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SGLQDKVVIVTGAGGGLGRAYARFVAANGGLVVVNDLGGARDGSGAGTSMADAVVDEIRRDGGQAVASYD SVADPDGAKAIVDTALSGFGAVHGVISNAGILRDGAFHKMTDDNWDAVLKVHLYGGYHVIRAAWPHLREQ RYGRVVVATSTSGLYGNFGQSNYGAAKAGLVGLIKTLAIEGAKYGITANAVAPLAATRMTADIAPQELLD KLDPDLVAPAVGYLVSEQNHDSGSVFVVGGGLVQRVEVFENDGVTFSKPPPLAEIAARWGEISDMSAAKL GTNPV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5078 | - | - | 100% (286) | peroxisomal hydratase-dehydrogenase-epimerase |
| M. avium 104 | MAV_5146 | - | e-114 | 71.84% (277) | peroxisomal multifunctional enzyme type 2 |
| M. avium 104 | MAV_5205 | - | 1e-59 | 47.98% (248) | oxidoreductase, short chain dehydrogenase/reductase family |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0153 | - | 1e-115 | 70.97% (279) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_0741 | - | 1e-109 | 67.14% (283) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0148 | - | 1e-114 | 70.97% (279) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 4e-26 | 37.05% (251) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_4604c | - | 1e-112 | 70.18% (275) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0360 | - | 1e-114 | 70.50% (278) | short-chain type dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_0096 | - | 1e-106 | 67.26% (281) | peroxisomal hydratase-dehydrogenase-epimerase |
| M. thermoresistible (build 8) | TH_4061 | - | 1e-135 | 82.69% (283) | PUTATIVE peroxisomal hydratase-dehydrogenase-epimerase |
| M. ulcerans Agy99 | MUL_4759 | - | 1e-114 | 70.50% (278) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_0106 | - | 1e-110 | 68.20% (283) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5078|M.avium_104 --------------------------------------------------
TH_4061|M.thermoresistible__bu --------------------------------------------------
Mb0153|M.bovis_AF2122/97 --------------------------------------------------
Rv0148|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0360|M.marinum_M --------------------------------------------------
MUL_4759|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0741|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0106|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0096|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4604c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
MAV_5078|M.avium_104 -----------MSGLQDKVVIVTGAGG-----------------------
TH_4061|M.thermoresistible__bu --------------VQDKVIVVTGAGG-----------------------
Mb0153|M.bovis_AF2122/97 -----------MPGVQDRVIVVTGAGG-----------------------
Rv0148|M.tuberculosis_H37Rv -----------MPGVQDRVIVVTGAGG-----------------------
MMAR_0360|M.marinum_M -----------MPGVQDRVVVVTGAGG-----------------------
MUL_4759|M.ulcerans_Agy99 -----------MPGVQDRVVVVTGAGG-----------------------
Mflv_0741|M.gilvum_PYR-GCK -----------MPGVQDRVIVVTGAGG-----------------------
Mvan_0106|M.vanbaalenii_PYR-1 -----------MPGVQDRVIVVTGAGG-----------------------
MSMEG_0096|M.smegmatis_MC2_155 --------------MQDR-VVVTGAGG-----------------------
MAB_4604c|M.abscessus_ATCC_199 -----------MPGVQDRVIVVTGAGG-----------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
:* :: .. **
MAV_5078|M.avium_104 GLGRAYARFVAANGGLVVVNDLGGARDGS---------------------
TH_4061|M.thermoresistible__bu GLGRAYARFLAANGALVVVNDLGGARDGS---------------------
