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LISQRPTLSEEVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVLHEFTTVPGVKE DVTAIILNLKSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHNPELHIATLNDKGKLEVELVVE RGRGYVPAVQNRASGAEIGRIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKSSITPRDALASA GKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVSRTES DLLDIRNFGQKSIDEVKVKLHQLGLSLKDSPPSFDPSQVAGYDVATGTWSTEAAYDDQDYAETEQL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4398 | rpoA | - | 100% (347) | DNA-directed RNA polymerase subunit alpha |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3486c | rpoA | 0.0 | 96.83% (347) | DNA-directed RNA polymerase subunit alpha |
| M. gilvum PYR-GCK | Mflv_4970 | - | 0.0 | 91.24% (354) | DNA-directed RNA polymerase subunit alpha |
| M. tuberculosis H37Rv | Rv3457c | rpoA | 0.0 | 96.83% (347) | DNA-directed RNA polymerase subunit alpha |
| M. leprae Br4923 | MLBr_01957 | rpoA | 0.0 | 95.10% (347) | DNA-directed RNA polymerase subunit alpha |
| M. abscessus ATCC 19977 | MAB_3770c | - | 0.0 | 92.00% (350) | DNA-directed RNA polymerase subunit alpha |
| M. marinum M | MMAR_1090 | rpoA | 0.0 | 97.41% (347) | DNA-directed RNA polymerase (alpha chain), RpoA |
| M. smegmatis MC2 155 | MSMEG_1524 | rpoA | 1e-179 | 89.71% (350) | DNA-directed RNA polymerase subunit alpha |
| M. thermoresistible (build 8) | TH_0032 | rpoA | 1e-179 | 90.03% (351) | PROBABLE DNA-DIRECTED RNA POLYMERASE (ALPHA CHAIN) RPOA |
| M. ulcerans Agy99 | MUL_0848 | rpoA | 0.0 | 97.41% (347) | DNA-directed RNA polymerase subunit alpha |
| M. vanbaalenii PYR-1 | Mvan_1436 | - | 0.0 | 92.86% (350) | DNA-directed RNA polymerase subunit alpha |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4970|M.gilvum_PYR-GCK MLISQRPTLSEEVVAENRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAA
Mvan_1436|M.vanbaalenii_PYR-1 MLISQRPTLSEDVLAENRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAA
MSMEG_1524|M.smegmatis_MC2_155 MLISQRPTLSEETVAENRSRFVIEPLEPGFGYTLGNSLRRTLLSSIPGAA
Mb3486c|M.bovis_AF2122/97 MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAA
Rv3457c|M.tuberculosis_H37Rv MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAA
MMAR_1090|M.marinum_M MLISQRPTLSEEVLTDSRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAA
MUL_0848|M.ulcerans_Agy99 MLISQRPTLSEEVLTDSRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAA
MAV_4398|M.avium_104 MLISQRPTLSEEVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAA
MLBr_01957|M.leprae_Br4923 MLISQRPTLSEDILTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAA
MAB_3770c|M.abscessus_ATCC_199 MLISQRPTLSEETLAENRSRFVIEPLEPGFGYTLGNSLRRTLLSSIPGAA
TH_0032|M.thermoresistible__bu MLISQRPTLSEEPISEYRSRFIIEPLEPGFGYTLGNSLRRTLLSSIPGAA
***********: ::: **:*:****************************
Mflv_4970|M.gilvum_PYR-GCK VTSIRIDGVLHEFTTVPGVKEDVTDIILNLKGLVVSSEEDEPVTMYLRKQ
Mvan_1436|M.vanbaalenii_PYR-1 VTSIRIDGVLHEFTTVPGVKEDVTDIILNLKGLVVSSEEDEPVTMYLRKQ
