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PVMPTDDTGAWELPNELVLLRDTVRRFMDAHVHPLEEKLDHDTVGLPRDQLVALQAEARELGLWALQTPE QYGGAGLSVLGQVVVAEEAAKCRMGAFFPALGAFGGNPPNIMFKASPEQFAKYAQPIIDGTMTKAYTAIT EASGGSDPARAIQLKAVRDGDSYVLNGSKMWISHAPDADWGVVYARTGEGRNGISAFILEKDTPGVTFSR IPVMASFSPYELHFDNVRIPAEQMVGAEGQGFALASDFLVHGRIVYAAGPIGIAQSALDMTCQWAKDRDV FGGRLADKQGIQWMLVDSEVDLRAARLLMYQAAWNADLGRNVRVDASVAKMYGTEAAYKVLDRCIQIHGA LGISTELPLERWFRDLRVKRLGEGATEVQREVIARSLVK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1896 | - | - | 100% (390) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_2606 | - | 0.0 | 90.32% (372) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_4243 | - | 2e-52 | 32.48% (391) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3302c | fadE25 | 3e-52 | 32.56% (387) | acyl-CoA dehydrogenase FADE25 |
| M. gilvum PYR-GCK | Mflv_4743 | - | 7e-52 | 32.82% (387) | butyryl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv3274c | fadE25 | 3e-52 | 32.56% (387) | acyl-CoA dehydrogenase FADE25 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 9e-52 | 33.07% (387) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3618c | - | 2e-52 | 33.78% (376) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_1262 | fadE25 | 3e-52 | 32.56% (387) | acyl-CoA dehydrogenase FadE25 |
| M. smegmatis MC2 155 | MSMEG_0108 | - | 8e-53 | 35.48% (341) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3846 | - | 1e-55 | 33.07% (387) | PUTATIVE acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2626 | fadE25 | 3e-53 | 33.07% (387) | acyl-CoA dehydrogenase FadE25 |
| M. vanbaalenii PYR-1 | Mvan_1719 | - | 3e-52 | 33.07% (387) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4743|M.gilvum_PYR-GCK MQAEKSVPRNSLPAATALKLPTSSKEMLMASWAGNPSFDLFQLPEEHQEL
Mvan_1719|M.vanbaalenii_PYR-1 ----------------------------MASWAGNPSFDLFQLPEEHQEL
MMAR_1262|M.marinum_M ----------------------------MAGWAGNPSFDLFQLPEEHQEL
MUL_2626|M.ulcerans_Agy99 ----------------------------MAGWAGNPSFDLFQLPEEHQEL
MAB_3618c|M.abscessus_ATCC_199 -------------------------------MAGNPSFDLFKLGEEHDEL
Mb3302c|M.bovis_AF2122/97 ----------------------------MVGWAGNPSFDLFKLPEEHDEM
Rv3274c|M.tuberculosis_H37Rv ----------------------------MVGWAGNPSFDLFKLPEEHDEM
MLBr_00737|M.leprae_Br4923 ----------------------------MVGWSGNPLFDLFKLPEEHNEL
TH_3846|M.thermoresistible__bu ----------------------------MAAWSGNPSFELFQLPEEHIAL
MSMEG_0108|M.smegmatis_MC2_155 -----------------------------------MSVDRLLPSEEARDL
