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M. leprae Br4923 MLBr_02157 (-)

annotation: putative DNA helicase
coordinates: 2559261 - 2560910
length: 549

MTDGPLIVQSDKTVLLEVNHKLADAARAAIAPFAELERAPEHVHTYRITPLALWNARAAGHDAEQVVDTL
ISHARYAVPQPLLVDIVDTMARYGRLQLVKNPAHGLTLVSLDRTVLEEVLHNKKIAPMVGGRIDDDTVVV
HPSERGRIKQLLLKIGWPAEDLAGYVDGEAHPIILHQDGWQLRDYQRLAADSFWSGGSGVVVLPCGAGKT
LVGAAAMAKTGATTLILVTNIVVARQWKRELITHTSLTEDEIGEYSGERKEIRPVTISTYQMITHRTKGE
YRHLELFNSRDWGLIIYDEVHLLPAPVFRMTADLQSKRRLGLTATLIREDGREGDVFSLIGPKRYDTPWK
DLEEQGWIAPAKCVEVRVTLTNNERMTYATAEPEERYRVCSTAHSKIAVVKSVLSRHPGEQTLVIGAYLD
QLNELGSELNAPIIQGSTRTKEREALFDAFRRGEVFTLVVSKVANFSIDLPEAAVAVQVSGTFGSRQEEA
QRLGRLLRPKADGGGAIFYSVVARDSLDAEYAAHRQRFLAEQGYSYIIRDADDLLGPAI
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_02157--100% (549)putative DNA helicase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0884c-0.091.14% (542) DNA helicase
M. gilvum PYR-GCKMflv_1697-0.086.34% (549) type III restriction enzyme, res subunit
M. tuberculosis H37RvRv0861cercc30.091.33% (542) DNA helicase ErcC3
M. abscessus ATCC 19977MAB_0860c-0.086.70% (549) DNA helicase
M. marinum MMMAR_4671ercc30.089.25% (549) DNA helicase Ercc3
M. avium 104MAV_0990-0.091.07% (549) DNA or RNA helicase of superfamily protein II
M. smegmatis MC2 155MSMEG_5706-0.087.07% (549) DNA or RNA helicase of superfamily protein II
M. thermoresistible (build 8)-----
M. ulcerans Agy99MUL_0289ercc30.088.56% (542) DNA helicase Ercc3
M. vanbaalenii PYR-1Mvan_5056-0.087.25% (549) type III restriction enzyme, res subunit

CLUSTAL 2.0.9 multiple sequence alignment


Mb0884c|M.bovis_AF2122/97           -------------------------------------------MQSDKTV
Rv0861c|M.tuberculosis_H37Rv        -------------------------------------------MQSDKTV
MAV_0990|M.avium_104                ------------------------------------MSDGPLIVQSDKTV
MLBr_02157|M.leprae_Br4923          ------------------------------------MTDGPLIVQSDKTV
MMAR_4671|M.marinum_M               ------------------------------------MTDGPLIVQSDKTV
MUL_0289|M.ulcerans_Agy99           -------------------------------------------MQSDKTV
Mflv_1697|M.gilvum_PYR-GCK          ------------------------------------MTDGPLIVQSDKTV
Mvan_5056|M.vanbaalenii_PYR-1       ------------------------------------MTDGPLIVQSDKTV
MSMEG_5706|M.smegmatis_MC2_155      MSLSAFSAPSARRTVCQRVRNNGQDEFPAEQRSGQRMTDGPLIVQSDKTV
MAB_0860c|M.abscessus_ATCC_199      ------------------------------------MTDGPLIVQSDKTV
                                                                               :******

Mb0884c|M.bovis_AF2122/97           LLEVDHELAGAARAAIAPFAELERAPEHVHTYRITPLALWNARAAGHDAE
Rv0861c|M.tuberculosis_H37Rv        LLEVDHELAGAARAAIAPFAELERAPEHVHTYRITPLALWNARAAGHDAE
MAV_0990|M.avium_104                LLEVDHELAGAARAAIAPFAELERAPEHVHTYRITPLALWNARAAGHDAE
MLBr_02157|M.leprae_Br4923          LLEVNHKLADAARAAIAPFAELERAPEHVHTYRITPLALWNARAAGHDAE
MMAR_4671|M.marinum_M               LLEVDHEQAGAARAAIAPFAELERAPEHVHTYRITPLALWNARAAGHDAE
MUL_0289|M.ulcerans_Agy99           LLEVDHEQAGAARAAIAPFAELERAPEHVHTYRITPLALWNARAAGHDAE
Mflv_1697|M.gilvum_PYR-GCK          LLEVDHEQAGAARAAIAPFAELERAPEHIHTYRITPLALWNARAAGHDAE
Mvan_5056|M.vanbaalenii_PYR-1       LLEVDHEQAGAARAAIAPFAELERAPEHVHTYRITPLALWNARAAGHDAE
MSMEG_5706|M.smegmatis_MC2_155      LLEVDHELAGAARAAIAPFAELERAPEHVHTYRITPLALWNARAAGHDAE
MAB_0860c|M.abscessus_ATCC_199      LLEVDHDQADAARQAIAPFAELERAPEHVHTYRITPLALWNARAAGHDAE
                                    ****:*. *.*** **************:*********************

