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VNIAEHALAAAQSPALITDGGTISYGELHDRSRRVAAALHELGLRRGDGVAVVLPNRPEFLEITWGCQLS GLYYTPVNTHFTADEVVYVIDDSDAKAVFVDASLPGIAARLRSANPAVHIGVGGKLPGWRDYEGVLGVAG DAPPVSDGSEMLYSSGTTGRPKAVRRPLPQDGNGSWAQSVLELALIHKYGMTQRSVYLSPAPLYHAAGVN YTMAVNRVGAASIIMRKFDAETVLRLIETHRVTHAQFVPTMFVRMLKLPEAVRDRYDVSSLRCVIHAAAP CPVDVKHRMMRWFGPIIHEYYGGTEGFAGTTIGPQEWLAHPGSVGIPLAPVHVLDEDGREVPVGQTGELY FEGGPDFEYFKDPVKTASVYNERGWRSLGDMGHLDEDGYLYLTDRSTFTIVSGGVNIYPQEVENLLVMHP KLLDAAVFGVPNDEFGEEVKAVVQPADGVPPGPDLAAELIAYCRAHLAGYKCPRTVEFDTLPRDPNGKLY KRRIRERYWQGRESRIV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2951 | - | - | 100% (507) | acyl-CoA synthase |
| M. avium 104 | MAV_4961 | - | e-132 | 47.43% (506) | acyl-CoA synthetase |
| M. avium 104 | MAV_2547 | - | e-130 | 47.63% (506) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0220 | fadD4 | 1e-133 | 49.30% (499) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0449 | - | 1e-131 | 46.72% (518) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv0214 | fadD4 | 1e-132 | 49.20% (498) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-59 | 31.82% (506) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_3435 | - | 1e-129 | 47.54% (509) | acyl-CoA synthetase |
| M. marinum M | MMAR_0452 | fadD4 | 1e-129 | 46.80% (515) | fatty-acid-CoA ligase FadD4 |
| M. smegmatis MC2 155 | MSMEG_0257 | - | 1e-137 | 49.21% (506) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4613 | - | 1e-138 | 49.80% (508) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_1191 | fadD2 | 1e-56 | 30.94% (501) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0218 | - | 1e-135 | 47.49% (518) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0220|M.bovis_AF2122/97 ------------------------MPRGELYKRFRLVMGGIAPCGSGRRA
Rv0214|M.tuberculosis_H37Rv ------------------------MPRGELYKRFRLVMGGIAPCGSGRRA
MMAR_0452|M.marinum_M --------------------------------------------------
Mflv_0449|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0218|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0257|M.smegmatis_MC2_155 --------------------------------------------------
TH_4613|M.thermoresistible__bu --------------------------------------------------
MAB_3435|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2951|M.avium_104 --------------------------------------------------
MLBr_02546|M.leprae_Br4923 ---------MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVA
MUL_1191|M.ulcerans_Agy99 MPNLSDLPGVAKIQQYVDRGAAELHYVRKIIESGAFRLESPLNYAAMATE
Mb0220|M.bovis_AF2122/97 ATYPRRMQIRPYIAAD--KPAVILYPSGTVISFDELEARANRLAHWFRQA
Rv0214|M.tuberculosis_H37Rv ATYPRRMQIRPYIGAD--KPAVILYPSGTVISFDELEARANRLAHWFRQA
MMAR_0452|M.marinum_M ------MQIRQHVGAD--KPAVILHPSGTVVSFDELEARANRLAHRFRRA
Mflv_0449|M.gilvum_PYR-GCK ------MQIRDTAVATPDKPAVIMYPAGTVVTFGELEARANRLAHLFRDA
Mvan_0218|M.vanbaalenii_PYR-1 ------MQIRDTAVATPDKPAIIMYPSGTVVTFGELEARANRLAHLFRDA
MSMEG_0257|M.smegmatis_MC2_155 ------MQIREHVGAN--KPAIILYPSGTVVTFDELEARANRLAHHFRNQ
TH_4613|M.thermoresistible__bu ------MQIREHAEATPDKPAVILYPSDKVVTFGELEARANRLAHFFREN
