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TRTRIAVRNLPRDWTDNAIRLIQADARRSADTHLLRYPLPSAWAGDADVALYLKDETTHVTGSLKHRLAR SLFLYALCNGWIGEGTTVVEASSGSTAVSEAYFAALLGLPFVAVMPESTSAAKVALIESQGGRCHFVADS SQVYAEAERVARQSGGHYLDQFTNAERATDWRGNNNIAESIFEQMRDEKHPVPAWIVVGAGTGGTSATIG RYIRYRRHATRLCVVDPEHSAFFAAYAEGRDDVVASRSSRIEGIGRPRVEPSFLPGVVDRMVAVPDAASV AAARHVSAVLGRRVGPSTGTNVWGAFGLLAELVSQGRGGSVVTLLADSGDRYADTYFDDEWVAAQGLDPA GPAAALAEFERSCAWQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0444 | - | - | 100% (367) | cysteine synthase/cystathionine beta-synthase family protein |
| M. avium 104 | MAV_2052 | cysK | 5e-18 | 27.80% (277) | cysteine synthase A |
| M. avium 104 | MAV_1201 | - | 1e-14 | 26.58% (301) | cystathionine beta-synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3709 | - | 1e-180 | 88.12% (345) | lyase |
| M. gilvum PYR-GCK | Mflv_1363 | - | 1e-171 | 81.64% (354) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
| M. tuberculosis H37Rv | Rv3684 | - | 1e-180 | 88.12% (345) | lyase |
| M. leprae Br4923 | MLBr_02396 | cysM2 | 1e-18 | 27.99% (293) | cystathionine beta-synthase |
| M. abscessus ATCC 19977 | MAB_0406c | - | 1e-158 | 76.55% (354) | cysteine synthase/cystathionine beta-synthase family protein |
| M. marinum M | MMAR_5173 | cysK | 0.0 | 85.71% (364) | cysteine synthase CysK |
| M. smegmatis MC2 155 | MSMEG_6203 | - | 1e-168 | 78.77% (358) | cysteine synthase/cystathionine beta-synthase family protein |
| M. thermoresistible (build 8) | TH_1707 | - | 1e-168 | 79.44% (360) | PROBABLE LYASE |
| M. ulcerans Agy99 | MUL_4259 | cysK | 0.0 | 85.16% (364) | cysteine synthase CysK |
| M. vanbaalenii PYR-1 | Mvan_5444 | - | 1e-168 | 79.66% (354) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1363|M.gilvum_PYR-GCK MSAPDPWSDRSSRPRGPDRSSRPRCHLQSRIWVDNAVRLIEADARRSADT
Mvan_5444|M.vanbaalenii_PYR-1 MS-----------PSGPCR--------QSRAWVDNAVRLIEADAHRSADT
Mb3709|M.bovis_AF2122/97 --------------------------------------MIEADARRSADT
Rv3684|M.tuberculosis_H37Rv --------------------------------------MIEADARRSADT
MMAR_5173|M.marinum_M ---------MSGQARVAVRS-------LARDWTDNAVRLIEADARRSADT
MUL_4259|M.ulcerans_Agy99 ---------MSGQARVAVRS-------LARDWTDNAVRLIEADARRSADT
MAV_0444|M.avium_104 ----------MTRTRIAVRN-------LPRDWTDNAIRLIQADARRSADT
MSMEG_6203|M.smegmatis_MC2_155 -----------MTVSTVSRS-------GPREWVDNAVRLIEADATRSADT
TH_1707|M.thermoresistible__bu ----MGRGAVGRSTAGASRT-------QPREWVHRAIRLIEADARRSADT
MAB_0406c|M.abscessus_ATCC_199 ---------------------------MSRAWADNAVRLIEADARRSADT
MLBr_02396|M.leprae_Br4923 ------------------------------------MRIAQHISDLIGGT
: : : ..*
Mflv_1363|M.gilvum_PYR-GCK HLLRYPLPSRWCSEVDVALYLKDETTHITGSLKHRLARSLFLYALCNGWI
