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SSRLVREIGAAAESSPNALYVGSVDAPREITWRAVEEQAHGMSNSLAARGIGRGDTVAVLAAEACDVAPL AQALWLRGAALTMLQQPTPRSDLAVWIADTVRACRMLGAALVVVGDPFEMAADALAAEGLIVCAVGSLRG TGPAAVVDTNDNDIAMRQLTSGSTGIPKAVEISHGNLVANIDASCQAVGITVDTVMASWLPLCHDMGMVG FICIPMKTGNTVVVIRTDEFLRRPIVWAEMLSKFRANVTAGPNFAYSVLARVLERADPESINLSALRVAV NGAEPIDHRDLENLATVGARFGMGSGVPTPFYGLAEAALTVSAGAFGAPAVVDYVSRQRLSEDHFAEPVA ADAQGAQPVVCVGLPIPDMQIRITRDGQLQDARKVGVIELCSPSIGKRYVTVDGTIPLVDDAGWFDTGDL GYLDELGRLYVCGRAKDMIVLAGRNLYPHDIERAAASVEGVRKGCVAALRLDTDREGFAVLAEVYDRFDE SELTQLRRAIAARVSSHVGHAPREVRLLAPGSLPKTTSGKLRREGARALM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3272 | - | - | 100% (541) | fatty acyl-AMP ligase |
| M. marinum M | MMAR_4476 | pks16 | e-119 | 43.01% (544) | polyketide synthase Pks16 |
| M. marinum M | MMAR_4970 | - | e-107 | 40.77% (542) | acyl-coenzyme A synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1041 | pks16 | 1e-121 | 43.93% (544) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_5217 | - | 1e-123 | 44.49% (544) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1013 | pks16 | 1e-121 | 43.93% (544) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_00243 | - | 1e-118 | 42.65% (544) | long-chain-fatty-acid--CoA ligase |
| M. abscessus ATCC 19977 | MAB_1140 | - | 1e-115 | 42.44% (549) | acyl-CoA synthetase |
| M. avium 104 | MAV_1150 | - | 1e-120 | 44.12% (544) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5435 | - | 1e-120 | 43.20% (544) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3958 | - | 1e-122 | 44.57% (534) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4648 | pks16 | 1e-119 | 43.01% (544) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1051 | - | 1e-123 | 44.12% (544) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00243|M.leprae_Br4923 -MSKFTEKMFRNARESSKGIVTGEPHNPVRHTWGQVHERASRIAGGLAGV
MUL_4648|M.ulcerans_Agy99 -MSRFTEKMFRNARETTKGMVTGEPHTPVRHTWGEVHERARQIAGGLAAA
Mb1041|M.bovis_AF2122/97 -MSRFTEKMFHNARTATTGMVTGEPHMPVRHTWGEVHERARCIAGGLAAA
Rv1013|M.tuberculosis_H37Rv -MSRFTEKMFHNARTATTGMVTGEPHMPVRHTWGEVHERARCIAGGLAAA
MAV_1150|M.avium_104 -MSRFTEKMYRNARTAKTGMVTGEPHNPVRHTWGEVHERARRIAGGLAAA
MSMEG_5435|M.smegmatis_MC2_155 -MSRFTEKMYRNARTVTTGMVTGEPHEPVRHTWGEVHERARRIAGGLAAA
TH_3958|M.thermoresistible__bu --------MFHNARTATTGMVTGEPHAPVRHTWGEVHERARRIAGGLAAA
MAB_1140|M.abscessus_ATCC_1997 -MSRFTDELYANALSSSKGMVTGEPDTPVRHTWKQVHERAKQVAGGLAGA
Mflv_5217|M.gilvum_PYR-GCK -MSQFTETMYANAHRSSKGLNTGEPHSPVRHTWEEVHQRARRIAGGLAAA
Mvan_1051|M.vanbaalenii_PYR-1 -MSRFTETMFANAHLSTKGFNTGEPHSPVRHSWEEVHQRARRVAGGLAAA
MMAR_3272|M.marinum_M MSSRLVREIGAAAESSPNALYVGSVDAPREITWRAVEEQAHGMSNSLAAR
: * ..: .*. . * . :* *.::* ::..**.
