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LTDFEFDAPTVIRIKRDGGRLSDAAIDWVIDAYTEGRVAPEQMSALLMAIVLQGMDRGETARWTSAMLAS GPRLDFSDLRAGGAPLVTVDKHSTGGVGDKITLPLVPVVVACGGTVPQASGRGLGHTGGTLDKLESISGF TATLSNQQVREQLCDVGAAIFAAGELAPADAKLYALRDITGTVESLPLIASSIMSKKLAEGAGALVLDVK VGSGAFLKSETQSRELAHTMVELGAAHGVPTRALLTDMNCPLGSTVGNALEVAEALEVLDGGGPPDVVEL TVRLAAEMLDLVGIDGLDPAETLRDGSAMDRFRRLIAAQGGELAKPLPIGAHSETVRAGRGGTMGDIDAM AVGLAAWRLGAGRSRPGARVQHGAGIRIHRRPGEPVAAGEPLFTLYTDTPERFGAAVAELAAGFSVADSA PTTRPLIIDRISR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1205 | deoA | - | 100% (433) | thymidine phosphorylase DeoA |
| M. marinum M | MMAR_3236 | trpD | 4e-05 | 25.00% (164) | anthranilate phosphoribosyltransferase TrpD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3343c | deoA | 0.0 | 85.38% (431) | thymidine phosphorylase |
| M. gilvum PYR-GCK | Mflv_4842 | deoA | 0.0 | 74.88% (430) | thymidine phosphorylase |
| M. tuberculosis H37Rv | Rv3314c | deoA | 0.0 | 85.61% (431) | thymidine phosphorylase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3671c | deoA | 1e-158 | 68.07% (429) | thymidine phosphorylase |
| M. avium 104 | MAV_4295 | deoA | 0.0 | 82.86% (426) | thymidine phosphorylase |
| M. smegmatis MC2 155 | MSMEG_1675 | deoA | 1e-174 | 75.43% (411) | thymidine phosphorylase |
| M. thermoresistible (build 8) | TH_2179 | deoA | 0.0 | 76.06% (426) | PROBABLE THYMIDINE PHOSPHORYLASE DEOA (TDRPASE) (PYRIMIDINE |
| M. ulcerans Agy99 | MUL_1365 | deoA | 0.0 | 99.54% (433) | thymidine phosphorylase |
| M. vanbaalenii PYR-1 | Mvan_1591 | deoA | 0.0 | 76.62% (432) | thymidine phosphorylase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1205|M.marinum_M ---------MTDFEFDAPTVIRIKRDGGRLSDAAIDWVIDAYTEGRVAPE
MUL_1365|M.ulcerans_Agy99 ---------MTDFEFDAPTVIRIKRDGGRLSDAAIDWVIDAYTEGRVAPE
Mb3343c|M.bovis_AF2122/97 ---------MTDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADE
Rv3314c|M.tuberculosis_H37Rv ---------MTDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADE
MAV_4295|M.avium_104 ----------MRPGFDAPTVIRTKRDGGRLSDAAIDWVIDAYTRGLVAEE
Mflv_4842|M.gilvum_PYR-GCK ---MSFDAAGPISHLDAPSVIRTKRDGGALSDEAIDWVIDAYTRGEVAEA
Mvan_1591|M.vanbaalenii_PYR-1 ---------MTQFTFDMPSIIRTKRDGGVLSDDAIDWVIDAYTHGRVAEA
TH_2179|M.thermoresistible__bu VTRATFHASGAGSAFDAPTVIRIKRDGGVLSDEAIDWVIDAYTHGRIADE
MSMEG_1675|M.smegmatis_MC2_155 ----------------------------MLSDDAIDWVIDNYTRGRVADE
