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SGALLVAGTSSDAGKSVVVAGLCRLLARRGVRVAPFKAQNMSNNSAVTVEGGEIGRAQAIQARAAGLEPS VRFNPVLLKPGSDRTSQLVIKGQVAESVTATSYVQHRDRLAALVLNELTCLRDEFDAVICEGAGSPAEIN LRATDLANMGLARAADLAVILVGDIDRGGLLAHLFGTVAVLDPQDQALIAGFVVNKFRGDPALLQPGLRR LHDITGRPTYGVLPYADGLWLDAEDSLSVLAHRVVGAPDPPLGDDWLRVAAVRLPRISNSTDVEALACEP GVLVRWVSEPSDVADADLVVIPGSKATVADLSWVRERGLADAITAHAAAGRPVLGICGGFQMLCRRIDDR VESGAGEVAGLGLLDADIAFHPTKTLRRWQRPLAGYEIHHGRVSRCAEHSWFDSDAEPQGLVRGAVFGTH WHGLLDNDDFRRAWLVRVAEAAGRRFVPGDTDVAARRDAQLDLAADLLAAHLDVDAVLGLLDGPPPRPRL ATRLCR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3720 | cobQ | - | 100% (497) | cobyric acid synthase |
| M. avium 104 | MAV_3184 | hisH | 3e-06 | 39.02% (82) | imidazole glycerol phosphate synthase subunit HisH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0261c | cobQ1 | 1e-125 | 53.07% (505) | cobyric acid synthase |
| M. gilvum PYR-GCK | Mflv_0360 | - | 1e-128 | 53.14% (493) | cobyric acid synthase |
| M. tuberculosis H37Rv | Rv0255c | cobQ1 | 1e-125 | 53.07% (505) | cobyric acid synthase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3163c | - | 0.0 | 69.64% (504) | cobyric acid synthase |
| M. marinum M | MMAR_3838 | cobQ1 | 1e-123 | 51.93% (491) | cobyric acid synthase CobQ1 |
| M. smegmatis MC2 155 | MSMEG_2588 | cobQ | 0.0 | 72.38% (496) | cobyric acid synthase |
| M. thermoresistible (build 8) | TH_1392 | cobQ | 0.0 | 75.51% (494) | cobyric acid synthase CobQ |
| M. ulcerans Agy99 | MUL_3770 | cobQ1 | 1e-124 | 52.55% (491) | cobyric acid synthase |
| M. vanbaalenii PYR-1 | Mvan_0377 | - | 1e-128 | 52.81% (498) | cobyric acid synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0360|M.gilvum_PYR-GCK ---MTG--LLVAGTTSDAGKTAVTTGLCRALARRGVKVAPYKAQNMSNNS
Mvan_0377|M.vanbaalenii_PYR-1 ---MTG--LLIAGTTSDAGKTAVTTGLCRALARRGLKVAPYKAQNMSNNS
Mb0261c|M.bovis_AF2122/97 ---MSG--LLVAGTTSDAGKSAVTAGLCRALARRGVRVAPFKAQNMSNNS
Rv0255c|M.tuberculosis_H37Rv ---MSG--LLVAGTTSDAGKSAVTAGLCRALARRGVRVAPFKAQNMSNNS
MMAR_3838|M.marinum_M ---MPG--LLVAGTTSDAGKSTLTAGLCRAFARRGVRVAPFKAQNMSNNS
MUL_3770|M.ulcerans_Agy99 ---MPG--LLVAGTTSDAGKSTLTAGLCRAFARRGVRVAPFKAQNMSNNS
MSMEG_2588|M.smegmatis_MC2_155 ---MTGGALLVAGTTSDAGKSMLVGGLCRLLVRKGLSVAPFKAQNMSNNS
