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NPVFVDADTGIDDALALIYLLASTDADLVGIASTGGNTSVDQVCTNNLGVLELCRAGDIPVARGADQPLT GQWPHRANTHGPKGLGYAELPPTNRELATYDAAAAWVRMAHAYRGKLTGLVTGPLTNLARALRAEPALPA MLSRLVIMGGMFDADGNDVGADWNIRVDPEAASEVFAAWTGQQRLPIVCSLNLTRKVAMTPDILARLTCA AGPSALTRVIQDAVRFYFESHRDRGFGYLAYLHDPLAAAIALDPQLVTTQVATVDVVLADIPTRGMTVAD RSGKHPPNARIGVSVDPAVFFERFIQRVAAFARRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1152 | iunH | - | 100% (316) | inosine-uridine nucleoside hydrolase, IunH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3425 | iunH | 1e-122 | 69.21% (315) | nucleoside hydrolase IunH |
| M. gilvum PYR-GCK | Mflv_4897 | - | 2e-97 | 56.72% (335) | inosine/uridine-preferring nucleoside hydrolase |
| M. tuberculosis H37Rv | Rv3393 | iunH | 1e-122 | 69.21% (315) | nucleoside hydrolase IunH |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3711 | - | 1e-101 | 57.61% (335) | putative nucleoside hydrolase IunH |
| M. avium 104 | MAV_4342 | - | 1e-107 | 58.58% (338) | inosine-uridine preferring nucleoside hydrolase |
| M. smegmatis MC2 155 | MSMEG_1621 | - | 1e-105 | 60.47% (344) | pyrimidine-specific ribonucleoside hydrolase RihA |
| M. thermoresistible (build 8) | TH_0487 | - | 5e-96 | 55.29% (340) | pyrimidine-specific ribonucleoside hydrolase RihA |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1526 | - | 1e-100 | 56.97% (337) | inosine/uridine-preferring nucleoside hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4897|M.gilvum_PYR-GCK -----MSGD-SHPVFLDVDTGVDDAMALVYLLASPEADVVGIASTAGNVG
Mvan_1526|M.vanbaalenii_PYR-1 -----MSGG-RHPVFVDVDTGVDDAMALVYLFGSPDADLVGIASTAGNVG
TH_0487|M.thermoresistible__bu VGGVTTPGDERIPVFADVDTGVDDALALMYLLGCPEVRLVGIASTAGNVP
MSMEG_1621|M.smegmatis_MC2_155 -----------MPVFADVDTGVDDAMALAYLLASSDADLVGIASTAGNIG
MAB_3711|M.abscessus_ATCC_1997 ----------MVPVFADVDTGVDDALGLIYLLASEDAEIVGIASTAGNVS
MAV_4342|M.avium_104 -------MAAVTPVFVDVDTGVDDALALMYLFASPDADVVGIASTGGNVA
Mb3425|M.bovis_AF2122/97 ----------MSVVFADVDTGIDDALAVIYLLASPDADLVGIASTGGNIA
Rv3393|M.tuberculosis_H37Rv ----------MSVVFADVDTGIDDALAVIYLLASPDADLVGIASTGGNIA
MMAR_1152|M.marinum_M ----------MNPVFVDADTGIDDALALIYLLASTDADLVGIASTGGNTS
** *.***:***:.: **:.. :. :******.**
Mflv_4897|M.gilvum_PYR-GCK VDDVCRNNLALLELCGTTGIPVSRGSATPLVAPLRTAEDTHGPRGLGYAR
Mvan_1526|M.vanbaalenii_PYR-1 VDDVCRNNLALLELCGVTGVPVSRGSETPLVAPLRTAEDTHGPQGLGYAR
TH_0487|M.thermoresistible__bu VHQVCRNNLDLLHMCGVTDVPVSKGAERPLRAQLRTAEDTHGPQGLGYAT
MSMEG_1621|M.smegmatis_MC2_155 VHQVCINNLGLLELCGAPDIPVSRGAEQPLAAPLRTAEDTHGPEGLGYAR
MAB_3711|M.abscessus_ATCC_1997 VDHVCANNLGLLELCKAPQIPVSKGVAEPLSAALRTAEDTHGPTGLGYAL
