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MAETPESTTKPATVTSQPRYDRSGRLSQVLAWVGIIAGAVFIAAVIFFSATFLGWYSGGHYSWHRGGAAG QLSPRSSQQSAPSQTLRLKVELPFIGLYVHTGGVAVDTAGNVYVASGGNDRVLKLPAGSSTQVELPFTGL KSPMGVAVDTVGNVYVTDSFHNRVLKLPAGSSTQVELPFTGLHRPGGVAVDAAGNVYVTDFVDNRMLKLP AGSSTQVELPFTGLHFPMGVAVDSAGNVYVTNDDNNRVLKLPAGSTTQVELPFTGLHHPVAVAVDTAGNV YAADHDNNRVLKLPAGSSTQVELPFTGLTGPMGVAVDSAGNVYVTNHDNDEVLELPAPYAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2539 | - | - | 100% (341) | hypothetical protein MMAR_2539 |
| M. marinum M | MMAR_4577 | pknD | 6e-75 | 59.52% (252) | transmembrane serine/threonine-protein kinase D PknD |
| M. marinum M | MMAR_3398 | - | 4e-67 | 53.69% (244) | transmembrane serine/threonine-protein kinase D |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0954c | pknDb | 9e-70 | 55.06% (267) | serine/threonine protein kinase D |
| M. gilvum PYR-GCK | Mflv_1786 | - | 7e-09 | 29.31% (174) | SMP-30/gluconolaconase/LRE domain-containing protein |
| M. tuberculosis H37Rv | Rv0931c | pknD | 9e-70 | 55.06% (267) | transmembrane serine/threonine-protein kinase D PKND |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. avium 104 | MAV_4238 | - | 4e-68 | 48.36% (304) | serine/threonine-protein kinase PknD |
| M. smegmatis MC2 155 | MSMEG_6254 | - | 2e-06 | 46.03% (63) | hypothetical protein MSMEG_6254 |
| M. thermoresistible (build 8) | TH_3578 | - | 2e-07 | 43.48% (69) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4817 | - | 8e-10 | 31.91% (188) | hypothetical protein MUL_4817 |
| M. vanbaalenii PYR-1 | Mvan_5408 | - | 5e-13 | 46.07% (89) | hypothetical protein Mvan_5408 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6254|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5408|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3578|M.thermoresistible__bu --------------------------------------------------
Mflv_1786|M.gilvum_PYR-GCK --------------------------------------------------
MUL_4817|M.ulcerans_Agy99 --------------------------------------------------
Mb0954c|M.bovis_AF2122/97 --------------------------------------------------
Rv0931c|M.tuberculosis_H37Rv MSD--AVPQVGSQFGPYQLLRLLGRGGMGEVYEAEDTRKHRVVALKLISP
MAV_4238|M.avium_104 MSDNGPAAQVGSWFGPYRLVRLLRQGGMGEVYEAEDTRKHRLVALKLISQ
MMAR_2539|M.marinum_M --------------------------------------------------
MSMEG_6254|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5408|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3578|M.thermoresistible__bu --------------------------------------------------
Mflv_1786|M.gilvum_PYR-GCK --------------------------------------------------
MUL_4817|M.ulcerans_Agy99 --------------------------------------------------
Mb0954c|M.bovis_AF2122/97 --------------------------------------------------
Rv0931c|M.tuberculosis_H37Rv QYSDNAVFRARMQREADTAGRLTEPHIVPIHDYGEINGQFFVEMRMIDGT
MAV_4238|M.avium_104 QFSGNPEFSARLQREADIAGRLTEPHVVPIHDYGEIDGRFFVEMRLVDGI
MMAR_2539|M.marinum_M --------------------------------------------------