MSMEG_1524|M.smegmatis_MC2_155 VTSIRIDGVLHEFTTVPGVKEDVTDIILNLKGLVVSSDDDEPVTMYLRKQ
Mb3486c|M.bovis_AF2122/97 VTSIRIDGVLHEFTTVPGVKEDVTEIILNLKSLVVSSEEDEPVTMYLRKQ
Rv3457c|M.tuberculosis_H37Rv VTSIRIDGVLHEFTTVPGVKEDVTEIILNLKSLVVSSEEDEPVTMYLRKQ
MMAR_1090|M.marinum_M VTSIRIDGVLHEFTTVPGVKEDVTDIILNLKALVVSSEEDEPVTMYLRKQ
MUL_0848|M.ulcerans_Agy99 VTSIRIDGVLHEFTTVPGVKEDVTDIILNLKALVVSSEEDEPVTMYLRKQ
MAV_4398|M.avium_104 VTSIRIDGVLHEFTTVPGVKEDVTAIILNLKSLVVSSEEDEPVTMYLRKQ
MLBr_01957|M.leprae_Br4923 VTSIRIDGVLHEFTTVPGVKEDVTEIILNLKGLVVSSEEDEPVTMYLRKQ
MAB_3770c|M.abscessus_ATCC_199 VTSIRIDGVLHEFTTVPGVKEDVTDIILNLKSLVVSSEEDEPVTMYLRKQ
TH_0032|M.thermoresistible__bu VTSIRIDGVLHEFTTVPGVKEDVTDIILNLKGLVVSSEEDEPVTMYLRKQ
************************ ******.*****::***********
Mflv_4970|M.gilvum_PYR-GCK GPGEVTAGDIVPPAGVTVHNPDMHIATLNDKGKLEVELVVERGRGYVPAV
Mvan_1436|M.vanbaalenii_PYR-1 GPGEVTAGDIVPPAGVTVHNPDMHIATLNDKGKLEVELVVERGRGYVPAV
MSMEG_1524|M.smegmatis_MC2_155 GPGVVTAGDIVPPAGVTVHNPDMHIATLNDKGKLEVELVVERGRGYVPAV
Mb3486c|M.bovis_AF2122/97 GPGEVTAGDIVPPAGVTVHNPGMHIATLNDKGKLEVELVVERGRGYVPAV
Rv3457c|M.tuberculosis_H37Rv GPGEVTAGDIVPPAGVTVHNPGMHIATLNDKGKLEVELVVERGRGYVPAV
MMAR_1090|M.marinum_M GPGEVTAGDIVPPAGVTVHNPNMRIATLNDKGKLEVELVVERGRGYVPAV
MUL_0848|M.ulcerans_Agy99 GPGEVTAGDIVPPAGVTVHNPNMRIATLNDKGKLEVELVVERGRGYVPAV
MAV_4398|M.avium_104 GPGEVTAGDIVPPAGVTVHNPELHIATLNDKGKLEVELVVERGRGYVPAV
MLBr_01957|M.leprae_Br4923 GPGEVTAGDIVPPAGVTLHNPGMRIATLNDKGKIEAELVVERGRGYVPAV
MAB_3770c|M.abscessus_ATCC_199 GPGAVTAGDIVPPAGVTVHNPDMHIATLNDKGKLEIELVVERGRGYVPAV
TH_0032|M.thermoresistible__bu GPGEVTAADIVPPAGVTVHNPDMHIATLNDKGKLEVELVVERGRGYVPAV
*** ***.*********:*** ::*********:* **************
Mflv_4970|M.gilvum_PYR-GCK QNKASGAEIGRIPVDSIYSPVLKVTYKVEATRVEQRTDFDKLILDVETKN
Mvan_1436|M.vanbaalenii_PYR-1 QNKASGAEIGRIPVDSIYSPVLKVTYKVEATRVEQRTDFDKLILDVETKN
MSMEG_1524|M.smegmatis_MC2_155 QNKASGAEIGRIPVDSIYSPVLKVTYKVEATRVEQRTDFDKLIIDVETKN
Mb3486c|M.bovis_AF2122/97 QNRASGAEIGRIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKN
Rv3457c|M.tuberculosis_H37Rv QNRASGAEIGRIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKN
MMAR_1090|M.marinum_M QNRASGAEIGRIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKN
MUL_0848|M.ulcerans_Agy99 QNRASGAEIGRIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKN
MAV_4398|M.avium_104 QNRASGAEIGRIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKS
MLBr_01957|M.leprae_Br4923 QNRALGAEIGRIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKS
MAB_3770c|M.abscessus_ATCC_199 QNKASGAEIGRIPVDSIYSPVLKVTYNVEATRVEQRTDFDKLVLDVETKN
TH_0032|M.thermoresistible__bu QNKASGAEIGRIPVDSIYSPVLKVTYNVEATRVEQRTDFDKLILDVETKP
**:* *********************:*:*************::*****
Mflv_4970|M.gilvum_PYR-GCK SISPRDALASAGKTLVELFGLARELNIEAEGIEIGPSPAEADQAAHFALP
Mvan_1436|M.vanbaalenii_PYR-1 SITPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADQAAHFALP
MSMEG_1524|M.smegmatis_MC2_155 SISPRDALASAGGTLVELFGLARELNADSEHIEIGPSPAEADHIASFALP
