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SYDLLIRNGTIVDGLGGEPYVGDVAVRDGIIVAVGPPDDSVNGDAAGRVIDASGLLVTPGFVDLHTHYDG QSIWSDRLTPSSAHGVTTVLMGNCGVGFAPCRQQDHDVLVDVMAGVEDIPGVVMTDGLPWTWETFPEFMD ALEAGARDIDVAAFLPHSPLRVYVMGQRGADREPATPEDLATMRALAKQAIEMGALGFASSRLTIHKTES GSPIPSYDAARAEIEEIAKGVVDGGGGLLQFVPDIPAGGYQPVLQTVFDVAEEVGLPVTFSLVVGNVGEP SWPDAITMVENANKNAGEGTRFTAQLLPRPIGLIIGLQLSANPFVLYPSYREIAHLPLAERVAEMRKPDV RARILADKPGVGHPILYVAQAWDWIFPLTEDPNYEPAAADSIGARARARGVSPMEEAYDRLLDDDGHAML LVATSNMENNSLDTVGKLLHREDVVLGLGDGGAHYGMICDASYSTYFLTHWARDRASGRFSVAEAVRELT SVPARVAGLGDRGRIAVGYKADLNVIDHTALRLHKPVIRYDLPAGGRRLDQTAEGYVATVVSGQVIAENG VPTAARPGKLVRGRQSAPVPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0762 | - | - | 100% (582) | D-amino acid aminohydrolase |
| M. marinum M | MMAR_0213 | - | e-125 | 41.96% (591) | D-amino acid aminohydrolase |
| M. marinum M | MMAR_1795 | - | 5e-36 | 28.02% (621) | D-amino acid aminohydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2937c | - | 1e-38 | 29.00% (607) | D-amino acid aminohydrolase |
| M. gilvum PYR-GCK | Mflv_0136 | - | 0.0 | 75.22% (581) | amidohydrolase 3 |
| M. tuberculosis H37Rv | Rv2913c | - | 1e-38 | 29.00% (607) | D-amino acid aminohydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2965c | - | 4e-33 | 27.52% (596) | hypothetical protein MAB_2965c |
| M. avium 104 | MAV_4703 | - | 0.0 | 85.20% (581) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_0883 | - | 0.0 | 75.90% (581) | amidohydrolase family protein |
| M. thermoresistible (build 8) | TH_2847 | - | 0.0 | 75.56% (581) | PUTATIVE Amidohydrolase 3 |
| M. ulcerans Agy99 | MUL_1396 | - | 0.0 | 98.77% (568) | D-amino acid aminohydrolase |
| M. vanbaalenii PYR-1 | Mvan_0767 | - | 0.0 | 76.33% (583) | amidohydrolase 3 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0762|M.marinum_M -------------MSYDLLIRNGTIVDGLGGEPYVGDVAVRDGIIVAVGP
MUL_1396|M.ulcerans_Agy99 -------------------------MTGWGGEPYVGDVAVRDGIIVAVGP
MAV_4703|M.avium_104 -------------MTYDLIIRNGSIVDGLGGEPYVGDVAVRDGVIAAVG-
Mflv_0136|M.gilvum_PYR-GCK -------------MTYDLVIRGGTVVDGLGGEPFTADVAVTDGIIREVG-
Mvan_0767|M.vanbaalenii_PYR-1 -------------MTYDLVIRGGTVVDGLGGAPFTGDVAVRGGVIVSVG-
TH_2847|M.thermoresistible__bu -------------MTFDLVIRNGTIVDGLGGEPFTGDVAVADGVIVAVG-
MSMEG_0883|M.smegmatis_MC2_155 -----------MSHAFDLVIRGGTVVDGLGGEPVVGDVAVRDGVIVQVG-
Mb2937c|M.bovis_AF2122/97 MLAWRQLNDLEETVTYDVIIRDGLWFDGTGNAPLTRTLGIRDGVVATVAA
Rv2913c|M.tuberculosis_H37Rv MLAWRQLNDLEETVTYDVIIRDGLWFDGTGNAPLTRTLGIRDGVVATVAA
MAB_2965c|M.abscessus_ATCC_199 ------------MATFDLLVRGGLVFDGTGAPGRAVDVGIRGGNVVAMAP
. * * . :.: .* : :.