MSMEG_6254|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5408|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3578|M.thermoresistible__bu --------------------------------------------------
Mflv_1786|M.gilvum_PYR-GCK --------------------------------------------------
MUL_4817|M.ulcerans_Agy99 --------------------------------------------------
Mb0954c|M.bovis_AF2122/97 --------------------------------------------------
Rv0931c|M.tuberculosis_H37Rv SLRALLKQYGPLTPARAVAIVRQIAAALDAAHANGVTHRDVKPENILVTA
MAV_4238|M.avium_104 DLGSLLHREGPLAPPRAIAIIRQVAAALDAAHAAGVTHRDVTPGNILVTP
MMAR_2539|M.marinum_M --------------------------------------------------
MSMEG_6254|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5408|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3578|M.thermoresistible__bu --------------------------------------------------
Mflv_1786|M.gilvum_PYR-GCK ----------------------------MNARYAAQN-----PTAAEGWT
MUL_4817|M.ulcerans_Agy99 -------------------MVRAVIPVTRRLQHAGHYPVTRAPNVAEGWT
Mb0954c|M.bovis_AF2122/97 --------------------------------------------------
Rv0931c|M.tuberculosis_H37Rv SDFAYLVDFGIARAASDPGLTQTGTAVGTYNYMAPERFTGDEVTYRADIY
MAV_4238|M.avium_104 SDFAYLADFGIARAASDPGLTQVGTAIGTYYYMAPERFTDDEVTNSVDIY
MMAR_2539|M.marinum_M --------------------------------------------------
MSMEG_6254|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5408|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3578|M.thermoresistible__bu --------------------------------------------------
Mflv_1786|M.gilvum_PYR-GCK LRSVTAPSPLFGANGLRTGPDGRIYIAQVTGSQISALDPATGALETVSAK
MUL_4817|M.ulcerans_Agy99 LTRLTAPSRLFGANGLRTGPDGRVYIAQVTGSQISALDLSTGRLDTVCPK
Mb0954c|M.bovis_AF2122/97 --------------------------------------------------
Rv0931c|M.tuberculosis_H37Rv ALACVLGECLTGAPPYRADSVERLIAAHLMDPAPQPSQLRPGRVPPALDQ
MAV_4238|M.avium_104 SLACVLTECLTGVPPYRADTVERLVAAHLTKTAPPLSQLRPGGFPPALDR
MMAR_2539|M.marinum_M --------------------------------------------------
MSMEG_6254|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5408|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3578|M.thermoresistible__bu --------------------------------------------------
Mflv_1786|M.gilvum_PYR-GCK GGDIIAPDDVAFADDGTLFATEVMDGRVSAREPSGRTRVLRDDLPCANGI
MUL_4817|M.ulcerans_Agy99 GGAIIAPDDLAFDQDGNLYATEVMDGRVSVRAPDGHTRVLRDDIPSANGI
Mb0954c|M.bovis_AF2122/97 -----------------------------------------------MLA
Rv0931c|M.tuberculosis_H37Rv VIAKGMAKNPAERFMSAGDLAIAAHDALTTSEQHQATTILRRGDNATLLA
MAV_4238|M.avium_104 VIAKGMAKRPEDRYRTAGEFAAAAHEALTTSEQRKAATILRDGQIAALGA
MMAR_2539|M.marinum_M -----------------------------------------------MAE
MSMEG_6254|M.smegmatis_MC2_155 -------------------------------------------MSETPS-
Mvan_5408|M.vanbaalenii_PYR-1 -------------------------------------------MTETP--
TH_3578|M.thermoresistible__bu -------------------------------------------MTDAPE-
Mflv_1786|M.gilvum_PYR-GCK TVDRGRLFVGECRDGGRLMELPLDGGEPRILLENLPSPN---AMEVGPDG
MUL_4817|M.ulcerans_Agy99 TFHQGRLFVGECRDGGRLLELDLNGGAPRVLARNLPSPN---AMEVGPDG
Mb0954c|M.bovis_AF2122/97 TPADTGLSQSESGIAGAGTGPPTPGAARWSPGDSATVAGPLAADSRGGNW
