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VGLAVHSESVLINDGGLATELEARGNDLSDPLWSARLLTDAPQEIVAVHVAYFRAGATIATTVSYQASFE GFAARGIGRDQAIRLMRRSVALASAARDEISAGGLCVAASVGPYGAALADGSEYRGRYGLSVAALARWHR PRLEVLADAGADVLALETIPDIDEAEALVDLVRSVGVPAWLSYTINGTRTRAGQPLAEAFAVAAGVPKIV AVGVNCCAPDDVLAAIQIANIGKPIIVYPNSGERWDYRTWTGPRRFSAQLALQWTAAGARIVGGCCRVRP ADIAELTKALASR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01478 | mmuM | - | 100% (293) | homocysteine methyltransferase |
| M. leprae Br4923 | MLBr_01307 | metH | 3e-09 | 24.19% (310) | 5-methyltetrahydrofolate-homocysteine methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2485 | mmuM | 1e-127 | 78.84% (293) | homocysteine methyltransferase |
| M. gilvum PYR-GCK | Mflv_3053 | metH | 8e-16 | 28.66% (314) | B12-dependent methionine synthase |
| M. tuberculosis H37Rv | Rv2458 | mmuM | 1e-127 | 78.84% (293) | homocysteine methyltransferase |
| M. abscessus ATCC 19977 | MAB_2129 | metH | 5e-16 | 27.67% (318) | B12-dependent methionine synthase |
| M. marinum M | MMAR_4825 | metH | 2e-16 | 28.04% (321) | 5-methyltetrahydrofolate--homocysteine methyltransferase, |
| M. avium 104 | MAV_1715 | mmuM | 1e-120 | 78.70% (277) | homocysteine methyltransferase |
| M. smegmatis MC2 155 | MSMEG_4185 | metH | 5e-16 | 27.44% (317) | B12-dependent methionine synthase |
| M. thermoresistible (build 8) | TH_0958 | metH | 7e-07 | 24.18% (306) | Probable 5-methyltetrahydrofolate--homocystein |
| M. ulcerans Agy99 | MUL_0395 | metH | 2e-16 | 28.04% (321) | B12-dependent methionine synthase |
| M. vanbaalenii PYR-1 | Mvan_3474 | metH | 4e-14 | 29.39% (279) | B12-dependent methionine synthase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2129|M.abscessus_ATCC_1997 --------------------------MT--NLQP-----NVRPDCTEALT
Mvan_3474|M.vanbaalenii_PYR-1 --------------------------MN--SADPNIWEPNIRPDCTDELK
MSMEG_4185|M.smegmatis_MC2_155 --------------------------MN--AVRSETLAPNIRPDCTDALT
Mflv_3053|M.gilvum_PYR-GCK --------------------------MEGAHVNAVEFEPNIRPDCTEELT
MMAR_4825|M.marinum_M ---------------------------------MSAFEPNIRPDCTDALT
MUL_0395|M.ulcerans_Agy99 MWVERRCNGSPVPRRYPPRSAESRTPSATEGINVSAFEPNIRPDCTDALT
TH_0958|M.thermoresistible__bu ------------------------MKQVAHDDYAVGVTPVDTAVYDTDLL
Mb2485|M.bovis_AF2122/97 -------------------------------------------------M
Rv2458|M.tuberculosis_H37Rv -------------------------------------------------M
MLBr_01478|M.leprae_Br4923 -----------------------------------------------MGL
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 AALEQRILVIDGAMGTAIQRDRPDEAGYRGERFADWPSDLVGNNDLLTLT
Mvan_3474|M.vanbaalenii_PYR-1 VALGRRIVVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLTLT
