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MDCKRVVVGVSGGIAAYKACTVVRQLIDAGHEVRVIPTESALRFVGTATFEALSGQPVYTDVFDDIPAVS HVYLGKQADLVVVAPATADLLARAVHGRADDLLTATLLTARCPIMFAPAMHTEMWLHPATVDNVATLRRR GAIVLEPASGRLTGTDSGAGRLPEAEEITTLAQLLLERHDALPYDLTGRKLLVTSGGTRESIDPVRFIGN RSSGKQGYAVARVAVQRGAEVTLIAGHTAGLTNPAGVDVVHVGSAQQLGDAVSKHAPDFDVLVMAAAVAD FRPAQVATAKIKKGPDDQDEPLIELVYNEDVLAAAVRARTHGQLPNMRAIVGFAAETGDASGDVLFHARA KLRRKGCDLLVVNAVGDGRAFEVDNNDGWLLASDGTELALQHGSKMLMASRIVDGIVTFLHGLPDLRGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00543 | dfp | - | 100% (419) | bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1426 | dfp | 0.0 | 87.04% (409) | bifunctional phosphopantothenoylcysteine |
| M. gilvum PYR-GCK | Mflv_3738 | - | 0.0 | 79.17% (408) | bifunctional phosphopantothenoylcysteine |
| M. tuberculosis H37Rv | Rv1391 | dfp | 0.0 | 87.04% (409) | bifunctional phosphopantothenoylcysteine |
| M. abscessus ATCC 19977 | MAB_2821c | - | 1e-176 | 76.47% (408) | bifunctional phosphopantothenoylcysteine |
| M. marinum M | MMAR_2204 | dfp | 0.0 | 85.61% (410) | DNA/pantothenate metabolism flavoprotein, Dfp |
| M. avium 104 | MAV_3383 | coaBC | 0.0 | 86.31% (409) | bifunctional phosphopantothenoylcysteine |
| M. smegmatis MC2 155 | MSMEG_3054 | coaBC | 0.0 | 81.33% (407) | bifunctional phosphopantothenoylcysteine |
| M. thermoresistible (build 8) | TH_0823 | dfp | 1e-169 | 77.44% (390) | PROBABLE DNA/PANTOTHENATE METABOLISM FLAVOPROTEIN HOMOLOG DFP |
| M. ulcerans Agy99 | MUL_1790 | dfp | 0.0 | 85.85% (410) | bifunctional phosphopantothenoylcysteine |
| M. vanbaalenii PYR-1 | Mvan_2669 | - | 0.0 | 79.36% (407) | bifunctional phosphopantothenoylcysteine |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3738|M.gilvum_PYR-GCK -MAAK-------RIIVGVAGGIAAYKAATVVRQLTEAGHSVRVVPTESAL
Mvan_2669|M.vanbaalenii_PYR-1 -MERK-------RIIVGVAGGIAAYKAATVVRQLTEAGHSVRVVPTESAL
MSMEG_3054|M.smegmatis_MC2_155 MSARK-------RIVVGVAGGIAAYKACTVVRQLTEAGHSVRVVPTESAL
TH_0823|M.thermoresistible__bu -----------------------------VVRQLSEAGHDVRVVPTESAL
Mb1426|M.bovis_AF2122/97 MVDHKRIPK---QVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESAL
Rv1391|M.tuberculosis_H37Rv MVDHKRIPK---QVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESAL
MMAR_2204|M.marinum_M -MDRK-------RIVVGVSGGIAAYKACTVVRQLTEAGHHVRVIPTESAL
MUL_1790|M.ulcerans_Agy99 -MDRK-------RIVVGVSGGIAAYKACTVVRQLTEAGHHVRVIPTESAL
MLBr_00543|M.leprae_Br4923 -MDCK-------RVVVGVSGGIAAYKACTVVRQLIDAGHEVRVIPTESAL