Rv0931c|M.tuberculosis_H37Rv TPADTGLSQSESGIAGAGTGPPTPGAARWSPGDSATVAGPLAADSRGGNW
MAV_4238|M.avium_104 GAAEQRSTHWPDSFA------PSP-SAETVVGPSPARAG---APSSGLIR
MMAR_2539|M.marinum_M TPESTTKP------------------ATVTSQPRYDRSG---RLSQVLAW
MSMEG_6254|M.smegmatis_MC2_155 ----------------DHPTTPVGTPAETPTATSGPVAPPPVAPPPAAVP
Mvan_5408|M.vanbaalenii_PYR-1 ----------------ESRTEPTAVATEQ---GRGELSP-----------
TH_3578|M.thermoresistible__bu ----------------PRPTEPQAPPAQP---AAAPPAVS----------
Mflv_1786|M.gilvum_PYR-GCK LLYYPLMTANEIWRIDPSGGEPQRVAADLGVPDAVKFDTDGFIVSTQVAS
MUL_4817|M.ulcerans_Agy99 LLYFPVMGANEIWRIDPDGGVPQCVAGDLRVPDAVKFDPHGHLVSTQVHS
Mb0954c|M.bovis_AF2122/97 PSQTGHSPAVPNALQASLGHAVPPAGNKRKVWAVVGAAAIVLVA--IVAA
Rv0931c|M.tuberculosis_H37Rv PSQTGHSPAVPNALQASLGHAVPPAGNKRKVWAVVGAAAIVLVA--IVAA
MAV_4238|M.avium_104 AAPTGSGRVY--APGPDFGRPVAPTDNKRKQWIIVGAVALVALVAFVVAV
MMAR_2539|M.marinum_M VGIIAGAVFIAAVIFFSATFLGWYSGG-HYSWHRGGAAGQLSPR------
MSMEG_6254|M.smegmatis_MC2_155 VAPAEAPRRHSRVVQAAAWVGIVAGVVFIVAVVFGTGFVLGKNSG--PGH
Mvan_5408|M.vanbaalenii_PYR-1 -----GSDRPNRLTQSAAWVGIVAGVVFIVAVIFFSGFFVGKQYG--GGY
TH_3578|M.thermoresistible__bu -----NAPRSSRLPQVAAWIAIVAGVLVIMAVIFFAGFFLGRVSDGFGGH
Mflv_1786|M.gilvum_PYR-GCK GQVLRIDPRTGEKTVLAQLNPGLDNLTFVGDRLFASNFTGEITEIGRDGQ
MUL_4817|M.ulcerans_Agy99 GEVLRINPRTGDRTVLAALHPGLDNLTFVGERLFVSSFTGEITEILGTGE
Mb0954c|M.bovis_AF2122/97 AGYLVLRPSWSPTQASGQTVLPFTGIDFRLSPSGVAVDSAGNVYVTSEGM
Rv0931c|M.tuberculosis_H37Rv AGYLVLRPSWSPTQASGQTVLPFTGIDFRLSPSGVAVDSAGNVYVTSEGM
MAV_4238|M.avium_104 VGYLSTASSGPAKQAGGQSVLPFNGIDFRLSPGGVTLDGAGNVYVTSEGM
MMAR_2539|M.marinum_M ----SSQQSAPSQTLRLKVELPFIGLYVHTG--GVAVDTAGNVYVASGGN
. .: . : *
MSMEG_6254|M.smegmatis_MC2_155 HH----RGHDRPEIMMFH-------------------RG--GPPPMM-PG
Mvan_5408|M.vanbaalenii_PYR-1 RDG---RGMSYPGGMMGP-------------------GGMMGPGGMMGPG
TH_3578|M.thermoresistible__bu HH-----RMHWHDRMP--------------------------SRYFDHPG
Mflv_1786|M.gilvum_PYR-GCK TSALLPGGLNWPLDLTVS-DGRLYVADGTYFYRVGPDGALETVGMLFSPG
MUL_4817|M.ulcerans_Agy99 TRTTLPGGLTWPLGLAVAADGDLYIADGTYFYVLLADGTLRVGGMLFSAG
Mb0954c|M.bovis_AF2122/97 YGRVVKLATGSTGTTVLP------------------FNGLYQPQGLAVDG
Rv0931c|M.tuberculosis_H37Rv YGRVVKLATGSTGTTVLP------------------FNGLYQPQGLAVDG
MAV_4238|M.avium_104 YGRVVKLAAGSGATTVLP------------------FNGLYQPQGLAVDG
MMAR_2539|M.marinum_M D-RVLKLPAGSSTQVELP------------------FTGLKSPMGVAVDT
.
MSMEG_6254|M.smegmatis_MC2_155 ---------------------------MGPG----HMRPG--GGMFGPG-
Mvan_5408|M.vanbaalenii_PYR-1 GM-------------------------MGPGGPGGMMGPGGPGGMMGPGS
TH_3578|M.thermoresistible__bu -----------------------------PGPR------------FSPS-
Mflv_1786|M.gilvum_PYR-GCK YPGFLRGVVAVGGDEFVVTTSGGQVARYRPGAGETDFLATDFDQLYGVDV
MUL_4817|M.ulcerans_Agy99 YPGFLRGVAALGSGEFAVTTSNGEVARYRPWASETEVLATGLDQLYGVAV
Mb0954c|M.bovis_AF2122/97 AGTVYVTD-----------FNNRVVTLAAGSNNQTVLPFDGLNYPEGLAV
Rv0931c|M.tuberculosis_H37Rv AGTVYVTD-----------FNNRVVTLAAGSNNQTVLPFDGLNYPEGLAV
MAV_4238|M.avium_104 AGTVYVAD-----------FNNRVLSMAAGSNSQKELPFSGLNYPEGVAV
MMAR_2539|M.marinum_M VGNVYVTDS----------FHNRVLKLPAGSSTQVELPFTGLHRPGGVAV
.