Mb0153|M.bovis_AF2122/97 GLGREYALTLAGEGASVVVNDLGGARDGT---------------------
Rv0148|M.tuberculosis_H37Rv GLGREYALTLAGEGASVVVNDLGGARDGT---------------------
MMAR_0360|M.marinum_M GLGREYALTLAREGASVVVNDLGGARDGT---------------------
MUL_4759|M.ulcerans_Agy99 GLGREYALTLAREGASVVVNDLGGARDGT---------------------
Mflv_0741|M.gilvum_PYR-GCK GLGREYALTLAREGASVVVNDLGGARDGT---------------------
Mvan_0106|M.vanbaalenii_PYR-1 GLGREYALTLAREGASVVVNDLGGARDGT---------------------
MSMEG_0096|M.smegmatis_MC2_155 GLGREYALTLAREGASVVVNDLGGARDGT---------------------
MAB_4604c|M.abscessus_ATCC_199 GLGREYALTLAGEGASVVVNDLGGARDGS---------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
** . :: : * . * :* : *.:
MAV_5078|M.avium_104 --------------------------------------------------
TH_4061|M.thermoresistible__bu --------------------------------------------------
Mb0153|M.bovis_AF2122/97 --------------------------------------------------
Rv0148|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0360|M.marinum_M --------------------------------------------------
MUL_4759|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0741|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0106|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0096|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4604c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
MAV_5078|M.avium_104 -------------------GAGTSMADAVVDEIRRDGGQAVAS-------
TH_4061|M.thermoresistible__bu -------------------GAGTSMADTVVEEIRAAGGRAVAN-------
Mb0153|M.bovis_AF2122/97 -------------------GAGSAMADEVVAEIRDKGGRAVAN-------
Rv0148|M.tuberculosis_H37Rv -------------------GAGSAMADEVVAEIRDKGGRAVAN-------
MMAR_0360|M.marinum_M -------------------GAGSAMADQVVTEIREGGGRAVAN-------
MUL_4759|M.ulcerans_Agy99 -------------------GAGSAMADQVVTEIREGGGRAVAN-------
Mflv_0741|M.gilvum_PYR-GCK -------------------GAGSAMADEVVKEIKDAGGRAVAN-------
Mvan_0106|M.vanbaalenii_PYR-1 -------------------GAGSAMADEVVKEIKAAGGRAVAN-------
MSMEG_0096|M.smegmatis_MC2_155 -------------------GSGSAMADQVVAEIKEAGGRAVAN-------
MAB_4604c|M.abscessus_ATCC_199 -------------------GAGSAMADGVVDEIKAAGGRAVAN-------
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
*:. .:. :. : *.:.**
MAV_5078|M.avium_104 -YDSVADPDG---------AKAIVDTALSGFGAVHG-----VISNAGILR
TH_4061|M.thermoresistible__bu -YSSVASAEG---------AAEIVQTALDEFGAVHG-----VVSNAGILR
Mb0153|M.bovis_AF2122/97 -YDSVATEDG---------AANIIKTALDEFGAVHG-----VVSNAGILR
Rv0148|M.tuberculosis_H37Rv -YDSVATEDG---------AANIIKTALDEFGAVHG-----VVSNAGILR
MMAR_0360|M.marinum_M -YDSVATEDG---------AANIIKTALDEFGAVHG-----VVSNAGILR
MUL_4759|M.ulcerans_Agy99 -YDSVATEDG---------AANIIKTALDEFGAVHG-----VVSNAGILR
Mflv_0741|M.gilvum_PYR-GCK -YDSVAEPEG---------AANIIKTAVDEFGKVDG-----VVSNAGILR
Mvan_0106|M.vanbaalenii_PYR-1 -YDSVAEPEG---------AANIIKTAVDEFGKVDG-----VVSNAGILR
MSMEG_0096|M.smegmatis_MC2_155 -YDSVAESEG---------AENIIKTAIDEFGKIDG-----VVSNAGILR
MAB_4604c|M.abscessus_ATCC_199 -YDSVATEEG---------AANIVKTALDEFGAIHG-----VVSNAGILR
MLBr_02565|M.leprae_Br4923 ALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITR
...* * * :.. . : .* ::.**** *
MAV_5078|M.avium_104 DGAFHKMTDDNWDAVLKVHLYGGYHVIRAAWPHLREQRYGRVVVATSTSG
TH_4061|M.thermoresistible__bu DGAFHKMSDDDWDAVQKVHLYGGFYVLRAAWPHFREQSFGRVVVATSTSG
Mb0153|M.bovis_AF2122/97 DGTFHKMSFENWDAVLKVHLYGGYHVLRAAWPHFREQSYGRVVVATSTSG