MMAR_0762|M.marinum_M PDDSVNGDAAGRVIDASGLLVTPGFVDLHTHYDGQSIWSDRLTPSSAHGV
MUL_1396|M.ulcerans_Agy99 PDDSVNGDAAGRVIDASGLLVTPGFVDLHTHYDGQSIWSDRLTPSSAHGV
MAV_4703|M.avium_104 ---AVNGATANREIDATGRLVTPGFVDLHTHYDGQAVWSERLTPSSAHGV
Mflv_0136|M.gilvum_PYR-GCK ----AVGSAGAREIDATGLLVTPGFVDLHTHYDGQAIWSDRLTPSSAHGV
Mvan_0767|M.vanbaalenii_PYR-1 ----TVDAAGAREIDATGLLVTPGFVDLHTHYDGQAIWSDRLTPSSAHGV
TH_2847|M.thermoresistible__bu ----TADGSGRREIDATGLLVTPGFIDLHTHYDGQSIWSDRLNPSSAHGV
MSMEG_0883|M.smegmatis_MC2_155 ----EVAGTGAREIDAAGLLVTPGFVDLHTHYDGQAIWSDRLNPSSSHGV
Mb2937c|M.bovis_AF2122/97 G--ALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGV
Rv2913c|M.tuberculosis_H37Rv G--ALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGV
MAB_2965c|M.abscessus_ATCC_199 ---DLPAADADQVIDAGGKWVIPGMVDVHTHYDAEVLVSPGLGESVRHGV
. :** * * **::*:*****.: : . * * ***
MMAR_0762|M.marinum_M TTVLMGNCGVGFAPCRQQDHDVLVDVMAGVEDIPGVVMTDGLP--WTWET
MUL_1396|M.ulcerans_Agy99 TTVLMGNCGVGFAPCRQQDHDVLVDVMAGVEDIPGLVMTDGLP--WTWET
MAV_4703|M.avium_104 TTVVMGNCGVGFAPCRQSDHDVLVDVMAGVEDIPGVVMTDGLP--WTWET
Mflv_0136|M.gilvum_PYR-GCK TTAVMGNCGVGFAPCRPADHDVLVDVMAGVEDIPGVVMVDGLP--WQWET
Mvan_0767|M.vanbaalenii_PYR-1 TTAVMGNCGVGFAPCRPADHDVLVDVMAGVEDIPGVVMVDGLP--WHWET
TH_2847|M.thermoresistible__bu TTALMGNCGVGFAPCRPEDHDVLVDVMAGVEDIPGVVMAEGLP--WTWET
MSMEG_0883|M.smegmatis_MC2_155 TTAVMGNCGVGFAPCRAEDHDVLVDVMAGVEDIPGVVMTEGLN--WHWET
Mb2937c|M.bovis_AF2122/97 TTVLLGNCSLSTVYANSED---AADLFSRVEAVPREFVLGALRDNQTWST
Rv2913c|M.tuberculosis_H37Rv TTVLLGNCSLSTVYANSED---AADLFSRVEAVPREFVLGALRDNQTWST
MAB_2965c|M.abscessus_ATCC_199 TSVIYGNCSMSAVYADPED---VADLFARVEALPWDAVHSALKEHKDWDG
*:.: ***.:. . . * .*::: ** :* : .* *.
