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DWPAVAAAAAAELPATAPVAVTLANRVIACSSAARAAGVRRGLRRREAAARCPQLHVSTADADRDARFFE AVIAAVDDLVPRAEVLRPGLLVLPVRGAARYFGSEEAAAERLVDAVAVSSVAGAECQVGIADRLSTAVLA ARAGRIVEPGGDAKFLSVLSVRQLATEPSLSGPGREELTDLLWRMGIRTIGQFAALARGDVASRFGADGV AAHRLARGEPERPPSGREPPAELEAVLDCDPPIDRVDAAAFAGRSLAGTLHQALMAAGVGCTRLAIHAVT GSGEERHRVWRCAEPLTEDATADRVRWQLDGWLSNRTARDRPTAPVTLLRLRAVEVVSAEALQLPLWGGL GEEDRLRARRALVRVQGLLGPEAVQVPVRSGGRGPAERITLIPLGDEPVPQADPDLPWPGRLPEPSPAVL LDDPVELLDAQNNPIRVSSRGLFSADPARLVVHGRGERLCWWGGPWPVDERWWDDRGQGGGRTARAQVLL ESERALLLCYRQRRWYLEGSYE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4344 | - | - | 100% (513) | hypothetical protein MAV_4344 |
| M. avium 104 | MAV_3232 | - | 9e-07 | 30.83% (133) | DNA polymerase IV |
| M. avium 104 | MAV_0172 | - | 9e-07 | 27.96% (186) | DNA polymerase IV |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3426c | - | 0.0 | 83.43% (519) | hypothetical protein Mb3426c |
| M. gilvum PYR-GCK | Mflv_4898 | - | 0.0 | 76.57% (525) | hypothetical protein Mflv_4898 |
| M. tuberculosis H37Rv | Rv3394c | - | 0.0 | 83.43% (519) | hypothetical protein Rv3394c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3712c | - | 0.0 | 70.02% (517) | hypothetical protein MAB_3712c |
| M. marinum M | MMAR_1151 | - | 0.0 | 85.77% (513) | hypothetical protein MMAR_1151 |
| M. smegmatis MC2 155 | MSMEG_1622 | - | 0.0 | 79.96% (519) | putative DNA repair polymerase |
| M. thermoresistible (build 8) | TH_0486 | - | 1e-134 | 78.64% (295) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0916 | - | 0.0 | 85.77% (513) | hypothetical protein MUL_0916 |
| M. vanbaalenii PYR-1 | Mvan_1523 | - | 0.0 | 79.22% (515) | hypothetical protein Mvan_1523 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3426c|M.bovis_AF2122/97 MMAS--ARVLAIWCMDWPAVAAAAAAGLSATAPVAVTLANRVIACSATAR
Rv3394c|M.tuberculosis_H37Rv MMAS--ARVLAIWCMDWPAVAAAAAAGLSATAPVAVTLANRVIACSATAR
MMAR_1151|M.marinum_M MNSGPPSRVLAIWCMDWPAVAAAAAADQPVTAPVAVTLANRVIACSSTAR
MUL_0916|M.ulcerans_Agy99 MNSGPPSRVLAIWCMDWPAVAAAAAADQPVTAPVAVTLANRVIACSSTAR
MAV_4344|M.avium_104 --------------MDWPAVAAAAAAELPATAPVAVTLANRVIACSSAAR
MSMEG_1622|M.smegmatis_MC2_155 --MPEGSRVLALWCMDWPAVAAAGAAGLPPTAPIAVTLANRVIACSAAAR
