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VELLKLAVILALWAAVAGAFVSVLYRRQSDADQSRVRDLKLVYDLQLDREISARREYELTVESQLRRELA SELRAQAADDLAELRAELSALRTSLEILFDTDLGQRPALGAFEGEPQPERAYSEWERNGENPRDTPVDWV PSDRVTSAPQEHPPGRHDETAIIDVPEEPLMPPRPQQPAPPRRERPRYQEPPGPTEPRFEPRYQPPPAAA ATPPPPETPPDPPREPQPEPQPEPQPQPQGRDWQPVGAEGQWLPPGSPGSNWAGADAESTGGRRRARHSG ADEAWDGMPVEPVPPPPYAESGRRARSRHSAEYRDYGVRNFAPGSEPPAGPAPAPPPPAAATPPPPAAPA PSGPAAGAPPPPRLAPPPAAEHTPRHGGEPEPADPRRARDASGTGGQSVADLLARLQVQPSEGGRRRRRE G
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0549 | - | - | 100% (421) | hypothetical protein MAV_0549 |
| M. avium 104 | MAV_4644 | - | 6e-12 | 28.39% (236) | hypothetical protein MAV_4644 |
| M. avium 104 | MAV_1722 | - | 8e-11 | 51.61% (62) | secreted protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3634c | - | 3e-93 | 51.88% (426) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1422 | - | 2e-74 | 42.28% (447) | hypothetical protein Mflv_1422 |
| M. tuberculosis H37Rv | Rv3604c | - | 2e-93 | 51.88% (426) | transmembrane protein |
| M. leprae Br4923 | MLBr_00228 | - | 1e-110 | 53.58% (433) | hypothetical protein MLBr_00228 |
| M. abscessus ATCC 19977 | MAB_0539 | - | 3e-69 | 39.75% (488) | hypothetical protein MAB_0539 |
| M. marinum M | MMAR_5107 | - | 1e-111 | 54.86% (432) | transmembrane protein rich in alanine, arginine and proline |
| M. smegmatis MC2 155 | MSMEG_6099 | - | 2e-78 | 41.33% (525) | transmembrane protein rich in alanine |
| M. thermoresistible (build 8) | TH_2933 | - | 3e-50 | 43.87% (310) | PUTATIVE hypothetical protein Mjls_5150 |
| M. ulcerans Agy99 | MUL_4186 | - | 1e-110 | 54.19% (430) | transmembrane protein rich in alanine, arginine and proline |
| M. vanbaalenii PYR-1 | Mvan_5366 | - | 2e-82 | 45.72% (444) | hypothetical protein Mvan_5366 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1422|M.gilvum_PYR-GCK ---------------------MTVLLVLAIAASSALVFTSRVELLRLAVI
Mvan_5366|M.vanbaalenii_PYR-1 MTDPTRGARLRRGGRRPGWILMTVLLVLAIAASSALVFTNRVELLKLAVI
MSMEG_6099|M.smegmatis_MC2_155 -----------------------MLLVLAILASSALVFTNRVELLKLAVI
TH_2933|M.thermoresistible__bu MTVLTRGSRPRRGGRRPGWVLLTALLVLAIAASSALVFTNRVELLKLAVI
MMAR_5107|M.marinum_M MTVLSRGARVRRGGRRPGWVLLTTLLVLAIGASSALVFTNRVELLKLAVV
MUL_4186|M.ulcerans_Agy99 MTVLSRGARVRRGGRRPGWVLLTTLLVLAIGASSALVFTNRVELLKLAVV
Mb3634c|M.bovis_AF2122/97 MTVLSRGARVRRGGRRPGWVLLTALLVLAIGASSALVFTDRVELLKLAVL
Rv3604c|M.tuberculosis_H37Rv MTVLSRGARVRRGGRRPGWVLLTALLVLAIGASSALVFTDRVELLKLAVL
MLBr_00228|M.leprae_Br4923 MTVLSRGGRVRRGGRRPGWVLLTVSLILAMGASSALVFTNRVELLKLAVI
MAV_0549|M.avium_104 -----------------------------------------MELLKLAVI
MAB_0539|M.abscessus_ATCC_1997 MTMPTRAAKPRRGSRRPGWALLTALLVLAIGSGIALVFTDKAIYLRVGLL
