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M. leprae Br4923 MLBr_02219 (purQ)

annotation: phosphoribosylformylglycinamidine synthase I
coordinates: 2635930 - 2636604
length: 224

NARIGVITFPGTLDDVDAARAARHVGAEAVSLWHADADLKGVDAVVVPGGFSYGDYLRAGAIARLSPIMT
EVVDAVQRGMPVLGICNGFQVLCEAGLLPGALIRNVGLHFICRDVWLRVISTSTAWTSRFEPETDLLVSL
KSGEGRYVASENVLDELDGEGRVVFRYHDNINGSLRDIAGISSANGRVVGMMPHPEHAIEVLTGPSDDGL
GLFYSALDSVLAS*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_02219purQ-100% (224)phosphoribosylformylglycinamidine synthase I

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0812purQ1e-11489.19% (222) phosphoribosylformylglycinamidine synthase I
M. gilvum PYR-GCKMflv_1625-1e-10479.91% (224) phosphoribosylformylglycinamidine synthase subunit I
M. tuberculosis H37RvRv0788purQ1e-11489.19% (222) phosphoribosylformylglycinamidine synthase I
M. abscessus ATCC 19977MAB_0698-1e-10479.46% (224) phosphoribosylformylglycinamidine synthase I
M. marinum MMMAR_4897purQ1e-11387.95% (224) phosphoribosylformylglycinamidine synthase I, PurQ
M. avium 104MAV_0736purQ1e-11387.44% (223) phosphoribosylformylglycinamidine synthase subunit I
M. smegmatis MC2 155MSMEG_5831purQ1e-10277.13% (223) phosphoribosylformylglycinamidine synthase subunit I
M. thermoresistible (build 8)TH_0567purQ1e-10378.57% (224) PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE I PURG
M. ulcerans Agy99MUL_0401purQ1e-11387.50% (224) phosphoribosylformylglycinamidine synthase I
M. vanbaalenii PYR-1Mvan_5128-1e-10580.36% (224) phosphoribosylformylglycinamidine synthase subunit I

CLUSTAL 2.0.9 multiple sequence alignment


Mb0812|M.bovis_AF2122/97            MTARIGVVTFPGTLDDVDAARAARQVGAEVVSLWHADADLKGVDAVVVPG
Rv0788|M.tuberculosis_H37Rv         MTARIGVVTFPGTLDDVDAARAARQVGAEVVSLWHADADLKGVDAVVVPG
MAV_0736|M.avium_104                MTARIGIITFPGTLDDVDAARAARRVGAQPVSLWHADADLKGVDAVVVPG
MLBr_02219|M.leprae_Br4923          MNARIGVITFPGTLDDVDAARAARHVGAEAVSLWHADADLKGVDAVVVPG
MMAR_4897|M.marinum_M               MTARIGVITFPGTLDDVDAARAIRLVGAEAVNLWHADADLKGVEAVVVPG
MUL_0401|M.ulcerans_Agy99           MTARIGVITFPGTLDDVDAARAIRLVGAEAVNLWHADADLKGVEAVVVPG
Mflv_1625|M.gilvum_PYR-GCK          MTARVGVITFPGTLDDIDAARAVRLAGGEAVNLWHADADLKGVDAVIVPG
Mvan_5128|M.vanbaalenii_PYR-1       MTARVGVITFPGTLDDIDAARAVRLAGAEAVSLWHADADLKGVDAVVVPG
MSMEG_5831|M.smegmatis_MC2_155      MTTRVGVITFPGTLDDIDAARAVRLAGAEAVSLWHADADLHGVDAVVVPG
TH_0567|M.thermoresistible__bu      MSARIGVITFPGTLDDVDAARAVRLAGAEPVTLWHGDADLKGVDAVIVPG
MAB_0698|M.abscessus_ATCC_1997      MTARIGVITFPGTLDDVDAARAARLSGAEAVSLWHDDADLKSVDAVIVPG
                                    *.:*:*::********:***** *  *.: *.*** ****:.*:**:***

Mb0812|M.bovis_AF2122/97            GFSYGDYLRAGAIARFAPVMDEVVAAADRGMPVLGICNGFQVLCEAGLLP
Rv0788|M.tuberculosis_H37Rv         GFSYGDYLRAGAIARFAPVMDEVVAAADRGMPVLGICNGFQVLCEAGLLP
MAV_0736|M.avium_104                GFSYGDYLRAGAIARFAPVMTEVVDAARRGMPVLGICNGFQVLCEAGLLP
MLBr_02219|M.leprae_Br4923          GFSYGDYLRAGAIARLSPIMTEVVDAVQRGMPVLGICNGFQVLCEAGLLP
MMAR_4897|M.marinum_M               GFSYGDYLRAGAIARFAPVMGEVVSAAQRGMPVLGICNGFQVLCEAGLLP
MUL_0401|M.ulcerans_Agy99           GFSYGDYLRAGAIARFAPVMGEVVSAARRGMPVLGICNGFQVLCEAGLLP
Mflv_1625|M.gilvum_PYR-GCK          GFSYGDYLRAGAIARFAPVMGEVVAAAGRGMPVLGICNGFQVLCEAGLLP
Mvan_5128|M.vanbaalenii_PYR-1       GFSYGDYLRAGAIAKFAPVMGEVIEAAGRGMPVLGICNGFQVLCEAGLLP
MSMEG_5831|M.smegmatis_MC2_155      GFSYGDYLRCGAIAKFAPVMGSVVEAANKGMPVLGICNGFQVLCEAGLLP
TH_0567|M.thermoresistible__bu      GFSYGDYLRAGAIAKFAPVMGEVIEQAGRGLPVLGICNGFQVLCEAGLLP
MAB_0698|M.abscessus_ATCC_1997      GFSYGDYLRAGAIARFAPVMRSVVDAAAQGLPILGICNGFQVLCEAGLLP
                                    *********.****:::*:* .*:  . :*:*:*****************