TH_0486|M.thermoresistible__bu --------------------------------------------------
Mflv_4898|M.gilvum_PYR-GCK ----MAGRVLALWCMDWPAVAASAAAELPPTTPVAVTLANRVIACSAAAR
Mvan_1523|M.vanbaalenii_PYR-1 ----MQSRVLALWCMDWPAVAAAAAADLPPTVPVAVTLANRVIACSAAAR
MAB_3712c|M.abscessus_ATCC_199 -----------MWCPDWPAVAAAAMADLPATRPVAVTLANRVTACTAAAR
Mb3426c|M.bovis_AF2122/97 AAGVRRGLRRREAAARCPQLFIATADADRDARLFEGVIAAVDDLVPRAEL
Rv3394c|M.tuberculosis_H37Rv AAGVRRGLRRREAAARCPQLFIATADADRDARLFEGVIAAVDDLVPRAEL
MMAR_1151|M.marinum_M AVGVRRGLRRREAAARCPQLHIATADADRDARFFEGVVAAVDDLVPRAEV
MUL_0916|M.ulcerans_Agy99 AVGVRRGLRRREAAARCPQLHIATADADRDARFFEGVVAAVDDLVPRAEV
MAV_4344|M.avium_104 AAGVRRGLRRREAAARCPQLHVSTADADRDARFFEAVIAAVDDLVPRAEV
MSMEG_1622|M.smegmatis_MC2_155 AAGVRRGLRRREAQARCPDLHVVTADPARDARHFERVTAAVDELVPRAEV
TH_0486|M.thermoresistible__bu --------------------------------------------------
Mflv_4898|M.gilvum_PYR-GCK AAGVRRGLRRRESQARCPELHVAAADPARDARHFENVTLAVDELVPRAEV
Mvan_1523|M.vanbaalenii_PYR-1 AVGVRRGLRRRESQARCPGLHVVTADPARDARHFENVTAAVDDLVPRAEV
MAB_3712c|M.abscessus_ATCC_199 ALGVRRGMRRRESQARCPQLHIAVADADRDARFFEPMIAAVDDLVPGAEI
Mb3426c|M.bovis_AF2122/97 LRPGLLVLPVRGPARFFGSEQMAAERLIDAVAA---AGAECQVGIADRLS
Rv3394c|M.tuberculosis_H37Rv LRPGLLVLPVRGPARFFGSEQMAAERLIDAVAA---AGAECQVGIADRLS
MMAR_1151|M.marinum_M LRPGLLVLPVRGAARFFGSEQQAAERLIDAVAA---AGAECQVGIADRLS
MUL_0916|M.ulcerans_Agy99 LRPGLLVLPVRGAARFFGSEQQAAERLIDAVAA---AGAECQVGIADRLS
MAV_4344|M.avium_104 LRPGLLVLPVRGAARYFGSEEAAAERLVDAVAVSSVAGAECQVGIADRLS
MSMEG_1622|M.smegmatis_MC2_155 LRPGLLVLSVRGAARYFGSEDAAAERLVDAVAA---TGVECQVGIADQLS
TH_0486|M.thermoresistible__bu --------------------------------------------------
Mflv_4898|M.gilvum_PYR-GCK LRPGLLALSVRGAARYFGSEVAAAERLVDAVAA---VGAECQVGIADQLP
Mvan_1523|M.vanbaalenii_PYR-1 LRPGLLALSVRGAARYFGSEQTAAERLVDAVAA---VGAECQVGVADQLP
MAB_3712c|M.abscessus_ATCC_199 LRPGLLALPVTGAARYFGSEHAAAERLADAVSV---AGAECQVGIADQMS
Mb3426c|M.bovis_AF2122/97 TAVFAARAGRIVEPGGDARFLSLLSIRQLATEPSLSGPGRDDLTDLLWRM
Rv3394c|M.tuberculosis_H37Rv TAVFAARAGRIVEPGGDARFLSLLSIRQLATEPSLSGPGRDDLTDLLWRM
MMAR_1151|M.marinum_M TAVFAARAGRVVEPGHDARFLSALSVRQLAAEPSLSGPGRDELTDLLWRM
MUL_0916|M.ulcerans_Agy99 TAVFAARAGRVVEPGHDARFLSALSVRQLAAEPSLSGPGRDELTDLLWRM