MAB_3435|M.abscessus_ATCC_1997 ------MYPGAHAAQFPDKPAVVMAGSGATLTYGELDRQSRRLARHWYDS
MAV_2951|M.avium_104 ------MNIAEHALAAAQSPALITD--GGTISYGELHDRSRRVAAALHEL
MLBr_02546|M.leprae_Br4923 MRKWGDLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAK
MUL_1191|M.ulcerans_Agy99 IAKWGEFGMLPSFNARRHPHRAACIDEEGEFTYQQLDEAGHAVANALLAK
: .:: :*. .. :*
Mb0220|M.bovis_AF2122/97 GLREDDVVAILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAYIVDN
Rv0214|M.tuberculosis_H37Rv GLREDDVVAILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAYIVDN
MMAR_0452|M.marinum_M GLREGDAVAILMENNEHIHAVMWAARRSGLYYVPINTHLTAAEAAYIIEN
Mflv_0449|M.gilvum_PYR-GCK GLVEGDAVALLMENNEHFHAVMWAARRAGLYYVPINTHLTAAEVAYIVDN
Mvan_0218|M.vanbaalenii_PYR-1 GLVEGDAVAILMENNEHIHAVMWAARRAGLYYVPISTHLTAAEVAYIVDN
MSMEG_0257|M.smegmatis_MC2_155 GLQEGDVVAILMENNSHIHTVMWAARRSGLYYVPISTHLTAAEAAYIVDN
TH_4613|M.thermoresistible__bu GLREGDTVAILMENNDHIFTAMWAARRSGLYYVPINTHLTAAEAAYIIDN
MAB_3435|M.abscessus_ATCC_1997 GLRKGDHVALLSDNVPEVFVVYWAALRSGLYITSVNHHLAPAEVSYIVND
MAV_2951|M.avium_104 GLRRGDGVAVVLPNRPEFLEITWGCQLSGLYYTPVNTHFTADEVVYVIDD
MLBr_02546|M.leprae_Br4923 GVRGGDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSER
MUL_1191|M.ulcerans_Agy99 GVSAGDGVAILARNHRWFLIANYGAARAGARIILLNSEFSGPQIKEVSER
*: .* :*:: * . :.. * :. .:: : : :
Mb0220|M.bovis_AF2122/97 SGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAG-----------GGLV
Rv0214|M.tuberculosis_H37Rv SGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAG-----------GGLV
MMAR_0452|M.marinum_M SGAKAIVGSAALRDTCAGLGEHLRAGPPELLILAGPE---------GCLT
Mflv_0449|M.gilvum_PYR-GCK SGAKAIVGSAKLADTLAGLEAELPNGLPQLLLVAG-AELSATSASGGDVD
Mvan_0218|M.vanbaalenii_PYR-1 SGAKAIVGSAKLKDTLAGLAEELPNGLPPLRLIAGGAESSATSASS-ELE
MSMEG_0257|M.smegmatis_MC2_155 SGAKAIVGSAKMRDVLAGLGDELPNGLPDTLLIAD-----------GDLD
TH_4613|M.thermoresistible__bu SAAKAIIGSAALRDTLADLGEHLPGGLPELRMITD-----------SDLP
MAB_3435|M.abscessus_ATCC_1997 SGSSALVVAAGVREQAEAILDDTP--AVTLRLAFG-----------GDVR
MAV_2951|M.avium_104 SDAKAVFVDASLP----GIAARLRSANPAVHIGVG-----------GKLP
MLBr_02546|M.leprae_Br4923 EGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEP--------PGST
MUL_1191|M.ulcerans_Agy99 EGAKLIIYDDEYTGAVSKAEPPLGKLRALGVNPDSEED--------SGST
. :. :.
Mb0220|M.bovis_AF2122/97 GWMTYPECVADQPDTPIEDEREGDLLQYSSGTTGRPKGIKRELPHVSPD-
Rv0214|M.tuberculosis_H37Rv GWMTYPECVADQPDTPIEDEREGDLLQYSSGTTGRPKGIKRELPHVSPD-
MMAR_0452|M.marinum_M GWEPYPQCVADQPDTAIDDELEGDLLQYSSGTTGRPKGIKRELLHVAPD-
Mflv_0449|M.gilvum_PYR-GCK GWQRYPECVADKLETPIADEIDGDLLQYSSGTTGRPKGIKRELPHLPPA-
Mvan_0218|M.vanbaalenii_PYR-1 GWQRYPECVADKPDTPIADEIEGDLLQYSSGTTGRPKGIKRELPHVPPS-
MSMEG_0257|M.smegmatis_MC2_155 GWLRYPEAVADLPDTPIDDELDGDLLQYSSGTTGRPKGIKRELPHVHPS-
TH_4613|M.thermoresistible__bu GWQRYPECVAGQPDTPIADELEGDLLQYSSGTTGRPKGIKRELPHVPPS-
MAB_3435|M.abscessus_ATCC_1997 GYDSYEDALDGASDEPLPAQPAGSDMLYSSGTTGRPKGIKVPLTDRQVD-
MAV_2951|M.avium_104 GWRDYEGVLGVAGDAPPVS--DGSEMLYSSGTTGRPKAVRRPLPQDGNGS
MLBr_02546|M.leprae_Br4923 DETLAELIARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAP-
MUL_1191|M.ulcerans_Agy99 DETLAELIARSSTAPAPKAGKHASIIILTSGTTGTPKGANRSTPPTLAP-
. . .. : :***** **. .