MSMEG_6254|M.smegmatis_MC2_155 ---G--APAERGEFR-GPQAPD---RSETPTTAPARP-------------
Mvan_5408|M.vanbaalenii_PYR-1 WGPG--GMMGPGSWGPGMMGPG---QQPSPTTTPAVPTTPQR--------
TH_3578|M.thermoresistible__bu ---------APGTRPAPPTEP----AAPSPTATP-RP-------------
Mflv_1786|M.gilvum_PYR-GCK AGDGSIVFAELGTGRVLRLDDG---RVETLASGLRQPVGVAIDADGAPLV
MUL_4817|M.ulcerans_Agy99 AGSGALFVAERGAGRVLSVRPD---GVEVMASGLSDPVGVAVTADGRCVV
Mb0954c|M.bovis_AF2122/97 DTQGAVYVADRGNNRVVKLAAGSKTQTVLPFTGLNDPDGVAVDNSGNVYV
Rv0931c|M.tuberculosis_H37Rv DTQGAVYVADRGNNRVVKLAAGSKTQTVLPFTGLNDPDGVAVDNSGNVYV
MAV_4238|M.avium_104 DSQGGVYVADRGNSRVLKLAAGSQNQTVLPFTGLNNPDGVAVDPAGNVYV
MMAR_2539|M.marinum_M DAAGNVYVTDFVDNRMLKLPAGSSTQVELPFTGLHFPMGVAVDSAGNVYV
: *
MSMEG_6254|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5408|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3578|M.thermoresistible__bu --------------------------------------------------
Mflv_1786|M.gilvum_PYR-GCK SESGAGRVVRVSSGAVDTVIDGLQRPQGLHVRDNRLYIVDAGAKELVEFD
MUL_4817|M.ulcerans_Agy99 TEADAGRVR--TLGDTGTLLDGLQCPQGVAICDRQVYVIDSGAKQLVAVD
Mb0954c|M.bovis_AF2122/97 TDTDNNRVVKLEAESN-----------------NQVVLPFTDITAPWGIA
Rv0931c|M.tuberculosis_H37Rv TDTDNNRVVKLEAESN-----------------NQVVLPFTDITAPWGIA
MAV_4238|M.avium_104 ADTDNNRVVKLDAASN-----------------TQSELPFHDLSVPWGIA
MMAR_2539|M.marinum_M TNDDNNRVLKLPAGST-----------------TQVELPFTGLHHPVAVA
MSMEG_6254|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5408|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3578|M.thermoresistible__bu --------------------------------------------------
Mflv_1786|M.gilvum_PYR-GCK LGTKARSTIATGLPVGPPPGVEPKPLKGMPPFSGPQGPFAGITSGPDGTL
MUL_4817|M.ulcerans_Agy99 LGSRTRHTIAWDLPVGAPAGVTPNPLRGMPPFSGPEGPFAAITPGPDATL
Mb0954c|M.bovis_AF2122/97 VDEAGTVYVTEHNTNQVVKLLAGSTTSTVLPFTGLNTPLAVAVDSDRTVY
Rv0931c|M.tuberculosis_H37Rv VDEAGTVYVTEHNTNQVVKLLAGSTTSTVLPFTGLNTPLAVAVDSDRTVY
MAV_4238|M.avium_104 VDNGGTVYVTEHDKNDVVKYPPGATSGTVLPFTALNTPLAVAVDRDQSVY
MMAR_2539|M.marinum_M VDTAGNVYAADHDNNRVLKLPAGSSTQVELPFTGLTGPMGVAVDSAGNVY
MSMEG_6254|M.smegmatis_MC2_155 ------------------
Mvan_5408|M.vanbaalenii_PYR-1 ------------------
TH_3578|M.thermoresistible__bu ------------------
Mflv_1786|M.gilvum_PYR-GCK FVSADGDGSVLAVSRG--
MUL_4817|M.ulcerans_Agy99 YISADADGSVLALRRES-
Mb0954c|M.bovis_AF2122/97 VADRGNDRVVKLTS----
Rv0931c|M.tuberculosis_H37Rv VADRGNDRVVKLTS----
MAV_4238|M.avium_104 VADRGDDRVVKLAQ----
MMAR_2539|M.marinum_M VTNHDNDEVLELPAPYAS