MAV_4344|M.avium_104 TAVLAARAGRIVEPGGDAKFLSVLSVRQLATEPSLSGPGREELTDLLWRM
MSMEG_1622|M.smegmatis_MC2_155 TAVFAARAGRIIAPGEDASFLSDLSIRQLATEPALAAPDRDALADLLWRM
TH_0486|M.thermoresistible__bu --------------------------------------------------
Mflv_4898|M.gilvum_PYR-GCK TAVFAARVGRIIDPGGDGPFLAELSIRQLSGEPSLASASREELVDLLWRM
Mvan_1523|M.vanbaalenii_PYR-1 TAVFAARAGRIIDAGEDAAFLSGLSIRQLAAEPSLAPAPREALTDLLWRM
MAB_3712c|M.abscessus_ATCC_199 TAVYAARHAALVPPGGDAQFLAPLSVKELAAEPSLCHPQREDLVDLLWRM
Mb3426c|M.bovis_AF2122/97 GIRTIGQFAALSRTDVASRFGADAVAAHRFARGEPERAPCGREPPPDLAA
Rv3394c|M.tuberculosis_H37Rv GIRTIGQFAALSRTDVASRFGADAVAAHRFARGEPERAPCGREPPPDLAA
MMAR_1151|M.marinum_M GIRTVGQFAALSRTDVASRFGADAVAAHRFARGEPERLPSGCEPPPELGA
MUL_0916|M.ulcerans_Agy99 GIRTVGQFAALSRTDVASRFGADAVAAHRFARGEPERLPSGCEPPPELGA
MAV_4344|M.avium_104 GIRTIGQFAALARGDVASRFGADGVAAHRLARGEPERPPSGREPPAELEA
MSMEG_1622|M.smegmatis_MC2_155 GIRTLGQFAALSRTDVASRFGADAVVAHRFARGEPARAPSGRDPAAELDA
TH_0486|M.thermoresistible__bu -------------------------VSRPVVRX-------------DLDA
Mflv_4898|M.gilvum_PYR-GCK GIRTIGQFAELSRSDVASRFGADGVTAHRIARGEPARGPSGREPEAELDA
Mvan_1523|M.vanbaalenii_PYR-1 GIRTIGQFAELSRSDVASRFGADAVAAHRIARGEPGRGPSGREPEAELDA
MAB_3712c|M.abscessus_ATCC_199 GIRTIGAFAELARADVASRFDDDAVQAHRHARAESQRPPSGHAVPAELGV
:: .* :* .
Mb3426c|M.bovis_AF2122/97 ELACDPPIDRVDAAAFAGRSLAAELHRALMAAGVGCTRLAIHAVTANGEE
Rv3394c|M.tuberculosis_H37Rv ELACDPPIDRVDAAAFAGRSLAAELHRALMAAGVGCTRLAIHAVTANGEE
MMAR_1151|M.marinum_M VLRCDPPIDRVDAAAFAGRALASELHQALLAAGVGCTRLAIHAVTDSGEE
MUL_0916|M.ulcerans_Agy99 VLRCDPPIDRVDAAAFAGRALASELHQALLAAGVGCTRLAIHAVTDSGEE
MAV_4344|M.avium_104 VLDCDPPIDRVDAAAFAGRSLAGTLHQALMAAGVGCTRLAIHAVTGSGEE
MSMEG_1622|M.smegmatis_MC2_155 VLDCDPPIERVDAAAFAGRSLAVTLHRSLEAAGVGCTRLAIHAVTANGEQ
TH_0486|M.thermoresistible__bu VLDCDPPIDRIDAAAFAGRSLAGVLHRSLADAGVGCTRLAIHAVTANGEE
Mflv_4898|M.gilvum_PYR-GCK VMNCDPPIDRVDAAAFAGRSLAGVLHRSLEAAGVGCTRLAIHAMTANGQE
Mvan_1523|M.vanbaalenii_PYR-1 VLNCDPPVDRVDAAAFAGRSLAGELHRSLEAAGVGCTRLAIHAVTATGQE
MAB_3712c|M.abscessus_ATCC_199 ELSCDPPIDRVDAAAFAGRTLAVRLHERLSSAGVACSRLAIHAVTVDGQE
: ****::*:********:** **. * ***.*:******:* *::
Mb3426c|M.bovis_AF2122/97 RSRVWRCAEPLTEDATADRVRWQLDGWLNNRNAR------------DRPT