*::.::
Mflv_1422|M.gilvum_PYR-GCK LALWAAVVAAFVSVIYRRQSDSDQAKVRDLKLVYDLQLEREISARREYEL
Mvan_5366|M.vanbaalenii_PYR-1 LALWAAVVAAFVSVIYRRQSDADQAKVRDLKLVYDLQLDREISARREYEL
MSMEG_6099|M.smegmatis_MC2_155 LALWAAVVAAFVSVIYRRQSDLDQAKARDLKLVYDLQLDREISARREYEL
TH_2933|M.thermoresistible__bu LSLWAAVAAAFVSVIYRRQSDIDQAKARDLKLVYDLQLDREISARREYEL
MMAR_5107|M.marinum_M LALWAAVAGAFVSVLYRRQAEADQARARDMKLVYDLQLDREISARREYEL
MUL_4186|M.ulcerans_Agy99 LALWAAVAGAFVSVLYRRQAEADQARARDMKLVYDLQLDREISARREYEL
Mb3634c|M.bovis_AF2122/97 LALWAAVAGAFVSVLYRRQSDVDQARVRDLKLVYDLQLDREISARREYEL
Rv3604c|M.tuberculosis_H37Rv LALWAAVAGAFVSVLYRRQSDVDQARVRDLKLVYDLQLDREISARREYEL
MLBr_00228|M.leprae_Br4923 LALWAAVAGAFVSVFYRRQSDADQSRVRNLKLVYDLQLDREISARREYEL
MAV_0549|M.avium_104 LALWAAVAGAFVSVLYRRQSDADQSRVRDLKLVYDLQLDREISARREYEL
MAB_0539|M.abscessus_ATCC_1997 LALWAAVIASFAALTYRRQSDTDQAKVRDQKLVYDLQLEREISARREYEL
*:***** .:*.:: ****:: **::.*: ********:***********
Mflv_1422|M.gilvum_PYR-GCK SVESHLRRELASELQAQSSDEVASLRAELAALRANLEYLFDADLSHRPAL
Mvan_5366|M.vanbaalenii_PYR-1 AVETHLRRELASELRAQSADEVAALRAELAALRANLEFLFDTDLSHRPAI
MSMEG_6099|M.smegmatis_MC2_155 TVETQLRRELASELRAQAADEVAALRAELAALRANLEILFDADLAHRPAL
TH_2933|M.thermoresistible__bu TLETQLRRELAAELQAQQSDEVAALRAELAALRANLEILFDTDLAHRPAL
MMAR_5107|M.marinum_M AVESQLRRELAAELRGAAADEVAALRAELASLRTSLGILFDADLEQRPAL
MUL_4186|M.ulcerans_Agy99 AVESQLRRELAAELRGAAADEVAALRAELASLRTSLGILFDADVEQRPAL
Mb3634c|M.bovis_AF2122/97 TLESQLRRELASELRAPAADEVAALRAELAALRTSLEILFDADLEHRPAL
Rv3604c|M.tuberculosis_H37Rv TLESQLRRELASELRAPAADEVAALRAELAALRTSLEILFDADLEHRPAL
MLBr_00228|M.leprae_Br4923 TVESQLRRELASELRSQAADEVLALRAELAALRTNLEILFDTDLQHRPAL
MAV_0549|M.avium_104 TVESQLRRELASELRAQAADDLAELRAELSALRTSLEILFDTDLGQRPAL
MAB_0539|M.abscessus_ATCC_1997 TVESRLRQQLAGEIEAQAADEIATLRAELAALRTNLEILFNTDLSDRPAI
::*::**::**.*:.. :*:: *****::**:.* **::*: .***:
Mflv_1422|M.gilvum_PYR-GCK ETER----TAGR---VTS-------------SRIDTEDDVVAAAEEPDAP
Mvan_5366|M.vanbaalenii_PYR-1 ETER----TAGR---VSS-------------SRIDTQEDFR-AAEEPYAP
MSMEG_6099|M.smegmatis_MC2_155 ETDRAAARPAGR---VHA-------------SRLDVPDVETTDIRDYRSE
TH_2933|M.thermoresistible__bu ETER----TTVR---AYSD-----------WAREEPAGRLVASRYDATGP
MMAR_5107|M.marinum_M ETVDR-ESRTAR---AVADRLQNGESP---ATDWLPSDRIAMARRDENLN
MUL_4186|M.ulcerans_Agy99 ETVDR-ESRTAR---AVADRLQNGESP---ATDWLPSDRIAMARRDENLN
Mb3634c|M.bovis_AF2122/97 GTGEK-EARAAR--------ALDGESP---PADWVSSDRVMAVRGGDGAS
Rv3604c|M.tuberculosis_H37Rv GTVEK-EARAAR--------ALDGESP---PADWVSSDRVMAVRGGDGAS
MLBr_00228|M.leprae_Br4923 AGAEAPQAKAAPPTCAYSNWVRDGQSK---PVDWVPSNRVTSVRQDRVTN
MAV_0549|M.avium_104 GAFEG-EPQPER---AYSEWERNGENPRDTPVDWVPSDRVTSAPQEHPPG
MAB_0539|M.abscessus_ATCC_1997 EHDPIRALGPWPG--AEPQPVPTTSTAAFAHSVREPQPAVADEYQDVTAV
.