MAV_1896|M.avium_104 -----------------------------MPVMPTDDTGAWELPNELVLL
:* :
Mflv_4743|M.gilvum_PYR-GCK RAAIRALAEKEIAPHAADVDENAR-FPQEALDALVAN----GFNAVHVPE
Mvan_1719|M.vanbaalenii_PYR-1 RAAIRALAEKEIAPHAADVDENSR-FPQEALDALNAS----GFNAVHVPE
MMAR_1262|M.marinum_M RAAIRALAEKEIAPHAADVDENSR-FPQEALDALNAS----GFNAVHVPE
MUL_2626|M.ulcerans_Agy99 RAAIRALAEKEIAPHAADVDENSR-FPQEALDALNAS----GFNALHVPE
MAB_3618c|M.abscessus_ATCC_199 RAAIRGLAEKEIAPHAKDVDEKAR-FPQEALDALVAS----GFNAVHVPE
Mb3302c|M.bovis_AF2122/97 RSAIRALAEKEIAPHAAEVDEKAR-FPEEALVALNSS----GFNAVHIPE
Rv3274c|M.tuberculosis_H37Rv RSAIRALAEKEIAPHAAEVDEKAR-FPEEALVALNSS----GFNAVHIPE
MLBr_00737|M.leprae_Br4923 RATIRALAEKEIAPHAADVDQRAR-FPEEALAALNAS----GFNAIHVPE
TH_3846|M.thermoresistible__bu REAIRALAEKEIAPYAAEVDEKAR-FPEEALAALNSS----GFSAIHVPE
MSMEG_0108|M.smegmatis_MC2_155 IALTREVADKVLDPIVDEHERNET-YPEGVFAQLGAA----GLLSLPQPE
MAV_1896|M.avium_104 RDTVRRFMDAHVHPLEEKLDHDTVGLPRDQLVALQAEARELGLWALQTPE
* . : : * . :. *. : * : *: :: **
Mflv_4743|M.gilvum_PYR-GCK EYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMG--LILRGSDEL
Mvan_1719|M.vanbaalenii_PYR-1 EFGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMG--LILRGSDEL
MMAR_1262|M.marinum_M EYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMG--LILRGSDDL
MUL_2626|M.ulcerans_Agy99 EYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMG--LILRGSDEL
MAB_3618c|M.abscessus_ATCC_199 EYDGQGADSVAACIVIEEVARVCASSSLIPAVNKLGTMG--LILNGSDEL
Mb3302c|M.bovis_AF2122/97 EYGGQGADSVATCIVIEEVARVDASASLIPAVNKLGTMG--LILRGSEEL
Rv3274c|M.tuberculosis_H37Rv EYGGQGADSVATCIVIEEVARVDASASLIPAVNKLGTMG--LILRGSEEL
MLBr_00737|M.leprae_Br4923 EYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMG--LILRGSEEL
TH_3846|M.thermoresistible__bu EYGGQGADSVATCIVIEEVARVDCSASLIPAVNKLGTMG--LILRGSEEL
MSMEG_0108|M.smegmatis_MC2_155 QWGGGGQPYEVYLQVLEEIAARWAAVAVAVSVHSLSSHP--LLAFGTDEQ
MAV_1896|M.avium_104 QYGGAGLSVLGQVVVAEEAAKCRMG-AFFPALGAFGGNPPNIMFKASPEQ
::.* * * ** * . :. :: :. :: .: :
Mflv_4743|M.gilvum_PYR-GCK KQKVLPSLAAGESMASYALSEREAG--SDAASMRTRAKADGDDWILNGAK
Mvan_1719|M.vanbaalenii_PYR-1 KKKVLPSIASGEAMASYALSEREAG--SDAAAMRTRAKADGDDWILNGAK
MMAR_1262|M.marinum_M KKQVLPSLADGAAMASYALSEREAG--SDAGAMRTRAKADGDDWILNGTK
MUL_2626|M.ulcerans_Agy99 KKQVLPSLADGAAMASYALSEREAG--SDAGAMRTRAKADGDDWILNGTK
MAB_3618c|M.abscessus_ATCC_199 KKQVLPAIASGEAMASYALSEREAG--SDAASMRTRAKADGDDWIINGSK
Mb3302c|M.bovis_AF2122/97 KKQVLPALAAEGAMASYALSEREAG--SDAASMRTRAKADGDHWILNGAK