MSMEG_4185|M.smegmatis_MC2_155 AALRQRILVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLNLT
Mflv_3053|M.gilvum_PYR-GCK AALRERIMVIDGAMGTAIQRDRPDEAGYRGDRFTEWPTALQGNNDLLNLT
MMAR_4825|M.marinum_M AALGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLT
MUL_0395|M.ulcerans_Agy99 ATLGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPSDLVGNNDLLSLT
TH_0958|M.thermoresistible__bu ETLSRRVMVGDGAMGTQLQAADLTLDDFNG---------LEGCNEILNET
Mb2485|M.bovis_AF2122/97 ELVSDSVLISDGGLATELEARGHDLS-------------DPLWSARLLVD
Rv2458|M.tuberculosis_H37Rv ELVSDSVLISDGGLATELEARGHDLS-------------DPLWSARLLVD
MLBr_01478|M.leprae_Br4923 AVHSESVLINDGGLATELEARGNDLS-------------DPLWSARLLTD
MAV_1715|M.avium_104 -------MLLDGGLATELEARGHDLS-------------DPLWSARLLAD
:: **.:.* :: . *
MAB_2129|M.abscessus_ATCC_1997 QPHIIEGIHREYLEAGADILETNTFNANAVSLSDYGME-ELSYELNYAGA
Mvan_3474|M.vanbaalenii_PYR-1 QPQIIEGIHREYLEAGADILETNTFNANAVSLSDYGME-KLSYELNYAGA
MSMEG_4185|M.smegmatis_MC2_155 QPHIIEAIHREYLDAGADLLETNTFNANAVSLSDYGMQ-ELAYELNYAGA
Mflv_3053|M.gilvum_PYR-GCK QPQIIEAIHREYLDAGADILETNTFNANAISLSDYDMT-DLAYELNYAGA
MMAR_4825|M.marinum_M QPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMA-ELAYELNYAGA
MUL_0395|M.ulcerans_Agy99 QPQIIEGIHREYLQAGADILETNTFNANAVSLSDYDMA-ELAYELNYAGA
TH_0958|M.thermoresistible__bu RPDVIAEIHRNYLAAGADAVETNTFGCNLSNLGDYDIA-DKIRSLSEQGT
Mb2485|M.bovis_AF2122/97 APHAITAVHTAYFRAGAQIATTASYQASFEGFAARGIGHDDATVLLRRSV
Rv2458|M.tuberculosis_H37Rv APHAITAVHTAYFRAGAQIATTASYQASFEGFAARGIGHDDATVLLRRSV
MLBr_01478|M.leprae_Br4923 APQEIVAVHVAYFRAGATIATTVSYQASFEGFAARGIGRDQAIRLMRRSV
MAV_1715|M.avium_104 APQEIGAVHAAYFRAGAMIATTASYQASFEGFAARGISRSDTAGLLRRSV
*. * :* *: *** * :: .. .:. .: . * ..
MAB_2129|M.abscessus_ATCC_1997 ALARVAADEYSTPAKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLV
Mvan_3474|M.vanbaalenii_PYR-1 ALARKACDEFSTPDKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLV
MSMEG_4185|M.smegmatis_MC2_155 ALARAACDEYSTPDKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLA
Mflv_3053|M.gilvum_PYR-GCK ALARKAADEYSTADKPRYVAGAIGPTTRTASISPDVNDPGARNVSYDQLV
MMAR_4825|M.marinum_M ALARAAADEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLV
MUL_0395|M.ulcerans_Agy99 ALARAAADEFSTPEKPRYVAGALGPTTRTASISPDVNDPGARNVSYDQLV
TH_0958|M.thermoresistible__bu AIARRVADEMSTPDHRRYVLAAMGPGTKLPTLG---------HTEFGVIR
Mb2485|M.bovis_AF2122/97 ELAQAARDEVGVGGL--SVAASVGPYG--AALADGSEYRGCYGLSVAALM
Rv2458|M.tuberculosis_H37Rv ELAQAARDEVGVGGL--SVAASVGPYG--AALADGSEYRGYYGLSVAALM
MLBr_01478|M.leprae_Br4923 ALASAARDEISAGGL--CVAASVGPYG--AALADGSEYRGRYGLSVAALA
MAV_1715|M.avium_104 ELAKAARDEAGVAG---YVAASVGPYG--AALADGSEYRGRYGLSVRQLE
:* . ** .. * .::** .::. . :
MAB_2129|M.abscessus_ATCC_1997 AAYLEAANGLVDGGADIILVETIFDSLNAKAAVFAIETLFEQRGRRWPII