TH_1392|M.thermoresistible__bu ---MTGGALLVAGTTSDAGKSVLVAGLCRLLARKGIRVAPFKAQNMSNNS
MAV_3720|M.avium_104 ---MSG-ALLVAGTSSDAGKSVVVAGLCRLLARRGVRVAPFKAQNMSNNS
MAB_3163c|M.abscessus_ATCC_199 MTGAVSGALLVGGVSSDAGKSLVVTGLCRLLARKGIRVAPFKAQNMSNNS
. **:.*.:*****: :. **** :.*:*: ***:*********
Mflv_0360|M.gilvum_PYR-GCK MVCTSVDGAGAEIGRAQWVQALAARATPEPAMNPVLLKPGSDRRSHVVLM
Mvan_0377|M.vanbaalenii_PYR-1 MVCAGDDG-GVEIGRAQWVQALAARATPEAAMNPVLLKPGSDRRSHVVLM
Mb0261c|M.bovis_AF2122/97 MVCRGPDGTGVEIGRAQWVQALAARTTPEAAMNPVLLKPASDHRSHVVLM
Rv0255c|M.tuberculosis_H37Rv MVCRGPDGTGVEIGRAQWVQALAARTTPEAAMNPVLLKPASDHRSHVVLM
MMAR_3838|M.marinum_M MVCQGPGGAGVEIGRAQWVQALAANATPEAAMNPVLLKPGSDHRSHVVLM
MUL_3770|M.ulcerans_Agy99 MVCQGPGGAGVEIGRAQWVQALAANATPEAAMNPVLLKPGSDHRSHVVLM
MSMEG_2588|M.smegmatis_MC2_155 AVT----VEGGEIGRAQAMQARAAGLAPSVRFNPILLKPGGDRTSQLVVR
TH_1392|M.thermoresistible__bu AVT----VEGGEIGRAQAMQARAAGLEPSVRFNPILLKPGGDRTSQLVVR
MAV_3720|M.avium_104 AVT----VEGGEIGRAQAIQARAAGLEPSVRFNPVLLKPGSDRTSQLVIK
MAB_3163c|M.abscessus_ATCC_199 VVT----VDGGEIGRAQALQARACGLEPSVRFNPVLLKPGSDRTSQLVVR
* * ****** :** *. *. :**:****..*: *::*:
Mflv_0360|M.gilvum_PYR-GCK GRPWGQVSSSDWLEGRRALATAAHEAFDELASRYEVVVAEGAGSPTEINL
Mvan_0377|M.vanbaalenii_PYR-1 GRPWGHVSSSDWLEGRRALAAAAHAAYDDLAGRYDVIVAEGAGSPTEINL
Mb0261c|M.bovis_AF2122/97 GKPWGEVASSSWCAGRRALAEAACRAFDALAARYDVVVAEGAGSPAEINL
Rv0255c|M.tuberculosis_H37Rv GKPWGEVASSSWCAGRRALAEAACRAFDALAARYDVVVAEGAGSPAEINL
MMAR_3838|M.marinum_M GRSWGELASSNWFEGRQVLAETAHRAFDDLAARYDVVVAEGAGSPAEINL
MUL_3770|M.ulcerans_Agy99 GRSWGELASSNWFEGRQVLADTAHRAFDDLAARYDVVVAEGAGSPAEINL
MSMEG_2588|M.smegmatis_MC2_155 GQVTGSVAAADYINHRDHLAAVVADELSSLREDFDAVICEGAGSPAEINL
TH_1392|M.thermoresistible__bu GEVSGSVAAGDYIRHRDRLRAVVAEELTALRTEFDVVLCEGAGSPAEINL
MAV_3720|M.avium_104 GQVAESVTATSYVQHRDRLAALVLNELTCLRDEFDAVICEGAGSPAEINL
MAB_3163c|M.abscessus_ATCC_199 GRATGNVSARSYVEHREELRQVVAEDLRTLREEYDVVICEGAGSVAEINL
*. ::: .: * * . * ::.::.***** :****
Mflv_0360|M.gilvum_PYR-GCK RAGDYVNLGLARHAGLPTVVVGDIDRGGVFAAFFGTVALLSPQDQALIAG
Mvan_0377|M.vanbaalenii_PYR-1 RAGDYVNLGLARHAGLPTVVVGDIDRGGVFAAFFGTVALLSPEDQALIAG
Mb0261c|M.bovis_AF2122/97 RAGDYVNMGLARHAGLPTIVVGDIDRGGVFAAFLGTVALLAAEDQALVAG
