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TAELPDWGSGRLETNVAALTPDKVASLLQVEHLLDQRWPETCIEPSLTRISALMDVLGSPQLSYPSIHVA GTNGKTSVTRMVDALLTALHQRTGRFTSPHLQSVVERIAIDSKPISPAQYVATYREVEPFVQMIDAQSQS SGGPALSKFEVVTAMAFAAFANAPVDIAVVEVGLGGRWDATNVINASVAVITPVSIDHVEYLGNDVAAIA REKAGIITKAPEGAPDTVVVIGRQVPAAMGVLLAQSAHAGARVVRQDSEFAVLDRQVAIGGQVLQLQGLG GVYNDIYLPLHGEHQAHNAVLVLAAVEAFYGAGVQRQLDVEAVRSGFAAVISPGRLERMRSAPTVFIDAA HNPAGANALARTLSDEFNFRTLVGVLSVLANKDVDGILAALELVLDYIVVTDNGSPRALDVESLALVARE RFGPDRVISAANLRDAIDAATALVDDAAANEEIEGLGVSGRGIVITGSVITAGIARTLFGRDPQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01471 | folC | - | 100% (485) | folylpolyglutamate synthase |
| M. leprae Br4923 | MLBr_00915 | murC | 3e-06 | 29.95% (187) | UDP-N-acetylmuramate--L-alanine ligase |
| M. leprae Br4923 | MLBr_00909 | murE | 5e-06 | 25.37% (402) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2474c | folC | 0.0 | 78.67% (483) | folylpolyglutamate synthase protein FolC |
| M. gilvum PYR-GCK | Mflv_2631 | - | 0.0 | 71.34% (471) | FolC bifunctional protein |
| M. tuberculosis H37Rv | Rv2447c | folC | 0.0 | 78.67% (483) | folylpolyglutamate synthase protein FolC |
| M. abscessus ATCC 19977 | MAB_1604 | - | 0.0 | 68.79% (471) | folylpolyglutamate synthase FolC |
| M. marinum M | MMAR_3771 | folC | 0.0 | 77.53% (485) | folylpolyglutamate synthase protein FolC |
| M. avium 104 | MAV_1725 | - | 0.0 | 76.86% (484) | FolC protein |
| M. smegmatis MC2 155 | MSMEG_4226 | murC | 3e-07 | 27.12% (295) | UDP-N-acetylmuramate--L-alanine ligase |
| M. thermoresistible (build 8) | TH_0610 | folC | 0.0 | 69.52% (479) | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC |
| M. ulcerans Agy99 | MUL_3718 | folC | 0.0 | 77.11% (485) | folylpolyglutamate synthase protein FolC |
| M. vanbaalenii PYR-1 | Mvan_3950 | - | 0.0 | 72.69% (465) | FolC bifunctional protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2474c|M.bovis_AF2122/97 MNSTNSGP-PDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTR
Rv2447c|M.tuberculosis_H37Rv MNSTNSGP-PDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTR
MAV_1725|M.avium_104 MTEPPDWA-PEH-DVPDPVPTPDEIAALLQVEHLLDQRWPETKIEPSLTR
MMAR_3771|M.marinum_M MSFDPPDW-TGLAQGSDAEPTPDELASLLQVEHLLDQRWPETRIEPSLTR
MUL_3718|M.ulcerans_Agy99 MSFDPPDW-TGLAQGSDAEPTPDELASLLQVEHLLDQRWPETRIEPSLTR
