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RMLRRLRRATVAAAVWLATVCLVASCANADPLGSATGSVKSIVVGSGDFPESQVIAEIYAQVLQANGFDV GRRLGIGSRETYILALKDHSIDLVPEYIGNLLLYFQPDATVTMLDAVELELYKRLPGDLSILTPSPASDT DTVTVTAATAARWNLKTIADLAPHSADVKFAAPSAFQTRPSGLPGLRHKYSLDIAPGNFVTINDGGGAVT VRALVEGTATAANLFSTSAAIPQNHLVVLEDPEHNFLAGNIVPLVNSRKKSDHLKDVLDAVSAKLTTAGL AELNAAVSGNSGVDPDQAARKWVRDNGFDHPVRQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3759c | proX | - | 100% (315) | POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) BINDING LIPOPROTEIN PROX |
| M. tuberculosis H37Rv | Rv1244 | lpqZ | 6e-10 | 24.59% (305) | lipoprotein LpqZ |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3785c | proX | 1e-177 | 99.37% (315) | osmoprotectant (glycine betaine/carnitine/choline/L-proline) |
| M. gilvum PYR-GCK | Mflv_1207 | - | 1e-102 | 60.63% (315) | substrate-binding region of ABC-type glycine betaine transport |
| M. leprae Br4923 | MLBr_01093 | - | 5e-10 | 24.25% (268) | lipoprotein |
| M. abscessus ATCC 19977 | MAB_0261 | - | 1e-101 | 59.22% (309) | amino acid ABC transporter substrate-binding protein |
| M. marinum M | MMAR_5302 | proX | 1e-141 | 77.39% (314) | osmoprotectant (glycine betaine/carnitine/choline/L-proline) |
| M. avium 104 | MAV_0317 | - | 1e-131 | 75.25% (299) | ABC transporter, quaternary amine uptake transporter (QAT) |
| M. smegmatis MC2 155 | MSMEG_6334 | - | 6e-83 | 66.96% (227) | ABC transporter, quaternary amine uptake transporter (QAT) |
| M. thermoresistible (build 8) | TH_0699 | - | 2e-14 | 27.11% (273) | permease binding-protein component |
| M. ulcerans Agy99 | MUL_4377 | proX | 1e-141 | 77.07% (314) | osmoprotectant (glycine betaine/carnitine/choline/L-proline) |
| M. vanbaalenii PYR-1 | Mvan_5601 | - | 1e-109 | 64.63% (311) | substrate-binding region of ABC-type glycine betaine transport |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3759c|M.tuberculosis_H37Rv MRMLRRLRRATVAAAVWLATVCLVASCANADPLG--SATGSVKS------
Mb3785c|M.bovis_AF2122/97 MRMLRRLRRATVAAAVWLATVCLVASCANADPLG--SATGSVKS------
MMAR_5302|M.marinum_M MGTLRRMCRATLAAALCVVTVCSVAACGSSDPFG--TTGCDVNS------
MUL_4377|M.ulcerans_Agy99 MGTLRRMCRATLAAALCVVMVCSVAACGSSDPFG--TTSCDINS------
MAV_0317|M.avium_104 -------------MAVLLTTMFVVAACSNSDPLG--AQVRSPDS------
Mflv_1207|M.gilvum_PYR-GCK -MTVTRRTGAAYIPVVLALIAVLLAACGSSNPLGGGEISGDLKT------
MSMEG_6334|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5601|M.vanbaalenii_PYR-1 -MICSRRTRRAAVAVAIALLAAVLSACGSSNPLGGGEISGDLKS------
MAB_0261|M.abscessus_ATCC_1997 -------MRRAAQLLVAVMAAIFFSGCGSANPLGGGPLSGNLNT------
TH_0699|M.thermoresistible__bu -------MVRGIALLCTVLLAAVTAGCGLQSSSGAVLKADPGSIGYYESL