MLBr_00243|M.leprae_Br4923 GVGHGDAVGVLVGVPVEIAPTAQGLWMRGASLTMLHQPTPRTDLAVWEED
MUL_4648|M.ulcerans_Agy99 GVGPGDAVGVLAGAPVEIAPTAQGLWIRGASLTMLHQPTPRTDLALWAED
Mb1041|M.bovis_AF2122/97 GVGLGDVVGVLAGFPVEIAPTAQALWMRGASLTMLHQPTPRTDLAVWAED
Rv1013|M.tuberculosis_H37Rv GVGLGDVVGVLAGFPVEIAPTAQALWMRGASLTMLHQPTPRTDLAVWAED
MAV_1150|M.avium_104 GIGPGDAVGVLAGFPVEIAPTAQGLWMRGASLTMLHQPTPRTDLAVWADD
MSMEG_5435|M.smegmatis_MC2_155 GIGHGDAVGVLAGFPVEIAPTAQGVWMRGASLTMLHQPTPRTDLAVWAED
TH_3958|M.thermoresistible__bu GVGHGDAVGVLAGWPVEIAPTAQALWIRGASLTMLHQPTPRTDLMMWAED
MAB_1140|M.abscessus_ATCC_1997 GLGPDDAIGMLVGMPVEIAPAIQAVWMRGASLTMLHQPTPRTDLAVWAED
Mflv_5217|M.gilvum_PYR-GCK GVGHGDAVAMLAGAPVEIAPAAQGVWMRGASVTMVHQPTPRTDLIRWADE
Mvan_1051|M.vanbaalenii_PYR-1 GVGPGDAVAMLAGAPVEIAPAAQGVWMRGASVTMVHQPTPRTDLVRWAEE
MMAR_3272|M.marinum_M GIGRGDTVAVLAAEACDVAPLAQALWLRGAALTMLQQPTPRSDLAVWIAD
*:* .*.:.:*.. . ::** *.:*:***::**::*****:** * :
MLBr_00243|M.leprae_Br4923 TTTVIDMIEAKAVIISDPFMAVAPILEARGVKVVTVEQLLAADPVDPIET
MUL_4648|M.ulcerans_Agy99 TTTVVDMIEAKAVVISDPFMAAAPVLEERGIRVLTFEQLLASEPIDPVEV
Mb1041|M.bovis_AF2122/97 TMTVIGMIEAKAVIVSEPFLVAIPILEQKGMQVLTVADLLASDPIGPIEV
Rv1013|M.tuberculosis_H37Rv TMTVIGMIEAKAVIVSEPFLVAIPILEQKGMQVLTVADLLASDPIGPIEV
MAV_1150|M.avium_104 TMNVIGMIEAKAVVVSEPFLVAIPVLQEKDIKVLTVADLLASDPIDPVEV
MSMEG_5435|M.smegmatis_MC2_155 TMNVIGMIELKAVIISEPFLVATPVLEEKGILVLKVADLLAADPIDPVET
TH_3958|M.thermoresistible__bu TMNVIGMIAAKVVVVSDPFTAAIPVLEERGIKVLTVEQLLAADPIDPVDT
MAB_1140|M.abscessus_ATCC_1997 TLKVVDMIGAKAVIVSAPFDAAAPVLEEKGVIVVHIKDLWDADPIEPLEA
Mflv_5217|M.gilvum_PYR-GCK TTSVIDMISASAVVISDPFMAAAPLLSGMGMTVLSIADLLTAEPIDPVDT
Mvan_1051|M.vanbaalenii_PYR-1 TTAVITMIDAKAVVISDPFMAAAPVLEGLGMTVLTIADLLAADRVDPVET
MMAR_3272|M.marinum_M TVRACRMLGAALVVVGDPFEMAADALAAEGLIVCAVGSLRGTGPAAVVDT
* . *: *::. ** . * .: * . .* : ::.