Mvan_3474|M.vanbaalenii_PYR-1 AAYLDAASGLVDGGADLLIVETIFDTLNAKAAVFAIETLFEDRGRRWPVI
MSMEG_4185|M.smegmatis_MC2_155 EAYLEAARGLVDGGADLIIVETIFDTLNAKAAIFAIETLFEERGRRWPVI
Mflv_3053|M.gilvum_PYR-GCK AAYLEAANGLVDGGSDLIMIETIFDSLNAKAAVFAVETLFEERGRRWPVI
MMAR_4825|M.marinum_M AAYLEAANGLVDGGADIIIIETIFDSLNAKAAVFAVETLFEDRGRRWPVI
MUL_0395|M.ulcerans_Agy99 AAYLEAANGLVDGGADIIIIETIFDSLNAKAAVFAVETLFEDRGRRWPVI
TH_0958|M.thermoresistible__bu DAYIEAALGMLDGGADAILIETCQDLLQLKAAVLGARRAMARAGRHIPII
Mb2485|M.bovis_AF2122/97 KWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSY---
Rv2458|M.tuberculosis_H37Rv KWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSY---
MLBr_01478|M.leprae_Br4923 RWHRPRLEVLADAGADVLALETIPDIDEAEALVDLVRSVGVPAWLSY---
MAV_1715|M.avium_104 DWHRPRLEVLADADADVLAAETIPDVDEAEALVNLVRSLGVPAWLSY---
: : *..:* : ** * : :* : .
MAB_2129|M.abscessus_ATCC_1997 ISGTITDASGRTLSGQVTEAFWNAIRHARPIAVGLNCALGAPEMRPYIAE
Mvan_3474|M.vanbaalenii_PYR-1 ISGTITDASGRTLSGQVTEAFWNSVRHARPLAVGLNCALGAPEMRPYLAE
MSMEG_4185|M.smegmatis_MC2_155 ISGTITDASGRTLSGQVTEAFWNSIRHAQPLAVGLNCALGAPEMRPYIAE
Mflv_3053|M.gilvum_PYR-GCK ISGTITDASGRTLSGQVTEAFWNAIRHAKPLAVGLNCALGAPEMRPYIAE
MMAR_4825|M.marinum_M ISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGLNCALGAPEMRPYIAE
MUL_0395|M.ulcerans_Agy99 ISGTITDASGRTLSGQVTEAFWNAIRHAKPIAVGLNCALGAPEMRPYIAE
TH_0958|M.thermoresistible__bu TH-VTVETTGTMLLGSEIGAALTAIEPLGVDVIGLNCATGPAEMSEHLRY
Mb2485|M.bovis_AF2122/97 ----TINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCA-PDDVLPAIAF
Rv2458|M.tuberculosis_H37Rv ----TINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCA-PDDVLPAIAF
MLBr_01478|M.leprae_Br4923 ----TINGTRTRAGQPLAEAFAVAAGVPKIVAVGVNCCA-PDDVLAAIQ-
MAV_1715|M.avium_104 ----TIDGAHTRAGQPLADAFAVAAGAPEIVAFGVNCCA-PDDVLPAIG-
: : * : ..*:**. . :: :
MAB_2129|M.abscessus_ATCC_1997 MSRIADTFVSCYPNAGLPNAFG---EYDESPEHQAGYLAEFAEAGLVN--
Mvan_3474|M.vanbaalenii_PYR-1 MSRIADTFVSCYPNAGLPNAFG---EYDESPTRQAGYVAEFAEAGLVN--
MSMEG_4185|M.smegmatis_MC2_155 MSRIADTFVSCYPNAGLPNAFG---EYDESPKRQASYVEEFAEAGFVN--
Mflv_3053|M.gilvum_PYR-GCK VARIADTFVSCYPNAGLPNAFG---EYDESPERQASYIAEFAEAGLVN--
MMAR_4825|M.marinum_M MARIADTFVSCYPNAGLPNAFG---EYDETPEHQAGYIAEFADAGLVN--
MUL_0395|M.ulcerans_Agy99 MARIADTFVSCYPNAGLPNAFG---EYDETPEHQAGYIAEFADAGLVN--
TH_0958|M.thermoresistible__bu LSRHSRLPVSVMPNAGLPVLGPDGAVYPLRPDELAEALAGFVSEFGLS--
Mb2485|M.bovis_AF2122/97 AVAHTGKPVIVYPNSGEGWDGR--RRAWVGPRRFSGSSGQLAREWVAAGA
Rv2458|M.tuberculosis_H37Rv AVAHTGKPVIVYPNSGEGWDGR--RRAWVGPRRFSGSSGQLAREWVAAGA
MLBr_01478|M.leprae_Br4923 -IANIGKPIIVYPNSGERWD----YRTWTGPRRFS---AQLALQWTAAGA
MAV_1715|M.avium_104 PARAVGKPVIVYPNSGEHWDG----RAWTGRSKFS---AELASQWISAGA
: **:* . : :.