Rv3274c|M.tuberculosis_H37Rv KKQVLPALAAEGAMASYALSEREAG--SDAASMRTRAKADGDHWILNGAK
MLBr_00737|M.leprae_Br4923 KKQVLPSLAAEGAMASYALSEREAG--SDAASMRTRAKADGDDWILNGFK
TH_3846|M.thermoresistible__bu KKQVLPAVASGEAMASYALSEREAG--SDAASMRTRAVADGDDWILNGSK
MSMEG_0108|M.smegmatis_MC2_155 KQRWLPGMLSGEQIGAYSLSEPQAG--SDAAALRCAARRDGDGFVLNGSK
MAV_1896|M.avium_104 FAKYAQPIIDGTMTKAYTAITEASGGSDPARAIQLKAVRDGDSYVLNGSK
: : :*: :* . * ::: * *** :::** *
Mflv_4743|M.gilvum_PYR-GCK CWITNGGKSDWYTVMAVNDPDKGANGISAFMVHVDDEGFSIGPKERKLGI
Mvan_1719|M.vanbaalenii_PYR-1 CWITNGGKSSWYTVMAVTDPDKGANGISAFMVHIDDEGFTIGPKERKLGI
MMAR_1262|M.marinum_M CWITNGGKSSWYTVMAVTDPEKGANGISAFMVHKDDEGFVVGPKERKLGI
MUL_2626|M.ulcerans_Agy99 CWITNGGKSSWYTVMAVTDPENGANGISAFVVHKDDEGFVVGPKERKLGI
MAB_3618c|M.abscessus_ATCC_199 CWITNGGKSSWYTVMAVTDPEKKANGISAFMVHKDDEGFTVGPLEHKLGI
Mb3302c|M.bovis_AF2122/97 CWITNGGKSTWYTVMAVTDPDRGANGISAFMVHKDDEGFTVGPKERKLGI
Rv3274c|M.tuberculosis_H37Rv CWITNGGKSTWYTVMAVTDPDRGANGISAFMVHKDDEGFTVGPKERKLGI
MLBr_00737|M.leprae_Br4923 CWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGI
TH_3846|M.thermoresistible__bu CWITNGGKSTWYTVMAVTDPDKGANGISAFMVHKDDEGFTVGPKERKLGI
MSMEG_0108|M.smegmatis_MC2_155 AWITHGGRADFYTLFARTG--EGSKGVSCFLVPGDLPGLSFGKPEEKMGL
MAV_1896|M.avium_104 MWISHAPDADWGVVYARTG--EGRNGISAFILEKDTPGVTFS---RIPVM
**::. : : .: * .. . :*:*.*:: * *. .. . :
Mflv_4743|M.gilvum_PYR-GCK KGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIA
Mvan_1719|M.vanbaalenii_PYR-1 KGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIA
MMAR_1262|M.marinum_M KGSPTTELYFENCRVPGDRMIGEPGTGFKTALATLDHTRPTIGAQAVGIA
MUL_2626|M.ulcerans_Agy99 KGSPTTELYFENCRVPGDRMIGEPGTGFKTALATLDHTRPTIGAQAVGIA
MAB_3618c|M.abscessus_ATCC_199 KGSPTAELYFENCRIPGDRIIGEPGTGFKTALQTLDHTRPTIGAQALGIA
Mb3302c|M.bovis_AF2122/97 KGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIA
Rv3274c|M.tuberculosis_H37Rv KGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIA
MLBr_00737|M.leprae_Br4923 KGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIA
TH_3846|M.thermoresistible__bu KGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIA
MSMEG_0108|M.smegmatis_MC2_155 HAVPTTSAFYDNARIDADRLIGTEGQGLSIAFSALDSGRLGIAAVAVGIA
MAV_1896|M.avium_104 ASFSPYELHFDNVRIPAEQMVGAEGQGFALASDFLVHGRIVYAAGPIGIA
. .. . .::: *: .::::* * *: * * * .* .:***
Mflv_4743|M.gilvum_PYR-GCK QGALDAAIEYTKDRKQFGKSISDFQAVQFMLADMAMKVEAARLMVYSAAA
Mvan_1719|M.vanbaalenii_PYR-1 QGALDASLEYVKDRKQFGKSISEFQAVQFMLADMAMKVEAARLMVYSAAA