MLBr_00243|M.leprae_Br4923 DEDDLALMQLTSGSTGSPKAVQITHRNVYSNVEAMFIGVRYNVEKDVMIS
MUL_4648|M.ulcerans_Agy99 GEDELALMQLTSGSTGSPKAVQITHRNLFANLEAMYISAEYDAETDVMVS
Mb1041|M.bovis_AF2122/97 GEDDLALMQLTSGSTGSPKAVQITHRNIYSNAEAMFVGAQYDVDKDVMVS
Rv1013|M.tuberculosis_H37Rv GEDDLALMQLTSGSTGSPKAVQITHRNIYSNAEAMFVGAQYDVDKDVMVS
MAV_1150|M.avium_104 GEDDLALMQLTSGSTGSPKAVQITHRNIYSNAEAMFIGAQYDVDKDVMVS
MSMEG_5435|M.smegmatis_MC2_155 GEDDLALMQLTSGSTGSPKAVQITHRNIHSNAEAMFVGAKYDVEKDVMVS
TH_3958|M.thermoresistible__bu SEDDVALMQLTSGSTGSPKAVVITHRNIYSNAEAMFVGAQYDVDNDVMVS
MAB_1140|M.abscessus_ATCC_1997 DEDSVALMQLTSGSTGSPKAVKITHRNLYANAHGMYVASKYKPEIDVMVS
Mflv_5217|M.gilvum_PYR-GCK CDDDIALMQLTSGSTGSPKAVQITHANIVANADAMTAGCDFDIDTDVIVS
Mvan_1051|M.vanbaalenii_PYR-1 SDDDIALMQLTSGSTGSPKAVQITHANIVANADAMTAGCNFDIDTDVIVS
MMAR_3272|M.marinum_M NDNDIAMRQLTSGSTGIPKAVEISHGNLVANIDASCQAVGITVDT-VMAS
::.:*: ******** **** *:* *: :* .. . : *: *
MLBr_00243|M.leprae_Br4923 WLPCFHDMGMIGFLTVPMYFGAELVKVTPIDFLRDTLLWAKLIDKYKGTV
MUL_4648|M.ulcerans_Agy99 WLPLFHDMGMIGFLTVPMYFAGELVKVTPMDFMRDTLLWAKLIDKYKGTM
Mb1041|M.bovis_AF2122/97 WLPCFHDMGMVGFLTIPMFFGAELVKVTPMDFLRDTLLWAKLIDKYQGTM
Rv1013|M.tuberculosis_H37Rv WLPCFHDMGMVGFLTIPMFFGAELVKVTPMDFLRDTLLWAKLIDKYQGTM
MAV_1150|M.avium_104 WLPCFHDMGMVGFLTIPMYFGAELVKVTPMDFLRDTLLWAKLIDKYKGTM
MSMEG_5435|M.smegmatis_MC2_155 WLPCFHDMGMVGFLTIPMYFGAELVKVTPMDFLRDTLLWAKLIDKYKGTM
TH_3958|M.thermoresistible__bu WLPCFHDMGMIGFLTVPMYFGAELVKVTPMDFLRDTLLWARLIDKYKGTM
MAB_1140|M.abscessus_ATCC_1997 WLPLFHDMGMVGFLTVPMFFGAELVKITPMDFMRDVLLWGRLIDKYKGTM
Mflv_5217|M.gilvum_PYR-GCK WLPCFHDMGMTGYLTVPMYFGAELVKITPMDFLGDILLWPRLIHKYRGTM
Mvan_1051|M.vanbaalenii_PYR-1 WLPCFHDMGMTGYLTVPMYFGAELVKVTPMDFLSDILLWPRLIDKYRGTM
MMAR_3272|M.marinum_M WLPLCHDMGMVGFICIPMKTGNTVVVIRTDEFLRRPIVWAEMLSKFRANV
*** ***** *:: :** . :* : . :*: ::* .:: *::..:
MLBr_00243|M.leprae_Br4923 ICGPNFAYSLFTKRLRKQAKPGQFDLSTLRIAMSGAEPVDPADVEDLIDA
