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TIMDEPLRYEKLDGGVAIVTNTDAPRNRMGLAYVERLSEVVDDIAADDEIRAFVITADGLENFSVGMNLK ELPTGIQAAGSVDAFFDRRLDLIQRIENMGKPSVATLFGHCLGAGLELPLGCTFRLAAAEGASIGLPELH LGSTPAWGGSARLAKTVGRQHALGMVLRAKTVTGPQAHAIGLVDEVWPLDELKDRATQLALELAGQPALA VRAMLGAFHDCEHRTLDELLAAERRAIHATLSSDDAREGMMAFLEKRPPVFNQPKRPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0245 | echA8_7 | - | 100% (269) | enoyl-CoA hydratase, EchA8_7 |
| M. marinum M | MMAR_4396 | echA8 | 2e-27 | 31.20% (250) | enoyl-CoA hydratase EchA8 |
| M. marinum M | MMAR_4676 | fadB | 5e-21 | 35.23% (193) | fatty oxidation protein FadB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1099c | echA8 | 6e-28 | 31.60% (250) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2036 | - | 9e-27 | 29.57% (257) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv1070c | echA8 | 6e-28 | 31.60% (250) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 3e-27 | 31.17% (247) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_1185c | - | 4e-25 | 29.18% (257) | enoyl-CoA hydratase |
| M. avium 104 | MAV_1195 | - | 2e-28 | 32.79% (247) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_5277 | - | 3e-26 | 29.57% (257) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_4102 | - | 1e-27 | 31.58% (247) | PUTATIVE short chain enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_4868 | echA8_7 | 1e-149 | 98.12% (266) | enoyl-CoA hydratase, EchA8_7 |
| M. vanbaalenii PYR-1 | Mvan_4681 | - | 2e-27 | 31.13% (257) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1099c|M.bovis_AF2122/97 ------MTYETILVERDQRVGIITLNRPQALNALNSQVMNEVTSAATELD
Rv1070c|M.tuberculosis_H37Rv ------MTYETILVERDQRVGIITLNRPQALNALNSQVMNEVTSAATELD
MLBr_02402|M.leprae_Br4923 ------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAAKELD
MAV_1195|M.avium_104 MTDSTDRTFETILVEREERVGIITLNRPKALNALNTQVMNEVTTAATDFD
Mflv_2036|M.gilvum_PYR-GCK ------MTFETILVDRDDRVATITLNRPKALNALNTQVMNEVTTAAAELD
Mvan_4681|M.vanbaalenii_PYR-1 ---MGSQNFETIIVERDDRVATITLNRPKALNALNSQVMDEVTTAAAELD
MSMEG_5277|M.smegmatis_MC2_155 -----MSDFETILVTRTDRVATIQLNRPKALNALNSQVMTEVTAAAAELD
TH_4102|M.thermoresistible__bu ---MSAKNYETILVTREDRVGIITLNRPKALNALNSQVMTEVTDAAAEFD
MAB_1185c|M.abscessus_ATCC_199 ---MTSHNFETILTERIDRVAVITLNRPKALNALNSQVMNEVTTAAAEFD
MMAR_0245|M.marinum_M ----MTIMDEPLRYEKLDGGVAIVTNTDAPRNRMGLAYVERLSEVVDDIA
MUL_4868|M.ulcerans_Agy99 -------MDEPLRYEKLDGGVAIVTNTDAPRNRMGLAYVERLSEVVDDIA
:.: : * * . * :. : .:: .. ::
Mb1099c|M.bovis_AF2122/97 DDPDIGAIIITGS-AKAFAAGADIKEMAD----LTFADAFTADFFATWGK
Rv1070c|M.tuberculosis_H37Rv DDPDIGAIIITGS-AKAFAAGADIKEMAD----LTFADAFTADFFATWGK
