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VTVSQITHRQLSVNGIDMHIAEQGEGPAVVLCHGFPGLWYTWRHQLAALSAAGYRAIAPDMRGYGRTTAP RDAAAYDRGTTVGDLVGLLDALELRKAVFCGHDFGAHLVWDMPAWAADRVLALIQLSVPRTRRLPVKPSV GFNYLASQHFTHLEYFQEPGLAELELDAQPKAFLAALFHALSGANRYLDCWDHPARVNGKRNGYLDVLPN PPALPWNWLSEPDLDYYAAEFARTGFTGGLNWYRAEDLVWAQNEDLHDRPVEVPVAFIAGAADPVLEMLG RDPMTAMSDLVPGLRSALIVEGAGHFVQMERPDVVNHAMVEFLDSLPGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3764 | - | - | 100% (329) | epoxide hydrolase EphA |
| M. abscessus ATCC 19977 | MAB_0528c | - | 6e-67 | 43.12% (320) | epoxide hydrolase EphA |
| M. abscessus ATCC 19977 | MAB_0422c | - | 1e-17 | 27.38% (325) | epoxide hydrolase EphE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1973 | ephB | 1e-41 | 32.13% (361) | epoxide hydrolase EphB |
| M. gilvum PYR-GCK | Mflv_1415 | - | 6e-62 | 39.06% (320) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3617 | ephA | 6e-69 | 42.38% (328) | epoxide hydrolase EphA |
| M. leprae Br4923 | MLBr_02297 | - | 4e-17 | 27.14% (339) | putative hydrolase |
| M. marinum M | MMAR_5114 | ephA | 1e-66 | 41.18% (323) | epoxide hydrolase EphA |
| M. avium 104 | MAV_0539 | - | 2e-64 | 40.89% (313) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_6106 | - | 2e-64 | 42.33% (326) | epoxide hydrolase |
| M. thermoresistible (build 8) | TH_0992 | ephA | 1e-68 | 43.73% (327) | PROBABLE EPOXIDE HYDROLASE EPHA (EPOXIDE HYDRATASE) |
| M. ulcerans Agy99 | MUL_4193 | ephA | 3e-67 | 41.49% (323) | epoxide hydrolase EphA |
| M. vanbaalenii PYR-1 | Mvan_5373 | - | 8e-56 | 37.50% (320) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3617|M.tuberculosis_H37Rv -------------------MGAPTERLVDTNGVRLRVVE-----------
MAV_0539|M.avium_104 --------------------------------MRLRVTE-----------
MMAR_5114|M.marinum_M ------------------MVATSTERLVDTNGVRLRVTE-----------
MUL_4193|M.ulcerans_Agy99 ------------------MVATSTERLVDTNGVRLRVTE-----------
MSMEG_6106|M.smegmatis_MC2_155 -------------------MITPTERSVETNGVTLRVTE-----------
TH_0992|M.thermoresistible__bu -------------------VITPSERSVETNGVRLRLVE-----------
Mflv_1415|M.gilvum_PYR-GCK ----------------------MQSRMVHTNGITLRVFE-----------
Mvan_5373|M.vanbaalenii_PYR-1 MNSRWCFRAVRDRGCPFGESGAMRSRMVQTNGVTLRVTE-----------
MAB_3764|M.abscessus_ATCC_1997 -----------------MTVSQITHRQLSVNGIDMHIAE-----------
Mb1973|M.bovis_AF2122/97 --------------------MSQVHRILNCRGTRIHAVADS---------
MLBr_02297|M.leprae_Br4923 --------MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDC
::
Rv3617|M.tuberculosis_H37Rv -AGEPGAPVVILAHGFPELAYSWRHQIPALADAGYHVLAPDQRGYGGSSR
MAV_0539|M.avium_104 -AGDRGAPVVILAHGFPELAYSWRHQIDVLADAGYHVLAPDQRGYGGSDR
MMAR_5114|M.marinum_M -AGERGAPVVILAHGFPELAYSWRHQIPVLAEAGYHVLAPDQRGYGGSSR
MUL_4193|M.ulcerans_Agy99 -AGERGAPVVILAHGFPELAYSWRHQIPVLAEAGYHVLAPDQRGYGGSSR
MSMEG_6106|M.smegmatis_MC2_155 -AGERGNPVVVLAHGFPELAYSWRHQIPALAAAGYHVLAPDQRGYGGSSR
TH_0992|M.thermoresistible__bu -AGERGDPLVVLAHGFPELAYSWRHQIPALVDAGYHVMAPDQRGYGGSSA
Mflv_1415|M.gilvum_PYR-GCK -AGERSAPVVVLCHGFPELAFTWRHQISALAAAGFHVLAPDQRGYGGSDK
Mvan_5373|M.vanbaalenii_PYR-1 -AGEPGAPVVVLCHGFPELAFTWRHQVRALADAGFHVLAPDQRGYGGSDK
MAB_3764|M.abscessus_ATCC_1997 -QGE--GPAVVLCHGFPGLWYTWRHQLAALSAAGYRAIAPDMRGYGRTTA
Mb1973|M.bovis_AF2122/97 -PPDQQGPLVVLLHGFPESWYSWRHQIPALAGAGYRVVAIDQRGYGRSSK
MLBr_02297|M.leprae_Br4923 APSATARPLVMLLHGFGSFWWSWRHQLRGLTEA--RLVAVDLRGYGGSDK
* *:* *** ::****: * * : :* * **** :
Rv3617|M.tuberculosis_H37Rv PEAIEAYDIHRLTADLVGLLDDVGAERAVWVGHDWGAVVVWNAPLLHADR
MAV_0539|M.avium_104 PDAVEAYDIHQLTADLVGLLDDVGAQRAVWVGHDWGAAVVWNAPLLHPDR
MMAR_5114|M.marinum_M PEAIEDYDIHQLTADLVGLLDDVGAERAAWVGHDWGAVVVWNAPLLHPDR
MUL_4193|M.ulcerans_Agy99 PEAIEDYDIHQLTADLVGLLDDVGAERAAWVGHDWGAVVVWNAPLLHPDR
MSMEG_6106|M.smegmatis_MC2_155 PESIDDYDITKLTGDVVGLLDDIGAEHAAVIGHDWGAVVAWNAAQLHPDR
TH_0992|M.thermoresistible__bu PEAIEAYDITRLTADLMGLLDDIGAEKAAFIGHDWGALVVWNAALLYPDR
Mflv_1415|M.gilvum_PYR-GCK PGDAGVYNVAELTADVVGLLDDVGAERAALVGHDFGAVVAWGAPLLEPDR
Mvan_5373|M.vanbaalenii_PYR-1 PDAVDSYNVAELTADVVGLLDDLGAERAALVGHDFGAVVAWAAPLLQPDR
MAB_3764|M.abscessus_ATCC_1997 PRDAAAYDRGTTVGDLVGLLDALELRKAVFCGHDFGAHLVWDMPAWAADR
Mb1973|M.bovis_AF2122/97 YRVQKAYRIKELVGDVVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDR
MLBr_02297|M.leprae_Br4923 PP--RGYDGWTLAGDTAGLIRALGHSSATLVGHAEGGLACWATALLHPRL
* ..* *:: * ** *. * . .
Rv3617|M.tuberculosis_H37Rv VAAVAALSVPALPR----------AQVPPTQAFRSRFGEN-FFYILYFQE
MAV_0539|M.avium_104 VAAVAAMSVPVTPR----------PRLAPTQAWRKMFGEN-FFYILYFQE
MMAR_5114|M.marinum_M VAAVAGLSVPVLPR----------AQVPPIQAFRQRFGEH-FFYILYFQQ
MUL_4193|M.ulcerans_Agy99 VAAVAGLSVPVLPR----------AQVPPIQAFRQRFGEH-FFYILYFQQ
MSMEG_6106|M.smegmatis_MC2_155 VAAVGGLSVPPTPR----------STRPPTQAFRELVGEGKFFYILHFQE
TH_0992|M.thermoresistible__bu VAAVAGLSVPPVPR----------SLTRPTEAFRALVGEDNFFYILYFQE
Mflv_1415|M.gilvum_PYR-GCK FSAVAGLSLPPVPR----------PQVPTTQAFRRVFGDR-FMYILYFQE
Mvan_5373|M.vanbaalenii_PYR-1 FSSVAGLSLPPVPR----------PKVPTTQAFRRIFADR-FFYILYFQD
MAB_3764|M.abscessus_ATCC_1997 VLALIQLSVPRTRR----------LPVKPSVGFNYLASQH-FTHLEYFQE
Mb1973|M.bovis_AF2122/97 CAGVVGISVPFAGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYFAV
MLBr_02297|M.leprae_Br4923 VRAIALINSPHPAA------------LRRSMLTHRNQGYALLPTLLRYQL
.: :. * . . :
Rv3617|M.tuberculosis_H37Rv PGIADAELNGDPARTMR---------RMIGGLRPPG------DQSAAMRM
MAV_0539|M.avium_104 PGVADAELNADPAQVMR---------RMMGSLRTDG------DKAAGLRM
MMAR_5114|M.marinum_M PGVADAELNGDPARTMR---------RMIGGQRSPT------DQGAALRM
MUL_4193|M.ulcerans_Agy99 PGVADAELNGDPARTMR---------RMIGGQRSPT------DQGAALRM
MSMEG_6106|M.smegmatis_MC2_155 PGVADAEFDGDPARALR---------RMFGGLLPPE------NEEAAMRM
TH_0992|M.thermoresistible__bu PGVADAELDGDPARTMR---------RMFGGLTS--------DPDAAHRM
Mflv_1415|M.gilvum_PYR-GCK PGPADAELARDPATTFR---------RLFA--LTTG---------GAEMV
Mvan_5373|M.vanbaalenii_PYR-1 RGPADAELARDPAGTFR---------RLFA--MDVA------DEQSALRM
MAB_3764|M.abscessus_ATCC_1997 PGLAELELDAQPKAFLA---------ALFHALSGANRY---LDCWDHPAR
Mb1973|M.bovis_AF2122/97 QDGIITEIEEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDV
MLBr_02297|M.leprae_Br4923 PIWPERLLTRNNAAEIE---------RLVRSRSSAK-----WQACEDFAV
: : : :.
Rv3617|M.tuberculosis_H37Rv LAPGP------DGFIDRLPEPAGLP-AWISQEELDHYIGEFTRTGFTGGL
MAV_0539|M.avium_104 VAPGP------EGFLERLPEPDGLP-EWISQDELDHYIAEFSRTGFTGGL
MMAR_5114|M.marinum_M VAPGP------EGFIDRLPEPDTPP-SWISRDELDHYISEFTRTGFTGGL
MUL_4193|M.ulcerans_Agy99 VAPGP------EGFIDRLPEPDAPP-SWISRDELDHYISEFTRTGFTGGL
MSMEG_6106|M.smegmatis_MC2_155 LRPGP------EGLIDRLPEPSALP-DWISTGEFDHYVDAFTRTGFTGGL
TH_0992|M.thermoresistible__bu LQPGP------AGFIDRLPEPEALP-DWLTAEELDHYIAEFTRTGFTGGL
Mflv_1415|M.gilvum_PYR-GCK GDAGP------QGFLDRIPEPGGLP-DWISQADFDVYVDEFTRGGFTGPL
Mvan_5373|M.vanbaalenii_PYR-1 TEPGP------AGFLDRIPDPGRLP-DWISPPDFAVYVDEFRRGGFTAPL
MAB_3764|M.abscessus_ATCC_1997 VNGKR------NGYLDVLPNPPALPWNWLSEPDLDYYAAEFARTGFTGGL
Mb1973|M.bovis_AF2122/97 IRAGPLCMAEGARLKDAFVYPETMP-AWFTEADLDFYTGEFERSGFGGPL
MLBr_02297|M.leprae_Br4923 T-------------IDHLRIAIQIP-------AAAHCALEYQRWAVR---
: : . * : * ..
Rv3617|M.tuberculosis_H37Rv NWYRNFDRNWETTADLAGKTISVPSLFIAGTADPVLTFTRTD---RAAEV
MAV_0539|M.avium_104 NWYRNFDRNWETTPELDGAKIAVPCLFIGGTADPVLSFTRAD---RAAEV
MMAR_5114|M.marinum_M NWYRNFDRNWETTADLEGATITVPSLFMAGTKDPVLSFARSD---RASEV
MUL_4193|M.ulcerans_Agy99 NWYRNFDRNWETTADLEGATITVPSLFMAGTKDPVLSFARSD---RASEV
MSMEG_6106|M.smegmatis_MC2_155 NWYRNFDRNWELTAHLADAKITVPALFLAGAADPVLGFARPD---RARDL
TH_0992|M.thermoresistible__bu NWYRNMDRNWELTEHLAGATITAPALFLAGAADPVLGFMRPE---RATEV
Mflv_1415|M.gilvum_PYR-GCK NWYRCFDRNWELTAETPAPTIEVPALFVGGTEDATLAYTPRD---RVREV
Mvan_5373|M.vanbaalenii_PYR-1 NWYRCFDLNWELTADPPAPTIGVPALFVGGTADATLAYTPRH---RVREV
MAB_3764|M.abscessus_ATCC_1997 NWYRAEDLVWAQNEDLHDRPVEVPVAFIAGAADPVLEMLGRDPMTAMSDL
Mb1973|M.bovis_AF2122/97 SFYHNIDNDWHDLADQQGKPLTPPALFIGGQYD-VGTIWGAQAIERAHEV
MLBr_02297|M.leprae_Br4923 SQLRNEGRKFMKS---MSRPFSVPLLHVRGDADPYLLADSVD----RTRR
. : . : . * .: * * .
Rv3617|M.tuberculosis_H37Rv ISGPYREVLIDGAGHWLQQERPGEVTAALLEFLTGLELR---
MAV_0539|M.avium_104 ISGPYRHVMIDGAGHWLQQERPAEVNAALLDFLNGLELR---
MMAR_5114|M.marinum_M ITGPYREVMVEGAGHWLQQERPDEVNATLLDFLKGVQW----
MUL_4193|M.ulcerans_Agy99 ITGPYREVMVEGAGHWLQQERPDEVNATLLDFLKGVQW----
MSMEG_6106|M.smegmatis_MC2_155 IAGPYTEILLDGAGHWVQQERAEEVNAALIGFLHGLELQ---
TH_0992|M.thermoresistible__bu AVGPYRQVLLDGAGHWVQQERPQEVNAALIDFLRGLELQ---
Mflv_1415|M.gilvum_PYR-GCK VTGDYREVMIDGAGHWLTEERPDEVSRVLVDFLTTVR-----
Mvan_5373|M.vanbaalenii_PYR-1 VTGDYREVMIDGAGHWLTEERPDEVSRILLEFLTAAR-----
MAB_3764|M.abscessus_ATCC_1997 VPGLRSALIVEGAGHFVQMERPDVVNHAMVEFLDSLPGR---
Mb1973|M.bovis_AF2122/97 MPNYRGTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP----
MLBr_02297|M.leprae_Br4923 YAPHGRYVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS
: ..**: * . . : **