Mb0884c|M.bovis_AF2122/97           QVVDALVSYSRYAVPQPLLVDIVDTMARYGRLQLVKNPAHGLTLVSLDRA
Rv0861c|M.tuberculosis_H37Rv        QVVDALVSYSRYAVPQPLLVDIVDTMARYGRLQLVKNPAHGLTLVSLDRA
MAV_0990|M.avium_104                QVVDALVSFSRYAVPQPLLVDIVDTMARYGRLQLVKNPAHGLTLVSLDRA
MLBr_02157|M.leprae_Br4923          QVVDTLISHARYAVPQPLLVDIVDTMARYGRLQLVKNPAHGLTLVSLDRT
MMAR_4671|M.marinum_M               QVVDALVTHSRYAVPQPLLVDIVDTMARYGRLQLVKHPAHGLTLISLDRA
MUL_0289|M.ulcerans_Agy99           QVVDALVTHSRYAVPQPLLVDIVDTMARYGRLQLVKHPAHGLTLISLDRA
Mflv_1697|M.gilvum_PYR-GCK          QVVDALVSFSRYAVPQPLLVDIVDTMARYGRLQLVKHPAHGLTLVSFDRA
Mvan_5056|M.vanbaalenii_PYR-1       QVVDALVTFSRYAVPQPLLVDIVDTMARYGRLQLVKHPAHGLTLVSFDRA
MSMEG_5706|M.smegmatis_MC2_155      QVVDALVSFSRYPVPQPLLVDIVDTMARYGRLQLVKHPAHGLTLVSFDRA
MAB_0860c|M.abscessus_ATCC_199      QVVDALVTFSRYAVPQPLLVDIVDTMARYGRLQLVKHPAHGLTLVSLDRA
                                    ****:*::.:**.***********************:*******:*:**:

Mb0884c|M.bovis_AF2122/97           VLEEVLRNKKIAPMLGARIDDDTVVVHPSERGRVKQLLLKIGWPAEDLAG
Rv0861c|M.tuberculosis_H37Rv        VLEEVLRNKKIAPMLGARIDDDTVVVHPSERGRVKQLLLKIGWPAEDLAG
MAV_0990|M.avium_104                VLEEVLRNKKIAPMLGARIDDDTVVVHPSERGRVKQMLLKIGWPAEDLAG
MLBr_02157|M.leprae_Br4923          VLEEVLHNKKIAPMVGGRIDDDTVVVHPSERGRIKQLLLKIGWPAEDLAG
MMAR_4671|M.marinum_M               VLEEVLRNKKIAPMLGARIDDDTVIVHPSERGRVKQLLLKIGWPAEDLAG
MUL_0289|M.ulcerans_Agy99           VLEEVLRNKKIAPMLGARIDDDTVIVHPSERGRVKQLLLKIGWPAEDLAG
Mflv_1697|M.gilvum_PYR-GCK          VLEEVLRNKKIAPMLGARLDDDTVIVHNSERGRVKQMLLKIGWPAEDLAG
Mvan_5056|M.vanbaalenii_PYR-1       VLEEVLRNKKIAPMLGARLDDDTVIVHNSERGRVKQMLLKIGWPAEDLAG
MSMEG_5706|M.smegmatis_MC2_155      VLEEVLRNKKIAPMLGARIDDDTVIVHNSERGRVKQMLLKIGWPAEDLAG
MAB_0860c|M.abscessus_ATCC_199      VLEEVLRHKKIAPMFGARIDDDTIQVHPSERGRIKQMLLKIGWPAEDLAG
                                    ******::******.*.*:****: ** *****:**:*************