MLBr_01093|M.leprae_Br4923 -------------MRVGRLAALLLAGVGVFVAGGCATDRGDRHP------
Rv3759c|M.tuberculosis_H37Rv ----IVVGSGDFPESQVIAEIYAQVLQANGFDVGRRLGIGSRETYILALK
Mb3785c|M.bovis_AF2122/97 ----IVVGSGDFPESQVIAEIYAQVLQANGFDVGRRLGIGSRETYIPALK
MMAR_5302|M.marinum_M ----IVVGSGDFPESQIVAELYAQALRVNGFEVGMRLGIGSRETYIPALK
MUL_4377|M.ulcerans_Agy99 ----IVVGSGDFPESQIVAELYAQALRANGFEVGMRLGIGSRETYIPALK
MAV_0317|M.avium_104 ----IVVGSGDFPESQIIAEIYAQALQANGFDVGKRMGIGSRETYIPAIK
Mflv_1207|M.gilvum_PYR-GCK ----IKVGSADFTESKIIAEIYAQALEANDFTITRQFGIGSRETYIPAVQ
MSMEG_6334|M.smegmatis_MC2_155 ------------------------------------------------MQ
Mvan_5601|M.vanbaalenii_PYR-1 ----IKVGSADFTESKIIAEIYAQALEANGFTISRQFGIGSRETYIPAVR
MAB_0261|M.abscessus_ATCC_1997 ----LIVGSADFPESKTVAELYAQILQINGFDVTRQLGIGSRETYIPAVK
TH_0699|M.thermoresistible__bu DGVPITVAAKDFTEQLILGNMLATVLATAGAEVTNMSNTPGSFGVREALL
MLBr_01093|M.leprae_Br4923 ---ELVVGSKPDSESTLLAAIYVAALRSYGFGARGETGADP----MAMLD
:
Rv3759c|M.tuberculosis_H37Rv DHSIDLVPEYIGN-LLLYFQ-PDATVTMLDAVELELYKRLPGDLSILT-P
Mb3785c|M.bovis_AF2122/97 DHSIDLVPEYIGN-LLLYFQ-PDATVTMLDAVELELYKRLPGDLSILT-P
MMAR_5302|M.marinum_M DHSIDLVPEYIGN-LLLYFD-PHATVTLLDAVELELYRRLPGDLSVLT-P
MUL_4377|M.ulcerans_Agy99 DHSIDLVPEYIGN-LLLYFD-PHATVTLLDAVELELYRRLPGDLSVLT-P
MAV_0317|M.avium_104 DHSIDLVPEYIGN-LLLYFE-PASSATTLDAVEQELHRRLPADLSILT-P
Mflv_1207|M.gilvum_PYR-GCK DHSIDLIPEYTGN-LLQYFD-ADSTATTPDEVLLALFNALPGDLSILY-P
MSMEG_6334|M.smegmatis_MC2_155 DHSIDLIPEYTGN-LLQYFD-PETPATTPDAVLLGLFKALPGDLSILY-P
Mvan_5601|M.vanbaalenii_PYR-1 DHSIDLIPEYTGN-LLQYFD-PESAATTPDSVLLGLLKALPGDLSILY-P
MAB_0261|M.abscessus_ATCC_1997 DHSIDLIADYTGN-LLRYFD-PEATATKPDEVELALLRKLDGDLDILS-P
TH_0699|M.thermoresistible__bu QGRADIAPEYTGTGWINYLGNDEPIKDEVEQWSAVKHADAVNGLTWLP-P
MLBr_01093|M.leprae_Br4923 SGGFTVVPGFTGK-VLQILQ-PRAAVLSAARVYRAMVSALPEGIAAGDYT
. : . : *. : : . .: .
Rv3759c|M.tuberculosis_H37Rv SPASDTDTVTVTAATAARWNLKTIADLAPHSA-DVKFAAPS-AFQTRPSG
Mb3785c|M.bovis_AF2122/97 SPASDTDTVTVTAATAARWNLKTIADLAPHSA-DVKFAAPS-VFQTRPSG
MMAR_5302|M.marinum_M SPASDTDTVTVTGATAGKWNLKTIADLAPHSA-NLRFAAPS-AFQNRPSG
MUL_4377|M.ulcerans_Agy99 SPASDTDTVTVTSATAGKWNLKTIADLAPHSA-NLRFAAPS-AFQNRPSG
MAV_0317|M.avium_104 APATDTDTVSVTSQAANSWNLRTIGDLAPHSA-DVRFGAPS-AFATRPAG
Mflv_1207|M.gilvum_PYR-GCK SPAEDKDTLAVTEETAQRWNLTSIADLAARSP-EVKVGAPS-EFQTRYTG
MSMEG_6334|M.smegmatis_MC2_155 SPAEDKDTLAVTEETAQRWNLKSIEDLAQHSA-EVKVGGPS-EFQTRQTG
Mvan_5601|M.vanbaalenii_PYR-1 SPAEDKDTLAVSAETAQRWNLKSIADLAAHSA-EVKVGAPS-EFQTRQTG
MAB_0261|M.abscessus_ATCC_1997 SPAADADTLCVTRATAEKWNLRSIGDLAAHSA-EVTVGAPS-EFLHRSVG
TH_0699|M.thermoresistible__bu APLNNTYAFAIRESEAERLGVTKMSDLHRLDRRDLTFCVES-EFVNRNDG