MAB_3671c|M.abscessus_ATCC_199 --------MANTYAFDMPSIIATKRDGAELSPAAIDWLIGQYTSGDIGEE
** ****:: ** * :.
MMAR_1205|M.marinum_M QMSALLMAIVLQGMDRGETARWTSAMLASGPRLDFSDLRAGGAPLVTVDK
MUL_1365|M.ulcerans_Agy99 QMSALLMAIVLQGMDRGETARWTSAMLASGPRLDFSDLRAGGAPLVTVDK
Mb3343c|M.bovis_AF2122/97 QMSALLMAIVWRGMDRGEIARWTAAMLASGARLDFTDL-----PLATVDK
Rv3314c|M.tuberculosis_H37Rv QMSALLMAIVWRGMDRGEIARWTAAMLASGARLDFTDL-----PLATVDK
MAV_4295|M.avium_104 QMAALLMAILLRGMDGGETAAWTSAMLASGDRLDFSDLG-----VPTVDK
Mflv_4842|M.gilvum_PYR-GCK QMSALLMAIFLRGMTGHEIARWTAAMIASGERLDFSDLRRDGKPLALVDK
Mvan_1591|M.vanbaalenii_PYR-1 QMSALLMAIFLRGMTNGEIARWTAAMVDSGERLDFSDLRRDGKPLALVDK
TH_2179|M.thermoresistible__bu QMSALLMAIFLRGMTGPEIARWTSAMVASGERFDFTDLRRDGRPLALVDK
MSMEG_1675|M.smegmatis_MC2_155 QMSALLMAIFLRGMTPGEITRWTAAMVNSGERFDFTDLERDGRPLALVDK
MAB_3671c|M.abscessus_ATCC_199 QVAALLMAIYLRGMNGAETAAWTAAILASGERLDLSGLSR-----PTVDK
*::****** :** * : **:*:: ** *:*::.* ***
MMAR_1205|M.marinum_M HSTGGVGDKITLPLVPVVVACGGTVPQASGRGLGHTGGTLDKLESISGFT
MUL_1365|M.ulcerans_Agy99 HSTGGVGDKITLPLVPVVVACGGTVPQASGRGLGHTGGTLDKLESISGLT
Mb3343c|M.bovis_AF2122/97 HSTGGVGDKITLPLVPVVAACGGAVPQASGRGLGHTGGTLDKLESITGFT
Rv3314c|M.tuberculosis_H37Rv HSTGGVGDKITLPLVPVVAACGGAVPQASGRGLGHTGGTLDKLESITGFT
MAV_4295|M.avium_104 HSTGGVGDKITLPLVPVVAACGAAVPQASGRGLGHTGGTLDKLDAIAGFS
Mflv_4842|M.gilvum_PYR-GCK HSTGGVGDKITIPLVPVVMACGGAVPQAAGRGLGHTGGTLDKLESIPGFT
Mvan_1591|M.vanbaalenii_PYR-1 HSTGGVGDKITIPLVSVVMACGGAVPQAAGRGLGHTGGTLDKLESIPGFT
TH_2179|M.thermoresistible__bu HSTGGVGDKITIPLVPVVMACGGAVPQAAGRGLGHTGGTLDKLESIPGFS
MSMEG_1675|M.smegmatis_MC2_155 HSTGGVGDKLTIPLVPVVIACGAAVPQAAGRGLGHTGGTLDKLEAIPGFS
MAB_3671c|M.abscessus_ATCC_199 HSTGGVGDKISLPLVAVVAACGAAVPQLSGRGLGHTGGTLDKLESVAGIR
*********:::***.** ***.:*** :**************:::.*:
MMAR_1205|M.marinum_M ATLSNQQVREQLCDVGAAIFAAG-ELAPADAKLYALRDITGTVESLPLIA
MUL_1365|M.ulcerans_Agy99 ATLSNQQVREQLCDVGAAIFAAG-ELAPADAKLYALRDITGTVESLPLIA
Mb3343c|M.bovis_AF2122/97 ANLSNQRVREQLCDVGAAIFAAG-QLAPADAKLYALRDITGTVESLPLIA
Rv3314c|M.tuberculosis_H37Rv ANLSNQRVREQLCDVGAAIFAAG-QLAPADAKLYALRDITGTVESLPLIA
MAV_4295|M.avium_104 AQLPSRRVREQLREVGAAIFAAG-DLAPADAKLYALRDITATVESLPLIA
Mflv_4842|M.gilvum_PYR-GCK AEITKSQIRQQLCDLGAAIFAAG-ELAPADRKIYALRDVTATTESLPLIA