Mvan_5444|M.vanbaalenii_PYR-1 HLLRYPLPASWS--ADVALYLKDETTHITGSLKHRLARSLFLYALCNGWI
Mb3709|M.bovis_AF2122/97 HLLRYPLPAAWCTDVDVELYLKDETTHITGSLKHRLARSLFLYALCNGWI
Rv3684|M.tuberculosis_H37Rv HLLRYPLPAAWCTDVDVELYLKDETTHITGSLKHRLARSLFLYALCNGWI
MMAR_5173|M.marinum_M HLLRYPLPSAWSNDANVELYLKDETTHITGSLKHRLARSLFLYALCNGWI
MUL_4259|M.ulcerans_Agy99 HLLRYPLPSAWSNDANVELYLKDETTHITGSLKHRLARSLFLYALCNGWI
MAV_0444|M.avium_104 HLLRYPLPSAWAGDADVALYLKDETTHVTGSLKHRLARSLFLYALCNGWI
MSMEG_6203|M.smegmatis_MC2_155 HLLRYPLPAAWCDDVDVALYLKDESTHITGSLKHRLARSLFLYGLCNGWI
TH_1707|M.thermoresistible__bu HLLRYPLPEAWR-SADVQLYLKDESTHITGSLKHRLARSLFLYGLCNGWI
MAB_0406c|M.abscessus_ATCC_199 HLLRYPLPAAWADTVDVQLYLKDESTHITGSLKHRLARSLFLYALCNGFI
MLBr_02396|M.leprae_Br4923 PLVR---LNSVVPAGTGVVAAKVEYFNSGGSSKDRIAAKMIDAAEASGQL
*:* : * * : ** *.*:* .:: . ..* :
Mflv_1363|M.gilvum_PYR-GCK DEGTTVIEASSGSTAVSEAYFAAMLGLPFIAVMPESTSASKIALIESQGG
Mvan_5444|M.vanbaalenii_PYR-1 GEDTTVIEASSGSTAVSEAYFAAMLGLPFIAVMPASTSSSKVALIESQGG
Mb3709|M.bovis_AF2122/97 NENTTVVEASSGSTAVSEAYFAALLGLPFIAVMPAATSASKIALIESQGG
Rv3684|M.tuberculosis_H37Rv NENTTVVEASSGSTAVSEAYFAALLGLPFIAVMPAATSASKIALIESQGG
MMAR_5173|M.marinum_M GEGTTVVEASSGSTAVSEAYFAALLGLPFVAVMPAATSASKIALIEAQGG
MUL_4259|M.ulcerans_Agy99 GEGTTVVEASSGSTAVSEAYFAALLDLPFVAVMPAATSASKIALIEAQGG
MAV_0444|M.avium_104 GEGTTVVEASSGSTAVSEAYFAALLGLPFVAVMPESTSAAKVALIESQGG
MSMEG_6203|M.smegmatis_MC2_155 CEGTTIIEASSGSTAVSEAYFAALLGLPFIAVMTASTSPSKIALIEAQGG
TH_1707|M.thermoresistible__bu GEHTTIIEASSGSTAVSEAYFAALLGLPFIAVVPASTSSAKIELIEAQGG
MAB_0406c|M.abscessus_ATCC_199 GENTTIVEASSGSTAVSEAYFAQLLGLPFIAVMTASTSPSKIALIESQGG
MLBr_02396|M.leprae_Br4923 KPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVCPDKVSEDKRNVLLAYG-
*::*.:**.*.*. * .* . : * . .* * :: : *
Mflv_1363|M.gilvum_PYR-GCK RCHFVKRSAEVYAEAQRLAEQTGGHYLDQFTNAERATDWR---GNNNIAE
Mvan_5444|M.vanbaalenii_PYR-1 RCHFVDESAQVYDEAQRLAEETGGHYLDQFTNAERATDWR---GNNNIAE
Mb3709|M.bovis_AF2122/97 RCHFVQNSSQVYAEAERVAKETGGHYLDQFTNAERATDWR---GNNNIAE
Rv3684|M.tuberculosis_H37Rv RCHFVQNSSQVYAEAERVAKETGGHYLDQFTNAERATDWR---GNNNIAE
MMAR_5173|M.marinum_M RCHFVENSSQVYAEAERVAKETGGHYLDQFTNAERATDWR---GNNNIAE
MUL_4259|M.ulcerans_Agy99 RCHFVDNSSQVYAEAERVAKETGGHYLDQFTNAERATDWR---GNNNIAE
MAV_0444|M.avium_104 RCHFVADSSQVYAEAERVARQSGGHYLDQFTNAERATDWR---GNNNIAE
MSMEG_6203|M.smegmatis_MC2_155 RCHFVEKSSEVYEEAQRLADETGGHYLDQFTNAERATDWR---GNNNIAV
TH_1707|M.thermoresistible__bu RCHFVAEPSQVYAEAERLAEETGGHYLDQFTNAERATDWR---GNNNIAE
MAB_0406c|M.abscessus_ATCC_199 RCHFVDEAQQVYAEAQRLADETGGHYLDQFTNAERATDWR---GNNNIAE
MLBr_02396|M.leprae_Br4923 -AEVVVCPTAVPPDDPDSYYSVSDRLVAKIDGAWKPDQYANPAGPASHYE
...* . * : . ..: : :: .* :. :: * .