Mflv_1422|M.gilvum_PYR-GCK E----TEESPIIDVPAEPHPPEHEWAAAV---------------------
Mvan_5366|M.vanbaalenii_PYR-1 K----TDESPIIDVPAEPHPPEGEWAPR----------------------
MSMEG_6099|M.smegmatis_MC2_155 R----TEESPIIDVPAEPHPPEDEWSFDRRPADGGFDRRPADGGFDRRPA
TH_2933|M.thermoresistible__bu EDG--DDDSAIIDVAAEPHSPEGDWAPVH---------------------
MMAR_5107|M.marinum_M R----AEEA-IIDVPEVGVPPLDERDVQPGGG------------------
MUL_4186|M.ulcerans_Agy99 R----AEEA-IIDVPEVGVPPLDERDVQPGRG------------------
Mb3634c|M.bovis_AF2122/97 R----TDEASIIDVPEVGVPPVSG-GPR----------------------
Rv3604c|M.tuberculosis_H37Rv R----TDEASIIDVPEVGVPPVSG-GPR----------------------
MLBr_00228|M.leprae_Br4923 S----ADDTSIIDVPEEPLLPPRGQAPQQGGVL-----------------
MAV_0549|M.avium_104 R----HDETAIIDVPEEPLMPPRPQQPAPPRRER----------------
MAB_0539|M.abscessus_ATCC_1997 DEDSRTSEYPIIDVAEDPHHVDQEQAPPTPPYPTP---------------
.: ****.
Mflv_1422|M.gilvum_PYR-GCK -------DEHGGAHRR----------------SGEQETARRHRAD----A
Mvan_5366|M.vanbaalenii_PYR-1 -------GEAGGAHRR----------------SAEQ---PQWAPP----P
MSMEG_6099|M.smegmatis_MC2_155 DGGFDRRPADGGAHRFPSQPTPQPGPQFTPQPSDEPRRRRRRRLDEEQAP
TH_2933|M.thermoresistible__bu -------DTAGGATNR----------------------------------
MMAR_5107|M.marinum_M -------PFLQPPPPAPPGP----------EHPAEWVGPPQEAAPVQPDL
MUL_4186|M.ulcerans_Agy99 -------PFLQPPPPAPPGP----------EHPAEWVGPPQEAAPVQPDL
Mb3634c|M.bovis_AF2122/97 --------HYEAPPPP------------------------------QPEP
Rv3604c|M.tuberculosis_H37Rv --------HYEAPPPP------------------------------QPEP
MLBr_00228|M.leprae_Br4923 -------PHFEDPPS-------------------------------QSDS
MAV_0549|M.avium_104 -------PRYQEPPGPTEPR----------FEPRYQPPPAAAATPPPPET
MAB_0539|M.abscessus_ATCC_1997 -------PYYGAAQPHEPEP-----------------YQQPVSSGTHWRP
.
