANGFDVGRRLGIGSRETYILALK
MUL_4377|M.ulcerans_Agy99 ----IVVGSGDFPESQIVAELYAQALRANGFEVGMRLGIGSRETYIPALK
MAV_0317|M.avium_104 ----IVVGSGDFPESQIIAEIYAQALQANGFDVGKRMGIGSRETYIPAIK
Mflv_1207|M.gilvum_PYR-GCK ----IKVGSADFTESKIIAEIYAQALEANDFTITRQFGIGSRETYIPAVQ
MSMEG_6334|M.smegmatis_MC2_155 ------------------------------------------------MQ
Mvan_5601|M.vanbaalenii_PYR-1 ----IKVGSADFTESKIIAEIYAQALEANGFTISRQFGIGSRETYIPAVR
MAB_0261|M.abscessus_ATCC_1997 ----LIVGSADFPESKTVAELYAQILQINGFDVTRQLGIGSRETYIPAVK
TH_0699|M.thermoresistible__bu DGVPITVAAKDFTEQLILGNMLATVLATAGAEVTNMSNTPGSFGVREALL
MLBr_01093|M.leprae_Br4923 ---ELVVGSKPDSESTLLAAIYVAALRSYGFGARGETGADP----MAMLD
MMAR_3575|M.marinum_M ----YGLTFKEFRVTDAGGPRTVDALEAGEIQVGVLFTTDPR--------
Mb3785c|M.bovis_AF2122/97 DHSIDLVPEYIGN-LLLYFQ-PDATVTMLDAVELELYKRLPGDLSILT-P
Rv3759c|M.tuberculosis_H37Rv DHSIDLVPEYIGN-LLLYFQ-PDATVTMLDAVELELYKRLPGDLSILT-P
MUL_4377|M.ulcerans_Agy99 DHSIDLVPEYIGN-LLLYFD-PHATVTLLDAVELELYRRLPGDLSVLT-P
MAV_0317|M.avium_104 DHSIDLVPEYIGN-LLLYFE-PASSATTLDAVEQELHRRLPADLSILT-P
Mflv_1207|M.gilvum_PYR-GCK DHSIDLIPEYTGN-LLQYFD-ADSTATTPDEVLLALFNALPGDLSILY-P
MSMEG_6334|M.smegmatis_MC2_155 DHSIDLIPEYTGN-LLQYFD-PETPATTPDAVLLGLFKALPGDLSILY-P
Mvan_5601|M.vanbaalenii_PYR-1 DHSIDLIPEYTGN-LLQYFD-PESAATTPDSVLLGLLKALPGDLSILY-P
MAB_0261|M.abscessus_ATCC_1997 DHSIDLIADYTGN-LLRYFD-PEATATKPDEVELALLRKLDGDLDILS-P
TH_0699|M.thermoresistible__bu QGRADIAPEYTGTGWINYLGNDEPIKDEVEQWSAVKHADAVNGLTWLP-P
MLBr_01093|M.leprae_Br4923 SGGFTVVPGFTGK-VLQILQ-PRAAVLSAARVYRAMVSALPEGIAAGDYT
MMAR_3575|M.marinum_M --------LLAGDFVLLEDDRHAQPAESVTPILRDELRAAHGEHLAASID
* :
Mb3785c|M.bovis_AF2122/97 SPASDTDTVTVTAATAARWNLKTIADLAPHSA-DVKFAAPSVFQTRPSGL
Rv3759c|M.tuberculosis_H37Rv SPASDTDTVTVTAATAARWNLKTIADLAPHSA-DVKFAAPSAFQTRPSGL
MUL_4377|M.ulcerans_Agy99 SPASDTDTVTVTSATAGKWNLKTIADLAPHSA-NLRFAAPSAFQNRPSGL
MAV_0317|M.avium_104 APATDTDTVSVTSQAANSWNLRTIGDLAPHSA-DVRFGAPSAFATRPAGL
Mflv_1207|M.gilvum_PYR-GCK SPAEDKDTLAVTEETAQRWNLTSIADLAARSP-EVKVGAPSEFQTRYTGL
MSMEG_6334|M.smegmatis_MC2_155 SPAEDKDTLAVTEETAQRWNLKSIEDLAQHSA-EVKVGGPSEFQTRQTGL
Mvan_5601|M.vanbaalenii_PYR-1 SPAEDKDTLAVSAETAQRWNLKSIADLAAHSA-EVKVGAPSEFQTRQTGL
MAB_0261|M.abscessus_ATCC_1997 SPAADADTLCVTRATAEKWNLRSIGDLAAHSA-EVTVGAPSEFLHRSVGL
TH_0699|M.thermoresistible__bu APLNNTYAFAIRESEAERLGVTKMSDLHRLDRRDLTFCVESEFVNRNDGL
MLBr_01093|M.leprae_Br4923 TAAEDKPTLVVTPDTAKAWSGSDLSLVLSHCNELVVGIVAGTHTPSAVGS
MMAR_3575|M.marinum_M ALSAELTTARLAELNRRVLLGASAAAVAAEFLTKRRHGLTPRTPRRNQPA
