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VATVGSPVQINDPRVPPYKLLTFITVVVLAVIFTLVYIQFRGGFTPKTELTMLASRAGLVMDPGSKVTYN GVEIGRVGTISETVRDGKPAAKFTLEVYPRYLKLIPSNVNADIKATTVFGGKYVSLTTPAHPSPQKISSH TVIDARSVTTEINTLFQTITSIAEKVDPVKLNLTLSAAAQSLSGLGEKFGQSVVNANALLDDVNPRMPQA RKDIQGLAALGDTYADASPDLFDFLNNAVITSRTINAQQKDLDQALLSAAGFGNTGAELFTKGGPYLARG AQDLIPTAQLLDTYSPEIYCLMRNEHDALPATGAAEGGFNGYSLNMNTEALSGLGLIANPVSAVPVIASM VGGIVGVVGGAPNPYIYPENLPRVNARGGPGGAPGCWQKITRDLWPAPELIMDTGNSIAPYNHLDTGSPY ALEYVWGRQVGDNTINP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4125 | - | - | 100% (438) | virulence factor Mce family protein |
| M. avium 104 | MAV_4126 | - | 0.0 | 88.37% (430) | virulence factor Mce family protein |
| M. avium 104 | MAV_5015 | - | 0.0 | 88.17% (431) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0175 | mce1A | 0.0 | 68.35% (455) | MCE-family protein MCE1A |
| M. gilvum PYR-GCK | Mflv_0711 | - | 1e-145 | 57.24% (428) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0169 | mce1A | 0.0 | 68.35% (455) | MCE-family protein MCE1A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 0.0 | 72.73% (440) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 2e-57 | 34.54% (414) | MCE-family protein |
| M. marinum M | MMAR_0412 | mce1A | 0.0 | 71.06% (432) | MCE-family protein Mce1A |
| M. smegmatis MC2 155 | MSMEG_0134 | - | 1e-144 | 57.71% (428) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_0154 | - | 1e-138 | 53.97% (428) | virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_1062 | mce1A | 0.0 | 70.83% (432) | MCE-family protein Mce1A |
| M. vanbaalenii PYR-1 | Mvan_0134 | - | 1e-151 | 59.58% (428) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4125|M.avium_104 MVATVGSPVQ----INDPRVPPYKLLTFITVVVLAVIFTLVYIQFRGGFT
MLBr_02589|M.leprae_Br4923 ----MTSSTK----INASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFT
MMAR_0412|M.marinum_M ----MTKPGK----LNKVNEPPYKIAGIALFLVGLLILSLVYLQFRGDFD
MUL_1062|M.ulcerans_Agy99 ----MTKPGK----LNKVNEPPYKIAGIALFLVGLLILSLVYLQFRGDFD
Mb0175|M.bovis_AF2122/97 ----MTTPGK----LNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFT
Rv0169|M.tuberculosis_H37Rv ----MTTPGK----LNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFT
Mflv_0711|M.gilvum_PYR-GCK ----MTAP------MNTKRQPPYKIAGVVLALVTILILVLVYLQFRGDFL
Mvan_0134|M.vanbaalenii_PYR-1 ----MTVPQA---ALNTRRQPPYKLAGLVLAILTVIAVTLVYLQFRGDFM
TH_0154|M.thermoresistible__bu ----MTAP------LNAPRTPPYKIVGVVLLLVVALVVTLVWMQFRGAFT
MSMEG_0134|M.smegmatis_MC2_155 ----MTEPPAPTAPLNKPKTPPYKLAGLILGLVGVLVLALTWMQFRGQFE
MAB_4153c|M.abscessus_ATCC_199 -------------MSDTSTRRAVRLAGTVLASVLVLLTVLTYLAYNDAFA
: . : : : *.: :.. *
MAV_4125|M.avium_104 PKTELTMLASRAGLVMDPGSKVTYNGVEIGRVGTISETVRDGKPAAKFTL