Rv0255c|M.tuberculosis_H37Rv RAGDYVNMGLARHAGLPTIVVGDIDRGGVFAAFLGTVALLAAEDQALVAG
MMAR_3838|M.marinum_M RAGDYVNMGLACHAELPTIVVGDIDRGGVFAAFFGTIALLSAEDQALVAG
MUL_3770|M.ulcerans_Agy99 RAGDYVNMGLARHAELPTIVVGDIDRGGVFAAFFGTIALLSVEDQALVAG
MSMEG_2588|M.smegmatis_MC2_155 RATDLANMGLARAAALPVIVVGDIDRGGLLAHLHGTVAVLEPADQALVSG
TH_1392|M.thermoresistible__bu RATDLANLGLARAADLPIVLIGDIDRGGLLAHFFGTVAVLEPADQRLIAG
MAV_3720|M.avium_104 RATDLANMGLARAADLAVILVGDIDRGGLLAHLFGTVAVLDPQDQALIAG
MAB_3163c|M.abscessus_ATCC_199 RTTDIANMGLARAAGLPVVLVGDIDRGGVLAHLFGSVAVLEPADQRLVAG
*: * .*:*** * *. :::*******::* : *::*:* ** *::*
Mflv_0360|M.gilvum_PYR-GCK FVVNKFRGDVDLLAPGLRDLERLTGRRVYGTLPWHPDIWLDSEDALELAG
Mvan_0377|M.vanbaalenii_PYR-1 FVVNKFRGDPALLAPGLRDLERLTGRRVYGTLPWHPDLWLDSEDALELQG
Mb0261c|M.bovis_AF2122/97 FVVNKFRGDSDLLAPGLRDLERVTGRRVYGTLPWHPDLWLDSEDALDLQG
Rv0255c|M.tuberculosis_H37Rv FVVNKFRGDSDLLAPGLRDLERVTGRRVYGTLPWHPDLWLDSEDALDLQG
MMAR_3838|M.marinum_M FVVNKFRGDLDLLAPGLRDLEGVTGRQVFGTLPWHADLWLDSEDALDLTG
MUL_3770|M.ulcerans_Agy99 FVVNKFRGDLDLLAPGLRDLERVTGRQVFGTLPWHADLWLDSEDALDLTG
MSMEG_2588|M.smegmatis_MC2_155 FVVNKFRGDPSLLAPGLRQLAELTGRPTYGVIPFHDEIWLDTEDSVSVRP
TH_1392|M.thermoresistible__bu FVVNKFRGDPALLTPGLDELHRRTGRPTYGIIPFSDDLWLDAEDSVSVVS
MAV_3720|M.avium_104 FVVNKFRGDPALLQPGLRRLHDITGRPTYGVLPYADGLWLDAEDSLSVLA
MAB_3163c|M.abscessus_ATCC_199 FIVNKFRGDPTLLEPGLEQLATLTGRPTYGVLPYDDQLWLDAEDSVSVVA
*:******* ** *** * *** .:* :*: :***:**::.:
Mflv_0360|M.gilvum_PYR-GCK RRSAQSG-------ARRVAVIRLPRISNFTDVDALGLEPDLDVVFASHPG
Mvan_0377|M.vanbaalenii_PYR-1 RRSARPG-------ARRVAVVRLPRISNFTDVDAFGLEPDLDVVFASHPS
Mb0261c|M.bovis_AF2122/97 RRAAGTG-------ARRVAVVRLPRISNFTDVDALGLEPDLDVVFASDPR
Rv0255c|M.tuberculosis_H37Rv RRAAGTG-------ARRVAVVRLPRISNFTDVDALGLEPDLDVVFASDPR
MMAR_3838|M.marinum_M RRAASTG-------AHRVAVVRLPRISNFTDVDALGLEPDLDVVFASDPR
MUL_3770|M.ulcerans_Agy99 RRAASAG-------AHRVAVVRLPRISNFTDVDALGLEPDLDVVFASDPR
MSMEG_2588|M.smegmatis_MC2_155 GGLVGAPEPPRGEQTLTVAAIRLPRISNSTDIEALACEPGVVVRWVTDAA
TH_1392|M.thermoresistible__bu GRVVGTPQPPRGEQSLTVAAVRLPRISNSTDVEALACEPGVVVRWVADPT
MAV_3720|M.avium_104 HRVVGAPDPPLGDDWLRVAAVRLPRISNSTDVEALACEPGVLVRWVSEPS
MAB_3163c|M.abscessus_ATCC_199 SGQVGQTSDPIGQEWLRVAAVRLPRISNSTDIEALACEPGVTVRWAAHPA
. **.:******* **::*:. **.: * :.:..