Rv3394c|M.tuberculosis_H37Rv RSRVWRCAEPLTEDATADRVRWQLDGWLNNRNAR------------DRPT
MMAR_1151|M.marinum_M RTRVWRCAEPLTEEATADRVRWQLDGWLSSRNAR------------DRPT
MUL_0916|M.ulcerans_Agy99 RTRVWRCAEPLTEEATADRVRWQLDGWLSSRNAR------------DRPT
MAV_4344|M.avium_104 RHRVWRCAEPLTEDATADRVRWQLDGWLSNRTAR------------DRPT
MSMEG_1622|M.smegmatis_MC2_155 LERVWRCAEPLTEDATADRVRWQLDGWLNRR-TD------------DRPS
TH_0486|M.thermoresistible__bu LHRVWRCAEPLTEDATADRVRWQLDGWLNRRDLN------------SRPT
Mflv_4898|M.gilvum_PYR-GCK LERVWRCAEPLTEDATADRVRWQLDGWLNRRNPDRRAGAKRPGDGYGRPG
Mvan_1523|M.vanbaalenii_PYR-1 LERVWRCAEPLTEDATADRVRWQLDGWLNRRNPQ------------DRPA
MAB_3712c|M.abscessus_ATCC_199 LSRVWRCAEPLTEEATADRVRWQLDGWLARRRCL---------------D
***********:************** *
Mb3426c|M.bovis_AF2122/97 AAVTLLRLQAVETVSASEGLQLPLWGGLGEQDRLRARRALVRVQGLLGPE
Rv3394c|M.tuberculosis_H37Rv AAVTLLRLQAVETVSASEGLQLPLWGGLGEQDRLRARRALVRVQGLLGPE
MMAR_1151|M.marinum_M APVTQLRLQALEVVSA-EALQLPLWGGLGEEDRLRARRALVRVQGLLGPE
MUL_0916|M.ulcerans_Agy99 APVTQLRLQALEVVSA-EALQLPLWGGLGEEDRLRARRALVRVQGLLGPE
MAV_4344|M.avium_104 APVTLLRLRAVEVVSA-EALQLPLWGGLGEEDRLRARRALVRVQGLLGPE
MSMEG_1622|M.smegmatis_MC2_155 APITVLRLRPVEVVSS-AALQLPLWGGIGEEDRLRARRALVRVQGLLGPE
TH_0486|M.thermoresistible__bu APITVLRLHPVEVVSA-EALQLPLWGGIGEEDRMRARRALVRVQGLLGPE
Mflv_4898|M.gilvum_PYR-GCK APITVLRLRPVEVVSA-EALQLPLWGGVGEQDRLRARRALVRVQGLLGPE
Mvan_1523|M.vanbaalenii_PYR-1 APITVLRLRPVEVVSA-EALQLPLWGGVGEEDRLRARRALVRVQGLLGPE
MAB_3712c|M.abscessus_ATCC_199 GPVALLRLEPVEVVTA-EALQLTLWGAVGAEERQRARRALTRVQDLLGEE
..:: ***..:*.*:: .***.***.:* ::* ******.***.*** *
Mb3426c|M.bovis_AF2122/97 AVRVPVLSGGHGPAERITLTVLGLVAPEPVPQADPGQPWPGRLPDPSPAV
Rv3394c|M.tuberculosis_H37Rv AVRVPVLSGGHGPAERITLTVLGLVAPEPVPQADPGQPWPGRLPDPSPAV
MMAR_1151|M.marinum_M AVQVPVLSGGRGPTERITLTALG---DEPVPQADPGRPWPGQLPAPSPAV
MUL_0916|M.ulcerans_Agy99 AVQVPVLSGGRGPTERITLTALG---DEPVPQADPGQPWPGQLPAPSPAV
MAV_4344|M.avium_104 AVQVPVRSGGRGPAERITLIPLG---DEPVPQADPDLPWPGRLPEPSPAV
MSMEG_1622|M.smegmatis_MC2_155 AVQVPVLSGGRGPAERITFTALG---DEPVPQADPRQPWPGQLPEPSPTV
TH_0486|M.thermoresistible__bu AVQVPVLSGGRGPVERITLIPLG---DEPVPRADPDQPWPGRLPEPAPAV
Mflv_4898|M.gilvum_PYR-GCK AVKVPVLSGGRGPAERITLTPFG---DELVPQANPDQPWPGRLPEPSPTV
