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MTAMTATPLAAAAIAQLEAEGVDTVIGTVINPAGLALAKTVPVRRTNTFAYPGLGASPTWHGFAVDQSGI AFSDEVGVIGDQRLRIDLSALRAIGDGLAWAPAAFFEQDGAPVAACTRGTLARIEAALEEAGIEAMVGHE IEFLVVNPDGTQRPSTMWAQYGLAGVLEYEHFVRDVNASATAAGVGIEQFHPEYYANQFEISLTPHSPVT AADQLVLARIIIGRAARRHGLRVSLSPTPFADNVGCGAHQHFSLSTAEGPMFSEGPGAAGMTTAGEGAVA GVLRGLREAQGILCGSIVSGLRMRPGNWAGAYACWGTENREAAVRFVKHVPGAAYGGNVEVKIVDPSANP YLASAAILGLALDGIQRKVSLPQETVVDPAKLSDTDRDRAGILRLPDDPREVITALDNSETMRRVLGDAS IDAVVAVRKLMQERYTDLNPEQLANKFRMAWSL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2763 | glnA3 | - | 100% (453) | glutamine synthetase GlnA3 |
| M. marinum M | MMAR_3294 | glnA2 | 2e-28 | 27.99% (318) | glutamine synthetase GlnA2 |
| M. marinum M | MMAR_3289 | glnA1 | 9e-16 | 27.92% (240) | glutamine synthetase GlnA1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1910 | glnA3 | 0.0 | 76.00% (450) | glutamine synthetase |
| M. gilvum PYR-GCK | Mflv_3319 | - | 1e-168 | 63.58% (453) | glutamine synthetase, catalytic region |
| M. tuberculosis H37Rv | Rv1878 | glnA3 | 0.0 | 76.22% (450) | glutamine synthetase |
| M. leprae Br4923 | MLBr_01631 | glnA2 | 7e-25 | 26.56% (320) | glutamine synthase class II |
| M. abscessus ATCC 19977 | MAB_1920 | - | 3e-28 | 27.06% (340) | glutamine synthetase |
| M. avium 104 | MAV_2829 | glnA | 0.0 | 75.78% (450) | glutamine synthetase catalytic domain |
| M. smegmatis MC2 155 | MSMEG_3561 | glnA | 1e-164 | 62.25% (453) | glutamine synthetase catalytic domain |
| M. thermoresistible (build 8) | TH_3396 | - | 1e-28 | 27.19% (342) | PUTATIVE glutamine synthetase, type I |
| M. ulcerans Agy99 | MUL_1335 | glnA2 | 5e-29 | 28.30% (318) | glutamine synthetase GlnA2 |
| M. vanbaalenii PYR-1 | Mvan_2920 | - | 1e-107 | 45.56% (439) | glutamine synthetase, catalytic region |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3319|M.gilvum_PYR-GCK MAGMAAKPLAAAAIAQLEADGVATLIGTVVNPAGLIHAKTVPLRRMGSFA
MSMEG_3561|M.smegmatis_MC2_155 MTSRSGKPLAAAAIAQLESDGVATLIGTVANPAGLIHAKTVPLRRMSTFA
Mb1910|M.bovis_AF2122/97 ---MTATPLAAAAIAQLEAEGVDTVIGTVVNPAGLTQAKTVPIRRTNTFA
Rv1878|M.tuberculosis_H37Rv ---MTATPLAAAAIAQLEAEGVDTVIGTVVNPAGLTQAKTVPIRRTNTFA
MAV_2829|M.avium_104 ---MTGTPLAAAAIAQLEAEGVDTVIGTVVNPAGLTLAKTVPIRRTNTFA
MMAR_2763|M.marinum_M MTAMTATPLAAAAIAQLEAEGVDTVIGTVINPAGLALAKTVPVRRTNTFA
Mvan_2920|M.vanbaalenii_PYR-1 ----MEHPDPGVDVGHLRAEGVAIIAGSVTDLAGVTRAKYVPVARLGAFA
MLBr_01631|M.leprae_Br4923 -----MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKSVAIAPAELEGAF
MUL_1335|M.ulcerans_Agy99 -----MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGAF
TH_3396|M.thermoresistible__bu -----MDRQKEFVLRSLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGAF
MAB_1920|M.abscessus_ATCC_1997 -----MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKSVSIAPAELEGAF
: *. .: : . : * : :. .