MLBr_02589|M.leprae_Br4923 PKSKLTMLADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTL
MMAR_0412|M.marinum_M RKVKLTMFSERAGLVMDPGSKVTYNGVQIGRVDTISEITRDGKPAAKFVL
MUL_1062|M.ulcerans_Agy99 RKVKLTMFSERAGLVMDPGSKVTYNGVQIGRVDTISEITRDGKPAAKFVL
Mb0175|M.bovis_AF2122/97 PKTQLTMLSARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFIL
Rv0169|M.tuberculosis_H37Rv PKTQLTMLSARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFIL
Mflv_0711|M.gilvum_PYR-GCK PRTQLTMISARSGLSLDSGSKVTFNGVEIGKVSEVEETTVGGEPRAKILL
Mvan_0134|M.vanbaalenii_PYR-1 ARTQLTMISARSGLSMDPGAKVTYNGVEIGRVGNVEETSVDGEPRAKIIL
TH_0154|M.thermoresistible__bu PRTQLTLLADRAGLVMDPGSKVTFNGVEIGRVAQIHADTSDDRTRANIVL
MSMEG_0134|M.smegmatis_MC2_155 DKVQLTVLSGRAGLSMDPGSKVTFNGVPIGRLASIDVVEVDDNPEARLTL
MAB_4153c|M.abscessus_ATCC_199 DTKPITVVSPRAGLVMEEGGKVKFHGLQIGKVTSISYAN----DQAKLEL
:*:.: *:** :: *.*:.::*: **:: : *.: *
MAV_4125|M.avium_104 EVYPRYLKLIPSNVNADIKATTVFGGKYVSLTTPAHPSPQKISSHTVIDA
MLBr_02589|M.leprae_Br4923 DVYPRYLSLIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDA
MMAR_0412|M.marinum_M NVYPRYLPLIPENVDAQIKATTVFGGKYVSLTTPEHPSNKKLSAHSVINA
MUL_1062|M.ulcerans_Agy99 NVYPRYLPLIPENVDAQIKATTVFGGKYVSLTTPEHPSNKKLSAHSVINA
Mb0175|M.bovis_AF2122/97 DVDPRYIHLIPANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDV
Rv0169|M.tuberculosis_H37Rv DVDPRYIHLIPANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDV
Mflv_0711|M.gilvum_PYR-GCK EVNPKYLKLIPRNVNADISATTVFGNKYVSFTSPENPQSERISASDVIDV
Mvan_0134|M.vanbaalenii_PYR-1 DVNPKYLDLIPSNVNADISATTVFGNKYVSFTTPEDPRPERISASDVIDV
TH_0154|M.thermoresistible__bu DVDPKYVDLIPSNADVEIKASTVFGNKYVAFASPPDPSLTPITSAATIDV
MSMEG_0134|M.smegmatis_MC2_155 DVDPKYLDLIPENANVELRATTVFGNKYISFLSPKNPSAERLSASTPIRA
MAB_4153c|M.abscessus_ATCC_199 AVNAKDLRLIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTA
* .: : *** *. . : .:**** * : : :* .* : . : .
MAV_4125|M.avium_104 RSVTTEINTLFQTITSIAEKVDPVKLNLTLSAAAQSLSGLGEKFGQSVVN
MLBr_02589|M.leprae_Br4923 RSVTTEINTLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVN
MMAR_0412|M.marinum_M SAVTTEINTLFETLTSISEKVDPVKLNLTLSAAAEALTGLGNRFGEAIAN
MUL_1062|M.ulcerans_Agy99 SAVTIEINTLFETLTSISEKVDPVKLNLTLSAAAEALTGLGNRFGEAIAN
Mb0175|M.bovis_AF2122/97 RSVTTEINTLFQTLTSIAEKVDPVKLNLTLSAAAEALTGLGDKFGESIVN
Rv0169|M.tuberculosis_H37Rv RSVTTEINTLFQTLTSIAEKVDPVKLNLTLSAAAEALTGLGDKFGESIVN
Mflv_0711|M.gilvum_PYR-GCK TSVTTEFNTLFETVVEIAEQVDPIKLNQTLTATAQALDGLGDRFGESIIN
Mvan_0134|M.vanbaalenii_PYR-1 TSVTTEFNTLFETVVSLADQVDPIKLNQTLTATAQALDGLGDRFGESIIN
TH_0154|M.thermoresistible__bu TKVTTEFNTLFQTVVDIARQVDPIKLNQTLTATAQALDGLGDRFGESIID
MSMEG_0134|M.smegmatis_MC2_155 QGVTTEFNTLFETITAISEQVDPIKLNETLTAAAQALDGLGDKFGRSIVD
MAB_4153c|M.abscessus_ATCC_199 EAVALEVNTVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVE
*: *.**:*:.:. : ::**::** **:*..:.* * *:.**..: :