MAV_4342|M.avium_104 VEQVCENNLGLLQLCGLTGIPVSKGSGQTLTGPMRLPSKVHGPRGLGYAE
Mb3425|M.bovis_AF2122/97 VGQVCANNLSLLELCGAADIPVSKGADEPLGGRWPDHPKFHGPKGIGYAE
Rv3393|M.tuberculosis_H37Rv VGQVCANNLSLLELCGAADIPVSKGADEPLGGRWPDHPKFHGPKGIGYAE
MMAR_1152|M.marinum_M VDQVCTNNLGVLELCRAGDIPVARGADQPLTGQWPHRANTHGPKGLGYAE
* .** *** :*.:* :**::* .* . . *** *:***
Mflv_4897|M.gilvum_PYR-GCK LPEPTTTLTDHDAAQAWVRAARDHPGELIGIATGPLTNLALALRAESALP
Mvan_1526|M.vanbaalenii_PYR-1 LPAPTAALTDHDAAEAWVRAARAHPGELIGIATGPLTNLALALRAEPALP
TH_0487|M.thermoresistible__bu LPPGAGELTDHDAAEAWVRAARAHPGELIAIATGPLTNLALALRAEPELP
MSMEG_1621|M.smegmatis_MC2_155 LPATDRTLTTHDAAEAWIRAAHAHPGELIGLATGPLTNLALAMRAEPALP
MAB_3711|M.abscessus_ATCC_1997 LPESTRTLTDYDSAEAWVKAAHAYPGELVGLATGPLTNLALALRTEPELP
MAV_4342|M.avium_104 LPPSDHRVTDHDSASAWVRAAHAHPGELIGVATGPLTNLALALRAEPALP
Mb3425|M.bovis_AF2122/97 LPASNRRLTDYDATTAWIAAAHSHAGDLIGLVTGPLTNLALALRAEPALP
Rv3393|M.tuberculosis_H37Rv LPASNRRLTDYDATTAWIAAAHSHAGDLIGLVTGPLTNLALALRAEPALP
MMAR_1152|M.marinum_M LPPTNRELATYDAAAAWVRMAHAYRGKLTGLVTGPLTNLARALRAEPALP
** :: :*:: **: *: : *.* .:.******** *:*:*. **
Mflv_4897|M.gilvum_PYR-GCK RLLKRLVIMGGAFDYRGNTTPVAEWNVSVDPESAAETFSAWS--------
Mvan_1526|M.vanbaalenii_PYR-1 RLLGRLVIMGGAFDYRGNTTPVAEWNVSVDPESAAEVFAAWH--------
TH_0487|M.thermoresistible__bu RLVKRLVIMGGAFDYRGNTTPVAEWNVSVDPEAWWEVLAFWRGAWG----
MSMEG_1621|M.smegmatis_MC2_155 RLMRRLVIMGGAFDYKGNTTPVAEWNISVDPESAAEVFGGWDAAWGGRGD
MAB_3711|M.abscessus_ATCC_1997 KLLKRLVIMGGSFDYPGNTTPVAEWNVVVDPGATAEVYAAWG--------
MAV_4342|M.avium_104 TLLRRLVIMGGSYDHRGNTTAVAEWNISVDPEAAAEVLAGWGG------A
Mb3425|M.bovis_AF2122/97 RLLRRLVIMGGMFDGQ----PITEWNIRVDPEAASEVFTAWA--------
Rv3393|M.tuberculosis_H37Rv RLLRRLVIMGGMFDGQ----PITEWNIRVDPEAASEVFTAWA--------
MMAR_1152|M.marinum_M AMLSRLVIMGGMFDADGND-VGADWNIRVDPEAASEVFAAWT--------
:: ******* :* ::**: *** : *. *
Mflv_4897|M.gilvum_PYR-GCK RSGAGHLPIVLGLNLTEHAEMTPELLRRLAEAAGSTSTQMSVSDVRGTAS
Mvan_1526|M.vanbaalenii_PYR-1 RSGADHLPIVLGLNLTENVAMTPQLLSRLADAAGSTSTPMSALDPRGTES
TH_0487|M.thermoresistible__bu GSEPDHLPMVLGLNLTEHIEMTPTILSRLAAAAGCESTPLCESDERGTRS
MSMEG_1621|M.smegmatis_MC2_155 DAAPAHVPIVLGLNLTENVAMTPALLNRLATAAGSPSTAMSVRDERGTRS
MAB_3711|M.abscessus_ATCC_1997 AAGVQELPIVCGLNLTETIAMTPEHLVRLADAAGATTTPLSVLDSPSSRS
MAV_4342|M.avium_104 DVVRERLPILCGLDLTRKVAMTPDHLTRLATAADSGTRPLSADDEPGTRS
Mb3425|M.bovis_AF2122/97 --GQRQLPIVCGLDLTRRVAMTPDILARLASVCG----------------
Rv3393|M.tuberculosis_H37Rv --GQRQLPIVCGLDLTRRVAMTPDILARLASVCG----------------
MMAR_1152|M.marinum_M --GQQRLPIVCSLNLTRKVAMTPDILARLTCAAG----------------
.:*:: .*:**. *** * **: ...