Mflv_0360|M.gilvum_PYR-GCK SLADADLVVLPGTRATIADLAWLRSRGLDSALRRHVAAGRPVLGICGGFQ
Mvan_0377|M.vanbaalenii_PYR-1 ALADADLVVLPGTRSTIADLAWLRSRGLDRAVLAHAAAGRPVLGICGGFQ
Mb0261c|M.bovis_AF2122/97 ALDDADLIVLPGTRATIADLAWLRARDLDRALLVHVAAGKPLLGICGGFQ
Rv0255c|M.tuberculosis_H37Rv ALDDADLIVLPGTRATIADLAWLRARDLDRALLVHVAAGKPLLGICGGFQ
MMAR_3838|M.marinum_M GLGDADLIVVPGTRATIADLAWLRARGLDRALMAHVAAGKPLLGICGGFQ
MUL_3770|M.ulcerans_Agy99 GLGDADLIVVPGTRATIADLAWLRARGLDRALMAHVAAGKPLLGICGGFQ
MSMEG_2588|M.smegmatis_MC2_155 DLTGADLVVIPGSKATVTDLRWLRERGLAAGIAAHAAAGRAVLGVCGGFQ
TH_1392|M.thermoresistible__bu ELTDADAVVLPGSKATVADLTWLRDRGLADAIVAHAAAGRAVLGVCGGFQ
MAV_3720|M.avium_104 DVADADLVVIPGSKATVADLSWVRERGLADAITAHAAAGRPVLGICGGFQ
MAB_3163c|M.abscessus_ATCC_199 DIADADVVVIPGTKATVADLAWMRRHGVADAVVAHARSGGPVLGICGGFQ
: .** :*:**:::*::** *:* :.: .: *. :* .:**:*****
Mflv_0360|M.gilvum_PYR-GCK MLGRVIRDPHGVEGP---VAGVDGLGLLDVETTFGPDKVLRLPSGRWFGA
Mvan_0377|M.vanbaalenii_PYR-1 MLGRVIRDPHGVEGG---TSEADGLGLLDIETDFVADKALRLPEGQWEAT
Mb0261c|M.bovis_AF2122/97 MLGRVIRDPYGIEGPGGQVTEVEGLGLLDVETAFSPHKVLRLPRGEGLGV
Rv0255c|M.tuberculosis_H37Rv MLGRVIRDPYGIEGPGGQVTEVEGLGLLDVETAFSPHKVLRLPRGEGLGV
MMAR_3838|M.marinum_M MLGRVIRDPDGVEGP---VAEADGLGLLDVETTFGAEKVLRLPRGQGLGV
MUL_3770|M.ulcerans_Agy99 MLGRVIRDPDGVEGP---VAEADGLGLLDVETTFGAEKVLRLPRGQGLGV
MSMEG_2588|M.smegmatis_MC2_155 MLCSRIDDP--VESR---EGRVDGLGLLDADIEFAAQKTLRH----WETP
TH_1392|M.thermoresistible__bu MLCRRIDDR--VESG---VGRVDGLGLLDADIEFAADKTLRR----WERP
MAV_3720|M.avium_104 MLCRRIDDR--VESG---AGEVAGLGLLDADIAFHPTKTLRR----WQRP
MAB_3163c|M.abscessus_ATCC_199 MLATTIDDR--VESG---AGAVEGLGLLDIDIAFEPVKTLRR----WGPP
** * * :*. . ****** : * . *.**
Mflv_0360|M.gilvum_PYR-GCK PATGYEIHHGRITRGDGVDEFLD------GARCGQVFGTMWHGALEGDEL
Mvan_0377|M.vanbaalenii_PYR-1 SASGYEIHHGRITPGPGGDEFPG------GVRCGPVFGTMWHGAFEGDAL
Mb0261c|M.bovis_AF2122/97 PASGYEIHHGRITRGDTAEEFLG------GARDGPVFGTMWHGSLEGDAL
