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MSGSRPPGWEPEEPDPAADPIDHQPDPGGPPADEFPGEDFPAGGDHEDAVEPFDDSVEFDAADQTGQTDA YSRAYSAPESEHFTSGPYVPADLRLYDYDDYDEPAELDEEHGTARWPWVVGVAAIVAAIALVVSVSLLFA RTDTTKLANPNTTTASTPPLQDEITTTKPPPPTTPTGPRQVTYSVTGTKAPGDIISVTYVDASGRRRTQH NVYIPWSMTVTPISQSDVGSVEASSLFRVSRLNCSITTSDGTVLSSNSNDAPQTSC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2293 | - | - | 100% (266) | MmpS3 protein |
| M. avium 104 | MAV_4157 | - | 3e-14 | 34.88% (129) | hypothetical protein MAV_4157 |
| M. avium 104 | MAV_1668 | - | 3e-11 | 27.73% (220) | hypothetical protein MAV_1668 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2221c | mmpS3 | 3e-95 | 60.69% (318) | membrane protein |
| M. gilvum PYR-GCK | Mflv_2951 | - | 4e-74 | 59.46% (259) | hypothetical protein Mflv_2951 |
| M. tuberculosis H37Rv | Rv2198c | mmpS3 | 3e-95 | 60.69% (318) | membrane protein |
| M. leprae Br4923 | MLBr_00877 | mmpS3 | 2e-91 | 60.00% (315) | hypothetical protein MLBr_00877 |
| M. abscessus ATCC 19977 | MAB_1963 | - | 3e-54 | 44.22% (294) | MmpS family protein |
| M. marinum M | MMAR_3242 | mmpS3 | 1e-99 | 61.30% (323) | membrane protein MmpS3 |
| M. smegmatis MC2 155 | MSMEG_4265 | - | 2e-73 | 52.82% (301) | MmpS3 protein |
| M. thermoresistible (build 8) | TH_2395 | ffh | 3e-13 | 51.39% (72) | PROBABLE SIGNAL RECOGNITION PARTICLE PROTEIN FFH |
| M. ulcerans Agy99 | MUL_3555 | mmpS3 | 1e-100 | 61.30% (323) | membrane protein MmpS3 |
| M. vanbaalenii PYR-1 | Mvan_3562 | - | 2e-78 | 57.14% (287) | putative membrane protein MmpS3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2951|M.gilvum_PYR-GCK MSGP-NPGE-----------------------------------------
Mvan_3562|M.vanbaalenii_PYR-1 MSGP-NPPEEPGGQPA----------------------------------
MAV_2293|M.avium_104 MSGS-RPPGWEPEEPDPAADPIDHQPDPGGPPADEFPGEDFPAGGDHEDA
MLBr_00877|M.leprae_Br4923 MSGP-NPPGRENEESD-SGNELSGELDPHN-------------GVESVDE
Mb2221c|M.bovis_AF2122/97 MSGP-NPPGREPDEPE--SEPVSDTGDERA----------------SGNH
Rv2198c|M.tuberculosis_H37Rv MSGP-NPPGREPDEPE--SEPVSDTGDERA----------------SGNH
MMAR_3242|M.marinum_M MSGP-NPPGWEPDEPD-PAGDSSAELEPFGDTDDE------PDDALAGGE
MUL_3555|M.ulcerans_Agy99 MSGP-NPPGWEPDEPD-PAGDSSAELEPFGDTGDE------PDDALAGGE
MSMEG_4265|M.smegmatis_MC2_155 MSGP-NPTEPDANGSD--------LPDQTP-----------------GKH
MAB_1963|M.abscessus_ATCC_1997 MSGTDNPGSGNPGEVP---------------------------------D
TH_2395|M.thermoresistible__bu MSGP-NPPGSDSAGSDRPEPESGRAGDQPD--------------------
***. .*
Mflv_2951|M.gilvum_PYR-GCK ---PDNAA---DNPDTGQTDFYSRAYSAPESEQFVS-AYSAADIVPYD--
Mvan_3562|M.vanbaalenii_PYR-1 ---PDDATRGVDNPDTGQTDFYSRAYSAPESEQFVSPPYVPADASLYD--
MAV_2293|M.avium_104 VEPFDDSVEFDAADQTGQTDAYSRAYSAPESEHFTSGPYVPADLRLYD--
MLBr_00877|M.leprae_Br4923 LVPVPDSDLVTASDHTSETEVYSQAYSAPEAEHFTAVPYVPADLRLYD--
Mb2221c|M.bovis_AF2122/97 LPPVAGGGDKLPSDQTGETDAYSRAYSAPESEHVTGGPYVPADLRLYD--
Rv2198c|M.tuberculosis_H37Rv LPPVAGGGDKLPSDQTGETDAYSRAYSAPESEHVTGGPYVPADLRLYD--
MMAR_3242|M.marinum_M LEPVSESGQIEPVDPAQESEAYSRAYSAPESEQFISGAYLPADLSLYD--
MUL_3555|M.ulcerans_Agy99 LEPVSESGQIEPVDPAQESEAYSRAYSAPESEQFISGAYLPADLSLYD--
MSMEG_4265|M.smegmatis_MC2_155 AVPEEPTQVSGTDPETGETEFYSQAYSAPEAEQYTAGPYVPADVALYD--
MAB_1963|M.abscessus_ATCC_1997 LDGPNEEAAAPDSSGADSAAFHSQAYSAPESEQFTS-PYVP---------
TH_2395|M.thermoresistible__bu -PEQPSDDVADHAPETAETDFYSRAYSAPESEQFSSGPYVPPDAALYAXX
: .: :*:******:*: . .* .