MLBr_01093|M.leprae_Br4923 TAAEDKPTLVVTPDTAKAWSGSDLSLVLSHCN-ELVVGIVAGTHTPSAVG
:. : :. : * . : : :: . : . *
Rv3759c|M.tuberculosis_H37Rv LPGLRHKYSLDIAPGNFVTINDGGGAVTVRALVEGTATAANLFSTSAAIP
Mb3785c|M.bovis_AF2122/97 LPGLRHKYSLDIAPGNFVTINDGGGAVTVRALVEGTATAANLFSTSAAIP
MMAR_5302|M.marinum_M LRGLREKYGLDISPQNFVSINDGGGAVTVRALLDGTVDAADIFSTSPAIR
MUL_4377|M.ulcerans_Agy99 LRGLREKYGLDISPQNFVTINDGGGAVTVRALLDGTVDAADIFSTSPAIR
MAV_0317|M.avium_104 LPGLRQKYGLDIKPGNFVAIDDGGGAVTVRALLEGRVNAANIFTTSPAIP
Mflv_1207|M.gilvum_PYR-GCK LVGLKEKYGLDIAPANFVAISDGGGPATVQALSSGAITAANIFSTSPAIE
MSMEG_6334|M.smegmatis_MC2_155 LVGLKSKYGLDIAPANFVAISDGGGPATVQALNSGAITAANIFSTSPAIE
Mvan_5601|M.vanbaalenii_PYR-1 LVGLKEKYGLDIAPANFVAISDGGGPATVKALTDGTVTAANIFSTSPAIE
MAB_0261|M.abscessus_ATCC_1997 LAGLKANYGLDIPESRFVAISDGGGPATVKALVDGTITTANIFSTSPAIA
TH_0699|M.thermoresistible__bu LVPMLAAYDLSRAALDRVTVLDTG--VIYTATANGECNFGEVFSTDGRIP
MLBr_01093|M.leprae_Br4923 SCRLPAAREFPDYP------------TMFAALRAGQLTAGWTTTANPDLP
: : . * * . ::. :
Rv3759c|M.tuberculosis_H37Rv QNHLVVLEDPEHNFLAGNIVPLVNS--RKKSDHLKDVLDAVSAKLTTAGL
Mb3785c|M.bovis_AF2122/97 QNHLVVLEDPEHNFLAGNIVPLVNS--RKKSDHLKDVLDAVSAKLTTAGL
MMAR_5302|M.marinum_M QNHLVVLADPEHNFRAGNIVPLLNS--QKKSDRIKDVLDAVSAKLTTEGV
MUL_4377|M.ulcerans_Agy99 QNHLVVLADPEHNFRAGNIVPLLNS--QKKSDRIKDVLDAVSAKLTTEGV
MAV_0317|M.avium_104 QHHLVALDDPEHNFIAGNVVPLVNS--QKRSERLKLVLDAVSAKLTTPGV
Mflv_1207|M.gilvum_PYR-GCK QSRLVVLDDPENVFLAANVVPLVAS--QKMSAELKTVLDAVSAKLTTEAL
MSMEG_6334|M.smegmatis_MC2_155 QHHLVVLEDPKNVFLAANVVPLVAS--QKMSNELKTVLDAVSAKLTTEAL
Mvan_5601|M.vanbaalenii_PYR-1 RSALVVLEDPKNVFLAANVVPLVAS--QKMSNELKTVLDAVSAKLTTEAL
MAB_0261|M.abscessus_ATCC_1997 EHDLVVLDDPKFTFPAGNLVPLVNA--QKKSEKLKKVLDALSARLTTADL
TH_0699|M.thermoresistible__bu ALGLRVLDDDREFFPKYNMTEVVDTGLLEAHPEIAEIFAQLNPLITNEVM
MLBr_01093|M.leprae_Br4923 ADLIVLTDGKATLIQAENVVPLYRR--NVLTDRQMLAINEVAGVLDTAAL
: . : *:. : . : : : . :
Rv3759c|M.tuberculosis_H37Rv AELNAAVSGNSGVDPDQAARKWVRDNGFDHPVRQ
Mb3785c|M.bovis_AF2122/97 AELNAAVSGNSGVDPDQAARKWVRDNGFDHPVRQ
MMAR_5302|M.marinum_M AELNASVSGNGGIDPDEAARKWLHDNGFDHPIRP
MUL_4377|M.ulcerans_Agy99 AELNASVSGNGGIDPNEAARKWLHDNGFDHPIRP
MAV_0317|M.avium_104 AGLNAAVSGNSGVDPDQAARNWLRDNGLNHPIGP
Mflv_1207|M.gilvum_PYR-GCK IELNTSVEGNQGIDPDEAAQKWIADNGFDRPIGG
MSMEG_6334|M.smegmatis_MC2_155 IEMNTAVEGNAGVDPDEAAAKWVADNGFDKPITG
Mvan_5601|M.vanbaalenii_PYR-1 IELNTSVEGNQGVDPDEAARKWISDNGFDTPIGK
MAB_0261|M.abscessus_ATCC_1997 TGLNAAVSGNNGVDPKEAAQKWLTDKGFDKPVGA
TH_0699|M.thermoresistible__bu LALNAKVD-NDGADPALVARDWLIEQGLVR----
MLBr_01093|M.leprae_Br4923 IEMRRQVI--RGADSQAIADGWLAEHPMGR----
:. * * *. * *: :: :