MLBr_01471|M.leprae_Br4923 MTAELPDWGSGRLETNVAALTPDKVASLLQVEHLLDQRWPETCIEPSLTR
Mflv_2631|M.gilvum_PYR-GCK --------------MSAAEPTPDEIAALLQVEHLLDQRWPETKIEPGTGR
Mvan_3950|M.vanbaalenii_PYR-1 --------------MSSFEPKPDEIAALLQVEHLLDQRWPETKIEPSTAR
TH_0610|M.thermoresistible__bu ------------MEMTQPAPTPDEIAALLQVEHLLDQRWPETKLDPSTAR
MAB_1604|M.abscessus_ATCC_1997 -----------MSEPLSSEPSPDEIAALLQIEYLLDQRWPETKIEPSTDR
MSMEG_4226|M.smegmatis_MC2_155 ----MTGISLPPELQRVHMVGIGGAGMSGVARILLDRGGLVSGSDAKESR
. . . ***: : :. *
Mb2474c|M.bovis_AF2122/97 ISALMDLLGSPQRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSP
Rv2447c|M.tuberculosis_H37Rv ISALMDLLGSPQRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSP
MAV_1725|M.avium_104 ISALLDLLGSPQRAYPSIHVAGTNGKTSVARMIDALVTALHRRTGRTTSP
MMAR_3771|M.marinum_M ISALMDLLGSPQLSYPSIHIGGTNGKTSVARMVDALITALHQRTGRTTSP
MUL_3718|M.ulcerans_Agy99 ISALMDLLGSPQLSYPSIHIGGTNGKTSVARMFDALITALHQRTGRTTSP
MLBr_01471|M.leprae_Br4923 ISALMDVLGSPQLSYPSIHVAGTNGKTSVTRMVDALLTALHQRTGRFTSP
Mflv_2631|M.gilvum_PYR-GCK ISALLEMLGSPQQGYPSIHIGGTNGKTSVARMVDALLTAFSRRTGRTTSP
Mvan_3950|M.vanbaalenii_PYR-1 ISALMELLGSPQLGYPSIHIGGTNGKTSVARMVDSLLTALHRRTGRTISP
TH_0610|M.thermoresistible__bu IAALMEMLGSPQRGYPTIHIAGTNGKTSVARMVDALLRALHRRTGRTTSP
MAB_1604|M.abscessus_ATCC_1997 IVALMELLGSPQRAYPCIHVAGTNGKTSVTRMIDALLTALHRRTGRTTSP
MSMEG_4226|M.smegmatis_MC2_155 GVVALRARG------AEIRIGHDASSLDLLPGGPTAVVTTHAAIPKTNPE
. : * . *::. .. .: : : : : .
Mb2474c|M.bovis_AF2122/97 HLQSPVERISIDGKPISPAQYVATYR--EIEPLVALIDQQSQASAGKGGP
Rv2447c|M.tuberculosis_H37Rv HLQSPVERISIDGKPISPAQYVATYR--EIEPLVALIDQQSQASAGKGGP
MAV_1725|M.avium_104 HLQSAVERISIDAKPISPARYVDTYR--EIEPFVQMVDQQSQAAGG---P
MMAR_3771|M.marinum_M HLQSAVERISIDGKPITPAQYVQTYR--EIEPFVQMIDQQSQAAGG---P
MUL_3718|M.ulcerans_Agy99 HLQSAVERISIDGKPITPAQYVQTYR--EIEPFVQMIDQQSQAAGG---P
MLBr_01471|M.leprae_Br4923 HLQSVVERIAIDSKPISPAQYVATYR--EVEPFVQMIDAQSQSSGG---P
Mflv_2631|M.gilvum_PYR-GCK HLQSAVERISIDGVPISPAAYVDTYR--EIEPFVELVDQQSESAGG---P
Mvan_3950|M.vanbaalenii_PYR-1 HLQSAVERISIDGRPISPAAYVDTYR--EIEPFVELVDQQSQAAGG---P
TH_0610|M.thermoresistible__bu HLQSAVERIAIDGEPISPARYVEVYR--EIEPFVELVDKQSQAAGG---P
MAB_1604|M.abscessus_ATCC_1997 HLQSAVERIAIDGQPISPAKYVEIYS--EIEPFVELVDKQSQEQGG---P
MSMEG_4226|M.smegmatis_MC2_155 LVEARKRGIPVILRPVVLAKLMTGYTTLMVTGTHGKTTTTSMLIVALQHS
::: . *.: *: * : * : * . .