MAB_2129|M.abscessus_ATCC_1997 -LVGGCCGTAPAHIAEIAKVVEGVKPRDVPSIDVATRLSGLEPLN-ITDD
Mvan_3474|M.vanbaalenii_PYR-1 -LVGGCCGTTPAHIAEIARVVDGKPPRKVPEIPVATRLAGLEPLN-ITDD
MSMEG_4185|M.smegmatis_MC2_155 -LVGGCCGTTPAHIAEIAKVVEGKPPRQVPEIPVATRLSGLEPLN-IDED
Mflv_3053|M.gilvum_PYR-GCK -LVGGCCGTAPPHIAEIAKVVDGKTPRELPQIPVATRLSGLEPLN-INDE
MMAR_4825|M.marinum_M -LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLN-ISDD
MUL_0395|M.ulcerans_Agy99 -LVGGCCGTAPPHIAEIAKVVEGKAPRELPEIPVATRLSGLEPLN-ITDD
TH_0958|M.thermoresistible__bu -LVGGCCGTTPEHIRQVVDAVSG-VQRAGRQISYEPGLSSLYTSTPFAQD
Mb2485|M.bovis_AF2122/97 RIVGGCCRVRPIDIAEIGRALTTAPPRG----------------------
Rv2458|M.tuberculosis_H37Rv RIVGGCCRVRPIDIAEIGRALTTAPPRG----------------------
MLBr_01478|M.leprae_Br4923 RIVGGCCRVRPADIAELTKALASR--------------------------
MAV_1715|M.avium_104 RIVGGCCRVRPTDIAAVRRACSDGENSAKKSP------------------
:***** . * .* : .
MAB_2129|M.abscessus_ATCC_1997 SLFVNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMD
Mvan_3474|M.vanbaalenii_PYR-1 SLFVNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMD
MSMEG_4185|M.smegmatis_MC2_155 SLFVNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMD
Mflv_3053|M.gilvum_PYR-GCK SLFVNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMD
MMAR_4825|M.marinum_M SLFVNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMD
MUL_0395|M.ulcerans_Agy99 SLFENIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMD
TH_0958|M.thermoresistible__bu ASVLMIGERTNANGSKAFREAMIAEDYQRCLDIAKEQTRDGAHLLDLCVD
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 EGMIDGVAAMDRFTKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPI
Mvan_3474|M.vanbaalenii_PYR-1 EGMIDGVAAMDRFTKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPI
MSMEG_4185|M.smegmatis_MC2_155 EGMIDGVAAMDRFTKLIASEPDISRVPVMIDSSKWEVIEAGLKNVQGKPI
Mflv_3053|M.gilvum_PYR-GCK EGMIDGVAAMDRFTKLIASEPDISRVPVMIDSSKWEVIEAGLKNVQGKPI
MMAR_4825|M.marinum_M EGMIDGVAAMDRFTKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPI
MUL_0395|M.ulcerans_Agy99 EGMIDGVAAMDRFTKLIAAEPDISRVPVMIDSSKWEVIEAGLKNVQGKPI
TH_0958|M.thermoresistible__bu YVGRDGVADMKALASRLAT---ASTLPIMLDSTETDVLRAGLEHLGGRCA
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 VNSISMKEGE---EKFIREARLCRKYGAAVVVMAFDEKGQADNLERRKEI
Mvan_3474|M.vanbaalenii_PYR-1 VNSISMKEGE---EKFIREARLCRKYGAAVVVMAFDEQGQADNLERRKQI
MSMEG_4185|M.smegmatis_MC2_155 VNSISLKEGE---EKFVREARLCRKYGAAVVVMAFDEQGQADNLERRKQI
Mflv_3053|M.gilvum_PYR-GCK VNSISMKEGE---EKFIREAQLCRKYGAAVVVMAFDEQGQADNLERRKEI