Mb3486c|M.bovis_AF2122/97 SISPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALP
Rv3457c|M.tuberculosis_H37Rv SISPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALP
MMAR_1090|M.marinum_M SITPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALP
MUL_0848|M.ulcerans_Agy99 SITPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALP
MAV_4398|M.avium_104 SITPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALP
MLBr_01957|M.leprae_Br4923 SITPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALP
MAB_3770c|M.abscessus_ATCC_199 SISPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALP
TH_0032|M.thermoresistible__bu SISPRDAVASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIAAFALP
**:****:**** ************* ::* ***********: * ****
Mflv_4970|M.gilvum_PYR-GCK IDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIK
Mvan_1436|M.vanbaalenii_PYR-1 IDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIK
MSMEG_1524|M.smegmatis_MC2_155 IDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIK
Mb3486c|M.bovis_AF2122/97 IDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIK
Rv3457c|M.tuberculosis_H37Rv IDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIK
MMAR_1090|M.marinum_M IDDLDLTVRSYNCLKREGVHTVGELVSRTESDLLDIRNFGQKSIDEVKVK
MUL_0848|M.ulcerans_Agy99 IDDLDLTVRSYNCLKREGVHTVGELVSRTESDLLDIRNFGQKSIDEVKVK
MAV_4398|M.avium_104 IDDLDLTVRSYNCLKREGVHTVGELVSRTESDLLDIRNFGQKSIDEVKVK
MLBr_01957|M.leprae_Br4923 IDDLDLTVRSYNCLKREGVHTVGELVSRTESDLLDIRNFGQKSIDEVKVK
MAB_3770c|M.abscessus_ATCC_199 IEDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIK
TH_0032|M.thermoresistible__bu IDDLDLTVRSYNCLKREGIHTVGELVARTESDLLDIRNFGQKSIDEVKVK
*:****************:*******:*********************:*
Mflv_4970|M.gilvum_PYR-GCK LHQLGLSLKDSPASFDPSEVAGYDVATGTWN-SDAGYDSGYEADDNQDYA
Mvan_1436|M.vanbaalenii_PYR-1 LHQLGLSLKDSPASFDPSEVAGYDVATGTWN-SDAGYD----LEDNQDYA
MSMEG_1524|M.smegmatis_MC2_155 LHQLGLSLKDSPATFDPSEVAGYDAATGTWT-SDAGYD----LDDNQDYA
Mb3486c|M.bovis_AF2122/97 LHQLGLSLKDSPPSFDPSEVAGYDVATGTWS-TEGAYD-------EQDYA
Rv3457c|M.tuberculosis_H37Rv LHQLGLSLKDSPPSFDPSEVAGYDVATGTWS-TEGAYD-------EQDYA
MMAR_1090|M.marinum_M LHQLGLSLKDSPPSFDPSEVAGYDVATGTWS-TEGAYD-------DQDYA
MUL_0848|M.ulcerans_Agy99 LHQLGLSLKDSPPSFDPSEVAGYDVATGTWS-TEGAYD-------DQDYA
MAV_4398|M.avium_104 LHQLGLSLKDSPPSFDPSQVAGYDVATGTWS-TEAAYD-------DQDYA
MLBr_01957|M.leprae_Br4923 LHQLGLSLKDSPDSFDPSEVAGYDVTTGTWS-TDGAYD-------SQDYA
MAB_3770c|M.abscessus_ATCC_199 LHQLGLSLKDSPTSFDPSEVAGYDVATGTWS-DTGSYDF----DGDQDFA
TH_0032|M.thermoresistible__bu LHQLGLSLKDSPAGFDPSQVAGYDASSGTWSNETGGYEQ----DNDQDYA
************ ****:*****.::***. ..*: .**:*
Mflv_4970|M.gilvum_PYR-GCK ETEQL
Mvan_1436|M.vanbaalenii_PYR-1 ETEQL
MSMEG_1524|M.smegmatis_MC2_155 ETEQL
Mb3486c|M.bovis_AF2122/97 ETEQL
Rv3457c|M.tuberculosis_H37Rv ETEQL
MMAR_1090|M.marinum_M ETEQL
MUL_0848|M.ulcerans_Agy99 ETEQL
MAV_4398|M.avium_104 ETEQL
MLBr_01957|M.leprae_Br4923 ETEQL
MAB_3770c|M.abscessus_ATCC_199 ETEQL
TH_0032|M.thermoresistible__bu ETEQL
*****