MAV_4125|M.avium_104 ANALLDDVNPRMPQARKDIQGLAALGDTYADASPDLFDFLNNAVITSRTI
MLBr_02589|M.leprae_Br4923 GNSVLDDVNSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTI
MMAR_0412|M.marinum_M GNEILDDINPQMPQARRDIQQLAALGDVYADAAPDLFDFLNNSVPTARTI
MUL_1062|M.ulcerans_Agy99 GNEILDDINPQMPQARRDIQQLAALGDVYADAAPDLFDFLNNSVPTARTI
Mb0175|M.bovis_AF2122/97 ANTVLDDLNSRMPQSRHDIQQLAALGDVYADAAPDLFDFLDSSVTTARTI
Rv0169|M.tuberculosis_H37Rv ANTVLDDLNSRMPQSRHDIQQLAALGDVYADAAPDLFDFLDSSVTTARTI
Mflv_0711|M.gilvum_PYR-GCK GNQILAEINPQMPQIRRDNQLLADFGEVYSNAAPDLFDGLQNAVTTARTL
Mvan_0134|M.vanbaalenii_PYR-1 GNQILSEINPQMPQIRRDNQLLADLGDVYADAAPDLFDGLQNAVTTARTL
TH_0154|M.thermoresistible__bu GNAILDDLNPQMPQIRYDVQRLADLNAVYAAAAPDLFDGLENAVTTAQTL
MSMEG_0134|M.smegmatis_MC2_155 GNAILADVNPRMPQIRRDITGLANLGEVYADASPDLFDGLDNAVTTARTL
MAB_4153c|M.abscessus_ATCC_199 LDQYLDQLNPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTV
: * ::*.::* : * . .. *. ::.*:. *:. ::*:
MAV_4125|M.avium_104 NAQQKDLDQALLSAAGFGNTGAELFTKGGPYLARGAQDLIPTAQLLDTYS
MLBr_02589|M.leprae_Br4923 NQQQKDLDQVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYS
MMAR_0412|M.marinum_M NAQQHDLDAALLAAVGFGNTGADVFERGGPYLARGAADLVPSAQLLDTYS
MUL_1062|M.ulcerans_Agy99 NAQQHDLDAALLAAVGFGNTGADVFERGGPYLARGAADLVPSAQLLDTYS
Mb0175|M.bovis_AF2122/97 NAQQAELDSALLAAAGFGNTTADVFDRGGPYLQRGVADLVPTATLLDTYS
Rv0169|M.tuberculosis_H37Rv NAQQAELDSALLAAAGFGNTTADVFDRGGPYLQRGVADLVPTATLLDTYS
Mflv_0711|M.gilvum_PYR-GCK NEQQGDVDQALMAAVGFGNTGGDIFERGGPYLVRGARDLVPTSALLDKYS
Mvan_0134|M.vanbaalenii_PYR-1 NEQQGDVDQALMAAVGFGNTGGDVFERGGPYLARGAEDLVPTTALLDKYS
TH_0154|M.thermoresistible__bu YQERGNLDQTLLASIGFGNTAGEVFERGGPYLVRGSEDLVTVTEILDYHS
MSMEG_0134|M.smegmatis_MC2_155 NEQRGNLDQALVAAVGFGNTGGDIFERGGPYLVRGAQDLLPTSALLDEYS
MAB_4153c|M.abscessus_ATCC_199 VDQQQDLKATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYS
:: ::. .*::: *:**. : : . * . * . : :*. :*
MAV_4125|M.avium_104 PEIYCLMRNEHDALPATGAAEGGFNGYSLNMNTEALSGLGLIANPVSAVP
MLBr_02589|M.leprae_Br4923 PAIFCTLRNYHDIEPKVTSFLGG-NGYSINDHVELLSGLGFLLNPTSAIS
MMAR_0412|M.marinum_M PELFCTLRNYHDVEPQAYKFLGG-NGYSLNSHTTPLSALGMMLNPASLVP
MUL_1062|M.ulcerans_Agy99 PELFCTLRNYHDVEPQAYKFLGG-NGYSLNSHTTPLSALGMMLNPASLVP
Mb0175|M.bovis_AF2122/97 PELFCTIRNFYDADPLAKAAAGGGNGYSLRTNSEILSGIGISLLSPLALA
Rv0169|M.tuberculosis_H37Rv PELFCTIRNFYDADPLAKAASGGGNGYSLRTNSEILSGIGISLLSPLALA
Mflv_0711|M.gilvum_PYR-GCK PSFFCMMRNYHDVEPKIADALGG-NGYSLKTHSQVLGLG-----------
Mvan_0134|M.vanbaalenii_PYR-1 PSFFCMIRNYHDVEPKIADALGG-NGYSLKTHSEVLGLG-----------
TH_0154|M.thermoresistible__bu PALFCMIRNYHDVAPKVAASLGG-NGYSLRQHAFLVGP------------
MSMEG_0134|M.smegmatis_MC2_155 PALFCTIRNYHDAAPKLAGALGG-NGYSLLTNSLVVGV------------
MAB_4153c|M.abscessus_ATCC_199 PEIPCTLQAISKALVTFTPLIGGVRPGLFLTNSFPLGAP-----------
* : * :: . ** . : : :.