MMAR_4825|M.marinum_M VNSISMKEGE---EKFVREARLCRKYGAAVVVMAFDEKGQADNLERRKEI
MUL_0395|M.ulcerans_Agy99 VNSISMKEGE---EKFVREARLCRKYGAAVVVMAFDEKGQADNLERRKEI
TH_0958|M.thermoresistible__bu VNSVNYEDGAGPESRFHKTMELVAEHGAAVVALTIDEEGQARTAEHKVAI
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 CGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACAWIK
Mvan_3474|M.vanbaalenii_PYR-1 CGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHASYGIDFIEACAWIK
MSMEG_4185|M.smegmatis_MC2_155 CGRAYKTLTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACRWIK
Mflv_3053|M.gilvum_PYR-GCK CGRAYRILTEKVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACAWIK
MMAR_4825|M.marinum_M CGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACAWIK
MUL_0395|M.ulcerans_Agy99 CGRAYRILTEEVGFPAEDIIFDPNCFALATGIEEHATYGIDFIEACAWIK
TH_0958|M.thermoresistible__bu AERLIEDITTNWGVEKSSILVDCLTFTICTGQEESRRDGIETIEAIRELK
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 ENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAG
Mvan_3474|M.vanbaalenii_PYR-1 ENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAG
MSMEG_4185|M.smegmatis_MC2_155 ENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAG
Mflv_3053|M.gilvum_PYR-GCK ENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAG
MMAR_4825|M.marinum_M ENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAG
MUL_0395|M.ulcerans_Agy99 ENLPGVHISGGISNVSFSFRGNNPVREAIHAVFLFHAIKAGLDMGIVNAG
TH_0958|M.thermoresistible__bu KRHPDVQTTLGLSNISFGLN--PAARQVLNSVFLHECREAGLDSAIVHAS
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 ALVPYDSIDSELRDRIEDVVLNRRADAAERLLEIAERFNSTENSGGGDDR
Mvan_3474|M.vanbaalenii_PYR-1 ALVPYDSIDPELRDRIEDVVLNRREDAAERLLEIAERFNSK---GETEDA
MSMEG_4185|M.smegmatis_MC2_155 ALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNSK---DKGEDP
Mflv_3053|M.gilvum_PYR-GCK ALVPYDSIDPELRDRIEDVVLNRRADAAERLLEIAERFNKA---DKGEDP
MMAR_4825|M.marinum_M ALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTK---GKSEDP
MUL_0395|M.ulcerans_Agy99 ALVPYDSIDPELRERIEDVVLNRREDAAERLLEIAERFNTK---GKPEDP
TH_0958|M.thermoresistible__bu KILPMNRIDEKQREVALDLIYDRRREGYDPLQELMTMFEGVS-TADSKES
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 AAQEWRSLPVRERITHALVKGIDAHVDDDTEELRAEIAAAGGRPIEVIEG
Mvan_3474|M.vanbaalenii_PYR-1 GVAEWRSLPVRERITHALVKGIDAHVDDDTEELRAEIADAGGRPIEVIEG
MSMEG_4185|M.smegmatis_MC2_155 AAAEWRSLPVRERITHALVKGIDAHVDDDTEELRAEIAAAGGRPIEVIEG
Mflv_3053|M.gilvum_PYR-GCK QAAEWRSLPVRERITHALVKGIDAHVDDDTEELRAEIEAAGGRPIEVIEG
MMAR_4825|M.marinum_M AAAEWRSLPVRERITHALVKGIDAHVDADTEELRAEIAAAGGRPIEVIEG