Mb0884c|M.bovis_AF2122/97           YVDGEAHPISLHQEGWQLRDYQRLAADSFWAGGSGVVVLPCGAGKTLVGA
Rv0861c|M.tuberculosis_H37Rv        YVDGEAHPISLHQEGWQLRDYQRLAADSFWAGGSGVVVLPCGAGKTLVGA
MAV_0990|M.avium_104                YVDGEAHPISLTEDGWQLRDYQQMAADSFWSGGSGVVVLPCGAGKTLVGA
MLBr_02157|M.leprae_Br4923          YVDGEAHPIILHQDGWQLRDYQRLAADSFWSGGSGVVVLPCGAGKTLVGA
MMAR_4671|M.marinum_M               YVNGEAHPISLQPDGWELRDYQQLATDSFWAGGSGVVVLPCGAGKTLVGA
MUL_0289|M.ulcerans_Agy99           YVNGEAHPISLQPDGWELRDYQQLATDSFWAGGSGVVVLPCGAGKTLVGA
Mflv_1697|M.gilvum_PYR-GCK          YVDGEAHPIALEQDGWELRDYQQMAADSFWDGGSGVVVLPCGAGKTLVGA
Mvan_5056|M.vanbaalenii_PYR-1       YVDGEAHPIELAQDGWQLRDYQQMAADSFWDGGSGVVVLPCGAGKTLVGA
MSMEG_5706|M.smegmatis_MC2_155      YVDGEAHPITLEQDGWALRDYQEMAADSFWAGGSGVVVLPCGAGKTLVGA
MAB_0860c|M.abscessus_ATCC_199      YVDGEAHPITLAQDGWELRDYQQMAADSFWAGGSGVVVLPCGAGKTLVGA
                                    **:****** *  :** *****.:*:**** *******************

Mb0884c|M.bovis_AF2122/97           AAMAKAGATTLILVTNIVAARQWKRELVARTSLTENEIGEFSGERKEIRP
Rv0861c|M.tuberculosis_H37Rv        AAMAKAGATTLILVTNIVAARQWKRELVARTSLTENEIGEFSGERKEIRP
MAV_0990|M.avium_104                AAMAKAGATTLILVTNIVAARQWKRELVTRTSLTEDEIGEYSGERKEIRP
MLBr_02157|M.leprae_Br4923          AAMAKTGATTLILVTNIVVARQWKRELITHTSLTEDEIGEYSGERKEIRP
MMAR_4671|M.marinum_M               AAMAKAQATTLILVTNIVAARQWKRELVARTSLTEEEIGEYSGERKEIRP
MUL_0289|M.ulcerans_Agy99           AAMAKAQATTLILVTNIVAARQWKRELVARTSLTEEEIGEYSGERKEIRP
Mflv_1697|M.gilvum_PYR-GCK          AAMARAGATTLILVTNTVAGRQWKRELIARTTLTEEEIGEYSGERKEIRP
Mvan_5056|M.vanbaalenii_PYR-1       AAMAKAGATTLILVTNTVAGRQWKRELVARTSLTEEEIGEYSGERKEIRP
MSMEG_5706|M.smegmatis_MC2_155      AAMAKAGATTLILVTNTVAGRQWKRELVARTSLTEDEIGEYSGEKKEIRP
MAB_0860c|M.abscessus_ATCC_199      AAMAKAQATTLILVTNTVAGRQWKRELLARTSLTEDEIGEYSGERKEIRP
                                    ****:: ********* *..*******:::*:***:****:***:*****

Mb0884c|M.bovis_AF2122/97           ATISTYQMITRRTKGEYRHLELFDSRDWGLIIYDEVHLLPAPVFRMTADL
Rv0861c|M.tuberculosis_H37Rv        VTISTYQMITRRTKGEYRHLELFDSRDWGLIIYDEVHLLPAPVFRMTADL
MAV_0990|M.avium_104                VTISTYQMITRRTKGEYRHLELFDSRDWGLIIYDEVHLLPAPVFRMTADL
MLBr_02157|M.leprae_Br4923          VTISTYQMITHRTKGEYRHLELFNSRDWGLIIYDEVHLLPAPVFRMTADL
MMAR_4671|M.marinum_M               VTISTYQMITRRSKGEYRHLELFDSRDWGLIIYDEVHLLPAPVFRMTADL
MUL_0289|M.ulcerans_Agy99           VTISTYQMITRRSKGEYRHLELFDSRDWGLIIYDEVHLLPAPVFRMTADL
Mflv_1697|M.gilvum_PYR-GCK          VTIATYQVITRRTKGEYKHLELFDSRDWGLIVYDEVHLLPAPVFRMTADL
Mvan_5056|M.vanbaalenii_PYR-1       VTIATYQVITRRTKGEYKHLELFDSRDWGLIIYDEVHLLPAPVFRMTADL
MSMEG_5706|M.smegmatis_MC2_155      VTIATYQVITRRTKGEYKHLELFDSRDWGLIIYDEVHLLPAPVFRMTADL
MAB_0860c|M.abscessus_ATCC_199      VTIATYQVITRRTKGEYRHLELFDSRDWGLIVYDEVHLLPAPVFRMTADL
                                    .**:***:**:*:****:*****:*******:******************