Mflv_1422|M.gilvum_PYR-GCK AAQPQWAPPPPP-QQHPQQPPQPPQQPP---------------PPMPPPP
Mvan_5366|M.vanbaalenii_PYR-1 APAPPPPPPPPP-PPPPPPPAQQPPPPP---------------QPTPPPA
MSMEG_6099|M.smegmatis_MC2_155 APQAERQPTPPA-PPQTPPPAAPPQAPPRQAEPERAPEPQPAPQPAPQPA
TH_2933|M.thermoresistible__bu AGRPEPVPGAHS-AAHSATSDATPDATP----------------------
MMAR_5107|M.marinum_M HYEPHRRPPPAP-PVPN---AEPSPWRP----------------VAADGQ
MUL_4186|M.ulcerans_Agy99 HYEPHRRPPPAP-PVPN---AEPPLWRP----------------VAADGQ
Mb3634c|M.bovis_AF2122/97 LFEPRHRPPPLP-PQQE-----RPVWQP----------------VTSHGQ
Rv3604c|M.tuberculosis_H37Rv LFEPRHRPPPLP-PQQE-----RPVWQP----------------VTSHGQ
MLBr_00228|M.leprae_Br4923 RFEPRHRPPRSA-PLQELLQPHMKDWQP----------------DAADEQ
MAV_0549|M.avium_104 PPDPPREPQPEP-QPEPQPQPQGRDWQP----------------VGAEGQ
MAB_0539|M.abscessus_ATCC_1997 QPEPHVAQPPVPGHEQQFPAAAEPTQQPYWAARQ-----EDWDAAADGED
. . *
Mflv_1422|M.gilvum_PYR-GCK QTPPPGPQFPWLPPQQAP-----------PQQAPAQSSQWQPVPAEGQYI
Mvan_5366|M.vanbaalenii_PYR-1 QQPSPEPQFPWLPPAPPPRPQPRT-----PEPAPTASG-WKPVPAEGQWI
MSMEG_6099|M.smegmatis_MC2_155 PQPAPEPVSAWAPPPPPPSMPPLQ-----PSPTIEGGG-WQPAPAEGQWI
TH_2933|M.thermoresistible__bu ----------------------------------------GATPDAGQSX
MMAR_5107|M.marinum_M WLPPGAPGSHWVAEEAAGAETQDR-----SSGRRRRARHYGSDEGQGD--
MUL_4186|M.ulcerans_Agy99 WLPPGAPGSHWVAEEAAGAETQDR-----SSGRRRRARHYDSDEDQGD--
Mb3634c|M.bovis_AF2122/97 WLPAETPGSQWASVEPETTPAAP------PPGRRRRARHASPADQAYNPP
Rv3604c|M.tuberculosis_H37Rv WLPAETPGSQWASVEPETTPAAP------PPGRRRRARHASPADQAYNPP
MLBr_00228|M.leprae_Br4923 WLPPGTQDSAWTDVESASASVAA------PSGRRRRSRHSSLDEAAASSP
MAV_0549|M.avium_104 WLPPGSPGSNWAGADAES------------TGGRRRARHSGADEAWDGMP
MAB_0539|M.abscessus_ATCC_1997 WDPVPAPMAPPEQPAPQQAWNAPAPEWHVPQPPAPPPSAWAPAPAEGQWL
Mflv_1422|M.gilvum_PYR-GCK PAGAPGSNWVAPP----------AEDGHDEYVGRRRAPE-----------
Mvan_5366|M.vanbaalenii_PYR-1 PAGEPGSHWAAAH----------ANGDQGEYVGRRRAPD-----------
MSMEG_6099|M.smegmatis_MC2_155 PAGAPGSNWAAPVQPQNGASTESAPETSTEYVGRRRAPEPAENPEPTPPA
TH_2933|M.thermoresistible__bu XXAAAGSCGTSAP---------PTPNSRSTRACTTRSST-----------
MMAR_5107|M.marinum_M -IGEFDREYG--GRR---SRSRHSTDYRDYGVGRLGAGPPPGPGPAQPPP
MUL_4186|M.ulcerans_Agy99 -IGEFDREYG--GRR---SRSRHSTDYRDYGVGRLGAGPPPGPGPAQPPP
Mb3634c|M.bovis_AF2122/97 AYVELAAQYGESGR-----RSRHSAEHRDHDIGGSGAG-----TGERPPS
Rv3604c|M.tuberculosis_H37Rv AYVELAAQYGESGR-----RSRHSAEHRDHDIGGSGAG-----TGERPPS
MLBr_00228|M.leprae_Br4923 GEAETAQQHSGSGRR---ARSRHSAEYRAYSIEGITAKGSTPISQPTPPA
MAV_0549|M.avium_104 VEPVPPPPYAESGRR---ARSRHSAEYRDYGVRNFAPGSEPPAGPAPAPP
MAB_0539|M.abscessus_ATCC_1997 PPGTAGSNWASNEP-----VAPPSPYQAEPAAGGRHSGTPSRHQAPAAAE
: .