MUL_0395|M.ulcerans_Agy99 AAAEWRSLPVRERITHALVKGIDAHVDADTEELRAEIAAAGGRLIEVIEG
TH_0958|M.thermoresistible__bu RAAELAKLPVLERLAQRIVDGERNGLEADLDEAMTIKP-----PLEIINE
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 PLMDGMNVVGDLFGSGKMFLPQVVKSARVMKKAVAYLLPFIEAEKEDNGT
Mvan_3474|M.vanbaalenii_PYR-1 PLMDGMNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPFIEAEKAENGT
MSMEG_4185|M.smegmatis_MC2_155 PLMDGMNVVGDLFGSGKMFLPQVVKSARVMKKAVAYLLPYIEAEKKP---
Mflv_3053|M.gilvum_PYR-GCK PLMDGMNVVGDLFGSGKMFLPQVVKSARVMKKAVAYLLPYIEAEKADAGT
MMAR_4825|M.marinum_M PLMDGMNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPFIEAEKAQSGS
MUL_0395|M.ulcerans_Agy99 PLMDGMNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPFIEAEKAQSGS
TH_0958|M.thermoresistible__bu HLLAGMKVVGELFGAGQMQLPFVLQSAEVMKAAVAHLEPHMEKSEDDSG-
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 AGDSKSKDTNGTIVMATVKGDVHDIGKNIVGVVLQCNNFEVIDLGVMVPA
Mvan_3474|M.vanbaalenii_PYR-1 S---DSKDTNGTIVMATVKGDVHDIGKNIVGVVLQCNNFEVIDLGVMVPA
MSMEG_4185|M.smegmatis_MC2_155 ---GDAERSNGTIIMATVKGDVHDIGKNIVGVVLQCNNYTVIDLGVMVPA
Mflv_3053|M.gilvum_PYR-GCK T---GSKDTNGTIVMATVKGDVHDIGKNIVGVVLQCNNFEVIDLGVMVPA
MMAR_4825|M.marinum_M T---EQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNNYTVVDLGVMVPA
MUL_0395|M.ulcerans_Agy99 T---EQDKTNGIIIMATVKGDVHDIGKNIVGVVLQCNNYTVVDLGVMVPA
TH_0958|M.thermoresistible__bu ---------KGRIVLATVKGDVHDIGKNLVDIILTNNGYEVVNLGIKQPI
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 QKILDAAKEHDADIIGLSGLITPSLDEMANFAVEMERE--GLEIPLLIGG
Mvan_3474|M.vanbaalenii_PYR-1 QKILDAAKEHNADIIGLSGLITPSLDEMANFAVEMERE--GLEIPLLIGG
MSMEG_4185|M.smegmatis_MC2_155 QKILDAAKEHNADIIGLSGLITPSLDEMVNFAAEMERE--GMDIPLLIGG
Mflv_3053|M.gilvum_PYR-GCK QKILDAAREHDADIIGLSGLITPSLDEMSNFAVEMERA--GLEIPLLIGG
MMAR_4825|M.marinum_M EKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMERE--GMQIPLLIGG
MUL_0395|M.ulcerans_Agy99 EKILAAAREYDADIIGLSGLITPSLDEMVNFAAAMERE--GMQIPLLIGG
TH_0958|M.thermoresistible__bu STILEVAEDKNADVVGMSGLLVKSTVVMKENLEEMNARGVAERFPVLLGG
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 ATTSRAHTAVKISPRRKGPVVWVKDASRSVPVAAALLDDKQRPGLLEATE
Mvan_3474|M.vanbaalenii_PYR-1 ATTSRAHTAVKIAPRRGGPVVWVKDASRSVPVAAALLDDRQRPALLEATE
MSMEG_4185|M.smegmatis_MC2_155 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPALLEATE
Mflv_3053|M.gilvum_PYR-GCK ATTSRAHTAVKISPRRSGPVVWVKDASRSVPVAAALLDDKQRPALLEATE
MMAR_4825|M.marinum_M ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATA
MUL_0395|M.ulcerans_Agy99 ATTSRAHTAVKVAPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLEATA
TH_0958|M.thermoresistible__bu AALTRGYVEDDLSEIYEGEVYYARDAFEGLRLMDRIMSEK-RGGGPDPDS
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 KDYASLRERHAQKNERPTLTLEKARANRTPVEWDGYTPPVPAQGLGVREF
Mvan_3474|M.vanbaalenii_PYR-1 ADYASLRERHAQKNERPMLTLEKARANRTPVEWDGYTPPVPAQGLGVREF
MSMEG_4185|M.smegmatis_MC2_155 KDYASLRERHAQKNERPMVTLEKARANRTPIDWDGYTPPVPAQGLGIREF
Mflv_3053|M.gilvum_PYR-GCK KDYASLRERHAQKNDRPMLTLEKARANRTPIEWDGYTPPVPAQGVGVREF
MMAR_4825|M.marinum_M ADYAALRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREF
MUL_0395|M.ulcerans_Agy99 ADYAALRERHSQKNERPMLTLEKARANRTPIDWDGYTPPLPAQGLGVREF
TH_0958|M.thermoresistible__bu PEAIAAREKEAERKARRARSKRIAAERKAKEEPVEVPARSDVAADVEVPV
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 LDYDLAEVREYIDWQPFFNAWEMKGRFPDILNNPATGEAARKLHDDAQQI
Mvan_3474|M.vanbaalenii_PYR-1 KDYDLAELREYIDWQPFFNAWEMKGRFPDILNNPATGEAARKLYDDAQEM
MSMEG_4185|M.smegmatis_MC2_155 ENYDLSELRQYIDWQPFFNAWEMKGKFPDILNNPASGEAARKLYEEAQEM
Mflv_3053|M.gilvum_PYR-GCK IDYDLAELREYIDWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEM
MMAR_4825|M.marinum_M HDYDLAELREYIDWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEM
MUL_0395|M.ulcerans_Agy99 HDYDLAELREYIDWQPFFNAWEMKGRFPDILNNPATGEAARKLYNDAQEM
TH_0958|M.thermoresistible__bu PPFWGTRIVKGVAVADYAGTLDERALFLGQWGLRGARGGDGPSYEELVET
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 LDTLIKEKWLTANGVIGFFPANAVGP-------GFEDIEVYTDDTRTEVL
Mvan_3474|M.vanbaalenii_PYR-1 LDTLIKEKWLTANGVIGFFPANAS-P-------GGDDIVVYTDDTRTEVL
MSMEG_4185|M.smegmatis_MC2_155 LDTLIKEKWLTANGVIGFFPANAV----------GDDIEVYTDDTRTEVL
Mflv_3053|M.gilvum_PYR-GCK LDTLIKEKWLTANGVIGFFCANAV----------GDDIEVYTDDTRTEVL
MMAR_4825|M.marinum_M LDTLIREKWLTANGVIGFFPANAV----------GDDIEVYTDETRAEVL
MUL_0395|M.ulcerans_Agy99 LDTLIREKWLTANGVIGFFPANAV----------GDDIEVYTDETRAEVL
TH_0958|M.thermoresistible__bu EGRPRLRYWLDRLATEGILAHAAVVYGYFPAVSQGDDVIVLTEPEPDADE
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 TTLHNLRQQGEHRDGIPNRSLGDYIAPKETGLRDYIGAFAVTAGLGSQDK
Mvan_3474|M.vanbaalenii_PYR-1 TTLHNLRQQGEHRSGIPNRSLGDFIAPKESGLRDYIGAFAVTAGLGSQDK
MSMEG_4185|M.smegmatis_MC2_155 TTLRNLRQQGEHRDGIPNRSLGDFIAPKETGLADYIGAFAVTAGLGSAEK
Mflv_3053|M.gilvum_PYR-GCK TTLYNLRQQGEHRDGIPNRSQGDFIAPKETGLRDYIGAFAVTAGLGSQAK
MMAR_4825|M.marinum_M TTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQTK
MUL_0395|M.ulcerans_Agy99 TTLHNLRQQGEHRAGIPNRSLGDFIAPKDTGLADYVGAFAVTAGLGSQTK
TH_0958|M.thermoresistible__bu RFRFTFPRQQRGRFLCIADFIRSRELAAKTGQVDVLPFQLVTMGQPIADF