MMAR_0762|M.marinum_M FPEFMDALEAGARDIDVAAFLPHSPLRVYVMGQRGADREP--ATPEDLAT
MUL_1396|M.ulcerans_Agy99 FPEFMDALEAGARDIDVAAFLPHSPLRVYVMGQRGADREP--ATPEDLAT
MAV_4703|M.avium_104 FPEYLDTLEAGKRDIDVAAYLPHSPLRVYVMGQRGADREP--ATAEDLAK
Mflv_0136|M.gilvum_PYR-GCK FPEFLDAVASRQRDIDVAAFLPHSPLRVYVMGRRGVDREP--ATDEDLEM
Mvan_0767|M.vanbaalenii_PYR-1 FPEFLDALDAGARDIDVAAFLPHSPLRVYVMGRRGVDREP--AGPEDLAM
TH_2847|M.thermoresistible__bu FPQYLDAVASRPRDIDVAAYLPHSPLRVYVMGRRGVDREP--ATPDDLER
MSMEG_0883|M.smegmatis_MC2_155 FPEYLDALAARRLDIDVAAYLPHSPLRVYVMGQRGADREP--ATADDLAR
Mb2937c|M.bovis_AF2122/97 PAEYIEAIDALPLGPNVSSLLGHSDLRTAVLGLDRATDDTVRPTEAELAK
Rv2913c|M.tuberculosis_H37Rv PAEYIEAIDALPLGPNVSSLLGHSDLRTAVLGLDRATDDTVRPTEAELAK
MAB_2965c|M.abscessus_ATCC_199 PRGYRKVIESLPLGANVATLIGHSDIRAAVMGLARATDYDERPTAGELAR
: ..: : . :*:: : ** :*. *:* . . :*
MMAR_0762|M.marinum_M MRALAKQAIEMGALGFASSRLTIHKTES----GSPIPSYDAARAEIEEIA
MUL_1396|M.ulcerans_Agy99 MRALAKQAIEIGALGFASSRLTIHKTES----GSPIPSYDAARAEIEEIA
MAV_4703|M.avium_104 MRALAKEAVEVGALGFASSRLTIHKTES----GSPIPSYDAAREEIEQIA
Mflv_0136|M.gilvum_PYR-GCK MRKLAAEAVHAGALGFASSRFTLHKTES----GQPIPSYNADYAEIEAIA
Mvan_0767|M.vanbaalenii_PYR-1 MRKLAAEAVQAGALGFASSRFTLHKTES----GRPIPSYDADRAEIEAIA
TH_2847|M.thermoresistible__bu MRALAAEAVAAGALGFASSRFALHKTES----GSPIPTYDAAQEEIAAIA
MSMEG_0883|M.smegmatis_MC2_155 MRALAREAIEAGALGFASSRLATHRTEG----GRQIPSFEAAYEEIREIA
Mb2937c|M.bovis_AF2122/97 MAKLLDEALEAGMLGMSGMDAAIDKLDGDRFRSRALPSTFATWRERRKLI
Rv2913c|M.tuberculosis_H37Rv MAKLLDEALEAGMLGMSGMDAAIDKLDGDRFRSRALPSTFATWRERRKLI
MAB_2965c|M.abscessus_ATCC_199 MRAMVTDALDAGFVGLSTDRLRFSKLEGTRFAGRQLPSTYATWREYGALY
* : :*: * :*:: : :. . :*: * * :
MMAR_0762|M.marinum_M KGVVDGGGGLLQFVPDIPAGGYQPVLQTVFDVAEEVGLPVTFSLVVGNVG
MUL_1396|M.ulcerans_Agy99 KGVVDGGGGLLQFVPDIPAGGYQPVLQTVFDVAEEVGLPVTFSLVVGNVG
MAV_4703|M.avium_104 RGVVDGGGGLLQFVPDIPAGGYQPVLQTVFDVAEDVGLPLTFTLVVANSG
Mflv_0136|M.gilvum_PYR-GCK RGVQDGGGGLIQFVPDLVAGDYEPVLQTVFDAAADVGLPVTFTLAVGNAG