Mflv_3319|M.gilvum_PYR-GCK EPGLGASPVWHVFAIDQTGIVFGESTGVVGDQRIRIDLGALRILGDGFAW
MSMEG_3561|M.smegmatis_MC2_155 EPGLGASPVFHAFTIDQVGIVFSDAISVVGDQRIRIDLSTLRILGDGLAW
Mb1910|M.bovis_AF2122/97 NPGLGASPVWHTFCIDQCSIAFTADISVVGDQRLRIDLSALRIIGDGLAW
Rv1878|M.tuberculosis_H37Rv NPGLGASPVWHTFCIDQCSIAFTADISVVGDQRLRIDLSALRIIGDGLAW
MAV_2829|M.avium_104 DPGLGASPSWHAFAVDQTGIAFTAEVGVVGDQRLRIDLSALRIVGDGLAW
MMAR_2763|M.marinum_M YPGLGASPTWHGFAVDQSGIAFSDEVGVIGDQRLRIDLSALRAIGDGLAW
Mvan_2920|M.vanbaalenii_PYR-1 RSGMGVSPSWSVFCVDS-GIAFTPTIGVAGDLRIRIDPEDLRVVDAGVAW
MLBr_01631|M.leprae_Br4923 EEGIGFD---GSSIEGFARVSESDTVAHPDPSTFQILPWATTAGHHHSAR
MUL_1335|M.ulcerans_Agy99 EEGIGFD---GSSIEGFARVSESDTVAHPDPSTFQVLPWVTDAGHHHSAR
TH_3396|M.thermoresistible__bu EEGIGFD---GSAIEGFARVSEADMVARPDPSTFQVLPWTGDSGKHYSAR
MAB_1920|M.abscessus_ATCC_1997 EEGIGFD---GSSIEGFARVSESDTVAHPDPSTFQVLPWTTSAGKHHSAR
*:* . . : . . ::: *
Mflv_3319|M.gilvum_PYR-GCK APGSFYTQDGAPDPYCARGALRRVSQRLADAGISALVGHEIEFVLVGP--
MSMEG_3561|M.smegmatis_MC2_155 APGAFFDQDGAPDPYCSRYALQRVADRLETAGLTAQVGHEMEFVLVGP--
Mb1910|M.bovis_AF2122/97 APAGFFEQDGTPVPACSRGTLSRIEAALADAGIDAVIGHEVEFLLVDA--
Rv1878|M.tuberculosis_H37Rv APAGFFEQDGTPVPACSRGTLSRIEAALADAGIDAVIGHEVEFLLVDA--
MAV_2829|M.avium_104 APAAFFAQDGTPIPSCARGTLKRVEAALADAGIDAAIGHEVEFVLVAP--
MMAR_2763|M.marinum_M APAAFFEQDGAPVAACTRGTLARIEAALEEAGIEAMVGHEIEFLVVNP--
Mvan_2920|M.vanbaalenii_PYR-1 APGTLNDQHGHPAPLCTRTLLSRVERAAADRGLDVRMGGELECTMLSA--
MLBr_01631|M.leprae_Br4923 MFCDITMPDGSSSWADPRHVLRRQLTKANDLGFSCYVHPEIEFFLLKAGP
MUL_1335|M.ulcerans_Agy99 IFCDITMPDGSPSWADPRHVLRRQLIKANELGFSCYVHPEIEFFLLNPGP
TH_3396|M.thermoresistible__bu MFCDITMPDGSPSWADPRHVLRRQLAKAGDQGFTCYVHPEIEFFLLKPGP
MAB_1920|M.abscessus_ATCC_1997 MFCDIKLPDGSPSWSDPRHVLRRQLAKASDLGFSCYVHPEIEFFLLKNLP
: .* . .* * * *: : *:* ::
Mflv_3319|M.gilvum_PYR-GCK -DG---ARLPAHLWAQYGLAGVLEHEGFVRDVTAAANASGVAIEQFHPEY
MSMEG_3561|M.smegmatis_MC2_155 -DG---SRLPSLMWAQYGLAGLLEFEGFVREVTDSANASGVAIEQFHPEY