Mflv_1363|M.gilvum_PYR-GCK SIFEQLGEETHPVPEWIVVGAGTGGTSATIGRYLRYRR-YPTRLCVVDPE
Mvan_5444|M.vanbaalenii_PYR-1 SIFQQMGQETHPVPEWIVVGAGTGGTSATIGRYLRYRR-HPTRLCVVDPE
Mb3709|M.bovis_AF2122/97 SIYVQMREEKHPTPEWIVVGAGTGGTSATIGRYIRYRR-HATRLCVVDPE
Rv3684|M.tuberculosis_H37Rv SIYVQMREEKHPTPEWIVVGAGTGGTSATIGRYIRYRR-HATRLCVVDPE
MMAR_5173|M.marinum_M SIFAQMGEEQHPIPEWIVVGAGTGGTSATIGRYIRYRR-HTTRLCVVDPE
MUL_4259|M.ulcerans_Agy99 SIFAQMGEEQHPIPEWIVVGAGTGGTSATIGRYIRYRR-HTTRLCVVDPE
MAV_0444|M.avium_104 SIFEQMRDEKHPVPAWIVVGAGTGGTSATIGRYIRYRR-HATRLCVVDPE
MSMEG_6203|M.smegmatis_MC2_155 SIYEQMRLERHPIPEWIVVGAGTGGTSATIGRFIRYRR-HATRLCVVDPE
TH_1707|M.thermoresistible__bu SIFQQMSAEPHPIPEWIVVGAGTGGTSATIGRYVRYRC-HDTRLCVVDPE
MAB_0406c|M.abscessus_ATCC_199 SIFTQMHHEKHPLPTWIVVGAGTGGTSATIGRYIRYRR-YPTQLCVVDPD
MLBr_02396|M.leprae_Br4923 TTGPEIWADTDGRVTHFVAGIGTGGTITGVGRYLKEVSGGLVRIIGADPE
: :: : . :*.* ***** : :**::: .:: .**:
Mflv_1363|M.gilvum_PYR-GCK NSAFYPSYQQG-VDVVIDASSRIEGIGRPRVEPSFLPGVVDRMVSVPDSG
Mvan_5444|M.vanbaalenii_PYR-1 NSAFYPSYQSGDPDVVTAASSRIEGIGRPRVEPSFIPGVVDRMISVPDSG
Mb3709|M.bovis_AF2122/97 NSAFFPAYSEGRYDIVMPTSSRIEGIGRPRVEPSFLPGVVDRMVAVPDAA
Rv3684|M.tuberculosis_H37Rv NSAFFPAYSEGRYDIVMPTSSRIEGIGRPRVEPSFLPGVVDRMVAVPDAA
MMAR_5173|M.marinum_M NSAFFPAYAEDRYDIVMPKSSRIEGIGRPRVEPSFLPGVVDCMVSVPDAA
MUL_4259|M.ulcerans_Agy99 NSAFFPAYAEDRYDIVMPKSSRIEGIGRPRVEPSFLPGVVDCMVSVPDAA
MAV_0444|M.avium_104 HSAFFAAYAEGRDDVVASRSSRIEGIGRPRVEPSFLPGVVDRMVAVPDAA
MSMEG_6203|M.smegmatis_MC2_155 NSAFYPSYAQGRP-VETGASSRIEGIGRPRVEPSFMPEVVDRMIAVPDAA
TH_1707|M.thermoresistible__bu NSAFFPAYAQGLDDVVTTESSRIEGIGRQRVEPSFLPGVVDRMIAVPDAA
MAB_0406c|M.abscessus_ATCC_199 NSAFYPSYLAR-RDVVTGISSRIEGIGRPRVEPSFLPSVVDRMEQIPDAY
MLBr_02396|M.leprae_Br4923 GSVYSGG---------TGRPYLVEGVGEDFWPAAYDPMVPDQIIAVSDSD
*.: . . :**:*. .:: * * * : :.*:
Mflv_1363|M.gilvum_PYR-GCK SVAAAHHVSRVLGRRVGPSTGTNVWGAFGLLAEMVAEGRSGSVVTLLADS
Mvan_5444|M.vanbaalenii_PYR-1 SVAAAHHVSRVLGRRVGPSTGTNIWGAFGLLAEMAAQGCSGSVVTLLADS
Mb3709|M.bovis_AF2122/97 SIAAARHVSAVLGRRVGPSTGTNLWGAFGLLAEMVKQGRSGSVVTLLADS
Rv3684|M.tuberculosis_H37Rv SIAAARHVSAVLGRRVGPSTGTNLWGAFGLLAEMVKQGRSGSVVTLLADS
MMAR_5173|M.marinum_M SIAAARHVSAVLGRRVGPSTGTNLWGAFGLLAEMVADGRSGSVVTLLADS
MUL_4259|M.ulcerans_Agy99 SIAAARHVSAVLGRRVGPSTGTNLWGAFGLLAEMVADGRSGSVVTLLADS
MAV_0444|M.avium_104 SVAAARHVSAVLGRRVGPSTGTNVWGAFGLLAELVSQGRGGSVVTLLADS
MSMEG_6203|M.smegmatis_MC2_155 SVAAAHYASNVLGRRVGPSTGTNLWGAFGLLAEMMREGRSGSVVTLIADS
TH_1707|M.thermoresistible__bu SVAAAHHASRVLGRRVGPSTGTHLWGAFTLLAEMVAEGRRGSVVTLLADS
MAB_0406c|M.abscessus_ATCC_199 SVALTRHASAVLGRRVGASTGTNLCGAFRLISEMAATGLGGSVVTLLADS
MLBr_02396|M.leprae_Br4923 SFNMTRRLAREEAMLVGGSCGMAVVAALQVAEEAGP---AALVVVLLPDG
*. :: : . ** * * : .*: : * . **.*:.*.