Mb0884c|M.bovis_AF2122/97           QSKRRLGLTATLIREDGREGDVFSLIGPKRYDAPWKDIEAQGWIAPAECV
Rv0861c|M.tuberculosis_H37Rv        QSKRRLGLTATLIREDGREGDVFSLIGPKRYDAPWKDIEAQGWIAPAECV
MAV_0990|M.avium_104                QSKRRLGLTATLVREDGREGDVFSLIGPKRYDAPWKDIEAQGWIAPAECV
MLBr_02157|M.leprae_Br4923          QSKRRLGLTATLIREDGREGDVFSLIGPKRYDTPWKDLEEQGWIAPAKCV
MMAR_4671|M.marinum_M               QSKRRLGLTATLIREDGREGDVFSLIGPKRYDAPWKDIEAQGWIAPAECV
MUL_0289|M.ulcerans_Agy99           QSKRRLGLTATLIREDGREGDVFSLIGPKRYDAPWKDIEAQGWIAPAECV
Mflv_1697|M.gilvum_PYR-GCK          QSRRRLGLTATLIREDGREGDVFSLIGPKRYDAPWKDIEAQGWIAPAECV
Mvan_5056|M.vanbaalenii_PYR-1       QSRRRLGLTATLIREDGREGDVFSLIGPKRYDAPWKDIEAQGWIAPAECV
MSMEG_5706|M.smegmatis_MC2_155      QSRRRLGLTATLIREDGREGDVFSLIGPKRYDAPWKDIEAQGWIAPAECI
MAB_0860c|M.abscessus_ATCC_199      QSRRRLGLTATLIREDGREGDVFSLIGPKRYDAPWKDIEAQGWIAPAECI
                                    **:*********:*******************:****:* *******:*:

Mb0884c|M.bovis_AF2122/97           EVRVTMTDSERMMYATAEPEERYRICSTVHTKIAVVKSILAKHPDEQTLV
Rv0861c|M.tuberculosis_H37Rv        EVRVTMTDSERMMYATAEPEERYRICSTVHTKIAVVKSILAKHPDEQTLV
MAV_0990|M.avium_104                EVRVTMTDNERMMYATAEPEERYRLCSTVHTKIAVVKSILDKHPGEQTLV
MLBr_02157|M.leprae_Br4923          EVRVTLTNNERMTYATAEPEERYRVCSTAHSKIAVVKSVLSRHPGEQTLV
MMAR_4671|M.marinum_M               EVRVTMTDSERMTYATAEPEERYRLCSTVHTKIAVVKSILQRHPGEQTLV
MUL_0289|M.ulcerans_Agy99           EVRVTMTDSERMAYATAEPEERYRLCSTVHTKIAVVKSILQRHPGEQTLV
Mflv_1697|M.gilvum_PYR-GCK          EVRVTMTDNERMLYATAEPEERYKLCATAHTKIAVVKSILDRHPNEPTLV
Mvan_5056|M.vanbaalenii_PYR-1       EVRVTMTDNERMMYATAEPDERYKLCATAHTKIAVVKSILERHPDEPTLV
MSMEG_5706|M.smegmatis_MC2_155      EVRVTMTDNERMLYATSEPDERYKLCSTVHTKIAVVRSILERHPNEPTLV
MAB_0860c|M.abscessus_ATCC_199      EVRVTLTDNERMIYATAEADERYKLCSTAHTKINVVKSILARHPGAPTLV
                                    *****:*:.*** ***:*.:***::*:*.*:** **:*:* :**.  ***