Mflv_4897|M.gilvum_PYR-GCK TASNPLIRVLEDAMRFYFEFHHDQGEGYLAHVHDPLAAAVALDTTLVRYR
Mvan_1526|M.vanbaalenii_PYR-1 AASNPVIRVLEDAMRFYFEFHFDQGEGYLAHLHDPVAAAVALDTALVQCR
TH_0487|M.thermoresistible__bu TAANPLIRVIEDAMRFYCEFHFDQGEGYLAHLHDPLAAAVALDPELVRFR
MSMEG_1621|M.smegmatis_MC2_155 TAANPLIRVLEDAMRFYFEFHFDTGDGYLAHLHDPLAAAVALDPELVRCR
MAB_3711|M.abscessus_ATCC_1997 GASNSLLRFIEDAAHFYFEFHMKQGEGFLAHMHDPFAAAVALDPSLVQTR
MAV_4342|M.avium_104 AAANPLIRVIEDAMRFYLEAYHDLGHGYQAHMHDPLAAAVALDPTLVATR
Mb3425|M.bovis_AF2122/97 --SSPVMRVIEDALRFYFESHEARGHGYLAYMHDPLAAAVAMDPELLTTR
Rv3393|M.tuberculosis_H37Rv --SSPVMRVIEDALRFYFESHEARGHGYLAYMHDPLAAAVAMDPELLTTR
MMAR_1152|M.marinum_M --PSALTRVIQDAVRFYFESHRDRGFGYLAYLHDPLAAAIALDPQLVTTQ
...: *.::** :** * : * *: *::***.***:*:*. *: :
Mflv_4897|M.gilvum_PYR-GCK SAPVDVELTGTLTRGMTIADWSGHWGREPNALIGVEVDPAVFFDRFIARV
Mvan_1526|M.vanbaalenii_PYR-1 PAPVDVELTGTLTRGMTIADWSHRWGREPNALIGVDVDPDAFFDRFIARV
TH_0487|M.thermoresistible__bu AAAVDVELTGTLTRGMTIADWSGRWGREPNALIGVEVDPATFFDRFIERV
MSMEG_1621|M.smegmatis_MC2_155 QTTVDVELTGTLTRGMTVADWRGHWGRRPNALIGMEVDPTVFFDRFISRV
MAB_3711|M.abscessus_ATCC_1997 SATVDVELTGDLTRAMTIADWKGQWGQRPNAQIAVETDPEVFFQRFIERV
MAV_4342|M.avium_104 PATVEIELTGTLTRAMTVTDWSGR--REPNALIGIDVDSAAFFDRFIERV
Mb3425|M.bovis_AF2122/97 TATVDVD----PT-GATVTDWSGK--RNPNARIGMSVDPAVFFDRFVERI
Rv3393|M.tuberculosis_H37Rv TATVDVD----PT-GATVTDWSGK--RNPNARIGMSVDPAVFFDRFVERI
MMAR_1152|M.marinum_M VATVDVVLADIPTRGMTVADRSGK--HPPNARIGVSVDPAVFFERFIQRV
:.*:: * . *::* : : *** *.:..*. .**:**: *:
Mflv_4897|M.gilvum_PYR-GCK GAFAAALDHS---
Mvan_1526|M.vanbaalenii_PYR-1 GAFAQQLAGVSRR
TH_0487|M.thermoresistible__bu GPLAKRLA-----
MSMEG_1621|M.smegmatis_MC2_155 GAFAQRLTSHS--
MAB_3711|M.abscessus_ATCC_1997 SVFARTVDDAR--
MAV_4342|M.avium_104 GPFARRVGGGR--
Mb3425|M.bovis_AF2122/97 GRFARRT------
Rv3393|M.tuberculosis_H37Rv GRFARRT------
MMAR_1152|M.marinum_M AAFARRA------
. :*