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 IMEFKADLDDYSAILLESIADRLAEAFAERMHQRVRTEFWG----FQPDE
Mvan_3474|M.vanbaalenii_PYR-1 IMEFKAALDDYSAILLESLADRLAEAFAERMHERVRKEFWG----YQPDE
MSMEG_4185|M.smegmatis_MC2_155 IAEFKADHDDYSAILLESLADRLAEAFAERMHQRVRTELWA----YQPDE
Mflv_3053|M.gilvum_PYR-GCK IMEFKAALDDYSAILLESLADRLAEAFAERMHERVRTEFWG----YQPDE
MMAR_4825|M.marinum_M IVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWG----YQPDE
MUL_0395|M.ulcerans_Agy99 IVEFKEALDDYSAILLESIADRLAEAFAERMHQRVREEFWG----YQPDE
TH_0958|M.thermoresistible__bu ANELFASNAYRDYLEVHGIGVQLTEAFAEYWHRRIREELRFGDRAMAAED
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 QLDNEALIGEKYRGIRPAPGYPACPEHTEKVTLFDLLDVTKRTGIELTES
Mvan_3474|M.vanbaalenii_PYR-1 QLDNDALIGEKYVGIRPAPGYPACPEHTEKATLWKLMDVKERTGIELTES
MSMEG_4185|M.smegmatis_MC2_155 ELDNEALIAERYRGIRPAPGYPACPEHTEKATLFKLLDVTERTGIELTES
Mflv_3053|M.gilvum_PYR-GCK QLDNNALIAERYVGIRPAPGYPSCPEHTEKATLFGLLDATERTGIELTES
MMAR_4825|M.marinum_M QLDNEALIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTES
MUL_0395|M.ulcerans_Agy99 QLDNEALIGERYVGIRPAPGYPACPEHTEKTTLFELMDVTKRTGIELTES
TH_0958|M.thermoresistible__bu PESVEEYFKLGYRGARFSFGYGACPDLEDRKKMMELLEP-ERIGVVLSEE
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 MAMWPGAAVSGWYFAHPQSQYFVVGRLAQDQVADYAKRKGWTLQEAERWL
Mvan_3474|M.vanbaalenii_PYR-1 MAMWPGAAVSGWYFSHPQSQYFVVGRLAQDQVADYAKRKGWTLAEAERWL
MSMEG_4185|M.smegmatis_MC2_155 MAMWPGAAVSGWYFSHPQSQYFVVGRLAQDQVADYARRKGWTLQEAERWL
Mflv_3053|M.gilvum_PYR-GCK MAMWPGAAVSGWYFSHPQSQYFVVGRLAQDQVADYARRKGWTLQEAERWL
MMAR_4825|M.marinum_M MAMWPGAAVSGWYFSHPQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWL
MUL_0395|M.ulcerans_Agy99 MAMWPGAAVSGWYFSHPQSQYFVVGRMAQDQVADYAKRKGWTLPEAERWL
TH_0958|M.thermoresistible__bu LQLHPEQSTDAFVLHHPEAKYFNV--------------------------
Mb2485|M.bovis_AF2122/97 --------------------------------------------------
Rv2458|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01478|M.leprae_Br4923 --------------------------------------------------
MAV_1715|M.avium_104 --------------------------------------------------
MAB_2129|M.abscessus_ATCC_1997 GPNLGYNPED
Mvan_3474|M.vanbaalenii_PYR-1 APNLGYNPED
MSMEG_4185|M.smegmatis_MC2_155 APNLGYNPED
Mflv_3053|M.gilvum_PYR-GCK APNLGYNPED
MMAR_4825|M.marinum_M GPNLGYNPED
MUL_0395|M.ulcerans_Agy99 GPNLGYNPED
TH_0958|M.thermoresistible__bu ----------
Mb2485|M.bovis_AF2122/97 ----------
Rv2458|M.tuberculosis_H37Rv ----------
MLBr_01478|M.leprae_Br4923 ----------
MAV_1715|M.avium_104 ----------