Rv0255c|M.tuberculosis_H37Rv PASGYEIHHGRITRGDTAEEFLG------GARDGPVFGTMWHGSLEGDAL
MMAR_3838|M.marinum_M TASGYEIHHGRITAGDAAQQFLG------GARDGQVFGTMWHGSLEGDAL
MUL_3770|M.ulcerans_Agy99 TASGYEIHHGRITAGDAAQQFLG------GARDGQVFGTMWHGSLEGDAL
MSMEG_2588|M.smegmatis_MC2_155 -LHGYEIHHGQVAR-SAETDWLG-----IGLRRGAVYGTHWHGLLDNDAL
TH_1392|M.thermoresistible__bu -LRGYEIHHGQVTR-SAADDWHG-----VGLRRGAVCGTHWHGLLDNDEL
MAV_3720|M.avium_104 -LAGYEIHHGRVSR-CAEHSWFDSDAEPQGLVRGAVFGTHWHGLLDNDDF
MAB_3163c|M.abscessus_ATCC_199 GLTGYEIHHGTVTR-SAVPPWLT--DHDEGAVDGAVWGTHWHGVLDNDDF
******* :: : * * * ** *** ::.* :
Mflv_0360|M.gilvum_PYR-GCK RSRFLQEALGVAPSG-------VSFPAAREARLDLLGDLVERHLDVDALL
Mvan_0377|M.vanbaalenii_PYR-1 RARFLTETLGVPASG-------ASFPKAREDRIDLLGDLVEEHLDVDALL
Mb0261c|M.bovis_AF2122/97 REAFLRETLGLAPSG-------SCFLAARERRLDLLGDLVERHLDVDALL
Rv0255c|M.tuberculosis_H37Rv REAFLRETLGLAPSG-------SCFLAARERRLDLLGDLVERHLDVDALL
MMAR_3838|M.marinum_M REAFLRETLGLTGSG-------TSFSAARERRLDLLGDLVERHLDVDALL
MUL_3770|M.ulcerans_Agy99 REAFLRETLGLTESG-------TSFSAARERRLDLLGDLVERHLDVDALL
MSMEG_2588|M.smegmatis_MC2_155 RRDWLTEVAAAAGRDGFVVADDVDVSARRDAQLDLMADLIENHLDVGAIL
TH_1392|M.thermoresistible__bu RRQWLSEAAVAAGRHGFVVADDIDVGARRDRQLDQIADLLTAHLDLDALF
MAV_3720|M.avium_104 RRAWLVRVAEAAGRR--FVPGDTDVAARRDAQLDLAADLLAAHLDVDAVL
MAB_3163c|M.abscessus_ATCC_199 RRAWLTQAAAAAGRSGFAVAADTNVGDRRAAQLDRLADLVGTHVDVDALE
* :* .. . . * ::* .**: *:*:.*:
Mflv_0360|M.gilvum_PYR-GCK DLAKTG----PVAGLPFLPPGAP-
Mvan_0377|M.vanbaalenii_PYR-1 RLAEHA----PPQGLPFLPPGSP-
Mb0261c|M.bovis_AF2122/97 NLARHG----CPPTLPFLAPGAP-
Rv0255c|M.tuberculosis_H37Rv NLARHG----CPPTLPFLAPGAP-
MMAR_3838|M.marinum_M ALARHG----CAPALPFLPPGAP-
MUL_3770|M.ulcerans_Agy99 ALARHG----CAPALPFLPPGAP-
MSMEG_2588|M.smegmatis_MC2_155 DLLEH-----GAPHRPTMSTALHV
TH_1392|M.thermoresistible__bu ALLED-----GPPPRPVLRTDVI-
MAV_3720|M.avium_104 GLLD------GPPPRPRLATRLCR
MAB_3163c|M.abscessus_ATCC_199 SVWEESGLPASAPSYPVIAARVE-
: * : .