Mvan_1523|M.vanbaalenii_PYR-1 AVKVPVLSGGRGPAERITFTPLG---DELVPQADPGQPWPGRLPEPSPTV
MAB_3712c|M.abscessus_ATCC_199 SVQVGVISGGRGPAERITLVPLG---DELRPRADPSAPWPGKLPDPAPVV
:*:* * ***:**.****: :* * *:*:* ****:** *:*.*
Mb3426c|M.bovis_AF2122/97 LFDDPVDLLDAQGNPIRVTSRGMFSADPARLRVRGRDDR---------LR
Rv3394c|M.tuberculosis_H37Rv LFDDPVDLLDAQGNPIRVTSRGMFSADPARLRVRGRDDR---------LR
MMAR_1151|M.marinum_M LLDDPVELLDVQGNPVRVTSRGMFSTAPARLVVGGRDDR---------LH
MUL_0916|M.ulcerans_Agy99 LLDDPVELLDVQGNPVRVTSRGMFSTAPARLVVGGRDDR---------LH
MAV_4344|M.avium_104 LLDDPVELLDAQNNPIRVSSRGLFSADPARLVVHGRGER---------LC
MSMEG_1622|M.smegmatis_MC2_155 LLDDPVELLDAQGNPVRVNSRGLFSSDPSRLSGAGKRDG--------VLR
TH_0486|M.thermoresistible__bu LLDDPVELLDAEGNPVRVTGRGLFSSEPVRLAGADAADSRVLPAGGARLR
Mflv_4898|M.gilvum_PYR-GCK LLDDPVELFDAEGNPVRVTGRGLFSAEPSRLHAPGRSGQ---------LS
Mvan_1523|M.vanbaalenii_PYR-1 LLDDPVELFDAEGNPVRVTGRGLFSTDPVRLHAPGRSGR---------LS
MAB_3712c|M.abscessus_ATCC_199 LSDEPVELLDVDGAPVTVTGRGMFSGEPARVRRGNGRWE---------LS
* *:**:*:*.:. *: *..**:** * *: . *
Mb3426c|M.bovis_AF2122/97 WWAGPWPDDERWWDP----DRASGRTARAQVLL-DGDPGTALLLCYRQRR
Rv3394c|M.tuberculosis_H37Rv WWAGPWPDDERWWDP----DRASGRTARAQVLL-DGDPGTALLLCYRQRR
MMAR_1151|M.marinum_M WWAGPWPVDERWWDP----DLGKGRTARAQVLL-GDE--RALLLCYRQRR
MUL_0916|M.ulcerans_Agy99 WWAGPWPVDERWWDP----DLGKGRTARAQVLL-GDE--RALLLCYRQRR
MAV_4344|M.avium_104 WWGGPWPVDERWWDDR---GQGGGRTARAQVLL-ESE--RALLLCYRQRR
MSMEG_1622|M.smegmatis_MC2_155 WWAGPWPVDERWWDPQ---NRGTGRTARAQVLLGDGEDALALLLCYRQRR
TH_0486|M.thermoresistible__bu WWAGPWPVDERWWDPDRTPNSRTGRTARAQVLL-DGEPQRALLLCYRQRR
Mflv_4898|M.gilvum_PYR-GCK WWAGPWPVDERWWDPS----SKSGRTARAQVLI---DETQALLLCYRQRR
Mvan_1523|M.vanbaalenii_PYR-1 WWAGPWPVDERWWDAAP---AKTGRTARAQVLLGA-DPAQALLLCYRRRR
MAB_3712c|M.abscessus_ATCC_199 WWAGPWPIDERWWEERE--PTSVSVAARAQVLLESSGGGQALLLHFRRQR
**.**** *****: . :******: **** :*::*
Mb3426c|M.bovis_AF2122/97 WYLEGSYE
Rv3394c|M.tuberculosis_H37Rv WYLEGSYE
MMAR_1151|M.marinum_M WYLEGSYE
MUL_0916|M.ulcerans_Agy99 WYLEGSYE
MAV_4344|M.avium_104 WYLEGSYE
MSMEG_1622|M.smegmatis_MC2_155 WYLEGAYE
TH_0486|M.thermoresistible__bu WYLEGSYE
Mflv_4898|M.gilvum_PYR-GCK WYLEGVYE
Mvan_1523|M.vanbaalenii_PYR-1 WYLEGVYE
MAB_3712c|M.abscessus_ATCC_199 WYVEGVYE
**:** **