Rv0148|M.tuberculosis_H37Rv DGTFHKMSFENWDAVLKVHLYGGYHVLRAAWPHFREQSYGRVVVATSTSG
MMAR_0360|M.marinum_M DGTFHKMTSENWDAVLKVHLYGGYNVVRAAWPHFREQSYGRVVVATSTSG
MUL_4759|M.ulcerans_Agy99 DGTFHKMTSENWDAVLKVHLYGGYNVVRAAWPHFREQSYGRVVVATSTSG
Mflv_0741|M.gilvum_PYR-GCK DGTFHKMEFANWDAVLKVHLYGGYNVIRAAWPHFRENGFGRVVVATSTSG
Mvan_0106|M.vanbaalenii_PYR-1 DGTFHKMEFANWDAVLKVHLYGGYNVIRAAWPHFRENGFGRVVVATSTSG
MSMEG_0096|M.smegmatis_MC2_155 DGTFHKMTYDNWDAVLKVHLYGGYNVIRAAWPHFREQSFGRVVVATSTSG
MAB_4604c|M.abscessus_ATCC_199 DGTFHKMTYDNWHAVQQVHLYGGYNITRAAWPHFREQGYGRIVVATSTSG
MLBr_02565|M.leprae_Br4923 DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMAG
* : :* *.** :*:* . : .. : . **::* :* :*
MAV_5078|M.avium_104 LYGNFGQSNYGAAKAGLVGLIKTLAIEGAKYGITANAVAP-LAATRMTAD
TH_4061|M.thermoresistible__bu IYGNFGQANYGAAKAGLIGLINTLAIEGAKYNTTANAIAP-LAATRMTAD
Mb0153|M.bovis_AF2122/97 LFGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHANALAP-IAATRMTQD
Rv0148|M.tuberculosis_H37Rv LFGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHANALAP-IAATRMTQD
MMAR_0360|M.marinum_M LFGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHSNAVAP-IAATRMTQD
MUL_4759|M.ulcerans_Agy99 LFGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHSNAVAP-IAATRMTQD
Mflv_0741|M.gilvum_PYR-GCK LFGNFGQANYGAAKLGLVGLINTLSQEGAKYNIKANAIAP-IAATRMTQD
Mvan_0106|M.vanbaalenii_PYR-1 LFGNFGQANYGAAKLGLVGLINTLAQEGAKYNIKANAVAP-IAATRMTQD
MSMEG_0096|M.smegmatis_MC2_155 LFGNFGQANYGAAKLGLVGLINTLAQEGAKYNIKTNAIAP-IAATRMTQD
MAB_4604c|M.abscessus_ATCC_199 LFGNFGQANYGAAKLGLVGLINTLALEGAKYNIHSNAIAP-IAATRMTAD
MLBr_02565|M.leprae_Br4923 IAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTAA
: ** **:**.:** *::** ::*: *: . **:** : *:**
MAV_5078|M.avium_104 IAPQELLDKLDPDLVAPAVGYLVSEQNHDSGSVFVVGGGLVQRVEVFEND
TH_4061|M.thermoresistible__bu IAPQELLDRLDPDLVAPAVGYLMSEQNQDSGSVFVVGGGLVQRVAQFQND
Mb0153|M.bovis_AF2122/97 ILPPEVLEKLTPEFVAPVVAYLCTEECADNASVYVVGGGKVQRVALFGND
Rv0148|M.tuberculosis_H37Rv ILPPEVLEKLTPEFVAPVVAYLCTEECADNASVYVVGGGKVQRVALFGND
MMAR_0360|M.marinum_M IMPPEVLEKLTPEFVAPVVAYLCTEECADNGSVFIVGGGKVQRAALFQND
MUL_4759|M.ulcerans_Agy99 IMPPEVLEKLTPEFVAPVVAYLCTEECADNGSVFIVGGGKVQRAALFQND
Mflv_0741|M.gilvum_PYR-GCK ILPPEVFEKLTPEYVAPIVSYLCTEEVPETASVFIVGGGKVQRVALFQNE
Mvan_0106|M.vanbaalenii_PYR-1 ILPPEVFEKLTPEYVAPIVSYLCTEEVPETASVFIVGGGKVQRVALFQNS
MSMEG_0096|M.smegmatis_MC2_155 ILPPEVFEKLTPEYVAPVVAYLMTEELEDTDSVFIVGGGKIQRTALFQNE
MAB_4604c|M.abscessus_ATCC_199 IASEAVLEQLPPAFVSPVVGYLCTEESTDNGSVFVVGGGKVQRVALFENA
MLBr_02565|M.leprae_Br4923 IP-------------------LATREVGRRLNSLLQGGLPVDVAETIAYF
* * :.: . : ** :: . :
MAV_5078|M.avium_104 GVTFSK-PPPLAEIAARWGEISDMSAAKLGTNPV--
TH_4061|M.thermoresistible__bu GVTFSA-PPTLDEITARWGEISDMSHAKPGTNPV--
Mb0153|M.bovis_AF2122/97 GANFDK-PPSVQDVAARWAEITDLSGAKIAG-FKL-
Rv0148|M.tuberculosis_H37Rv GANFDK-PPSVQDVAARWAEITDLSGAKIAG-FKL-
MMAR_0360|M.marinum_M GANFQT-PPSVQDIAAQWAQITDLSGAQKAG-FKL-
MUL_4759|M.ulcerans_Agy99 GANFQT-PPSVQDIAAQWAQITDLSGAQKAG-FKL-
Mflv_0741|M.gilvum_PYR-GCK GVTFTE-VPSVDDVAAKWGEITDLSAAERAT-FSLG
Mvan_0106|M.vanbaalenii_PYR-1 GVTFTE-VPSVDDVAARWGEITDLSAAERAT-FSLG
MSMEG_0096|M.smegmatis_MC2_155 GVTFSDGVPTVDDIAAKWNEITDLSAAQLAS-FKLG
MAB_4604c|M.abscessus_ATCC_199 GATFAS-PPTVDEVAARWGEIEDLATVTKAGPPSLA
MLBr_02565|M.leprae_Br4923 AIPASN--------AVTGNVIRVCGQAMLGA-----
. :. * . . .