MLBr_02402|M.leprae_Br4923 IDPDVGAILITGS-PKVFAAGADIKEMAS----LTFTDAFDADFFSAWGK
MAV_1195|M.avium_104 ADPGIGAIIITGS-AKAFAAGADIKEMAE----LTFADAYGADFFAPWGK
Mflv_2036|M.gilvum_PYR-GCK AEPGVGAIIVTGS-ERAFAAGADIKEMAS----LSFADVFSSDFFAAWGK
Mvan_4681|M.vanbaalenii_PYR-1 ADAGVGAIILTGS-EKAFAAGADIKEMAG----LSFADVFSSDFFAGWGK
MSMEG_5277|M.smegmatis_MC2_155 KDPGVGAIIVTGN-EKAFAAGADIKEMAD----LSFAEVFEADFFELWSK
TH_4102|M.thermoresistible__bu SDPGIGAIIVTGN-EKAFAAGADIKEMAD----LEFADVFAADFFAPWSK
MAB_1185c|M.abscessus_ATCC_199 ADHGIGAIIITGS-EKAFAAGADIKEMSE----QSFSDMFGSDFFSAWGK
MMAR_0245|M.marinum_M ADDEIRAFVITADGLENFSVGMNLKELPTGIQAAGSVDAFFDRRLDLIQR
MUL_4868|M.ulcerans_Agy99 ADDEIRAFVITADGLENFSVGMNLKELPTGIQAAGSVDAFFDRRLDLIQR
: : *:::*.. . *:.* ::**:. : : : :
Mb1099c|M.bovis_AF2122/97 LAAVRTPTIAAVAGYALGGGCELAMMCDVLIAADT-AKFGQPEIKLGVLP
Rv1070c|M.tuberculosis_H37Rv LAAVRTPTIAAVAGYALGGGCELAMMCDVLIAADT-AKFGQPEIKLGVLP
MLBr_02402|M.leprae_Br4923 LAAVRTPMIAAVAGYALGGGCELAMMCDLLIAADT-AKFGQPEIKLGVLP
MAV_1195|M.avium_104 LAALRTPTIAAVAGHALGGGCELAMMCDVLIAADT-AKFGQPEIKLGVLP
Mflv_2036|M.gilvum_PYR-GCK FAATRTPTIAAVAGYALGGGCELAMMCDILIAADT-AKFGQPEIKLGVLP
Mvan_4681|M.vanbaalenii_PYR-1 FAATRTPTIAAVAGYALGGGCELAMMCDILIAADT-AKFGQPEIKLGVLP
MSMEG_5277|M.smegmatis_MC2_155 FAATRTPTIAAVAGYALGGGCELAMMCDILIAADT-AKFGQPEIKLGVLP
TH_4102|M.thermoresistible__bu FAATRTPTIAAVAGYALGGGCELAMMCDLLIAADT-AKFGQPEIKLGVLP
MAB_1185c|M.abscessus_ATCC_199 LGAVRTPTIAAVSGYALGGGCELAMMCDVIIAAEN-ATFGQPEIKLGVLP
MMAR_0245|M.marinum_M IENMGKPSVATLFGHCLGAGLELPLGCTFRLAAAEGASIGLPELHLGSTP
MUL_4868|M.ulcerans_Agy99 IENMGKPSVATLFGHCLGAGLELPLGCTFRLAAEEGASIGLPELHLGSTP
: .* :*:: *:.**.* **.: * . :** *.:* **::** *
Mb1099c|M.bovis_AF2122/97 GMGGSQRLTRAIGKAKAMDLILTGRTMDAAEAERSGLVSRVVPADDLLTE
Rv1070c|M.tuberculosis_H37Rv GMGGSQRLTRAIGKAKAMDLILTGRTMDAAEAERSGLVSRVVPADDLLTE
MLBr_02402|M.leprae_Br4923 GMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLLPE
MAV_1195|M.avium_104 GMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVPADDLLTE
Mflv_2036|M.gilvum_PYR-GCK GMGGSQRLTRAIGKAKAMDLILTGRNMDAEEAERAGLVSRVVPADSLLSE
Mvan_4681|M.vanbaalenii_PYR-1 GMGGSQRLTRAIGKAKAMDLILTGRNMGAEEAERAGLVSRVVPADTLLEE
MSMEG_5277|M.smegmatis_MC2_155 GMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERAGLVSRLVPADTLIDE
TH_4102|M.thermoresistible__bu GMGGSQRLTRAIGKAKAMDLILTGRTIDAEEAERSGLVSRVVPADKLLDE
MAB_1185c|M.abscessus_ATCC_199 GMGGSQRLTRAIGKAKAMDMILTGRNMDAAEAERSGLVSRVVATESLLDE
MMAR_0245|M.marinum_M AWGGSARLAKTVGRQHALGMVLRAKTVTGPQAHAIGLVDEVWPLDELKDR
MUL_4868|M.ulcerans_Agy99 AWGGSARLAKTLGRQHALGMVLRAKTVTGPQAHAIGLVDEVWPLDELKDR
. *** **::::*: :*:.::* .:.: . :*. ***..: : * .