Mflv_2951|M.gilvum_PYR-GCK -------------------------------YDSYDATEEPAEFAPPPRW
Mvan_3562|M.vanbaalenii_PYR-1 -------------------------------YDTYDADAD-AELAPPPRW
MAV_2293|M.avium_104 -------------------------------YDDYDEPAELDEEHGTARW
MLBr_00877|M.leprae_Br4923 -------------------------------YD---ESSVYDEPGAAPRW
Mb2221c|M.bovis_AF2122/97 -------------------------------YDDYEESSDLDDELAAPRW
Rv2198c|M.tuberculosis_H37Rv -------------------------------YDDYEESSDLDDELAAPRW
MMAR_3242|M.marinum_M -------------------------------YDGYDDSLDEEDEPSTPRW
MUL_3555|M.ulcerans_Agy99 -------------------------------YDGYDDSLDEEDEPSTPRW
MSMEG_4265|M.smegmatis_MC2_155 -------------------------------YDNYDPASELVEGP-PPRW
MAB_1963|M.abscessus_ATCC_1997 -------------------------------YDEYETQLVDGEEPPPPRW
TH_2395|M.thermoresistible__bu XGGRNFVARVKERAKGAEVSAALNPAQQVVKIVNEELIAILGGETRPLKF
. ::
Mflv_2951|M.gilvum_PYR-GCK PWVVGVVAIVAAVALVVSVSVLVT-RTD-TDNLATPE--TTTRQAPPVQD
Mvan_3562|M.vanbaalenii_PYR-1 PWVVGIVAIVAAIALVVSVSVLVT-RSD-TDNLATPQ--TTTRPAPPVQD
MAV_2293|M.avium_104 PWVVGVAAIVAAIALVVSVSLLFA-RTD-TTKLANPN--TTTASTPPLQD
MLBr_00877|M.leprae_Br4923 PWVVGVAAILAAISLVVSVSLLFT-RTD-TSKLSTP---TTGRSTPPVQD
Mb2221c|M.bovis_AF2122/97 PWVVGVAAIIAAVALVVSVSLLVT-RPH-TSKLATG---DTTSSAPPVQD
Rv2198c|M.tuberculosis_H37Rv PWVVGVAAIIAAVALVVSVSLLVT-RPH-TSKLATG---DTTSSAPPVQD
MMAR_3242|M.marinum_M PWVVGVAAIMAAIALVASVSLLVT-RTD-STKLANP---ATTSSVPPVQD
MUL_3555|M.ulcerans_Agy99 PWVVGVAAIMAAIALVASVSLLVT-RTD-STKLANP---ATTSSVPPVQD
MSMEG_4265|M.smegmatis_MC2_155 PWVVGVTAIIAAIALVASVALLVA-RDDQTSNLATPRPSTTTSSAPPVQD
MAB_1963|M.abscessus_ATCC_1997 PWVVGVAAIIAAITLVASVALLVAGRSDETNGAAKSSTVIPTPSTTPWNE
TH_2395|M.thermoresistible__bu AKTPPTVIMLAGLQGSGKTTLAGKLAKWLRDKGHTPLLVACDLQRPGAVN
. . . ::*.: ..:: . . :
Mflv_2951|M.gilvum_PYR-GCK EILTTTP--PPPPPPPPTTEPPPPPPP----PETVTVTQPPPPPP-----
Mvan_3562|M.vanbaalenii_PYR-1 EFTTTEP--PPPP----TTEPPPPPP------ETVTVTEPPPPPPE----
MAV_2293|M.avium_104 EITTTKP--------PPP--------------------------------
MLBr_00877|M.leprae_Br4923 EITTVKP--------PPPSTETSTATE----TQTVTVTPLPPPSA-----
Mb2221c|M.bovis_AF2122/97 EITTTKPAPPPPPPAPPPTTEIPTATE----TQTVTVTPPPPPPP-----
Rv2198c|M.tuberculosis_H37Rv EITTTKPAPPPPPPAPPPTTEIPTATE----TQTVTVTPPPPPPP-----
MMAR_3242|M.marinum_M EITTTKPPPPPPPPPPPPSTEIPTATE----TQTVTVTPPPPPPPPP---
MUL_3555|M.ulcerans_Agy99 EITTTKPPPPPPPPPPPPSTEIPTATE----TQTVTVTPPPPPPPPP---
MSMEG_4265|M.smegmatis_MC2_155 EITTTTPPPVEPPPPPPPSEEAPPPPP----PETVTITEPPPAPAP----
MAB_1963|M.abscessus_ATCC_1997 IITTTTP--PPPPPPPPPTTEPPPPPPPPVVTETVTVEPPPPPPPP----
TH_2395|M.thermoresistible__bu QLQIVGERAGVAVFAPHPGVSASGAAEDGP-GDPVAVAAAGVAEAKAKLF
: . .