Mvan_0767|M.vanbaalenii_PYR-1 RGVDDAGGGLIQFVPDLVAGDYEPVLQTVFDVAADVGLPVTFTLAIGNAG
TH_2847|M.thermoresistible__bu RGVADAGGGLLQFVPDIPAGGYESVLRQVFEVGAETGLPVTFSLLTGNAG
MSMEG_0883|M.smegmatis_MC2_155 RGIADGGGGLIQFVPDIPAGGYQPVLQQVFDAAGETGLPVTFSLLVLNAG
Mb2937c|M.bovis_AF2122/97 S-VLRHRGRILQSAPDVDN----PVSALLFFLASSRIFNRRKGVRMSMLV
Rv2913c|M.tuberculosis_H37Rv S-VLRHRGRILQSAPDVDN----PVSALLFFLASSRIFNRRKGVRMSMLV
MAB_2965c|M.abscessus_ATCC_199 D-VVRRRGAVVQSNLDVEKR---PETIMHFLLSGARPWRR--SLKTTLLA
: * ::* *: . * . :
MMAR_0762|M.marinum_M EPSWPDAITMVENANKNAGEGT-RFTAQLLPRPIGLIIGLQLSANPFVLY
MUL_1396|M.ulcerans_Agy99 EPSWPDAITMVENANKNAGEGT-RFTAQLLPRPIGLIIGLQLSANPFVLY
MAV_4703|M.avium_104 DPTWPDAITMIEKANAAGGD----ITAQLLPRPIGLIIGLQLSANPFVLY
Mflv_0136|M.gilvum_PYR-GCK DPFFLDALTMVEKANANGGD----ITAQIFPRPIGLVLGLELSGNPFVMY
Mvan_0767|M.vanbaalenii_PYR-1 DPFFLDALRMVEKANSNGGH----ISAQIFPRPIGLMLGLELSGNPFVMY
TH_2847|M.thermoresistible__bu EPTWPQALNLVEKFNAAAGGAAPAVTAQVFPRPIGMVMSLELSANPFVMY
MSMEG_0883|M.smegmatis_MC2_155 EPLWREAMEMVEKANTSATSAAPRVTAQVFPRPIGLMIGLELSANPFVLY
Mb2937c|M.bovis_AF2122/97 SADAKSMPLAVHVFGLGTRVLNKLLGSQVRFQHLPVPFELYSDGIDLPVF
Rv2913c|M.tuberculosis_H37Rv SADAKSMPLAVHVFGLGTRVLNKLLGSQVRFQHLPVPFELYSDGIDLPVF
MAB_2965c|M.abscessus_ATCC_199 AFDLKSNRSVIKLLKAATGGLNPLLRSQVNFQLLAVPFHLYSDGMDLVIF
. :. . :*: : : : : * .. : ::
MMAR_0762|M.marinum_M PSY-REIAHLPLAERVA--EMRKPDVRARILADKP--GVGHPILYVAQAW
MUL_1396|M.ulcerans_Agy99 PSY-REIAHLPLAERVA--EMRKPDVRARILADKP--GGGHPILYVAQAW
MAV_4703|M.avium_104 PSY-REIAHLPLAERVA--QMRKPEVRARILADKP--GEGHPILYVAQMW
Mflv_0136|M.gilvum_PYR-GCK PSY-REIAALPLAERVA--EMRKPEVRERILNDTPA-SDGHPLMFAAQAW
Mvan_0767|M.vanbaalenii_PYR-1 PSY-REIAALPLAERVA--QMRKPEVRERILNDKPE-SDGHPLMFAAQAW
TH_2847|M.thermoresistible__bu PSY-REIAGLPLPQQVA--EMRKPEVRERILNDKPA-GDGHPLFFMTQAW
MSMEG_0883|M.smegmatis_MC2_155 PSY-QEIAGLPLPERVA--QMRKPEVRERILSDKPGGTPANPLVYLAQAW
Mb2937c|M.bovis_AF2122/97 EEFGAGTAALHLRDQLQRNELLADRSYRRSFRREFDRIKLGPSLWHRDFH
Rv2913c|M.tuberculosis_H37Rv EEFGAGTAALHLRDQLQRNELLADRSYRRSFRREFDRIKLGPSLWHRDFH