Mb0884c|M.bovis_AF2122/97           IGAYLDQLDELGAELGAPVIQGSTRTSEREALFDAFRRGEVATLVVSKVA
Rv0861c|M.tuberculosis_H37Rv        IGAYLDQLDELGAELGAPVIQGSTRTSEREALFDAFRRGEVATLVVSKVA
MAV_0990|M.avium_104                IGAYLDQLDELGEQLGAPVIQGSTRTKEREELFDAFRRGEVNTLVVSKVA
MLBr_02157|M.leprae_Br4923          IGAYLDQLNELGSELNAPIIQGSTRTKEREALFDAFRRGEVFTLVVSKVA
MMAR_4671|M.marinum_M               IGAYLDQLEELGTELDAPVIQGATKTREREALFDAFRRGEIATLVVSKVA
MUL_0289|M.ulcerans_Agy99           IGAYLDQLEELGTELDAPVIQGATKTREREALFDAFRRGEIATLVVSKVA
Mflv_1697|M.gilvum_PYR-GCK          IGAYLDQLDELGTELNAPVIQGSTKNAEREELFDGFRRGEIRTLVVSKVA
Mvan_5056|M.vanbaalenii_PYR-1       IGAYLDQLDELGTELNAPVIQGSTKNAEREALFDAFRRGEIRTLVVSKVA
MSMEG_5706|M.smegmatis_MC2_155      IGAYLDQLEELGQELDAPVIQGSTKNAEREALFDAFRRGEIRTLVVSKVA
MAB_0860c|M.abscessus_ATCC_199      IGAYLDQLDELGTELDAPVIQGSTKNAEREALFDAFRRGEIGTLVVSKVA
                                    ********:*** :*.**:***:*:. *** ***.*****: ********

Mb0884c|M.bovis_AF2122/97           NFSIDLPEAAVAVQVSGTFGSRQEEAQRLGRILRPKADGGGAIFYSVVAR
Rv0861c|M.tuberculosis_H37Rv        NFSIDLPEAAVAVQVSGTFGSRQEEAQRLGRILRPKADGGGAIFYSVVAR
MAV_0990|M.avium_104                NFSIDLPEAAVAVQVSGTFGSRQEEAQRLGRLLRPKSDGGGAVFYSVVAR
MLBr_02157|M.leprae_Br4923          NFSIDLPEAAVAVQVSGTFGSRQEEAQRLGRLLRPKADGGGAIFYSVVAR
MMAR_4671|M.marinum_M               NFSIDLPEASVAVQVSGTFGSRQEEAQRLGRLLRPKSDGGGAMFYSVVAR
MUL_0289|M.ulcerans_Agy99           NFSIDLPEASVAVQVSGTFGSRQEEAQRLGRLLRPKSDGGRAMFYSVVAR
Mflv_1697|M.gilvum_PYR-GCK          NFSIDLPEASVAVQVSGTFGSRQEEAQRLGRLLRPKADGGGAVFYSVVSR
Mvan_5056|M.vanbaalenii_PYR-1       NFSIDLPEASVAVQVSGTFGSRQEEAQRLGRLLRPKADGGGAVFYSVVSR
MSMEG_5706|M.smegmatis_MC2_155      NFSIDLPEASVAVQVSGTFGSRQEEAQRLGRLLRPKADGGGAVFYSVVSR
MAB_0860c|M.abscessus_ATCC_199      NFSIDLPEASVAVQVSGTFGSRQEEAQRLGRLLRPKADGGQAYFYSVVSR
                                    *********:*********************:****:*** * *****:*

Mb0884c|M.bovis_AF2122/97           DSLDAEYAAHRQRFLAEQGYGYIIRDADDLLGPAI-
Rv0861c|M.tuberculosis_H37Rv        DSLDAEYAAHRQRFLAEQGYGYIIRDADDLLGPAI-
MAV_0990|M.avium_104                DSLDAEYAAHRQRFLAEQGYGYIIRDADDLLGPAI-
MLBr_02157|M.leprae_Br4923          DSLDAEYAAHRQRFLAEQGYSYIIRDADDLLGPAI-
MMAR_4671|M.marinum_M               DSLDAEYAAHRQRFLAEQGYGYIIRDADDLLGPAI-
MUL_0289|M.ulcerans_Agy99           DSLDSEYAAHRQRFLAEQGYGYIIRDADDLLGPAI-
Mflv_1697|M.gilvum_PYR-GCK          DSLDAEYAAHRQRFLAEQGYGYVIKDADDLLGPTI-
Mvan_5056|M.vanbaalenii_PYR-1       DSLDAEYAAHRQRFLAEQGYGYVIKDADDLLGPAI-
MSMEG_5706|M.smegmatis_MC2_155      DSLDAEYAAHRQRFLAEQGYGYIIKDADDLLGPAI-
MAB_0860c|M.abscessus_ATCC_199      DTLDAEYAAHRQRFLAEQGYGYRITDADDLLGPTIG
                                    *:**:***************.* * ********:*