MUL_4648|M.ulcerans_Agy99 TAAPNFAYSLFAKRLRKQAKPGQFDLSSLRFALSGAEPVEPSDVEDLCEA
Mb1041|M.bovis_AF2122/97 TAAPNFAYALLAKRLRRQAKPGDFDLSTLRFALSGAEPVEPADVEDLLDA
Rv1013|M.tuberculosis_H37Rv TAAPNFAYALLAKRLRRQAKPGDFDLSTLRFALSGAEPVEPADVEDLLDA
MAV_1150|M.avium_104 TAAPNFAYALLAKRLRRQAKPGDFDLSTLRFALSGAEPVEPADVEDLLDA
MSMEG_5435|M.smegmatis_MC2_155 TAAPNFAYALLAKRLRRQAKPGDFDLSTLRFALSGAEPVEPADVEDFLDA
TH_3958|M.thermoresistible__bu TAAPNFAYALLAKRLRRQAKPGEFDLSTLRFALSGAEPVEPADVEDLIDA
MAB_1140|M.abscessus_ATCC_1997 TAAPNFAYSLFAKRLRNQAKPGDFDLSTLRFVLSGAEPVDPAVVEDLCDA
Mflv_5217|M.gilvum_PYR-GCK TAAPNFAYNLLARRLRRQATPGEFDLSSLRWALSGAEQVDPDDVEDLCAA
Mvan_1051|M.vanbaalenii_PYR-1 TAAPNFAYNLLARRLRRQADPGEFDLSSLRWALSGAEQVDPLDVEDLCDA
MMAR_3272|M.marinum_M TAGPNFAYSVLARVLER-ADPESINLSALRVAVNGAEPIDHRDLENLATV
..***** :::: *.. * * .::**:** .:.*** :: :*:: .
MLBr_00243|M.leprae_Br4923 GRPFGFRPEAILPAYGMAETTLAVSFSPVGEG-LLVDEVDADLLAALRRA
MUL_4648|M.ulcerans_Agy99 GAPFGLRPQAILPAYGMAEITLAVAFSECGAG-LVVDEVDADLMAALRRA
Mb1041|M.bovis_AF2122/97 GKPFGLRPSAILPAYGMAETTLAVSFSECNAG-LVVDEVDADLLAALRRA
Rv1013|M.tuberculosis_H37Rv GKPFGLRPSAILPAYGMAETTLAVSFSECNAG-LVVDEVDADLLAALRRA
MAV_1150|M.avium_104 GKPFGLKPSAILPAYGMAETTLAVSFSECNAG-LVVDEVDADLLAALRRA
MSMEG_5435|M.smegmatis_MC2_155 GKPFGLRPEAILPAYGMAETTLAVSFSPCGEG-LVVDEVDADLLAALRRA
TH_3958|M.thermoresistible__bu GKPFGLRPEAILPAYGMAETTLAVSFSECGAG-LIVDEVDADLLAALRRA
MAB_1140|M.abscessus_ATCC_1997 GKPFGFKPSAMVPAYGMAETALAVSFSEVEASGLVVDEVDADLLAALRRA
Mflv_5217|M.gilvum_PYR-GCK GAPFGLRPEAVIPAYGMAETTVAVSFSECGGG-MVVDEVDADLLAVLHRA
Mvan_1051|M.vanbaalenii_PYR-1 GAPFGLKPEAIVPAYGMAETTVAVSFSECGGG-MVVDEVDADLLAVLHRA
MMAR_3272|M.marinum_M GARFGMGSGVPTPFYGLAEAALTVSAGAFGAP-AVVDYVSRQRLSEDHFA
* **: . . * **:** :::*: . :** *. : :: : *
MLBr_00243|M.leprae_Br4923 VPATKGNI--RRLVSLGPLLDGLEVRIVDEDGNVLPSRGVGVIELRGESL
MUL_4648|M.ulcerans_Agy99 VPAAKGNT--RRLASLGPLLQGIEARIVDADGNVLPSRGVGVIELRGESV
Mb1041|M.bovis_AF2122/97 VPATKGNT--RRLATLGPLLQDLEARIIDEQGDVMPARGVGVIELRGESL