Mb1099c|M.bovis_AF2122/97 ARATATTISQMSASAARMAKEAVNRAFESSLSEGLLYERRLFHSAFATED
Rv1070c|M.tuberculosis_H37Rv ARATATTISQMSASAARMAKEAVNRAFESSLSEGLLYERRLFHSAFATED
MLBr_02402|M.leprae_Br4923 AKAVATTISQMSRSATRMAKEAVNRSFESTLAEGLLHERRLFHSTFVTDD
MAV_1195|M.avium_104 AKKVATTISQMSRSAARMAKEAVNRAFETTLAEGLLYERRLFHSTFATAD
Mflv_2036|M.gilvum_PYR-GCK AKAVAQTIAGMSLSASRMAKEAVDRAFETTLSEGLLYERRLFHSAFATDD
Mvan_4681|M.vanbaalenii_PYR-1 ARSVAKTIAGMSLSASRMAKEAVDRAFETTLTEGLLYERRLFHSAFATDD
MSMEG_5277|M.smegmatis_MC2_155 ALAVAQTIAGMSLSASRMAKEAVNRAFETSLTEGLLYERRLFHSAFATAD
TH_4102|M.thermoresistible__bu AKETAATIAAMSLSAARMAKEAVNRAFETSLAEGLLFERRVFHSAFATAD
MAB_1185c|M.abscessus_ATCC_199 AKAVAKTISEMSLSASMMAKEAVNRAFESSLAEGLLFERRIFHSAFGTAD
MMAR_0245|M.marinum_M ATQLALELAGQPALAVRAMLGAFHDCEHRTLDELLAAERRAIHATLSSDD
MUL_4868|M.ulcerans_Agy99 ATQLALELAGQPALAVRAMLGAFHDCDHRTLDDLLAAERRAIHATLSSDD
* * :: . * *.. . . :* : * *** :*::: : *
Mb1099c|M.bovis_AF2122/97 QSEGMAAFIEKRAPQFTHR----
Rv1070c|M.tuberculosis_H37Rv QSEGMAAFIEKRAPQFTHR----
MLBr_02402|M.leprae_Br4923 QSEGMAAFIEKRAPQFTHR----
MAV_1195|M.avium_104 QSEGMAAFVEKRAPNFTHR----
Mflv_2036|M.gilvum_PYR-GCK QTEGMNAFSEKRSPNFTHR----
Mvan_4681|M.vanbaalenii_PYR-1 QTEGMNAFTEKRSPNFTHR----
MSMEG_5277|M.smegmatis_MC2_155 QKEGMAAFAEKRAANFTHR----
TH_4102|M.thermoresistible__bu QSEGMAAFTEKRPPKFTHR----
MAB_1185c|M.abscessus_ATCC_199 QSEGMAAFVEKRPANFIHR----
MMAR_0245|M.marinum_M AREGMMAFLEKRPPVFNQPKRPR
MUL_4868|M.ulcerans_Agy99 AREGMMAFLEKRPPVFNRPKRPR
*** ** ***.. * :