Mb2474c|M.bovis_AF2122/97 AMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAP-VAVITP
Rv2447c|M.tuberculosis_H37Rv AMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAP-VAVITP
MAV_1725|M.avium_104 AMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVVNAP-VAVITP
MMAR_3771|M.marinum_M AMSKFEVLTAMAFAAFADAPVDVAVVEVGLGGRWDATNVINAP-VAVITP
MUL_3718|M.ulcerans_Agy99 AMSKFEVLTAMAFAAFADAPVDVAVVEVGLGGRWDATNVINAP-VAVITP
MLBr_01471|M.leprae_Br4923 ALSKFEVVTAMAFAAFANAPVDIAVVEVGLGGRWDATNVINAS-VAVITP
Mflv_2631|M.gilvum_PYR-GCK KMSKFEVVTAMAFAAFADAPVDVAVVEVGLGGRWDATNVVNAP-VAVITP
Mvan_3950|M.vanbaalenii_PYR-1 RMSKFEVVTAMAFAAFADAPVDVAVVEVGLGGRWDATNVINAP-VAVVTP
TH_0610|M.thermoresistible__bu ALSKFEVVTAMAFAAFADAPVDVAVVEVGMGGRWDATNIVNAP-VAVITP
MAB_1604|M.abscessus_ATCC_1997 AMSKFEVLVAMAFVAFADAPVDIAVVEVGLGGRWDATNIIDAP-VAVVTP
MSMEG_4226|M.smegmatis_MC2_155 GFDPSFAVGGELGEAGTNAHHGSGTTFVAEADESDGSLLEYTPNVAVVTN
:. .: . * ::* . ... *. ... *.: : :. ***:*
Mb2474c|M.bovis_AF2122/97 ISIDHVDYLGADIAGIAGEKAGIITRAPD------GSPDTVAVIGRQVPK
Rv2447c|M.tuberculosis_H37Rv ISIDHVDYLGADIAGIAGEKAGIITRAPD------GSPDTVAVIGRQVPK
MAV_1725|M.avium_104 ISIDHVDYLGHDLAGIAGEKAGIITRAPA------GAPDTVAVIAQQPPE
MMAR_3771|M.marinum_M ISIDHVDYLGDDIASIAGEKAGIIHKAAD------GSPDTVAVIGRQLPE
MUL_3718|M.ulcerans_Agy99 ISIDHVDYLGDDIASIAGEKAGIIHKAAD------GSPDTVAVIGRQLPE
MLBr_01471|M.leprae_Br4923 VSIDHVEYLGNDVAAIAREKAGIITKAPE------GAPDTVVVIGRQVPA
Mflv_2631|M.gilvum_PYR-GCK IGVDHVDYLGGTIAEIAGEKAGIITRQADDLVPT----DTVAVLARQVPE
Mvan_3950|M.vanbaalenii_PYR-1 IGIDHADYLGDTIAEIAGEKAGIITRQDDDLVPT----DTVAVLARQVPE
TH_0610|M.thermoresistible__bu IGVDHTDYLGDTVAEIAAEKAGIITRQDPGLVPEGTDPSTVAVIGRQPPE
MAB_1604|M.abscessus_ATCC_1997 IGIDHVEFLGPDLASIANEKAGIIKRHKLDAMTGEAGADTVAVIAQQQPE
MSMEG_4226|M.smegmatis_MC2_155 IEADHLDFFGSEQAYTAVFDSFVERIAPGGALVVCTDDPGAAALADRTDA
: ** :::* * * .: : ...:. :
Mb2474c|M.bovis_AF2122/97 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYS-DI
Rv2447c|M.tuberculosis_H37Rv VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYS-DI
MAV_1725|M.avium_104 VMEVLLAQCVQADAAVARAGSEFAVLGRQVAIGGQLLQLQGLGGVYS-DV
MMAR_3771|M.marinum_M AMEVLLAQAVRADAAVAREDSEFAVLGRQVAVGGQLLQLQGLGGVYS-DI
MUL_3718|M.ulcerans_Agy99 AMEVLLAQAVRADAAVAREDSEFAVLGRQVAVGGQLLQLQGLGGVYS-DI