Mb1910|M.bovis_AF2122/97 -DG---QRLPSTLWAQYGVAGVLEHEAFVRDVNAAATAAGIAIEQFHPEY
Rv1878|M.tuberculosis_H37Rv -DG---QRLPSTLWAQYGVAGVLEHEAFVRDVNAAATAAGIAIEQFHPEY
MAV_2829|M.avium_104 -DG---QRLPSTLWAQYGLAGVLEHEAFVRDVIGSATRAGIAIEQLHPEY
MMAR_2763|M.marinum_M -DG---TQRPSTMWAQYGLAGVLEYEHFVRDVNASATAAGVGIEQFHPEY
Mvan_2920|M.vanbaalenii_PYR-1 -DG---GPATTEPWSPYGIRTSLDRSAFLVDLATSAERAGLPLEQLHTEY
MLBr_01631|M.leprae_Br4923 EDGSMPIPVPVDNAGYFDQAVHDSALNFRRHAIEALEFMGISVEFSHHEG
MUL_1335|M.ulcerans_Agy99 EDG--TEPVPIDNAGYFDQAVHVSASKFRRHVIDALEFMGISVEFSHHEG
TH_3396|M.thermoresistible__bu HDG--SPPVPADTSGYFDQSVHDTAPNFRRHAIEALEQMGISVEFSHHEG
MAB_1920|M.abscessus_ATCC_1997 DDG--TAPIPADDAGYFDQAVHEAAPNFRRHAIDALESMGISVEFSHHEG
** . . :. * . : *: :* * *
Mflv_3319|M.gilvum_PYR-GCK GANQFEISLAPQPPVAAADHVTLMRIIVGRVARTYGMRASLSPVPFAGSV
MSMEG_3561|M.smegmatis_MC2_155 GANQFEISLAPLPPVAAADQLILMRIIVARVARRHGLRASLSPPPFAGGV
Mb1910|M.bovis_AF2122/97 GANQFEISLAPQPPVAAADQLVLTRLIIGRTARRHGLRVSLSPAPFAGSI
Rv1878|M.tuberculosis_H37Rv GANQFEISLAPQPPVAAADQLVLTRLIIGRTARRHGLRVSLSPAPFAGSI
MAV_2829|M.avium_104 GANQFELSLAPQPPVAAADQLILMRLIIGRAARRHGFRISLSPAPFAGDV
MMAR_2763|M.marinum_M YANQFEISLTPHSPVTAADQLVLARIIIGRAARRHGLRVSLSPTPFADNV
Mvan_2920|M.vanbaalenii_PYR-1 GHDQLEVSLAPDTPTAAADAVILARIVLGRVAARHGLRISFSPVPFEGAA
MLBr_01631|M.leprae_Br4923 APGQQEIDLRFADALSMADNVMTFRYVIKEVAIENGARASFMPKPFAQHP
MUL_1335|M.ulcerans_Agy99 APGQQEIDLRFADALSMADNVMTFRYVIKEVALEEGVRATFMPKPFGQHA
TH_3396|M.thermoresistible__bu APGQQEIDLRYADALSMADNVMTFRYVVKQVAISDGVRASFMPKPFAEHP
MAB_1920|M.abscessus_ATCC_1997 APGQQEIDLRYADALSMADNVMTFRNVVKEVAIIDGVHATFMPKPFSDHP
.* *:.* . : ** : * :: ..* * : :: * **
Mflv_3319|M.gilvum_PYR-GCK GSGAHQHFSLTRDDVPLFSGGDGPVGMTADGASAVAGVLNGLTEAQGVLS
MSMEG_3561|M.smegmatis_MC2_155 GSGSHQHFSLCRDDTPLLSGGNGARGMTEEGESAVAGLLAGLPAAQGVLC
Mb1910|M.bovis_AF2122/97 GSGAHQHFSLTMSEGMLFSGGTGAAGMTSAGEATVAGVLRGLPDAQGILC