MAB_2965c|M.abscessus_ATCC_199 EEFASGTAALDIRDQLQRVDLIKDEGYRRKFRKEMA-QKYGVVAWNRDMY
.: * * : ::: :: * : : :
MMAR_0762|M.marinum_M DWIFPLTEDPNYEPAAADSIGARARARGVSPMEEAYDRLLDDDGHAMLLV
MUL_1396|M.ulcerans_Agy99 DWIFPLTEDPNYEPAAADSIGARARARGVSPMEEAYDRLLDDDGHAMLLV
MAV_4703|M.avium_104 DWIYPLGDNPDYEPDPSTSIAARARARGVDPMEEAYDRLLDDDGRAMLLV
Mflv_0136|M.gilvum_PYR-GCK NYMFPLTDPPNYEPSPSDSIGARARARGVSPLEEAYDRLLDDDGHAMLLV
Mvan_0767|M.vanbaalenii_PYR-1 NYMFPLGEPPNYEPSPSDSIGARAQARGVSPLEEAYDRLLDDDGHAMLLV
TH_2847|M.thermoresistible__bu DWIYPLGEQPDYEPDASTSIAARARARGVSPLEEAYDRLLDDDGHAMLLI
MSMEG_0883|M.smegmatis_MC2_155 DWIFPLGPDANYEPDRSQSIAARARAHGVTPLEEAYDLLLEDDGHAILLG
Mb2937c|M.bovis_AF2122/97 DAVIVECPD---KSLIGKSFGAIADERGLHPLDAFLDVLVDNGERNVRWT
Rv2913c|M.tuberculosis_H37Rv DAVIVECPD---KSLIGKSFGAIADERGLHPLDAFLDVLVDNGERNVRWT
MAB_2965c|M.abscessus_ATCC_199 DTEIVGCPD---ESVVGKSFGQVADARGVQPVDAFLDLVSEYPG-KVRWH
: :. . *:. * :*: *:: * : : :
MMAR_0762|M.marinum_M ATSNMENNSLDTVGKLLHREDVVLGLGDGGAHYGMICDASYSTYFLTHWA
MUL_1396|M.ulcerans_Agy99 ATSNMENNSLDTVGKLLHREDVVLGLGDGGAHYGMICDASYSTYCLTHWA
MAV_4703|M.avium_104 ATSNLQGNSLDTVGELLHRDDVVLGLGDGGAHYGMICDASYSTYFLTHWA
Mflv_0136|M.gilvum_PYR-GCK TLANFRDGTLDTVAELIRRDDVVLGLGDGGAHYGMICDASFPTYMLTHWV
Mvan_0767|M.vanbaalenii_PYR-1 TLANFRDGSLDTVAELIRRDDVVLGLGDGGAHYGMICDASFPTYMLTHWV
TH_2847|M.thermoresistible__bu AMGNYENNSLDTVGQWMRRDDVVLGLGDGGAHYGMICDASYPTFLLAHWA
MSMEG_0883|M.smegmatis_MC2_155 ALANFYDNSLDTVGDLMTREDVVLGLGDGGAHYGMICDSSFPTYLLAHWA
Mb2937c|M.bovis_AF2122/97 TIVAN--HRPNQLNKLAAEPSVHMGFSDAGAHLRNMAFYNFGLRLLKRAR
Rv2913c|M.tuberculosis_H37Rv TIVAN--HRPNQLNKLAAEPSVHMGFSDAGAHLRNMAFYNFGLRLLKRAR
MAB_2965c|M.abscessus_ATCC_199 TTIAN--DRTDVLNEAVKYRHFQLGNNDSGAHLRNMSFYNAGLRLLKRVK
: : : . . :* .*.*** :. . * :
MMAR_0762|M.marinum_M RDRASGR--FSVAEAVRELTSVPARVAGLGDRGRIAVGYKADLNVID---
MUL_1396|M.ulcerans_Agy99 RDRASGR--FSVAEAVRELTSVPARVAGLGDRGRIAVGYKADLNVID---
MAV_4703|M.avium_104 RDRKSGR--FSVADAVRRLTSVPARVAGLGDRGRIAVGYKADLNVID---