Mflv_2951|M.gilvum_PYR-GCK -------------------------AEAPPPPPPQTTEAPPPPPTTTTPA
Mvan_3562|M.vanbaalenii_PYR-1 ------------------------TTAAPPPPPPATTEPPPPPPTTTTRA
MAV_2293|M.avium_104 ----------------------------------------------TTPT
MLBr_00877|M.leprae_Br4923 ------------------------TSTAVPPSSVVPPPPTTPTTTVTTLT
Mb2221c|M.bovis_AF2122/97 ------------------------ATTTAPPPATTTTAAAPPP-TTTTPT
Rv2198c|M.tuberculosis_H37Rv ------------------------ATTTAPPPATTTTAAAPPP-TTTTPT
MMAR_3242|M.marinum_M ----------------------ETSAAPPPAATTPTTPAAAPPPTTTTPA
MUL_3555|M.ulcerans_Agy99 ----------------------ETSAAPPPAATTPTTPAAAPPPTTTTPA
MSMEG_4265|M.smegmatis_MC2_155 ------------------------PPSSEEPAPPPATTTAPPATTTTPPA
MAB_1963|M.abscessus_ATCC_1997 ----------------------VTTHEAPPPVTTTTTPPPPPPPTTTTPA
TH_2395|M.thermoresistible__bu DVVIVDTAGRLGIDDELMNQAAAIRDAVDPDEVLFVLDAMIGQDAVTTAE
*.
Mflv_2951|M.gilvum_PYR-GCK GPRQ-------VTYSVTGTKAPGDIITVTYID-------ASGRSRTQRNV
Mvan_3562|M.vanbaalenii_PYR-1 GPRQ-------VTYSVTGTKAPGDIITVTYID-------ASGRSRTQRNV
MAV_2293|M.avium_104 GPRQ-------VTYSVTGTKAPGDIISVTYVD-------ASGRRRTQHNV
MLBr_00877|M.leprae_Br4923 GPRQ-------VTYSVTGTKAPGDIISVTYVD-------ASGRRRTQHNV
Mb2221c|M.bovis_AF2122/97 GPRQ-------VTYSVTGTKAPGDIISVTYVD-------AAGRRRTQHNV
Rv2198c|M.tuberculosis_H37Rv GPRQ-------VTYSVTGTKAPGDIISVTYVD-------AAGRRRTQHNV
MMAR_3242|M.marinum_M GPRQ-------VTYSVTGTKAPGDIISVTYVD-------ASGRRRTQHNV
MUL_3555|M.ulcerans_Agy99 GPRQ-------VTYSVTGTKAPGDIISVTYVD-------ASGRRRTQHNV
MSMEG_4265|M.smegmatis_MC2_155 GPRQ-------VTYSVTGTKAPGDIITITYVD-------GNGNRRTLRNV
MAB_1963|M.abscessus_ATCC_1997 GPRQ-------ITYSVTGSKAPLDRISITWTD-------GSGRTRVNPNV
TH_2395|M.thermoresistible__bu AFREGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFASAGEKLEDFDV
. *: : .: * ::: . *. :*
Mflv_2951|M.gilvum_PYR-GCK YIPWSLT-------------------------------------------
Mvan_3562|M.vanbaalenii_PYR-1 YIPWSLT-------------------------------------------
MAV_2293|M.avium_104 YIPWSMT-------------------------------------------
MLBr_00877|M.leprae_Br4923 YIPWSMT-------------------------------------------
Mb2221c|M.bovis_AF2122/97 YIPWSMT-------------------------------------------
Rv2198c|M.tuberculosis_H37Rv YIPWSMT-------------------------------------------
MMAR_3242|M.marinum_M YIPWSMT-------------------------------------------
MUL_3555|M.ulcerans_Agy99 YIPWSMT-------------------------------------------
MSMEG_4265|M.smegmatis_MC2_155 YIPWTFT-------------------------------------------
MAB_1963|M.abscessus_ATCC_1997 YIPWSIT-------------------------------------------
TH_2395|M.thermoresistible__bu FHPDRMAGRILGMGDVLTLIEQAEQVFDAQQAEEAAVKIGTGELTLEDFL
: * ::
Mflv_2951|M.gilvum_PYR-GCK --------VTPIS------------QSEVGSVQASSLFLVSKLNCSITTS
Mvan_3562|M.vanbaalenii_PYR-1 --------VTPIS------------QSEVGSVQASSLFMVSRLNCSITTS
MAV_2293|M.avium_104 --------VTPIS------------QSDVGSVEASSLFRVSRLNCSITTS