Rv1878|M.tuberculosis_H37Rv GSGAHQHFSLTMSEGMLFSGGTGAAGMTSAGEAAVAGVLRGLPDAQGILC
MAV_2829|M.avium_104 GSGAHQHFSLSMAEGPLFSGGAGTAGMTPAGENAVAGVIRGLPEAQGVLC
MMAR_2763|M.marinum_M GCGAHQHFSLSTAEGPMFSEGPGAAGMTTAGEGAVAGVLRGLREAQGILC
Mvan_2920|M.vanbaalenii_PYR-1 GNGAHLHLSLSDADGPLLSGGDGPHGLRTAGAQAIAGVLDTLPDLIGVYA
MLBr_01631|M.leprae_Br4923 GSAMHTHMSLFEGDVNAFHSDDDPLQLSDVGKSFIAGILEHASEISAVTN
MUL_1335|M.ulcerans_Agy99 GSAMHTHMSLFEGDVNAFHSPDDPLQLSEVGKSFIAGILEHASEISAVTN
TH_3396|M.thermoresistible__bu GSAMHTHMSLFEGDTNAFHSPDDPLQLSDVAKSFIAGILEHANEISAVTN
MAB_1920|M.abscessus_ATCC_1997 GSAMHTHMSLFEGDTNAFHNPDDPLQLSDVGKSFIAGILEHANEISAVTN
* . * *:** : : .. : . :**:: .:
Mflv_3319|M.gilvum_PYR-GCK GSVVSGLRMAPGHWSGAYACWGTENREAAVRYLTRGDANPYGAHVEVKII
MSMEG_3561|M.smegmatis_MC2_155 GSVLSGLRVQPGHWAGAHNCWGTENREAAVRFIIGGPSNPHGANVEVKVI
Mb1910|M.bovis_AF2122/97 GSIVSGLRMRPGNWAGIYACWGTENREAAVRFVKGGAGSAYGGNVEVKVV
Rv1878|M.tuberculosis_H37Rv GSIVSGLRMRPGNWAGIYACWGTENREAAVRFVKGGAGSAYGGNVEVKVV
MAV_2829|M.avium_104 GSIVSGLRMRPGNWAGAYACWGTENREAAVRFIVDGPGSPRGGNVEVKIV
MMAR_2763|M.marinum_M GSIVSGLRMRPGNWAGAYACWGTENREAAVRFVKHVPGAAYGGNVEVKIV
Mvan_2920|M.vanbaalenii_PYR-1 GSAASALRLKPGNWAGATACWGLENREAAVRLIAATPGNPHGANMELKLI
MLBr_01631|M.leprae_Br4923 QWVNSYKRLVVGGEAPTTASWGAANRSALVRVPMYTPHKTSSRRVEVRSP
MUL_1335|M.ulcerans_Agy99 QWVNSYKRLILGGEAPTAASWGAANRSALVRVPMYTPHKTSSRRIEVRSP
TH_3396|M.thermoresistible__bu QWVNSYKRLVHGGEAPTAASWGAANRSALVRVPMYTPHKASSRRVEVRSP
MAB_1920|M.abscessus_ATCC_1997 QWVNSYKRLVQGGEAPTAASWGAANRSALVRVPMYTPNKSSSRRIEVRSP
* *: * : .** **.* ** . . .:*::
Mflv_3319|M.gilvum_PYR-GCK DPSANPYLASATILGLALDGMTRGLGLPAEVAVDPSSLSQTARAEVGVTV
MSMEG_3561|M.smegmatis_MC2_155 DPSANPYLATATILGLALHGIDNRLPLPREVSVDPSALTDAQRTESGAEL
Mb1910|M.bovis_AF2122/97 DPSANPYLASAAILGLALDGMKTKAVLPSETTVDPTQLSDVDRDRAGILR
Rv1878|M.tuberculosis_H37Rv DPSANPYLASAAILGLALDGMKTKAVLPSETTVDPTQLSDVDRDRAGILR