Mflv_0136|M.gilvum_PYR-GCK RDRPSGR--LTVPEAVRELTSVPARVAGLGDRGRIAVGYKADLNVID---
Mvan_0767|M.vanbaalenii_PYR-1 RDRATGR--LSVQDAVRELTSVPARVAGLADRGRIAVGYKADLNVID---
TH_2847|M.thermoresistible__bu RDRASGR--LTVAEAVRALTSVPARVAGFGDRGRIAVGYKADLNVID---
MSMEG_0883|M.smegmatis_MC2_155 RDRAEGR--MSVPQAVRQLTSVPAQVAGLADRGRIAVGFKADLNVID---
Mb2937c|M.bovis_AF2122/97 DADRAGQPFLSIERAVYRLTGELAEWFGIG-AGTLRQGDRADFAVIDPTH
Rv2913c|M.tuberculosis_H37Rv DADRAGQPFLSIERAVYRLTGELAEWFGIG-AGTLRQGDRADFAVIDPTH
MAB_2965c|M.abscessus_ATCC_199 EAREAGTPFMSLEAAVHRLTGELGEWYGLD-AGRLRIGDTADIAVIDPAG
* ::: ** **. .. *: * : * **: ***
MMAR_0762|M.marinum_M -HTALRLHKPVIRYDLPAGGRRLDQTAEGYVATVVSGQVIAENG------
MUL_1396|M.ulcerans_Agy99 -HAALRLHKPVIRYDLPAGGRRLDQTAEGYVATVVSGQVIAENG------
MAV_4703|M.avium_104 -HAALRLHKPVISHDLPAGGRRLDQTADGYVATIVSGEIIAENG------
Mflv_0136|M.gilvum_PYR-GCK -ADTLRLHRPVIVKDLPGGGRRLDQTADGYVATIVSGEVIAENG------
Mvan_0767|M.vanbaalenii_PYR-1 -ADALTLHKPVIVNDLPAGGRRLDQTADGYVATIVSGEVIAENG------
TH_2847|M.thermoresistible__bu -HAALRLHRPVILHDLPSGGRRLDQRADGYVATVVSGHIIAENG------
MSMEG_0883|M.smegmatis_MC2_155 -HDALRLHKPVVTYDLPAGGRRLDQSADGYVATVVSGEVIAENG------
Mb2937c|M.bovis_AF2122/97 LDESVDGYHEEAVPYYGGLRRMVNRNDATVVATGVGGTVVFRGGQFGGQF
Rv2913c|M.tuberculosis_H37Rv LDESVDGYHEEAVPYYGGLRRMVNRNDATVVATGVGGTVVFRGGQFGGQF
MAB_2965c|M.abscessus_ATCC_199 LDDSLDEYHEQYMEEFG-VSRQVCRNDNAIAATIVGGQQVYSYG----TF
:: :: * : : .** *.* : *
MMAR_0762|M.marinum_M ---VPTAARPGKLVRGRQSAPVPA---
MUL_1396|M.ulcerans_Agy99 ---VPTAARPGKLVRGRQPAPVPA---
MAV_4703|M.avium_104 ---VPTAARPGKLVRGRRPGPAPLR--
Mflv_0136|M.gilvum_PYR-GCK ---EPTDARPGALIRGRRPAPVA----
Mvan_0767|M.vanbaalenii_PYR-1 ---QPTAARPGKLIRGRQPAPASA---
TH_2847|M.thermoresistible__bu ---VPTDARPGTLVRGRQPAPKVAG--
MSMEG_0883|M.smegmatis_MC2_155 ---VPTAARPGRLVRGRQSAPA-----
Mb2937c|M.bovis_AF2122/97 RDGYGQNVKSGRYLRAGELGAALSRSA
Rv2913c|M.tuberculosis_H37Rv RDGYGQNVKSGRYLRAGELGAALSRSA
MAB_2965c|M.abscessus_ATCC_199 VEGFGSTVKAGRFLAAS----------
.:.* : .