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M. marinum M MMAR_1873 (hoxN)

annotation: high-affinity nickel permease, HoxN
coordinates: 2279373 - 2280491
length: 372

ASNDLVSRSSWWSRLHSTLTPPEWWRLGAMFAFIAALHVVGWGTLVFLVEPAQLAVGSRAFGIGIGVTAY
TLGMRHAFDADHIAAIDNTTRKLMNDGQRPLATGFFFSLGHSTVVFGLAVLLATGIKTIIGPVREDSSRL
HHYTGLIGTSVSGLFLYLIAILNVIILAGILRVFFRLRRGEFSEAELEEQLNNRGLINRLLGRFTNSITK
SWHMYPVGLLFGLGFDTATEIALLVLAGTSAAAGLPWYAILCLPVLFTAGMCLLDTIDGSFMNFAYGWAF
SNPVRKIYYNITITALSVAVALLIGSVELLGLFADEFGWRGAFWDWIAGLNLNLVGFLVVGMFVVTWAAA
MLVWRFGRIEEKWTAAANSAT*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_1873hoxN-100% (372)high-affinity nickel permease, HoxN

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2881nicT1e-17075.54% (372) nickel-transport integral membrane protein
M. gilvum PYR-GCK-----
M. tuberculosis H37RvRv2856nicT1e-17075.54% (372) nickel-transport integral membrane protein
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_1897c-1e-11156.89% (334) high-affinity nickel-transporter NicT
M. avium 104MAV_3711-1e-16777.09% (358) transition metal uptake transporter, Ni2+-Co2+ transporter
M. smegmatis MC2 155-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99-----
M. vanbaalenii PYR-1-----

CLUSTAL 2.0.9 multiple sequence alignment


Mb2881|M.bovis_AF2122/97            MASSQLDRQRSRSAKMNRALTAAEWWRLGLMFAVIVALHLVGWLTVTLLV
Rv2856|M.tuberculosis_H37Rv         MASSQLDRQRSRSAKMNRALTAAEWWRLGLMFAVIVALHLVGWLTVTLLV
MAV_3711|M.avium_104                MTSTEIDRWPARATRFLGALAPAEWWRLASMLGAILALHLIGWLTLVLLV
MMAR_1873|M.marinum_M               MASNDLVSRSSWWSRLHSTLTPPEWWRLGAMFAFIAALHVVGWGTLVFLV
MAB_1897c|M.abscessus_ATCC_199      ------------------------------MSVAVIALHVLGWGMLIFLV
                                                                  *   : ***::**  : :**

Mb2881|M.bovis_AF2122/97            EPARLSLGGKAFGIGVGLTAYTLGLRHAFDADHIAAIDNTTRKLMSDGHR
Rv2856|M.tuberculosis_H37Rv         EPARLSLGGKAFGIGVGLTAYTLGLRHAFDADHIAAIDNTTRKLMSDGHR
MAV_3711|M.avium_104                APAQYSLGGKAFGVGVGLTAYTLGLRHAFDADHIAAIDNTTRKLMNDGQR
MMAR_1873|M.marinum_M               EPAQLAVGSRAFGIGIGVTAYTLGMRHAFDADHIAAIDNTTRKLMNDGQR
MAB_1897c|M.abscessus_ATCC_199      APAHFTVQGSVFGVGLGVTAYTLGMRHAFDADHIAAIDNTTRKLVADGRR
                                     **: :: . .**:*:*:******:*******************: **:*

Mb2881|M.bovis_AF2122/97            PLAVGFFFSLGHSTVVFGLAVMLVTGLKAIVGPVENDSSTLHHYTGLIGT
Rv2856|M.tuberculosis_H37Rv         PLAVGFFFSLGHSTVVFGLAVMLVTGLKAIVGPVENDSSTLHHYTGLIGT
MAV_3711|M.avium_104                PLAVGFFFSLGHSTVVFALAVLLACGVRTVVGPVRDDSSALHHYTGLIGT
MMAR_1873|M.marinum_M               PLATGFFFSLGHSTVVFGLAVLLATGIKTIIGPVREDSSRLHHYTGLIGT
MAB_1897c|M.abscessus_ATCC_199      PMSVGFWFSLGHSSIVFIMVGLLALGVKTLAANVSDEHSSLQQWTGVFGT
                                    *::.**:******::** :. :*. *:::: . * :: * *:::**::**