Mb0220|M.bovis_AF2122/97 -AAPGMMPALLDFWMDA-DSVYLSPAPMYHTAPSVWTMSALAAGVTTVVM
Rv0214|M.tuberculosis_H37Rv -AAPGMMPALLDFWMDA-DSVYLSPAPMYHTAPSVWTMSALAAGVTTVVM
MMAR_0452|M.marinum_M -AAPGMMSALVGYWMDA-DSIYLSPAPLYHTAPSVWSMSAQAGGITTVVL
Mflv_0449|M.gilvum_PYR-GCK -EVPGMMAMLVEFWMHP-DAVYLSPAPLYHTAPSVWSMQVQAGGITTVVM
Mvan_0218|M.vanbaalenii_PYR-1 -ESPGLMAALVSFWMHP-DAVYLSPAPLYHTAPSVWSMQTQAGGITTVVM
MSMEG_0257|M.smegmatis_MC2_155 -ENPGMMAALISFWMTP-DSVYLSPAPLYHTAPSVWSMQVQAAGHTTVVM
TH_4613|M.thermoresistible__bu -EAPGMLSMLVNVWMQPPDSVYLSPAPLYHTAPSMWSISAQAAGVTVVVL
MAB_3435|M.abscessus_ATCC_1997 -EPNPFAMLFAHLYGFNAETVYLSPAPIYHAAPLRFCGFVQSMGGTAVVM
MAV_2951|M.avium_104 WAQSVLELALIHKYGMTQRSVYLSPAPLYHAAGVNYTMAVNRVGAASIIM
MLBr_02546|M.leprae_Br4923 ------LGGILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLR
MUL_1191|M.ulcerans_Agy99 ------VGGILSHVPFKANEVTSLPAPMFHALGYLHATIAMFLGSTLVLR
: : ***::*: . * : ::
Mb0220|M.bovis_AF2122/97 EKFDAEGALDAIQRYRVTHAQFVPAMFVRMLKLPEAVRNSYDMSSLRRVI
Rv0214|M.tuberculosis_H37Rv EKFDAEGALDAIQRYRVTHAQFVPAMFVRMLKLPEAVRNSYDMSSLRRVI
MMAR_0452|M.marinum_M EKFDPEGALEAIQRHRVTHAQFVPAMFTRMLKLPESIRNSYDVSSLKRVM
Mflv_0449|M.gilvum_PYR-GCK EKFDAEGALDAIQKYKVTHGQFVPVMFARMLKLPEDVRKSYDVSSLQRVM
Mvan_0218|M.vanbaalenii_PYR-1 EKFDAEGALDAIAKHKVTHGQFVPVMFTRMLKLPEAVRKSYDVSSLERVM
MSMEG_0257|M.smegmatis_MC2_155 EKFDAEGCLEAIQKHRVTHGQFVPAMFTRMLKLPESVRNSYDVSSLKRVM
TH_4613|M.thermoresistible__bu EKFDPERCLEAIQKYRVTHGQFVPVMFTRMLKLPESVRNSYDVSSLKRVI
MAB_3435|M.abscessus_ATCC_1997 ERFEAEEALAAIEKYRITHSQWVPTMFVRMLKLPKEIRDRYDVSSLKVAV
MAV_2951|M.avium_104 RKFDAETVLRLIETHRVTHAQFVPTMFVRMLKLPEAVRDRYDVSSLRCVI
MLBr_02546|M.leprae_Br4923 RRFKPATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVF
MUL_1191|M.ulcerans_Agy99 RKFKPQLVLEDIEKHKVTAMVVVPVMLSRLLDAVEKIDKKPDLSSLKIVF
.:*.. * * :: * **.*: *:*. : : *:***. ..