Mvan_1591|M.vanbaalenii_PYR-1 AEISKTQIRQQLCELGAAIFAAG-ELAPADRKIYALRDVTATTESLPLIA
TH_2179|M.thermoresistible__bu AELTQAQIRRQLEEIGGAIFAAG-ELAPADRKMYALRDVTATVDSLPLIA
MSMEG_1675|M.smegmatis_MC2_155 AELTKTQIRQQLCGVGAAIFAAG-ELAPADRKIYALRDVTATTESLPLIA
MAB_3671c|M.abscessus_ATCC_199 VDLSNDQIRQQLSDVGAVICAAGASLAPADRKLYALRDITGTVESIPLIA
. :.. ::*.** :*..* *** .***** *:*****:*.*.:*:****
MMAR_1205|M.marinum_M SSIMSKKLAEGAGALVLDVKVGSGAFLKSETQSRELAHTMVELGAAHGVP
MUL_1365|M.ulcerans_Agy99 SSIMSKKLAEGAGALVLDVKVGSGAFLKSETQSRELAHTMVELGAAHGVP
Mb3343c|M.bovis_AF2122/97 SSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVP
Rv3314c|M.tuberculosis_H37Rv SSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVP
MAV_4295|M.avium_104 SSVMSKKLAEGAGALVLDVKVGSGALVKTEEQCRDLAHTMVGLGAAHGVP
Mflv_4842|M.gilvum_PYR-GCK SSVMSKKIAEGTKALVLDSKVGSGAFLDSEAESRELARTMVELGVEHGVQ
Mvan_1591|M.vanbaalenii_PYR-1 SSVMSKKIAEGTRALVLDTKVGSGAFLKTEAESRELARTMVELGTAHGVR
TH_2179|M.thermoresistible__bu SSVMSKKIAEGTRALVLDTKVGSGAFLKTEAEARELARTMIDLGTAHGLV
MSMEG_1675|M.smegmatis_MC2_155 SSIMSKKLAEGARALVLDVKVGRGAFLKTEAESRELARTMVELGNDYGVP
MAB_3671c|M.abscessus_ATCC_199 GSIMGKKLAEGTAALVLDVKVGAGAFMKSEQRARELASAMVDLGTAHGVA
.*:*.**:***: ***** *** **:: : ..*:** :*: ** :*:
MMAR_1205|M.marinum_M TRALLTDMNCPLGSTVGNALEVAEALEVLDGGGPPDVVELTVRLAAEMLD
MUL_1365|M.ulcerans_Agy99 TRALLTDMNCPLGSTVGNALEVAEALEVLDGGGPPDVVELTVRLAAEMLD
Mb3343c|M.bovis_AF2122/97 TRALLTEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLE
Rv3314c|M.tuberculosis_H37Rv TRALLTEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLE
MAV_4295|M.avium_104 TRALLTDMNRPLGATVGNALEVAEALEVLAGGGPPDVVELTLRLAAEMLA
Mflv_4842|M.gilvum_PYR-GCK TRALLTDMQTPLGRTVGNAVEVVESLEVLAGGGPDDVVELTLALAREMCD
Mvan_1591|M.vanbaalenii_PYR-1 TRALLTDMNTPLGRTVGNAVEVAESLEVLAGGGPDDVVELTLALAREMCD
TH_2179|M.thermoresistible__bu TRALLTDMHRPLGAAVGNAVEVAESVEVLAGGGPSDVVELTLALAAEMLD
MSMEG_1675|M.smegmatis_MC2_155 TRALLTDMNRPLGLSVGNAVEVAESLDVLAGGGPADVVELTVALAREMLA
MAB_3671c|M.abscessus_ATCC_199 TSALLTAMDTPLGATAGNAVEVQESLDVLAGGGPEDVVALTVTLAREMLA
* **** *. *** :.***:** *:::** **** *** **: ** **
MMAR_1205|M.marinum_M LVGIDGLDPAETLRDGSAMDRFRRLIAAQGGELA----KPLPIGAHSETV
MUL_1365|M.ulcerans_Agy99 LVGIDGRDPAETLRDGSAMDRFRRLIAAQGGELA----KPLPIGAHSETV
Mb3343c|M.bovis_AF2122/97 LAGIHGRDPAQTLRDGTAMDRFRWLVAAQGGDLS----KPLPIGSHSETV