: : : : :
Mb3785c|M.bovis_AF2122/97 PGLRHKYSLDIAPGNFVTINDGGGAVTVRALVEGTATAANLFSTSAAIPQ
Rv3759c|M.tuberculosis_H37Rv PGLRHKYSLDIAPGNFVTINDGGGAVTVRALVEGTATAANLFSTSAAIPQ
MUL_4377|M.ulcerans_Agy99 RGLREKYGLDISPQNFVTINDGGGAVTVRALLDGTVDAADIFSTSPAIRQ
MAV_0317|M.avium_104 PGLRQKYGLDIKPGNFVAIDDGGGAVTVRALLEGRVNAANIFTTSPAIPQ
Mflv_1207|M.gilvum_PYR-GCK VGLKEKYGLDIAPANFVAISDGGGPATVQALSSGAITAANIFSTSPAIEQ
MSMEG_6334|M.smegmatis_MC2_155 VGLKSKYGLDIAPANFVAISDGGGPATVQALNSGAITAANIFSTSPAIEQ
Mvan_5601|M.vanbaalenii_PYR-1 VGLKEKYGLDIAPANFVAISDGGGPATVKALTDGTVTAANIFSTSPAIER
MAB_0261|M.abscessus_ATCC_1997 AGLKANYGLDIPESRFVAISDGGGPATVKALVDGTITTANIFSTSPAIAE
TH_0699|M.thermoresistible__bu VPMLAAYDLSRAALDRVTVLDTG--VIYTATANGECNFGEVFSTDGRIPA
MLBr_01093|M.leprae_Br4923 CRLPAAREFPDYP------------TMFAALRAGQLTAGWTTTANPDLPA
MMAR_3575|M.marinum_M IVVGSANFAESVTVAELYAHALAGAGFLVERHLGIGNRDTYFPLLRDGTV
: * .
Mb3785c|M.bovis_AF2122/97 NHLVVLEDPEHNFLAGNIVPLVNS--RKKSDHLKDVLDAVSAKLTTAGLA
Rv3759c|M.tuberculosis_H37Rv NHLVVLEDPEHNFLAGNIVPLVNS--RKKSDHLKDVLDAVSAKLTTAGLA
MUL_4377|M.ulcerans_Agy99 NHLVVLADPEHNFRAGNIVPLLNS--QKKSDRIKDVLDAVSAKLTTEGVA
MAV_0317|M.avium_104 HHLVALDDPEHNFIAGNVVPLVNS--QKRSERLKLVLDAVSAKLTTPGVA
Mflv_1207|M.gilvum_PYR-GCK SRLVVLDDPENVFLAANVVPLVAS--QKMSAELKTVLDAVSAKLTTEALI
MSMEG_6334|M.smegmatis_MC2_155 HHLVVLEDPKNVFLAANVVPLVAS--QKMSNELKTVLDAVSAKLTTEALI
Mvan_5601|M.vanbaalenii_PYR-1 SALVVLEDPKNVFLAANVVPLVAS--QKMSNELKTVLDAVSAKLTTEALI
MAB_0261|M.abscessus_ATCC_1997 HDLVVLDDPKFTFPAGNLVPLVNA--QKKSEKLKKVLDALSARLTTADLT
TH_0699|M.thermoresistible__bu LGLRVLDDDREFFPKYNMTEVVDTGLLEAHPEIAEIFAQLNPLITNEVML
MLBr_01093|M.leprae_Br4923 DLIVLTDGKATLIQAENVVPLYRR--NVLTDRQMLAINEVAGVLDTAALI
MMAR_3575|M.marinum_M GLVPEYVGSLLAYLDGSRGSISDPP-QAHAVLAQALQGTGLGALQPAPAQ
: . . : :
Mb3785c|M.bovis_AF2122/97 ELNAAVSGNSGVDPDQAARKWVRDNGFDHPVRQ-
Rv3759c|M.tuberculosis_H37Rv ELNAAVSGNSGVDPDQAARKWVRDNGFDHPVRQ-
MUL_4377|M.ulcerans_Agy99 ELNASVSGNGGIDPNEAARKWLHDNGFDHPIRP-
MAV_0317|M.avium_104 GLNAAVSGNSGVDPDQAARNWLRDNGLNHPIGP-
Mflv_1207|M.gilvum_PYR-GCK ELNTSVEGNQGIDPDEAAQKWIADNGFDRPIGG-
MSMEG_6334|M.smegmatis_MC2_155 EMNTAVEGNAGVDPDEAAAKWVADNGFDKPITG-
Mvan_5601|M.vanbaalenii_PYR-1 ELNTSVEGNQGVDPDEAARKWISDNGFDTPIGK-
MAB_0261|M.abscessus_ATCC_1997 GLNAAVSGNNGVDPKEAAQKWLTDKGFDKPVGA-
TH_0699|M.thermoresistible__bu ALNAKVD-NDGADPALVARDWLIEQGLVR-----
MLBr_01093|M.leprae_Br4923 EMRRQVI--RGADSQAIADGWLAEHPMGR-----
MMAR_3575|M.marinum_M NKNGIVVTASTAAHYGLTKISDLGRAIGEPDGNG
. * : . :