Mb0220|M.bovis_AF2122/97 HAAAPCPVQIKEQMIHWWGPIIDEYYASSEASGSTLITAEDWLTHPGSVG
Rv0214|M.tuberculosis_H37Rv HAAAPCPVQIKEQMIHWWGPIIDEYYASSEASGSTLITAEDWLTHPGSVG
MMAR_0452|M.marinum_M HAAAPCPVEIKKQMMDWWGPIIDEYYASSEAIGSTLITAEDWLEHPGSVG
Mflv_0449|M.gilvum_PYR-GCK HAAAPCPVEIKKQMIDWWGPIVDEYYASSEAHGSTLITADQWLERPGSVG
Mvan_0218|M.vanbaalenii_PYR-1 HAAAPCPVDIKKQMIDWWGPIVDEYYASSEAHGSTLISAEDWLTHPGSVG
MSMEG_0257|M.smegmatis_MC2_155 HAAAPCPVDIKKQMIDWWGPIVDEYYASSEAIGATLITAEEWLKHPGSVG
TH_4613|M.thermoresistible__bu HAAAPCPVEIKKQMIDWWGPIIDEYYASSEAHGSTLISAEEWLQHPGSVG
MAB_3435|M.abscessus_ATCC_1997 HAAAPCPVEVKQSMIDWWGPILYEYYSSTEGNGVTFIDCATWLKRPGSVG
MAV_2951|M.avium_104 HAAAPCPVDVKHRMMRWFGPIIHEYYGGTEGFAGTTIGPQEWLAHPGSVG
MLBr_02546|M.leprae_Br4923 VSGSQLGAELATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINSATVG
MUL_1191|M.ulcerans_Agy99 VSGSQLGAELASRALKDLGPVIYNMYGSTEIAFATIAGPEDLQRNAATVG
:.: .:: : **:: : *..:* * ...:**
Mb0220|M.bovis_AF2122/97 -KPIQGGVHIVGADGSELPPNQPGEIYFEGG-YPFEYLNDPAKTAASRNK
Rv0214|M.tuberculosis_H37Rv -KPIQGGVHIVGADGSELPPNQPGEIYFEGG-YPFEYLNDPAKTAASRNK
MMAR_0452|M.marinum_M -KPMQGGVHILGADGVELPPGQAGEIYFEGG-YSFEYLNDPSKTAASRDK
Mflv_0449|M.gilvum_PYR-GCK -KPLTGVVHIVGEDGNELPAGQAGEIYFEGG-YDFEYLNDPDKTASSRHP
Mvan_0218|M.vanbaalenii_PYR-1 -KPLTGVVHIVGEDGEELPPGQAGEIYFEGG-YDFEYLNDPDKTASSRHP
MSMEG_0257|M.smegmatis_MC2_155 -KPLTGIVHVLDEDGNELPPGQAGEIFFEGG-QDFEYLNDAEKTASSRDA
TH_4613|M.thermoresistible__bu -KPMLGAVHILDEDGNELPPGQPGEIYFEGG-NSFEYLNDPEKTAASRHP
MAB_3435|M.abscessus_ATCC_1997 -SAALGVLHICDETGAELPAGEAGLVYFEREELPFSYHNDDEKTRSACHP
MAV_2951|M.avium_104 -IPLA-PVHVLDEDGREVPVGQTGELYFEGG-PDFEYFKDPVKTASVYNE
MLBr_02546|M.leprae_Br4923 PVVKGVKVKILDDSGKEVPRGQVGRIFVGNA-FPFEGYTGGGGKQIIDGL
MUL_1191|M.ulcerans_Agy99 PVVKGVKVKILDDNGNEVSQGQVGRIFVGNA-FPFEGYTGGGHKQIIDGL
::: . * *:. .: * ::. *. .. .