MAV_3383|M.avium_104 MYDRNRAFTRAARIVVGVSGGIAAYKACTVVRQLSEAGHSVRVIPTESAL
MAB_2821c|M.abscessus_ATCC_199 ----------MSRIIVGVGGGIAAYKACTVVRQLAEAGHSVRVVPTESAL
***** :*.* ***:******
Mflv_3738|M.gilvum_PYR-GCK KFVGAATFEALSGNPVHTGVFEDVHEVPHVRIGQAADLVVVAPATADLLA
Mvan_2669|M.vanbaalenii_PYR-1 KFVGAATFEALSGNPVHTGVFAEVHEVPHVRIGQAADLVVVAPATADLLA
MSMEG_3054|M.smegmatis_MC2_155 RFVGAATFEALSGNPVHTGVFTDVHEVQHVRIGQQADLVVIAPATADLLA
TH_0823|M.thermoresistible__bu KFVGAASFEALSGNPVHTGVFEDVPEVAHVRIGQQADLVVVAPATADLLA
Mb1426|M.bovis_AF2122/97 RFVGAATFEALSGEPVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLA
Rv1391|M.tuberculosis_H37Rv RFVGAATFEALSGEPVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLA
MMAR_2204|M.marinum_M RFIGAATFEALSGQPVHTGVFDDVPAVPHVQIGQQADLVVVAPATADLLA
MUL_1790|M.ulcerans_Agy99 RFIGAATFEALSGQPVHTGVFDDVPAVPHVQIGQQADLVVVAPATADLLA
MLBr_00543|M.leprae_Br4923 RFVGTATFEALSGQPVYTDVFDDIPAVSHVYLGKQADLVVVAPATADLLA
MAV_3383|M.avium_104 RFVGAATFEALSGQPVHTGVFNDVPEVPHVQLGKQADLVVVAPATADLLA
MAB_2821c|M.abscessus_ATCC_199 QFVGAATFEALSGEPARTGVFDDVPEVPHVRLGQDADLVVVAPATADLLS
:*:*:*:******:*. *.** :: * ** :*: *****:********:
Mflv_3738|M.gilvum_PYR-GCK RAAVGRADDLLTATLLTARCPVLYAPAMHTEMWQHPATVDNVATLRRRGC
Mvan_2669|M.vanbaalenii_PYR-1 RATIGRADDLLTATLLTARCPVLYAPAMHTEMWLHPATCDNVATLRRRGS
MSMEG_3054|M.smegmatis_MC2_155 RAVAGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGA
TH_0823|M.thermoresistible__bu RAAAGRADDLLTATLLTARCPVLFAPAMHTEMWFHPATVENVATLRRRGA
Mb1426|M.bovis_AF2122/97 RAAAGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGA
Rv1391|M.tuberculosis_H37Rv RAAAGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGA
MMAR_2204|M.marinum_M RAVAGRGDDLLTATLLTARCPVMFAPAMHTEMWLHPATVDNVATLRRRGA
MUL_1790|M.ulcerans_Agy99 RAVAGRGDDLLTATLLTARCPVMFAPAMHTEMWLHPATVDNVATLRRRGA
MLBr_00543|M.leprae_Br4923 RAVHGRADDLLTATLLTARCPIMFAPAMHTEMWLHPATVDNVATLRRRGA
MAV_3383|M.avium_104 RAVHGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGA
MAB_2821c|M.abscessus_ATCC_199 RAATGRADDLLTATLLTATCPVLFAPAMHTEMWLHPATQQNVATLRSRGA
**. **.*********** **:::********* **** :****** **.
Mflv_3738|M.gilvum_PYR-GCK VVMEPASGRLTGADTGPGRLPEAEEITTVAQLLLARGDALPHDLAGVRAL
Mvan_2669|M.vanbaalenii_PYR-1 IVMEPASGRLTGADTGPGRLPEAEEITTLAQLLLARNDALPYDLAGVKVL
MSMEG_3054|M.smegmatis_MC2_155 VVLEPASGRLTGADSGPGRLPEAEEITTLAQLLLERADALPYDMAGVKAL
TH_0823|M.thermoresistible__bu VVLEPASGRLTGADSGAGRLPEAEEITTLAKLLLDRADALPYDLPGVKVV
Mb1426|M.bovis_AF2122/97 VVLEPATGRLTGADSGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKLL
Rv1391|M.tuberculosis_H37Rv VVLEPATGRLTGADSGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKLL
MMAR_2204|M.marinum_M VVLEPASGRLTGSDTGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKVL
MUL_1790|M.ulcerans_Agy99 VVLEPASGRLTGSDAGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKVL
MLBr_00543|M.leprae_Br4923 IVLEPASGRLTGTDSGAGRLPEAEEITTLAQLLLERHDALPYDLTGRKLL
MAV_3383|M.avium_104 VVLEPAAGRLTGTDSGSGRLPEAEEITTLAHLLLERHDALPYDLAGCKML
MAB_2821c|M.abscessus_ATCC_199 VVLEPASGRLTGADTGPGRLPEAEEITTLAQLLLARPDALPHDLAGVRVL
:*:***:*****:*:*.***********:*:*** * ****:*:.* : :
Mflv_3738|M.gilvum_PYR-GCK VTAGGTREPIDPVRFIGNRSSGKQGYAVARVMAQRGADVTLIAGNTAGLI
Mvan_2669|M.vanbaalenii_PYR-1 VTAGGTREPIDPVRFIGNRSSGKQGYAMARVMAQRGADVTLIAGNTSGLI
MSMEG_3054|M.smegmatis_MC2_155 VTAGGTREPLDPVRFIGNRSSGKQGYAVARVLAQRGADVTLIAGNTAGLI
TH_0823|M.thermoresistible__bu VTAGGTREPIDPVRFIGNRSSGKQGYAMARVMAQRGAEVKLIAGNTAGLV
Mb1426|M.bovis_AF2122/97 VTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIAGHTAGLV
Rv1391|M.tuberculosis_H37Rv VTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIAGHTAGLV
MMAR_2204|M.marinum_M VTAGGTREPIDPVRFVGNRSSGKQGYAVARVAAQRGAEVTLIAGHTTGLI
MUL_1790|M.ulcerans_Agy99 VTAGGTREPIDPVRFVGNRSSGKQGYAVARVAAQRGAEVTLIAGHTTGLI
MLBr_00543|M.leprae_Br4923 VTSGGTRESIDPVRFIGNRSSGKQGYAVARVAVQRGAEVTLIAGHTAGLT
MAV_3383|M.avium_104 VTAGGTREPVDPVRFIGNRSSGKQGYAVARVAAQRGAEVTLIAGHTAGLI
MAB_2821c|M.abscessus_ATCC_199 VTAGGTREPLDPVRFIGNRSSGKQGYAIARVAAQRGAEVTLIAGHTVGLP
**:*****.:*****:***********:*** .****:*.****:* **
Mflv_3738|M.gilvum_PYR-GCK DPAGVHVVHVGSATQLRDAVSKHAPDANVLVMAAAVADFRPAHPATSKIK
Mvan_2669|M.vanbaalenii_PYR-1 DPAGVHVTHVGSAAQLRDAVSKHAPDANVLVMAAAVADFRPAHPAVNKIK
MSMEG_3054|M.smegmatis_MC2_155 DPAGVEMVHIGSATQLRDAVSKHAPDANVLVMAAAVADFRPAHVAAAKIK
TH_0823|M.thermoresistible__bu DPAGVEVSHVGSAAQMRDAVNKAAPEAHVLVMAAAVADFRPAHPAETKIK
Mb1426|M.bovis_AF2122/97 DPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIK
Rv1391|M.tuberculosis_H37Rv DPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIK
MMAR_2204|M.marinum_M DPAGVEVVHVSTAQQLDDAVSKHAPTADVLVMAAAVADFRPAQVSTAKIK
MUL_1790|M.ulcerans_Agy99 DPAGVEVVHVSTAQQLDDAVSKHAPTADVLVMAAAVADFRPAQVSTAKIK
MLBr_00543|M.leprae_Br4923 NPAGVDVVHVGSAQQLGDAVSKHAPDFDVLVMAAAVADFRPAQVATAKIK
MAV_3383|M.avium_104 DPAGVEVVHVSSAAQLGDAVSKRAPEADVLVMAAAVADFRPAHVAAAKIK
MAB_2821c|M.abscessus_ATCC_199 DPAGVEVVHISSAAQLQDAVTKHAPAAEALIMAAAVADFRPAHVATSKIK
:****.: *:.:* *: ***.* ** ..*:***********: : ***
Mflv_3738|M.gilvum_PYR-GCK KGPDATTDP--AIELIRNDDVLAGAVRARDDGQLPNMAAIVGFAAETGDA