MAV_4125|M.avium_104 VIASMVG--------------------GIVGVVGGAPNPYIYPENLPRVN
MLBr_02589|M.leprae_Br4923 IIGAGVLSQGLL------------APLGLAGVVNGAANPYIYPENLPRVN
MMAR_0412|M.marinum_M LLISQVGG-------------------LAAGLVGGAPNPYIYPENLPRVN
MUL_1062|M.ulcerans_Agy99 LLISQVGG-------------------LAAGLVGGAPNPYIYPENLPRVN
Mb0175|M.bovis_AF2122/97 TNGAAIGIGLVAGLIASPLAVAANLAGALPGIVGGAPNPYTYPENLPRVN
Rv0169|M.tuberculosis_H37Rv TNGAAIGIGLVAGLIAPPLAVAANLAGALPGIVGGAPNPYTYPENLPRVN
Mflv_0711|M.gilvum_PYR-GCK -----------------------------------AGNAYVYPDNLPRVN
Mvan_0134|M.vanbaalenii_PYR-1 -----------------------------------AGNAYVYPDNLPRVN
TH_0154|M.thermoresistible__bu ------------------------------------GNPYVYPDNLPRVN
MSMEG_0134|M.smegmatis_MC2_155 ------------------------------------GNPYVYPDNLPRVN
MAB_4153c|M.abscessus_ATCC_199 --------------------------------------VYTYPDSLPIVN
* **:.** **
MAV_4125|M.avium_104 ARGGP--GGAPGCWQKITRDLWP-APELIMDTG-NSIAPYNHLDTGSPYA
MLBr_02589|M.leprae_Br4923 ARGGP--GGAPGCWQHITRDLWP-TPELVMDTG-NSIAPYNHLDSGSPYA
MMAR_0412|M.marinum_M AHGGP--GGAPGCWQSITHDFWP-APELVMDTG-NSLAPYNHLETGSPFV
MUL_1062|M.ulcerans_Agy99 AHGGP--GGAPGCWQSITHDFWP-APELVMDTG-NSLAPYNHLETGSPFV
Mb0175|M.bovis_AF2122/97 ARGGP--GGAPGCWQPITRDLWP-APYLVMDTG-ASLAPYNHMEVGSPYA
Rv0169|M.tuberculosis_H37Rv ARGGP--GGAPGCWQPITRDLWP-APYLVMDTG-ASLAPYNHMEVGSPYA
Mflv_0711|M.gilvum_PYR-GCK AKGGP--GGRPGCWQPITRDLWP-APFLVLDTG-ASVAPYNHMELGQPLF
Mvan_0134|M.vanbaalenii_PYR-1 AKGGP--GGRPGCWQPITRDLWP-APFLVLDTG-ASIAPYNHMELGQPLL
TH_0154|M.thermoresistible__bu ATGGP--GGRPGCWQPITRDLWP-APYLVMDTG-ASLAPYNHIELGKPFA
MSMEG_0134|M.smegmatis_MC2_155 AKGGP--EGRPGCWQPITRDLWP-FPYLVMDTG-ASIAPYNHFELGQPMF
MAB_4153c|M.abscessus_ATCC_199 ASGGPNCRGLPNIPTKMQNGSWFRSPFLVTDNAYIPYKPLEELQVNAPDT
* *** * *. : .. * * *: *.. . * :.:: . *
MAV_4125|M.avium_104 LEYVWGRQVGDNTINP
MLBr_02589|M.leprae_Br4923 IEYVWGRQVGDNTINP
MMAR_0412|M.marinum_M LEYVWGRQVGDYTINP
MUL_1062|M.ulcerans_Agy99 LEYVWGRQVGDYTINP
Mb0175|M.bovis_AF2122/97 VEYVWGRQVGDNTINP
Rv0169|M.tuberculosis_H37Rv VEYVWGRQVGDNTINP
Mflv_0711|M.gilvum_PYR-GCK TEYVWGRQVGEHTINP
Mvan_0134|M.vanbaalenii_PYR-1 TEYVWGRQVGEHTINP
TH_0154|M.thermoresistible__bu IEYVWGRQIGEYTINP
MSMEG_0134|M.smegmatis_MC2_155 AEYVWGRQVGENTINP
MAB_4153c|M.abscessus_ATCC_199 LQYLYNGAFAKRSEF-
:*::. ... :