Mb0220|M.bovis_AF2122/97 HG--WVTVGDVGYLDDDGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHP
Rv0214|M.tuberculosis_H37Rv HG--WVTVGDVGYLDDDGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHP
MMAR_0452|M.marinum_M HG--WVTVGDVGYLDDQGYLFLTDRRHHMIISGGVNIYPQEAENILVTHP
Mflv_0449|M.gilvum_PYR-GCK QG--WKTVGDIGYVDEEGFLFLTDRRHHMIISGGVNIYPQEAENLLVTHP
Mvan_0218|M.vanbaalenii_PYR-1 QG--WKTVGDIGYLDDEGYLYLTDRRHHMIISGGVNIYPQEAENLLVTHP
MSMEG_0257|M.smegmatis_MC2_155 RG--WKTVGDIGYLDEEGYLYLTDRRHHMIISGGVNIYPQEAENMLVTHP
TH_4613|M.thermoresistible__bu KG--WVTVGDVGYVDEDGYLYLTDRRHHMIISGGVNIYPQEAENMLVTHP
MAB_3435|M.abscessus_ATCC_1997 AHDTWTTTGDIGYVDEDGFLYLTDRKAFMIISGGVNIYPQEIENALALHP
MAV_2951|M.avium_104 RG--WRSLGDMGHLDEDGYLYLTDRSTFTIVSGGVNIYPQEVENLLVMHP
MLBr_02546|M.leprae_Br4923 LS-----SGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHP
MUL_1191|M.ulcerans_Agy99 MS-----SGDVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEALISGHP
**:*:.*:.. *:::.* *:*** *::* * * : **
Mb0220|M.bovis_AF2122/97 KVLDAAVFGVPDDEMGQRVMAAVQTVDSADANDQFAGELLAWLRDRLSHF
Rv0214|M.tuberculosis_H37Rv KVLDAAVFGVPDDEMGQRVMAAVQTVDSADANDQFAGELLAWLRDRLSHF
MMAR_0452|M.marinum_M KVMDAAVFGVPDDEMGQRVMAVVQTVDPADATSQFGDELMEWLRDRLSHF
Mflv_0449|M.gilvum_PYR-GCK KVMDAAVFGIPDEEMGQRVKAVVQLVDQADATEEFADELIGWLRDRLAHY
Mvan_0218|M.vanbaalenii_PYR-1 KVMDAAVFGIPDEEMGQSVKAVVQTVDPADATEEFAAELISWLRDRLAHY
MSMEG_0257|M.smegmatis_MC2_155 KVMDAAVFGVPDDEMGQSVKGVVQTVDPADATPEFGEELLAWLRDRLAHY
TH_4613|M.thermoresistible__bu KVMDAAVFGVPDEEMGERVKAVVQLVDPSEASDELAAELIEWLRDRLAHY
MAB_3435|M.abscessus_ATCC_1997 AVLDVAVIGVPDAEMGESVKAVVQPADSSAAPRELAAELTDFLRERIARY
MAV_2951|M.avium_104 KLLDAAVFGVPNDEFGEEVKAVVQPADGVPPGPDLAAELIAYCRAHLAGY
MLBr_02546|M.leprae_Br4923 EVVEATAIGVDDKEWGARLRAFVVKKQDATID---EDAIKAYVRDHLARY
MUL_1191|M.ulcerans_Agy99 DVVEATALGVDDKEWGARLRAFVVKKPDTDLD---EETVKHYVRDHLARY
:::.:.:*: : * * : . * : : * ::: :
Mb0220|M.bovis_AF2122/97 KCPRSIAFEPQLPRTDTGKLYKSGLVEKYSV-------
Rv0214|M.tuberculosis_H37Rv KCPRSIAFEPQLPRTDTGKLYKSGLVEKYSV-------
MMAR_0452|M.marinum_M KCPRSVAFEAQLPRTDTGKLYKNGLIEKYSG-------
Mflv_0449|M.gilvum_PYR-GCK KCPRSLSFEEQLPRTDTGKLYKQELIKKYS--------
Mvan_0218|M.vanbaalenii_PYR-1 KCPRSLSFEAQLPRTDTGKLYKQELVKKHS--------
MSMEG_0257|M.smegmatis_MC2_155 KCPRSISFELQLPRTDTGKLYKQELIAKYS--------
TH_4613|M.thermoresistible__bu KCPRSISFEEQLPRTDTGKLYKQELIKKYS--------
MAB_3435|M.abscessus_ATCC_1997 KVPRSFDFTDTLPRTPTGKLAKGLLRQKYWEGAQ----
MAV_2951|M.avium_104 KCPRTVEFD-TLPRDPNGKLYKRRIRERYWQGRESRIV
MLBr_02546|M.leprae_Br4923 KVPREVIFLEELPRNPTGKVLKRELRDFEVH-------
MUL_1191|M.ulcerans_Agy99 KVPREVIFLEELPRNPTGKILKRELREMEIE-------
* ** . * *** .**: * :