Mb2881|M.bovis_AF2122/97            SISGAFLYLIGILNVIVLVGIVRVFAHLRRGDYD----EAELEQQLDNRG
Rv2856|M.tuberculosis_H37Rv         SISGAFLYLIGILNVIVLVGIVRVFAHLRRGDYD----EAELEQQLDNRG
MAV_3711|M.avium_104                SVSGVFLYAIALLNVVVLVGILRVLARVRRGDYDPHTDAAELERQLDNRG
MMAR_1873|M.marinum_M               SVSGLFLYLIAILNVIILAGILRVFFRLRRGEFS----EAELEEQLNNRG
MAB_1897c|M.abscessus_ATCC_199      AVSGTFLLLIGLLNLISLIGIYRIAKRMRGGEVD----EAALERELSNRG
                                    ::** **  *.:**:: * ** *:  ::* *: .     * **.:*.***

Mb2881|M.bovis_AF2122/97            LLIRFLGRFTKSLTKSWHMYPVGFLFGLGFDTATEIALLVLAGTSAAAGL
Rv2856|M.tuberculosis_H37Rv         LLIRFLGRFTKSLTKSWHMYPVGFLFGLGFDTATEIALLVLAGTSAAAGL
MAV_3711|M.avium_104                LMNRWLGRFTKSITQSWHCYPVGLLFGLGFDTATEVALLVLAGTSAAAGL
MMAR_1873|M.marinum_M               LINRLLGRFTNSITKSWHMYPVGLLFGLGFDTATEIALLVLAGTSAAAGL
MAB_1897c|M.abscessus_ATCC_199      GLNRLFGPLMAAIRKPWQMYPVGLLFGLGFDTVTEVSLLVIAGGAAVTGL
                                     : * :* :  :: :.*: ****:********.**::***:** :*.:**

Mb2881|M.bovis_AF2122/97            PWYAILCLPVLFAAGMCLLDTIDGSFMNFAYGWAFSSPVRKIYYNITVTG
Rv2856|M.tuberculosis_H37Rv         PWYAILCLPVLFAAGMCLLDTIDGSFMNFAYGWAFSSPVRKIYYNITVTG
MAV_3711|M.avium_104                PWYAILCLPVLFAAGMCLLDTIDGSFMNFAYGWAFSNPVRKIYYNIIITA
MMAR_1873|M.marinum_M               PWYAILCLPVLFTAGMCLLDTIDGSFMNFAYGWAFSNPVRKIYYNITITA
MAB_1897c|M.abscessus_ATCC_199      PWYAILVLPILFSAGMSLFDSLDGSLMNFAYDWAFQEPARKIYYNLVVTG
                                    ****** **:**:***.*:*::***:*****.***..*.******: :*.

Mb2881|M.bovis_AF2122/97            LSVAVALLIGSVELLGLIANQLGWQGPFWDWLGGLDLNTVGFVVVAMFAL
Rv2856|M.tuberculosis_H37Rv         LSVAVALLIGSVELLGLIANQLGWQGPFWDWLGGLDLNTVGFVVVAMFAL
MAV_3711|M.avium_104                LSVAVAWVIGSIELLVLFADEFGWRGSFWDWLGGLDLNTVGYVVVGMFVL
MMAR_1873|M.marinum_M               LSVAVALLIGSVELLGLFADEFGWRGAFWDWIAGLNLNLVGFLVVGMFVV
MAB_1897c|M.abscessus_ATCC_199      LSVAVAVLIGSQEIISILTEKLDITSGPLAAVGELDLAAMGYVIVALFIV
                                    ****** :*** *:: ::::::.  .     :. *:*  :*:::*.:* :

Mb2881|M.bovis_AF2122/97            TWAIALLVWHYGRVEERWTPAPDRTT-----
Rv2856|M.tuberculosis_H37Rv         TWAIALLVWHYGRVEERWTPAPDRTT-----
MAV_3711|M.avium_104                TWAVALLIWRYGRIEERWAGADPRAGTGREA
MMAR_1873|M.marinum_M               TWAAAMLVWRFGRIEEKWTAAANSAT-----
MAB_1897c|M.abscessus_ATCC_199      TWAAAALGWRYTGVRRRWGG-----------
                                    *** * * *::  :..:*