Mflv_1422|M.gilvum_PYR-GCK ---------------------QPSEDRRPPRGRHSAAGEQPQEPAVPDEE
Mvan_5366|M.vanbaalenii_PYR-1 ---------------------QVEPE--PPRGKHSAAGEEPTEAPAA---
MSMEG_6099|M.smegmatis_MC2_155 EPAPEPVPEQSAPVPPVMAPPEPPERPERPRGRHYAAGADAESAAAEQDD
TH_2933|M.thermoresistible__bu ----------------------------SPNGSRSSTTWSHGSPNGCEPG
MMAR_5107|M.marinum_M MAPAAPPWP----------GPQPAEPAAPRLAPPPAPDLASRHRRPEEER
MUL_4186|M.ulcerans_Agy99 MASAAPPWP----------GPQPAEPAAPRLAPPPAPDLASRHRRPEEER
Mb3634c|M.bovis_AF2122/97 ----------------------------PPMAPPPPAEPTRRHRTADTPP
Rv3604c|M.tuberculosis_H37Rv ----------------------------PPMAPPPPAEPTRRHRTADTPP
MLBr_00228|M.leprae_Br4923 GPAFAE--------------------QPPRLVPASPSDPVPRHRSADLLT
MAV_0549|M.avium_104 PPAAATPPPPAAPAP---SGPAAGAPPPPRLAPPPAAEHTPRHGGEPEPA
MAB_0539|M.abscessus_ATCC_1997 NTGGGHWAP------------EPSYPPPPAPEQPNYPESSGGHRAPETEP
.
Mflv_1422|M.gilvum_PYR-GCK PEQPDESDADG------------------------GAHTGGQSVAELLAR
Mvan_5366|M.vanbaalenii_PYR-1 PEAPAEPDADG------------------------GAHTGGQSVAELLAR
MSMEG_6099|M.smegmatis_MC2_155 TGETTPADAAAPALAAESATPPAPRRHRGADEEPRGQHANGQSAAELLAR
TH_2933|M.thermoresistible__bu CAAADLAAVPG---------------------------RGGGRLHRGAGR
MMAR_5107|M.marinum_M PDVAGSHDSDSQ--------------------------SGGQSVADLMAR
MUL_4186|M.ulcerans_Agy99 PDVAGSHDSDSQ--------------------------SGGQSVADLMAR
Mb3634c|M.bovis_AF2122/97 DDSGGLHARDPL--------------------------TGGQSVADLMAR
Rv3604c|M.tuberculosis_H37Rv DDSGGLHARDPL--------------------------TGGQSVADLMAR
MLBr_00228|M.leprae_Br4923 D---GVKGRDLA--------------------------AGGQSVADLMAR
MAV_0549|M.avium_104 D---PRRARDASG-------------------------TGGQSVADLLAR
MAB_0539|M.abscessus_ATCC_1997 EEKRGKRRAPEPEESEETR------------GRRRAEDTGGFSVADLLGR
.* .*
Mflv_1422|M.gilvum_PYR-GCK LQATPS--GGGGRRRRED---
Mvan_5366|M.vanbaalenii_PYR-1 LQAAPS--GGGRRRRRED---
MSMEG_6099|M.smegmatis_MC2_155 FQAAPT--TGGRRRRRDE---
TH_2933|M.thermoresistible__bu AAGAVH--RHRRHVRR-----
MMAR_5107|M.marinum_M LQVQPS--GGGRRRRRDG---
MUL_4186|M.ulcerans_Agy99 LQVQPS--GGGRRRRRDG---
Mb3634c|M.bovis_AF2122/97 LQVEST--GGGRRRRR-GE--
Rv3604c|M.tuberculosis_H37Rv LQVEST--GGGRRRRR-GE--
MLBr_00228|M.leprae_Br4923 LGAEST--DGGRRRRREGHYA
MAV_0549|M.avium_104 LQVQPS--EGGRRRRREG---
MAB_0539|M.abscessus_ATCC_1997 IQTDSSESGGGRRRRRED---
: **