Mvan_2669|M.vanbaalenii_PYR-1 KGPAGEGEP--TIELVRNDDVLAGAVRARADGQLPNMQAIVGFAAETGDA
MSMEG_3054|M.smegmatis_MC2_155 KG--ASEPS--SIDLVRNDDVLAGAVRARADGQLPNMRAIVGFAAETGDA
TH_0823|M.thermoresistible__bu KSSDPNAPA-PVIELTRTDDVLAGVVRSRADGQLPNMRAIVGFAAETGDA
Mb1426|M.bovis_AF2122/97 KGVEGP----PTIELLRNDDVLAGVVRARAHGQLPNMRAIVGFAAETGDA
Rv1391|M.tuberculosis_H37Rv KGVEGP----PTIELLRNDDVLAGVVRARAHGQLPNMRAIVGFAAETGDA
MMAR_2204|M.marinum_M KTADSP----PVIELLRNDDVLAGAVRAREDGQLPKMRAIVGFAAETGDA
MUL_1790|M.ulcerans_Agy99 KTADSP----PVIELLRNDDVLAGAVRAREDGQLPKMRAIVGFAAETGDA
MLBr_00543|M.leprae_Br4923 KGPDDQDE--PLIELVYNEDVLAAAVRARTHGQLPNMRAIVGFAAETGDA
MAV_3383|M.avium_104 KSASNETAP-PTIELVRNDDVLAGAVRARAHGQLPNMRAIVGFAAETGDA
MAB_2821c|M.abscessus_ATCC_199 KSHGAAGENDAPIELLRNADVLAGVVRARADGQLPKMRAIVGFAAETGDA
* *:* . ****..**:* .****:* ************
Mflv_3738|M.gilvum_PYR-GCK NGDVLFHARAKLTRKGCDLLVVNAVGENRAFEVDHNDGWLLSS----DGS
Mvan_2669|M.vanbaalenii_PYR-1 NGDVLFHARAKLRRKGCDLLVVNAVGENRAFEVDHNDGWLLSA----DGT
MSMEG_3054|M.smegmatis_MC2_155 NGDVLFHARAKLERKGCDLLVVNAVGENRAFEVDHNDGWLLSA----DGT
TH_0823|M.thermoresistible__bu SGDVLHHARAKLKRKGCDLLVVNAVGENRAFEVEDNAGWLLAA----DGA
Mb1426|M.bovis_AF2122/97 NGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLAS----DGT
Rv1391|M.tuberculosis_H37Rv NGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLAS----DGT
MMAR_2204|M.marinum_M NGDVLFHARQKLRRKSCDLLVVNAVGGDRAFEVDNNDGWLLAA----DGT
MUL_1790|M.ulcerans_Agy99 NGDVLFHARQKLRRKGCDLLVVNAVGGDRAFEVDNNDGWLLAA----DGT
MLBr_00543|M.leprae_Br4923 SGDVLFHARAKLRRKGCDLLVVNAVGDGRAFEVDNNDGWLLAS----DGT
MAV_3383|M.avium_104 SGDVLFHARAKLQRKGCDLLVVNAVGEGRAFEVDSNDGWLLAS----DGT
MAB_2821c|M.abscessus_ATCC_199 NGDVLFHARAKLKRKGCDLLVVNAVGEGRAFEVDSNDGWLLSAQSGGDIT
.****.*** ** **.********** .*****: * ****:: * :
Mflv_3738|M.gilvum_PYR-GCK ESALEHGSKTVIASRIVDAIAAFLHS---GAG-
Mvan_2669|M.vanbaalenii_PYR-1 ESALEHGSKTVIASRIVDAIAAFLRT---CA--
MSMEG_3054|M.smegmatis_MC2_155 ESALEHGSKTLMATRIVDSIAAFLKS---QDG-
TH_0823|M.thermoresistible__bu ESQLEHGSKTLMASRIVDAIAAFLQT---SGSA
Mb1426|M.bovis_AF2122/97 ESALQHGSKTLMASRIVDAIVTFLAG---CSS-
Rv1391|M.tuberculosis_H37Rv ESALQHGSKTLMASRIVDAIVTFLAG---CSS-
MMAR_2204|M.marinum_M EAALQHGSKTLMASRIVDAIVTFLD---SCRG-
MUL_1790|M.ulcerans_Agy99 EAALQHGSKTLMASRIVDAIVTFLD---SCRG-
MLBr_00543|M.leprae_Br4923 ELALQHGSKMLMASRIVDGIVTFLHGLPDLRGG
MAV_3383|M.avium_104 ESALQHGSKTLMASRIVDAIAAFLHG---DSG-
MAB_2821c|M.abscessus_ATCC_199 EVVLEHGTKVLMASRIVDAVAGLCQ--------
* *:**:* ::*:****.:. :