Rv3314c|M.tuberculosis_H37Rv LAGIHGRDPAQTLRDGTAMDRFRRLVAAQGGDLS----KPLPIGSHSETV
MAV_4295|M.avium_104 LAGVGDRDPADTLHDGTAMDRFRRLVAAQGGDLS----VPLPIGRHSETV
Mflv_4842|M.gilvum_PYR-GCK VAGLDGVDPAQTLRDGTAMDRFRDLVAAQGGDVDSLDAAMLPLGQHTETI
Mvan_1591|M.vanbaalenii_PYR-1 AAGLDGVDPAETLRDGTAMDRFRALVAAQGGDPD----AALPLGAHSETV
TH_2179|M.thermoresistible__bu AAGIDGEDPADTLRDGSAMDAYRALINAQGGDPD----ASLPRGAHTETV
MSMEG_1675|M.smegmatis_MC2_155 AAGIDGVDPAETLRDGSAMDRFRALVAAQGGDLS----LPLPIGAASETV
MAB_3671c|M.abscessus_ATCC_199 AAGIDGKDPAATLTDGTAMDVFRTMIHAQGGDLA----VPLPLGQCQETV
.*: . *** ** **:*** :* :: ****: ** * **:
MMAR_1205|M.marinum_M RAGRGGTMGDIDAMAVGLAAWRLGAGRSRPGARVQHGAGIRIHRRPGEPV
MUL_1365|M.ulcerans_Agy99 RAGRGGTMGDIDAMAVGLAAWRLGAGRSRPGARVQHGAGIRIHRRPGEPV
Mb3343c|M.bovis_AF2122/97 TAGASGTMGDIDAMAVGLAAWRLGAGRSRPGARVQHGAGVRIHRRPGEPV
Rv3314c|M.tuberculosis_H37Rv TAGASGTMGDIDAMAVGLAAWRLGAGRSRPGARVQHGAGVRIHRRPGEPV
MAV_4295|M.avium_104 TAPRGGTMGDIDAMAVGLAAWRLGAGRSRPGERVQAGAGLRIHRRPGEPV
Mflv_4842|M.gilvum_PYR-GCK SAPRSGTMGDIDAMAVGLAVWRLGAGRSVPGEQVQFGAGMRIHRKPGEAV
Mvan_1591|M.vanbaalenii_PYR-1 SAPRGGTMGDIDAMAVGLAVWRLGAGRSAPGEQVQFGAGMRIHRRPGEPV
TH_2179|M.thermoresistible__bu TAPRSGTMGDLDAMAVGMAVWRLGAGRSAPGEQVQHGAGLRIHRRPGDPV
MSMEG_1675|M.smegmatis_MC2_155 TAPRGGVMGDIDAMGVAMAAWRLGAGRAQPGEPVQLGAGVRLHRRPGEPV
MAB_3671c|M.abscessus_ATCC_199 LAPVGGVMRRIDAMPVGIAAWRLGAGRSRPGEAVQHGAGVRIHRRPGEAV
* .*.* :*** *.:*.*******: ** ** ***:*:**:**:.*
MMAR_1205|M.marinum_M AAGEPLFTLYTDTPERFGAAVAELAAGFSVADSAPTTRPLIIDRISR
MUL_1365|M.ulcerans_Agy99 AAGEPLFTLYTDTPERFGAAVAELAAGFSVADSAPTTRPLIIDRISR
Mb3343c|M.bovis_AF2122/97 VVGEPLFTLYTNAPERFGAARAELAGGWSIRDSPPQVRPLIVDRIV-
Rv3314c|M.tuberculosis_H37Rv VVGEPLFTLYTNAPERFGAARAELAGGWSIRDSPPQVRPLIVDRIV-
MAV_4295|M.avium_104 AAGEPLFTLHTDTPERFGAALAELDGGWNVGDGAPAPRPLIIDRIVT
Mflv_4842|M.gilvum_PYR-GCK AAGEPLFTLYTETPHRLAAAASELDGAWSVGDHAPPTRPLIIDRISM
Mvan_1591|M.vanbaalenii_PYR-1 AAGEPLFTLYTDTPERLAGAVSELDGAWSVGDEPPARRPLIIDRITG
TH_2179|M.thermoresistible__bu AAGEPLFTLYTDTPERFEAAIAELDGGFSVGDTAPDRRPLIIDRVV-
MSMEG_1675|M.smegmatis_MC2_155 AAGETLFTLYTDTPDRLPAALGELDGAWSVGDAPPQELPLIIDRID-
MAB_3671c|M.abscessus_ATCC_199 VAGEPLFTLYTDTQERLPAALDALEGGWEIG-AAPTATPLIIDRLPV
..**.****:*:: .*: .* * ..:.: .* ***:**: