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M. abscessus ATCC 19977 MAB_4395 (-)

annotation: aminoglycoside 2'-N-acetyltransferase
coordinates: 4478765 - 4479334
length: 189

MSAVSNMPTVPVIRTHTARLIHTADLDSETRCAARELLIEAFEGDFTEEDWEHCLGGMHALIWYHGILIA
HAAVVQRRLLYQDRVLRTGYVEGVAVDSDWRGNGLGTAIMDAAEQVLRGAYELGALSAGDDVAPFYRARG
WVPWLGSTPVMTADGIVPATDEGVHVLPMSSGVDPSGSLTCDWRAGDGW
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. abscessus ATCC 19977MAB_4395--100% (189)aminoglycoside 2'-N-acetyltransferase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0268caac6e-6060.11% (178) aminoglycoside 2'-N-acetyltransferase AAC (AAC(2')-IC)
M. gilvum PYR-GCKMflv_0379-9e-5456.18% (178) GCN5-related N-acetyltransferase
M. tuberculosis H37RvRv0262caac6e-6060.11% (178) aminoglycoside 2'-N-acetyltransferase AAC (AAC(2')-IC)
M. leprae Br4923MLBr_02551aac3e-5757.95% (176) aminoglycoside 2'-N-acetyltransferase
M. marinum MMMAR_0522aac2e-6160.80% (176) aminoglycoside 2'-N-acetyltransferase Aac
M. avium 104-----
M. smegmatis MC2 155MSMEG_0434-1e-5355.38% (195) aminoglycoside 2'-N-acetyltransferase (AAC(2')-Id)
M. thermoresistible (build 8)TH_0924-2e-5759.43% (175) AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE AAC (AAC(2')-IC)
M. ulcerans Agy99MUL_1185aac7e-6160.23% (176) aminoglycoside 2'-N-acetyltransferase Aac
M. vanbaalenii PYR-1Mvan_0302-6e-5357.30% (178) GCN5-related N-acetyltransferase

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_0434|M.smegmatis_MC2_155      MLTQHVSEARTRGAIHTARLIHTSDLDQETRDGARRMVIEAFRDPSGDSD
TH_0924|M.thermoresistible__bu      --------------VPTARLVHTSDLDKEAFESAREMVIEAFEG------
Mb0268c|M.bovis_AF2122/97           --------MHT--QVHTARLVHTADLDSETRQDIRQMVTGAFAG------
Rv0262c|M.tuberculosis_H37Rv        --------MHT--QVHTARLVHTADLDSETRQDIRQMVTGAFAG------
MMAR_0522|M.marinum_M               --------MHT--EVHTARLVHTADLDSETRQGIRQMVTAAFAG------
MUL_1185|M.ulcerans_Agy99           --------MHT--EVHTARLVHTADLDSETRQGIRQMVTAAFAG------
MLBr_02551|M.leprae_Br4923          --------MDTH-HVHTARLVHTADLDGETLRRLQQMVTDAFAG------
Mflv_0379|M.gilvum_PYR-GCK          ---------------MRARLVHTSDLDDETREDARRMVLDAFDG------
Mvan_0302|M.vanbaalenii_PYR-1       ---------------MRARLIHTSDLDDETREDARRMVIDAFDG------
MAB_4395|M.abscessus_ATCC_1997      MSAVSNMPTVPVIRTHTARLIHTADLDSETRCAARELLIEAFEG------
                                                     ***:**:*** *:    :.::  ** .      

MSMEG_0434|M.smegmatis_MC2_155      FTDDFTDDDWDHALGGMHALISHHGALIAHGAVVQRRLMYRGPDGRGHAL
TH_0924|M.thermoresistible__bu      ---EMTDTDWDNALGGMHALIQHRGTLIAHAAVVQRRLLYR-----STAL
Mb0268c|M.bovis_AF2122/97           ---DFTETDWEHTLGGMHALIWHHGAIIAHAAVIQRRLIYR-----GNAL
Rv0262c|M.tuberculosis_H37Rv        ---DFTETDWEHTLGGMHALIWHHGAIIAHAAVIQRRLIYR-----GNAL
MMAR_0522|M.marinum_M               ---DFTDHDWEHALGGMHALIWHRGAIIAHGAVVQRRLIYR-----GSAL
MUL_1185|M.ulcerans_Agy99           ---DFTDHDWGHALGGMHALIWHRGAIIAHGAVVQRRLIYR-----GSAL
MLBr_02551|M.leprae_Br4923          ---DFDETDWEHALGGMHALIWRHGTIIAHAAVVQRRLFYH-----GNAL
Mflv_0379|M.gilvum_PYR-GCK          ---DFSEDDWEHALGGMHALICQRGDVIGHAAVVQRRLYYG-----DMAL
Mvan_0302|M.vanbaalenii_PYR-1       ---DFADEDWEHALGGMHAVISLRGDVIGHAAVVQRRLYVG-----DRAL
MAB_4395|M.abscessus_ATCC_1997      ---DFTEEDWEHCLGGMHALIWYHGILIAHAAVVQRRLLYQ-----DRVL
                                       :: : ** : ******:*  :* :*.*.**:****        . .*