Mb0812|M.bovis_AF2122/97            GALTRNVGLHFICRDVWLRVASTSTAWTSRFEPDADLLVPLKSGEGRYVA
Rv0788|M.tuberculosis_H37Rv         GALTRNVGLHFICRDVWLRVASTSTAWTSRFEPDADLLVPLKSGEGRYVA
MAV_0736|M.avium_104                GALTRNVGLHFICRDVWLRVASTSTAWTSRFEPDADLLVPLKSGEGRYVA
MLBr_02219|M.leprae_Br4923          GALIRNVGLHFICRDVWLRVISTSTAWTSRFEPETDLLVSLKSGEGRYVA
MMAR_4897|M.marinum_M               GALTRNVGLHFVCRDAWLRVASTSTAWTSRFEPDADLLVPLKSGEGRYVA
MUL_0401|M.ulcerans_Agy99           GALTRNVGLHFVCRDAWLRVASTSTAWTSRFEPAADLLVPLKSGEGRYVA
Mflv_1625|M.gilvum_PYR-GCK          GALTRNENLHFICRDTWLEVASNSSAWTSRYEQGADLLVPLKSGEGRYVA
Mvan_5128|M.vanbaalenii_PYR-1       GALTRNAGLHFICRDTWLEVASNTTAWTTRYEQGADLLVPLKSGEGRYVA
MSMEG_5831|M.smegmatis_MC2_155      GALTRNAGLHFVCRDVWLEVASNTSAWTTRYETGADLLIPLKSGEGRYVA
TH_0567|M.thermoresistible__bu      GALTRNIGLHFICRDVWLEVASNSTAWTTRYDVGADLLIPLKSGEGRYVA
MAB_0698|M.abscessus_ATCC_1997      GALTRNAGLHFVCRDVWLGVDANNTAWSSRYERDADILVPLKSGEGRYVA
                                    *** ** .***:***.** * :..:**::*::  :*:*:.**********

Mb0812|M.bovis_AF2122/97            PEKVLDELEGEGRVVFRYHDNVNGSLRDIAGICSANGRVVGLMPHPEHAI
Rv0788|M.tuberculosis_H37Rv         PEKVLDELEGEGRVVFRYHDNVNGSLRDIAGICSANGRVVGLMPHPEHAI
MAV_0736|M.avium_104                PADVLDELEGEGRVVFRYHENLNGSQRDIAGVSSADGRVVGLMPHPEHAI
MLBr_02219|M.leprae_Br4923          SENVLDELDGEGRVVFRYHDNINGSLRDIAGISSANGRVVGMMPHPEHAI
MMAR_4897|M.marinum_M               SEQVLDELEAEDRVVFRYHDNVNGSLRDIAGISSANGRVVGLMPHPEHAI
MUL_0401|M.ulcerans_Agy99           SEQVLDELEAEDRVVFRYHDNVNGSLRDIAGISSANGRVVGLMPHPEHAI
Mflv_1625|M.gilvum_PYR-GCK          STEVLDELEGEGRVVFRYRENLNGSMRAIAGISSANGRVVGLMPHPEHAT
Mvan_5128|M.vanbaalenii_PYR-1       GEAVLDELEGEGRVVFRYRENLNGSMRGIAGVSSANGRVVGLMPHPEHAT
MSMEG_5831|M.smegmatis_MC2_155      SESVLDELEGEDRVVFRYRENLNGSMRDIAGICSENRRVVGLMPHPEHAT
TH_0567|M.thermoresistible__bu      PESVLDELEGEGRVVFRYRENLNGSQRDIAGISSANGRVVGLMPHPEHAT
MAB_0698|M.abscessus_ATCC_1997      SDDVLDELEGEGRVVFRYRENPNGSMRDIAGISSANGRVVGLMPHPEHAT
                                       *****:.*.******::* *** * ***:.* : ****:******* 

Mb0812|M.bovis_AF2122/97            EALTGPSDDGLGLFYSALDAVLTG-
Rv0788|M.tuberculosis_H37Rv         EALTGPSDDGLGLFYSALDAVLTG-
MAV_0736|M.avium_104                EALTGPSDDGLGLFYSVLDGVLAG-
MLBr_02219|M.leprae_Br4923          EVLTGPSDDGLGLFYSALDSVLAS-
MMAR_4897|M.marinum_M               EALTGPSDDGLGLFYSALDAVLAA-
MUL_0401|M.ulcerans_Agy99           EALTGPSDDGLGLFYSALDAVLAA-
Mflv_1625|M.gilvum_PYR-GCK          EALTGPSDDGLGIFYSALDAVLVA-
Mvan_5128|M.vanbaalenii_PYR-1       EALTGPSDDGLGIFYSALDAVLVS-
MSMEG_5831|M.smegmatis_MC2_155      EALTGPSDDGLGLFYSALDAILSV-
TH_0567|M.thermoresistible__bu      EALTGPSDDGLGMFLSVLDSVLTAA
MAB_0698|M.abscessus_ATCC_1997      EPLTGPSDDGLGIFYSALDAVLTAG
                                    * **********:* *.**.:*