Rv1013|M.tuberculosis_H37Rv VPATKGNT--RRLATLGPLLQDLEARIIDEQGDVMPARGVGVIELRGESL
MAV_1150|M.avium_104 VPATKGNT--RRLATLGPLLQDLEARIVDENGDVMPPRGVGVIELRGESV
MSMEG_5435|M.smegmatis_MC2_155 VPATKGNT--KRLASLGPLLNDLEARVVDENGEVMPARGVGVIELRGEPV
TH_3958|M.thermoresistible__bu VPASKGNT--RRLASLGPLLPDLEARVVDEDGNILPPRGVGIIELRGEPV
MAB_1140|M.abscessus_ATCC_1997 VPATRGNL--RHLATLGPLLPGIEARVVDEDLNVLPARGVGVIELRGESV
Mflv_5217|M.gilvum_PYR-GCK VPAAKGHT--RRLVALGRPLAGLEMRIVDEDGAALQPRGVGVIEVRGQSV
Mvan_1051|M.vanbaalenii_PYR-1 VPATKGHT--RRLVTLGRPLQGLELRVVDEDGAELPARGVGVIEVRGEPV
MMAR_3272|M.marinum_M EPVAADAQGAQPVVCVGLPIPDMQIRITR-DGQLQDARKVGVIELCSPSI
*.: . : :. :* : .:: *: : .* **:**: . .:
MLBr_00243|M.leprae_Br4923 TPGYITMGGFISAQDEHGWYDTGDLGYQMENGHIVVCGRVKDVIIMAGRN
MUL_4648|M.ulcerans_Agy99 TPGYLTMGGFIPAQDQLGWYDTGDLGYQMENGHVVVCGRVKDVIIMAGRN
Mb1041|M.bovis_AF2122/97 TPGYLTMGGFIPAQDEHGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRN
Rv1013|M.tuberculosis_H37Rv TPGYLTMGGFIPAQDEHGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRN
MAV_1150|M.avium_104 TPGYLTMGGFIPAQDENGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRN
MSMEG_5435|M.smegmatis_MC2_155 TPGYITMGGFVPAQDEYGWYDTGDLGYITEEGNIVVCGRVKDVIIMAGRN
TH_3958|M.thermoresistible__bu TPGYVTMGGFVPAQDEHGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRN
MAB_1140|M.abscessus_ATCC_1997 TPGYVTMGGFLAAQDENGWYNTGDLGYLTEKGHVVVCGRVKDVIIMAGRN
Mflv_5217|M.gilvum_PYR-GCK TRGYTTAAGFIAAQDDRGWYDTGDIGYLTEDGDVVVCGRLKDVIIMAGRN
Mvan_1051|M.vanbaalenii_PYR-1 TKGYTTVAGFIGAQDDRGWYDTGDIGYLTEVGDVVVCGRLKDVIIMAGRN
MMAR_3272|M.marinum_M GKRYVTVDGTIPLVDDAGWFDTGDLGYLDELGRLYVCGRAKDMIVLAGRN
* * * : *: **::***:** * * : **** **:*::****
MLBr_00243|M.leprae_Br4923 VYPTDIERAAGRVDGVRPGCAVAVRLDAGHS----RETFAVAVESNAFED
MUL_4648|M.ulcerans_Agy99 IYPTDIERAAGRVEGVRPGCAVAVRLDAGHS----RETFAVAVESNAFED
Mb1041|M.bovis_AF2122/97 IYPTDIERAAGRVDGVRPGCAVAVRLDAGHS----RESFAVAVESNAFED