MSMEG_0434|M.smegmatis_MC2_155      RCGYVEAVAVREDRRGDGLGTAVLDALEQVIRGAYQIGALSASDIARPMY
TH_0924|M.thermoresistible__bu      RCGYVEAVAVRKDWRGQGLAHALMDGIEQVLRGAYQLGALSVTEAGRHMY
Mb0268c|M.bovis_AF2122/97           RCGYVEGVAVRADWRGQRLVSALLDAVEQVMRGAYQLGALSSSARARRLY
Rv0262c|M.tuberculosis_H37Rv        RCGYVEGVAVRADWRGQRLVSALLDAVEQVMRGAYQLGALSSSARARRLY
MMAR_0522|M.marinum_M               RCGYVEGVAVREDWRGQGLATAVLDATEQVIRGAYELGALSSSAGARRLY
MUL_1185|M.ulcerans_Agy99           RCGYVEGVAVREDWRGQGLATAVLDATEQVIRGAYELGALSSSAGARRLY
MLBr_02551|M.leprae_Br4923          RCGYLEGVAVRKDCRGRGLVHALLDAIEQVIRGAYQFGALSSSDRARRVY
Mflv_0379|M.gilvum_PYR-GCK          RCGYVEGVAVTEEHRGQGLGGVLMDAVEQVVRGAYHLGALGASELGEPLY
Mvan_0302|M.vanbaalenii_PYR-1       RCGYVEGLAVREDHRGKRLGHALMDGVEQVVRGAYHLGGLSTTDLGKPLY
MAB_4395|M.abscessus_ATCC_1997      RTGYVEGVAVDSDWRGNGLGTAIMDAAEQVLRGAYELGALSAGDDVAPFY
                                    * **:*.:**  : **  *  .::*. ***:****.:*.*.       .*

MSMEG_0434|M.smegmatis_MC2_155      IARGWLSWEGPTSVLTPTEGIVRTPEDDRSLFVLPVDLPDGLELDTAREI
TH_0924|M.thermoresistible__bu      TSRGWLPWLGKTSVLSPTG-IVRTPEDDRSLYVLPIS----VELDTTAEI
Mb0268c|M.bovis_AF2122/97           ASRGWLPWHGPTSVLAPTG-PVRTPDDDGTVFVLPID----ISLDTSAEL
Rv0262c|M.tuberculosis_H37Rv        ASRGWLPWHGPTSVLAPTG-PVRTPDDDGTVFVLPID----ISLDTSAEL
MMAR_0522|M.marinum_M               TSRGWLPWHGPTSVLSPTG-PTPTPDDDGTVFVLPVD----ASLDTSAEL
MUL_1185|M.ulcerans_Agy99           TSRGWLPWHGPTSVLSPTG-PTPTPDDDGTVFVLPVD----ASLDTSAEL
MLBr_02551|M.leprae_Br4923          MSRGWLPWLGPTSVLAPTG-VIRTPDDDGSVFVLPVG----INPDTSSGL
Mflv_0379|M.gilvum_PYR-GCK          TRRGWIRWKGPTSVLAPSG-MTPTPDDDGAVFVLPADLPPSVTLDPGAPL
Mvan_0302|M.vanbaalenii_PYR-1       TVRGWVPWTGPTSVLALDG-ATRTPEDDGSLYVLPGELPASVTLDPTAPI
MAB_4395|M.abscessus_ATCC_1997      RARGWVPWLGSTPVMTADG---IVPATDEGVHVLPMS----SGVDPSGSL
                                      ***: * * *.*::       .*  *  :.***         *.   :

MSMEG_0434|M.smegmatis_MC2_155      TCDWRSGDPW
TH_0924|M.thermoresistible__bu      TCDWRDGDVW
Mb0268c|M.bovis_AF2122/97           MCDWRAGDVW
Rv0262c|M.tuberculosis_H37Rv        MCDWRAGDVW
MMAR_0522|M.marinum_M               MCDWRAGDVW
MUL_1185|M.ulcerans_Agy99           MCDWRAGDVW
MLBr_02551|M.leprae_Br4923          MCDWRAGNVW
Mflv_0379|M.gilvum_PYR-GCK          ACDWRGGDVW
Mvan_0302|M.vanbaalenii_PYR-1       ACDWRNGDVW
MAB_4395|M.abscessus_ATCC_1997      TCDWRAGDGW
                                     **** *: *