MMAR_1262|M.marinum_M QGALDAAIAYTKDRKQFGKSISDFQAVQFMLADMAMKVESARLMVYSAAA
MUL_2626|M.ulcerans_Agy99 QGALDAAIAYTKDRKQFGKSISDFQAVQFMLADMAMKVESARLMVYSAAA
MAB_3618c|M.abscessus_ATCC_199 QGALDQAIAYTKDRKQFGKSISDFQGVQFMLADMAMKVEAARLMVYTAAA
Mb3302c|M.bovis_AF2122/97 QGALDAAIAYTKDRKQFGESISTFQAVQFMLADMAMKVEAARLMVYSAAA
Rv3274c|M.tuberculosis_H37Rv QGALDAAIAYTKDRKQFGESISTFQAVQFMLADMAMKVEAARLMVYSAAA
MLBr_00737|M.leprae_Br4923 QGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAA
TH_3846|M.thermoresistible__bu QGALDAAIAYTKERKQFGRPVSDNQGVQFMLADMAMKIEAARLMVYSAAA
MSMEG_0108|M.smegmatis_MC2_155 QAALDEAVRYAHERTTFGRKIIDHQGLGFLLADMAAAVVSARATYLDAAR
MAV_1896|M.avium_104 QSALDMTCQWAKDRDVFGGRLADKQGIQWMLVDSEVDLRAARLLMYQAAW
*.*** : :.::* ** : *.: ::*.* : :** **
Mflv_4743|M.gilvum_PYR-GCK RAERGEGNLGFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMM
Mvan_1719|M.vanbaalenii_PYR-1 RAERGEGNLGFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMM
MMAR_1262|M.marinum_M RAERGESNLGFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMM
MUL_2626|M.ulcerans_Agy99 RAERGESNLGFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMM
MAB_3618c|M.abscessus_ATCC_199 RAERGEKNLGFISSASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERMM
Mb3302c|M.bovis_AF2122/97 RAERGEPDLGFISAASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERFM
Rv3274c|M.tuberculosis_H37Rv RAERGEPDLGFISAASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERFM
MLBr_00737|M.leprae_Br4923 RAERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFM
TH_3846|M.thermoresistible__bu RAERGEGDLGFISAASKCFASDVAMEVTTDAVQLFGGYGYTQDFPVERMM
MSMEG_0108|M.smegmatis_MC2_155 RRDAGLP-YSSQASVAKLVATDAAMKVTTDAVQVLGGVGYTRDFRVERYM
MAV_1896|M.avium_104 NADLGRN-VRVDASVAKMYGTEAAYKVLDRCIQIHGALGISTELPLERWF
. : * ::.:* .:: * :* .:*: *. * : :: :** :
Mflv_4743|M.gilvum_PYR-GCK RDAKITQIYEGTNQIQRVVMSRALLK-
Mvan_1719|M.vanbaalenii_PYR-1 RDAKITQIYEGTNQIQRVVMSRALLK-
MMAR_1262|M.marinum_M RDAKITQIYEGTNQIQRVVMSRALLR-
MUL_2626|M.ulcerans_Agy99 RDAKITQIYEGTNQIQRVVMSRALLR-
MAB_3618c|M.abscessus_ATCC_199 RDAKITQIYEGTNQIQRVVMSRALLTS
Mb3302c|M.bovis_AF2122/97 RDAKITQIYEGTNQIQRVVMSRALLR-
Rv3274c|M.tuberculosis_H37Rv RDAKITQIYEGTNQIQRVVMSRALLR-
MLBr_00737|M.leprae_Br4923 RDAKITQIYEGTNQIQRVVMSRALLR-
TH_3846|M.thermoresistible__bu RDAKITQIYEGTNQIQRVVMSRALLR-
MSMEG_0108|M.smegmatis_MC2_155 REAKITQIFEGTNQIQRLVISRGLGT-
MAV_1896|M.avium_104 RDLRVKRLGEGATEVQREVIARSLVK-
*: ::.:: **:.::** *::*.*