MAV_2829|M.avium_104 DPSANPYLASAAILGLALDGIKSQAALPPEVTVDPAALSDADRDRDGVVL
MMAR_2763|M.marinum_M DPSANPYLASAAILGLALDGIQRKVSLPQETVVDPAKLSDTDRDRAGILR
Mvan_2920|M.vanbaalenii_PYR-1 DASANPYLAAAAFLGSALRGIGRHLELPEEIPENP------AQSGVDTPA
MLBr_01631|M.leprae_Br4923 DSACNPYLAFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERLAMGYRE
MUL_1335|M.ulcerans_Agy99 DSACNPYLAFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERRTMGYRE
TH_3396|M.thermoresistible__bu DSACNPYLTFAVLLAAGLRGVEKGYVLGPEAEDNVWTLTPEERRAMGFKE
MAB_1920|M.abscessus_ATCC_1997 DSACNPYLTYAVLLAAGLRGVEQGYTLGPEAEDDVWGLTRAERQAMGYKE
*.:.****: *.:*. .* *: * : : : .
Mflv_3319|M.gilvum_PYR-GCK LPTDQTAILDALGASATMRDILGDAVVDAVIAVRRYEQEHYG-GLDPDAV
MSMEG_3561|M.smegmatis_MC2_155 LPCGQAETLPALDASPLIRGILGDEIVDAVLAVRRYEQKNFG-ELPPEEL
Mb1910|M.bovis_AF2122/97 LAADQADAIAVLDSSKLLRCILGDPVVDAVVAVRQLEHERYG-DLDPAQL
Rv1878|M.tuberculosis_H37Rv LAADQADAIAVLDSSKLLRCILGDPVVDAVVAVRQLEHERYG-DLDPAQL
MAV_2829|M.avium_104 LTDSAAEAIAALDDSELMRHILGDPVVDMVVAVRRLEQERYG-DLDPAQL
MMAR_2763|M.marinum_M LPDDPREVITALDNSETMRRVLGDASIDAVVAVRKLMQERYT-DLNPEQL
Mvan_2920|M.vanbaalenii_PYR-1 LPLGQREALDAMETSDVAAELLTPAIVEALVAVRRYESKTFG-GLPPAQI
MLBr_01631|M.leprae_Br4923 LPTSLDSALGAMEVSEFVAEALGEHVFDFFLRNKRAEWANYRSHVSLYEL
MUL_1335|M.ulcerans_Agy99 LPTSLDSALRAMESSELVAEALGEHVFDFFLRNKRREWATYRSHVTPYEL
TH_3396|M.thermoresistible__bu LPSSLGQALAEMERSELVAEALGEHVFDFFLRNKRAEWENYRSHVTPYEL
MAB_1920|M.abscessus_ATCC_1997 LPSTLENALIAMEGSELVAEALGEHVFDFFLRNKRAEWARYRSNVTPFEL
*. : : * * .: .: :: : : :
Mflv_3319|M.gilvum_PYR-GCK TEKFRLAWSV
MSMEG_3561|M.smegmatis_MC2_155 ADRFRLAWSV
Mb1910|M.bovis_AF2122/97 ADKFRMAWSV
Rv1878|M.tuberculosis_H37Rv ADKFRMAWSV
MAV_2829|M.avium_104 ADRFRMAWSL
MMAR_2763|M.marinum_M ANKFRMAWSL
Mvan_2920|M.vanbaalenii_PYR-1 CDALRLAWTC
MLBr_01631|M.leprae_Br4923 KTYLSL----
MUL_1335|M.ulcerans_Agy99 STYLSL----
TH_3396|M.thermoresistible__bu KNYLSL----
MAB_1920|M.abscessus_ATCC_1997 RAYLGL----
: :