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MKILVASRNPKKLAELSRVLESSGVSGVELVSLTDVPEYEEVPETGASFEDNALIKAREGVKHTGLACVA DDSGLAVDALNWMPGVLSARWSGRHGDDAANTALLLAQLSDIPDERRGAAFVSACALVTPEGEEVVVEGR WKGSIARIPAGQNGFGYDPIFVPRGGLRTAAELTPEEKDAVSHRGRALAALLPMLRNLVNLGRTAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1485 | - | - | 100% (206) | HAM1 protein homolog (NTPase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1376 | - | 1e-74 | 72.59% (197) | putative deoxyribonucleotide triphosphate pyrophosphatase |
| M. gilvum PYR-GCK | Mflv_2359 | - | 6e-69 | 69.73% (185) | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase |
| M. tuberculosis H37Rv | Rv1341 | - | 1e-74 | 72.59% (197) | putative deoxyribonucleotide triphosphate pyrophosphatase |
| M. leprae Br4923 | MLBr_01175 | - | 3e-68 | 67.50% (200) | putative deoxyribonucleotide triphosphate pyrophosphatase |
| M. marinum M | MMAR_4040 | - | 9e-75 | 71.21% (198) | Ham1-related NTPase |
| M. avium 104 | MAV_1558 | rdgB | 1e-71 | 71.07% (197) | putative deoxyribonucleotide triphosphate pyrophosphatase |
| M. smegmatis MC2 155 | MSMEG_4899 | rdgB | 7e-75 | 69.54% (197) | non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family |
| M. thermoresistible (build 8) | TH_1014 | - | 9e-71 | 66.34% (205) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3906 | - | 5e-75 | 71.21% (198) | putative deoxyribonucleotide triphosphate pyrophosphatase |
| M. vanbaalenii PYR-1 | Mvan_4286 | - | 4e-69 | 69.95% (183) | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1376|M.bovis_AF2122/97 ------------MALVTKLLVASRNRKKLAELRRVLDGAGLSGLTLLSLG
Rv1341|M.tuberculosis_H37Rv ------------MALVTKLLVASRNRKKLAELRRVLDGAGLSGLTLLSLG
MLBr_01175|M.leprae_Br4923 MGVSPSREAARGVALVTKLLVASRNWKKLAELRRVLDNAGLSGLTLVSLN
MAV_1558|M.avium_104 ---------------MSPLLVASRNRKKLAELRRVLDAAGVTGLTLVSLD
MMAR_4040|M.marinum_M ---------------MTKLLVASRNAKKLAELRRVLDAAGLSGVTLVSLN
MUL_3906|M.ulcerans_Agy99 --------------MVTKLLVASRNAKKLAELRRVLDAAGLSGVTLVSLN
MSMEG_4899|M.smegmatis_MC2_155 ---------------MTELLVASRNKKKLAELRRVLDAAGISGLRLLSLD
Mflv_2359|M.gilvum_PYR-GCK -------------------------------MRRVLDAAGVTGLTLVSLD
Mvan_4286|M.vanbaalenii_PYR-1 ----------------------------------MLDAAGVSGLTLLSLD
TH_1014|M.thermoresistible__bu ---------------MTRLLVATRNRKKLAELHRVLDAAGLTGLSLLSLD
MAB_1485|M.abscessus_ATCC_1997 ----------------MKILVASRNPKKLAELSRVLESSGVSGVELVSLT
:*: :*::*: *:**
Mb1376|M.bovis_AF2122/97 DVSPLPETPETGVTFEDNALAKARDAFSATGLASVADDSGLEVAALGGMP
Rv1341|M.tuberculosis_H37Rv DVSPLPETPETGVTFEDNALAKARDAFSATGLASVADDSGLEVAALGGMP
MLBr_01175|M.leprae_Br4923 DVVPFDEAPEAGATFEDNALAKARDAFAATGLASVADDSGLEAAALGGMP
MAV_1558|M.avium_104 DVAPFEEAPETGAVFEENALAKARDAFDATGLASVADDSGLEVAALNGMP
MMAR_4040|M.marinum_M DVAPFDEAPETGATFEENALIKAREAFAATGLPSVADDSGLTVAALNGMP
MUL_3906|M.ulcerans_Agy99 DVAPFDEAPETGATFEENALIKAREAFSATGLPSVADDSGLTVAALNGMP
MSMEG_4899|M.smegmatis_MC2_155 DVAPYDESPETGATFEENALAKARDGFEATGLACVADDSGITVAALNGMP