MLBr_01471|M.leprae_Br4923 AMGVLLAQSAHAGARVVRQDSEFAVLDRQVAIGGQVLQLQGLGGVYN-DI
Mflv_2631|M.gilvum_PYR-GCK AMEVLLAEAVRADAAVAREDSEFAILGRQVAIGGQLLELQGLGGVYT-DI
Mvan_3950|M.vanbaalenii_PYR-1 AMEVLLAQAVRCDAAVAREDSEFTVLGRQVAIGGQLLELQGLGGVYP-DI
TH_0610|M.thermoresistible__bu AMEAILREAVRADAVVARADAEFAVIGRQVAVGGQMLELRGLGGIYS-EI
MAB_1604|M.abscessus_ATCC_1997 AMEVLLRQTVEADAAVAREGSEFAVLSRQVAVGGQLLELQGLGGVYP-EI
MSMEG_4226|M.smegmatis_MC2_155 LGIRVLRYGSTGDNLAG------TLLSWEQQGTGAVAHIRLAGEHNPRAV
:* . . ::: : * : .:: * :
Mb2474c|M.bovis_AF2122/97 YLPLHGEHQAHNAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRL
Rv2447c|M.tuberculosis_H37Rv YLPLHGEHQAHNAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRL
MAV_1725|M.avium_104 YLPLHGEHQAHNAALALAAVEAFFGAGAQRQLDVDAVRAGFAAVTSPGRL
MMAR_3771|M.marinum_M YLPLHGEHQAHNAVVALAAVEAFFGAGAQRQLDVDAVRAGFAAVTSPGRL
MUL_3718|M.ulcerans_Agy99 YLPLHGEHQAHNAVVALAAVEAFFGAGAQRQLDVDAVRAGFAAVTSPGRL
MLBr_01471|M.leprae_Br4923 YLPLHGEHQAHNAVLVLAAVEAFYGAGVQRQLDVEAVRSGFAAVISPGRL
Mflv_2631|M.gilvum_PYR-GCK FLPLHGEHQAHNAVVALAAVEAFFGAGTDRQLDVDTVRAGFAAVTSPGRL
Mvan_3950|M.vanbaalenii_PYR-1 FLPLHGEHQAHNAVLALAAVEAFFGAGAQRQLDVDAVRAGFAAVTSPGRL
TH_0610|M.thermoresistible__bu FLPLHGEHQAHNAALALAAVEAFFGAGAQRQLDVDAVREGFASVINPGRM
MAB_1604|M.abscessus_ATCC_1997 FLPLHGEHQAHNAAVALAAVEAFFGAGADRQLDIEAIRSGFASVIIPGRL
MSMEG_4226|M.smegmatis_MC2_155 RLSVPGRHMALNALAALLAAREIG-APTDSVLDG---LAGFEGVRRRFEL
*.: *.* * ** .* :.. : * .: ** ** .* .:
Mb2474c|M.bovis_AF2122/97 ERMRSAPTVFIDAAHNPAGASALAQTLAHEFD---FRFLVGVLSVLGDK-
Rv2447c|M.tuberculosis_H37Rv ERMRSAPTVFIDAAHNPAGASALAQTLAHEFD---FRFLVGVLSVLGDK-
MAV_1725|M.avium_104 ERMRSAPTVFIDAAHNPAGAAALARTLADEFD---FRFLVGVLSVLADK-
MMAR_3771|M.marinum_M ERLRSSPTVFIDAAHNPAGAAALAQSLVAEFD---FRSLVGVIAVMADK-
MUL_3718|M.ulcerans_Agy99 ERLRSSPTVFIDAAHNPAGAAALAQSLVAEFD---FRSLVGVVAVMADK-
MLBr_01471|M.leprae_Br4923 ERMRSAPTVFIDAAHNPAGANALARTLSDEFN---FRTLVGVLSVLANK-
Mflv_2631|M.gilvum_PYR-GCK ERMRNAPTVFIDAAHNPAGAAALSEALRDEFD---FRYLVGVVSVMGDK-
Mvan_3950|M.vanbaalenii_PYR-1 ERLRSAPTVFIDAAHNPAGAAALVEALRDEFD---FRYLVGVVSVMGDK-
TH_0610|M.thermoresistible__bu ERVRSAPTVFVDAAHNPAGAAALAETLQSEFD---FRFLVGVVSVLAGK-
MAB_1604|M.abscessus_ATCC_1997 ERVRSAPAVFLDAAHNPHGAAALAETLQSEFD---FRRLVGVISVMGDK-
MSMEG_4226|M.smegmatis_MC2_155 VGTAAGARVFDDYAHHPTEVRATLEAARTVVDQNGGRVVVAFQPHLYSRT