MLBr_00877|M.leprae_Br4923 --------VTPIS------------QSDVGSVEAFSLFRVSKLNCLITTS
Mb2221c|M.bovis_AF2122/97 --------VTPIS------------QSDVGSVEASSLFRVSKLNCSITTS
Rv2198c|M.tuberculosis_H37Rv --------VTPIS------------QSDVGSVEASSLFRVSKLNCSITTS
MMAR_3242|M.marinum_M --------VTPIS------------QSDVGSVEASSLFRVSRLNCSITTS
MUL_3555|M.ulcerans_Agy99 --------VTPIS------------QSDVGSVEASSLFRVSRLNCSITTS
MSMEG_4265|M.smegmatis_MC2_155 --------MTPIS------------NSDVGSVEASSLFLVSRLNCSITAS
MAB_1963|M.abscessus_ATCC_1997 --------VTPIS------------NSEIGSVSASSFLRLSQLNCTITTS
TH_2395|M.thermoresistible__bu EQMQAIRKMGPIGNLLGMLPGAGQMKDALAAVDDKQLDRVQAIIRGMTPE
: **. :. :.:*. .: :. : :*..
Mflv_2951|M.gilvum_PYR-GCK ---DGQVLSSNTGNAAQTSC------------------------------
Mvan_3562|M.vanbaalenii_PYR-1 ---DGTVLSSNTSNAAQTSC------------------------------
MAV_2293|M.avium_104 ---DGTVLSSNSNDAPQTSC------------------------------
MLBr_00877|M.leprae_Br4923 ---DGTVLSSNSNDAPQTSC------------------------------
Mb2221c|M.bovis_AF2122/97 ---DGTVLSSNSNDGPQTSC------------------------------
Rv2198c|M.tuberculosis_H37Rv ---DGTVLSSNSNDGPQTSC------------------------------
MMAR_3242|M.marinum_M ---DGTVLSSNSNDAPQTSC------------------------------
MUL_3555|M.ulcerans_Agy99 ---DGTVLSSNSNDAPQTSC------------------------------
MSMEG_4265|M.smegmatis_MC2_155 ---DGTVLSSNANNSAQTAC------------------------------
MAB_1963|M.abscessus_ATCC_1997 ---DGQVLSSNNNNSAQATC------------------------------
TH_2395|M.thermoresistible__bu ERADPKIINASRRRRIAEGSGVTVAEVNQLVERFFEARKMMSQMAGQMGI
* ::.:. .
Mflv_2951|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3562|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2293|M.avium_104 --------------------------------------------------
MLBr_00877|M.leprae_Br4923 --------------------------------------------------
Mb2221c|M.bovis_AF2122/97 --------------------------------------------------
Rv2198c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3242|M.marinum_M --------------------------------------------------
MUL_3555|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4265|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1963|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2395|M.thermoresistible__bu PGIGRKNTRKAGKKGKKGQRGRKKGAGPTPPKVRNPLGAPMPGMPAGFPD
Mflv_2951|M.gilvum_PYR-GCK -----------------------------
Mvan_3562|M.vanbaalenii_PYR-1 -----------------------------
MAV_2293|M.avium_104 -----------------------------
MLBr_00877|M.leprae_Br4923 -----------------------------
Mb2221c|M.bovis_AF2122/97 -----------------------------
Rv2198c|M.tuberculosis_H37Rv -----------------------------
MMAR_3242|M.marinum_M -----------------------------
MUL_3555|M.ulcerans_Agy99 -----------------------------
MSMEG_4265|M.smegmatis_MC2_155 -----------------------------
MAB_1963|M.abscessus_ATCC_1997 -----------------------------
TH_2395|M.thermoresistible__bu LSQMPPGLDELPPGLADIDLSKLKFPGKK