Mflv_2359|M.gilvum_PYR-GCK DVPAFDEAPETGATFEENALAKARDAFAATGLPTVADDSGLEVDALNGMP
Mvan_4286|M.vanbaalenii_PYR-1 DVPPFDEAPETGATFEENAMAKARDAFAATGLPAVADDSGLEVDALNGMP
TH_1014|M.thermoresistible__bu DVPPFEDAPETGATFEENALAKARDAFRATGLPTVADDSGLEVDALNGMP
MAB_1485|M.abscessus_ATCC_1997 DVPEYEEVPETGASFEDNALIKAREGVKHTGLACVADDSGLAVDALNWMP
** : **:*. **:**: ***:.. ***. ******: . **. **
Mb1376|M.bovis_AF2122/97 GVLSARWSGRYGD----DAANTALLLAQLCDVPDERRGAAFVSACALVSG
Rv1341|M.tuberculosis_H37Rv GVLSARWSGRYGD----DAANTALLLAQLCDVPDERRGAAFVSACALVSG
MLBr_01175|M.leprae_Br4923 GVLSARWSGSYGD----DAGNTALLLAQLCDVPDERRSAAFVSACALVSE
MAV_1558|M.avium_104 GVLSARWSGRHGD----DAANTALLLAQLRDVPDERRAASFVSACALVSA
MMAR_4040|M.marinum_M GVLSARWSGNHGD----DAGNTALLLAQLRDVPEQRRGAAFVSACALVSG
MUL_3906|M.ulcerans_Agy99 GVLSARWSGNHGD----DAGNTALLLAQLRDVPEQRRGAAFVSACALVSG
MSMEG_4899|M.smegmatis_MC2_155 GVLSARWSGTHGN----DAANTELLLAQLADVPDERRGAAFVSACALVSA
Mflv_2359|M.gilvum_PYR-GCK GVLSARWSGRHGD----DAANTALLLGQIRDVPDARRGAAFVSACALVSG
Mvan_4286|M.vanbaalenii_PYR-1 GVLSARWAGRHGD----DAANTALLLGQLGDVPEERRGAAFVSACALVFG
TH_1014|M.thermoresistible__bu GVLSARWSATAGDAATRDRANTDLLLAQLADVPDGRRGAAFVSACALVYG
MAB_1485|M.abscessus_ATCC_1997 GVLSARWSGRHGD----DAANTALLLAQLSDIPDERRGAAFVSACALVTP
*******:. *: * .** ***.*: *:*: **.*:********
Mb1376|M.bovis_AF2122/97 SGE---VVVRGEWPGTIAREPRGDGGFGYDPVFVPYG---DDRTAAQLSP
Rv1341|M.tuberculosis_H37Rv SGE---VVVRGEWPGTIAREPRGDGGFGYDPVFVPYG---DDRTAAQLSP
MLBr_01175|M.leprae_Br4923 SDE---VVVRGVWPGTIAREPRGYGGFGYDSIFIPDGPGLGGRTVAQLRP
MAV_1558|M.avium_104 SGE---VVVRGEWPGRIACEPRGDGGFGYDPVFVPDD--AGGRTAAQLSP
MMAR_4040|M.marinum_M SGE---VVVRGEWPGAVAQEPRGAGGFGYDPVFIADG---ANRTAAELSP
MUL_3906|M.ulcerans_Agy99 SGE---VVVRGEWPGAVAQEPRGAGGFGYDPVFIADG---ANRTAAELSP
MSMEG_4899|M.smegmatis_MC2_155 SGS---TVVRGEWPGTVTREPRGDGGFGYDPVFLPEG---SERTAAELTP
Mflv_2359|M.gilvum_PYR-GCK PGEADCRVVRGEWRGTILREPRGDGGFGYDPVFLPAG---SERSAAELRP
Mvan_4286|M.vanbaalenii_PYR-1 PGEAERVVVRGEWRGSIVREARGDGGFGYDPVFLPTG---SARTAAELSP
TH_1014|M.thermoresistible__bu PGDEDHVVVRGVWPGRIARQPRGDGGFGYDPVFIPAG---ETRTAAELSP
MAB_1485|M.abscessus_ATCC_1997 EGEE--VVVEGRWKGSIARIPAGQNGFGYDPIFVPRG---GLRTAAELTP
.. **.* * * : . * .*****.:*:. . *:.*:* *
Mb1376|M.bovis_AF2122/97 AEKDAVSHRGRALALLLPALRSLATG-----
Rv1341|M.tuberculosis_H37Rv AEKDAVSHRGRALALLLPALRSLATG-----
MLBr_01175|M.leprae_Br4923 AEKDAFSHRFRALTLLMPALRVLAMRT----
MAV_1558|M.avium_104 AEKDAVSHRGRALRLLVPALETLARARG---
MMAR_4040|M.marinum_M AEKDAVSHRGRALTLLLPALRALVTTQS---
MUL_3906|M.ulcerans_Agy99 AEKDAVSHRGRALTLLLPALRALVTTQP---
MSMEG_4899|M.smegmatis_MC2_155 AEKDASSHRGRALTLLVPALRALEG------
Mflv_2359|M.gilvum_PYR-GCK EEKDASSHRGRALEALLPALRSLTWSGDRVQ
Mvan_4286|M.vanbaalenii_PYR-1 AEKDASSHRGRALAALLPSLRALI-------
TH_1014|M.thermoresistible__bu AEKDAASHRGRALAQLVPALRRLVS------
MAB_1485|M.abscessus_ATCC_1997 EEKDAVSHRGRALAALLPMLRNLVNLGRTAP
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