.. ** * **:* . * .: .: * :*.. . : .:
Mb2474c|M.bovis_AF2122/97 -DVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAE
Rv2447c|M.tuberculosis_H37Rv -DVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAE
MAV_1725|M.avium_104 -DVDGILAALQPVFHSVVVTHNGSPRALDVESLALAAREQFGPDRVSTAE
MMAR_3771|M.marinum_M -DVNGILAALEPAFDSIVVTHNGSPRALDVASLALAAEQYFGPDRVITAE
MUL_3718|M.ulcerans_Agy99 -DVNGILAALEPAFDSIVVTHNGSPRALDVASLALAAEQYFGPDRVITAE
MLBr_01471|M.leprae_Br4923 -DVDGILAALELVLDYIVVTDNGSPRALDVESLALVARERFGPDRVISAA
Mflv_2631|M.gilvum_PYR-GCK -DVDGILAALEPALDQIVVTHNGSPRALEAAALAVKAEEIFGPERVITAA
Mvan_3950|M.vanbaalenii_PYR-1 -DVDGILAALETAFDQIVVTHNGSPRALEVVALAVKAEEIFGPERVVTAS
TH_0610|M.thermoresistible__bu -DVDGILAALEPVFDQIIITHNGSPRALEIPVLAARAEERFGEERVLTAD
MAB_1604|M.abscessus_ATCC_1997 -DVAGILGALEPAFDEIVVTHNGSPRAMETDALAGIALEIFGEDRVVVAP
MSMEG_4226|M.smegmatis_MC2_155 ATFAHEFGAALSVADQVVVLDVYAAREQPMAGVSGATVADHVTAPVTYVP
. :.* . . ::: . :.* :: : . * .
Mb2474c|M.bovis_AF2122/97 NLRDAIDVATSLVDDAAADPDVAG--DAFSRTGIVITGSVVTAGAARTLF
Rv2447c|M.tuberculosis_H37Rv NLRDAIDVATSLVDDAAADPDVAG--DAFSRTGIVITGSVVTAGAARTLF
MAV_1725|M.avium_104 NLSDAIDVATALVDDAVRDGLVDGQAEDFAGTGIVITGSVVTAGAARTLF
MMAR_3771|M.marinum_M NLRDAVDAATALVDESAIDWEAQG--GSLSGTGIVITGSVVTAGAARTLF
MUL_3718|M.ulcerans_Agy99 NLRDAVDAATALVDESAIDWEAQG--GSLSGTGIVITGSVVTAGAAHTLF
MLBr_01471|M.leprae_Br4923 NLRDAIDAATALVDDAAANEEIEG--LGVSGRGIVITGSVITAGIARTLF
Mflv_2631|M.gilvum_PYR-GCK TLPDAIETATAVVEDSGSDGDAAG----MSGAGIVITGSVVTAGAARTLF
Mvan_3950|M.vanbaalenii_PYR-1 TLPDAIETATALVEESGSAGDAAG----MGGAGIVITGSVVTAGAARTLF
TH_0610|M.thermoresistible__bu TLADAIETATALVEDAGMEG--EG----FSGSGIVFTGSVVTAGAARSLF
MAB_1604|M.abscessus_ATCC_1997 TLLDAVETATAMVEEAAEDGGAEG----FSGTGIVITGSVVTAGAARTLF
MSMEG_4226|M.smegmatis_MC2_155 DFS-AVAAHVASIARSGDVILTMG-----AGDVTMLGGEILSELRLKDNR
: *: . .: : : * . :: *.::: :
Mb2474c|M.bovis_AF2122/97 GRDPQ---
Rv2447c|M.tuberculosis_H37Rv GRDPQ---
MAV_1725|M.avium_104 GRDPQ---
MMAR_3771|M.marinum_M GRDPQ---
MUL_3718|M.ulcerans_Agy99 GRDPQ---
MLBr_01471|M.leprae_Br4923 GRDPQ---
Mflv_2631|M.gilvum_PYR-GCK GKDPA---
Mvan_3950|M.vanbaalenii_PYR-1 GKDPA---
TH_0610|M.thermoresistible__bu GKEPQ---
MAB_1604|M.abscessus_ATCC_1997 GKDPQ---
MSMEG_4226|M.smegmatis_MC2_155 GMPGAGAS
*