Mflv_1363|M.gilvum_PYR-GCK GDRYIDTYFCDEWLSSQGIDPS----------------ESAGSLAEFERS
Mvan_5444|M.vanbaalenii_PYR-1 GDRYADTYFCDEWLTSHGIEPA----------------ESADVLSEFERS
Mb3709|M.bovis_AF2122/97 GDRYADTYFSDEWVSAQGLDPA----------------GPAAALVEFERS
Rv3684|M.tuberculosis_H37Rv GDRYADTYFSDEWVSAQGLDPA----------------GPAAALVEFERS
MMAR_5173|M.marinum_M GDRYAETYFNDEWVSAQGLDPT----------------DPAQALVEFERS
MUL_4259|M.ulcerans_Agy99 GDRYTETYFNDEWVSAQGLDPT----------------DPAQALVEFERS
MAV_0444|M.avium_104 GDRYADTYFDDEWVAAQGLDPA----------------GPAAALAEFERS
MSMEG_6203|M.smegmatis_MC2_155 GDRYTDTYFDADWLASQGLDPS----------------GPAEILTEFERS
TH_1707|M.thermoresistible__bu GDRYHDTYFNDEWLTKQGLDVS----------------AADAVLDEFERS
MAB_0406c|M.abscessus_ATCC_199 GDRYADTYFNDDWVTEQGFDLL----------------GPSVRLAEFEDA
MLBr_02396|M.leprae_Br4923 GRGYMSKIFNDAWMSSYGFLRSRLDGSTEQPIVGDVLRRKSGALPDLVHT
* * .. * *:: *: * :: :
Mflv_1363|M.gilvum_PYR-GCK GRWV----------------------------------------------
Mvan_5444|M.vanbaalenii_PYR-1 GRWP----------------------------------------------
Mb3709|M.bovis_AF2122/97 CRWT----------------------------------------------
Rv3684|M.tuberculosis_H37Rv CRWT----------------------------------------------
MMAR_5173|M.marinum_M CAWN----------------------------------------------
MUL_4259|M.ulcerans_Agy99 CAWN----------------------------------------------
MAV_0444|M.avium_104 CAWQ----------------------------------------------
MSMEG_6203|M.smegmatis_MC2_155 GSWS----------------------------------------------
TH_1707|M.thermoresistible__bu GRWP----------------------------------------------
MAB_0406c|M.abscessus_ATCC_199 GRWD----------------------------------------------
MLBr_02396|M.leprae_Br4923 HPSETVRDAIGILREYAVSQIPVVGAEPPVMAGEVVGSVSERELLSAVFE
Mflv_1363|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5444|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3709|M.bovis_AF2122/97 --------------------------------------------------
Rv3684|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5173|M.marinum_M --------------------------------------------------
MUL_4259|M.ulcerans_Agy99 --------------------------------------------------
MAV_0444|M.avium_104 --------------------------------------------------
MSMEG_6203|M.smegmatis_MC2_155 --------------------------------------------------
TH_1707|M.thermoresistible__bu --------------------------------------------------
MAB_0406c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02396|M.leprae_Br4923 GRASLADAVSEHMGPPLRLIGDGELVSVAGEALRDSDALMVVEKGKLVGV
Mflv_1363|M.gilvum_PYR-GCK -----------------
Mvan_5444|M.vanbaalenii_PYR-1 -----------------
Mb3709|M.bovis_AF2122/97 -----------------
Rv3684|M.tuberculosis_H37Rv -----------------
MMAR_5173|M.marinum_M -----------------
MUL_4259|M.ulcerans_Agy99 -----------------
MAV_0444|M.avium_104 -----------------
MSMEG_6203|M.smegmatis_MC2_155 -----------------
TH_1707|M.thermoresistible__bu -----------------
MAB_0406c|M.abscessus_ATCC_199 -----------------
MLBr_02396|M.leprae_Br4923 ITRYDLLGFLSEGAPLR