Rv1013|M.tuberculosis_H37Rv IYPTDIERAAGRVDGVRPGCAVAVRLDAGHS----RESFAVAVESNAFED
MAV_1150|M.avium_104 IYPTDIERAACRVEGVRPGCAVAVRLDAGHS----RETFAVAVESNAFQD
MSMEG_5435|M.smegmatis_MC2_155 IYPTDIERAAGRVEGVRPGCAVAVRLDAGHS----RETFAVAVESNAWQD
TH_3958|M.thermoresistible__bu IYPTDIERAAQRVEGVRPGGAVAVRLDAGHS----RETFAVAVESNAWQD
MAB_1140|M.abscessus_ATCC_1997 IYPTDIERAAGRVDGVRPGCAVAVRLEAGVDPKNQRETFAVVVESNAFEN
Mflv_5217|M.gilvum_PYR-GCK IFPADIERAASRVEGVRPGCAVAVRLDAGRS----RESFAVAVESKHFDD
Mvan_1051|M.vanbaalenii_PYR-1 IYPTDIERAAGRVDGVRPGCAVAVRLEAGRS----RETFAVAVECKDFGD
MMAR_3272|M.marinum_M LYPHDIERAAASVEGVRKGCVAALRLDTDRE------GFAVLAEVYDRFD
::* ****** *:*** * ..*:**::. . *** .* :
MLBr_00243|M.leprae_Br4923 TAEVRRIEHQVAHEVLKEVDVRPRNVVVLGPGTIPKTPSGKLRRASSVTL
MUL_4648|M.ulcerans_Agy99 PAEVRRIEHQVAHEVVAEVDVRPRNVVVLGPGTIPKTPSGKLRRSNSLTL
Mb1041|M.bovis_AF2122/97 PAEVRRIEHQVAHEVVAEVDVRPRNVVVLGPGTIPKTPSGKLRRANSVTL
Rv1013|M.tuberculosis_H37Rv PAEVRRIEHQVAHEVVAEVDVRPRNVVVLGPGTIPKTPSGKLRRANSVTL
MAV_1150|M.avium_104 PAEVRRIEHQVAREVVAEVDMRPRNVVVLGPGTIPKTPSGKLRRSNSVTL
MSMEG_5435|M.smegmatis_MC2_155 PAEVRRIEHQVAHEVVSEVDVRPRNVVVLGPGSIPKTPSGKLRRANSVSL
TH_3958|M.thermoresistible__bu PEEVRRIEHQVAHEVVAEVDVRPRNVVVLGPGSIPKTSSGKLRRSTSVSL
MAB_1140|M.abscessus_ATCC_1997 PDEVRRIEQQVAHEVVAEVDVRPRNVVVLGPGSIPKTPSGKLRRSTSVAL
Mflv_5217|M.gilvum_PYR-GCK EVEVRRVERQVAHEVFAEVDVRPRNVVVLEPGTIPKTPSGKLRRAHALSL
Mvan_1051|M.vanbaalenii_PYR-1 ETQVRRVERQVAHEVFAEVDVRPRNVVVLAPGTIPKTPSGKLRRAHALSL
MMAR_3272|M.marinum_M ESELTQLRRAIAARVSSHVGHAPREVRLLAPGSLPKTTSGKLRREGARAL
:: ::.: :* .* .*. **:* :* **::***.****** : :*
MLBr_00243|M.leprae_Br4923 VT-
MUL_4648|M.ulcerans_Agy99 VT-
Mb1041|M.bovis_AF2122/97 VT-
Rv1013|M.tuberculosis_H37Rv VT-
MAV_1150|M.avium_104 VT-
MSMEG_5435|M.smegmatis_MC2_155 VTQ
TH_3958|M.thermoresistible__bu VT-
MAB_1140|M.abscessus_ATCC_1997 VI-
Mflv_5217|M.gilvum_PYR-GCK VS-
Mvan_1051|M.vanbaalenii_PYR-1 VS-
MMAR_3272|M.marinum_M M--
: