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LAQGEDQVKRSDIKLVVVTGAGSGIGRAAAERFAQLGARVIVSDINEVAAEATVAAIRDAGGDSCARRLD VTDVNEFEDFARWVQSEHGVCDVVVNNAGIGILGEVIDTTESDWDRIVGINLLGMVHGARLFAQQMVDAN KPGHIVNVASAAAFLPMPNLASYSATKYAVKMFTDCIRGELAPNHIGASVICPGPIMTNIFSSATHTGAD EQEQVQRSALTGAAFEKIRSWHLIPGPQNVARAIESAVVYNRKTVLVRPEAYLVYLLRRLSPTLLYAFSN LIFGSRTITFAYRLGKNPTVARLLGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1382 | - | - | 100% (306) | putative oxidoreductase EphD |
| M. abscessus ATCC 19977 | MAB_4022c | - | 6e-61 | 50.57% (261) | oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0143c | - | 2e-56 | 45.21% (261) | putative oxidoreductase EphD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 3e-52 | 43.49% (269) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2937 | - | 1e-46 | 42.26% (265) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2214c | ephD | 3e-52 | 43.49% (269) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-52 | 44.32% (264) | short chain dehydrogenase |
| M. marinum M | MMAR_1932 | ephD_1 | 1e-50 | 39.41% (269) | short-chain dehydrogenase EphD_1 |
| M. avium 104 | MAV_2275 | - | 1e-52 | 45.59% (261) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 4e-51 | 44.49% (263) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 1e-51 | 43.94% (264) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3574 | ephD | 1e-50 | 43.23% (266) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3576 | - | 6e-49 | 42.75% (255) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2237c|M.bovis_AF2122/97 MPATQ---QMSR-LVDSPDGVRIAVYHEG--NPDGPTVVLVHGFPDSHVL
Rv2214c|M.tuberculosis_H37Rv MPATQ---QMSR-LVDSPDGVRIAVYHEG--NPDGPTVVLVHGFPDSHVL
MUL_3574|M.ulcerans_Agy99 MPATK---QAPQQFVDSAGGVRIAVYEEG--NPDSPTVVLVHGFPDSHVL
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSG--QPEGPAIVLVHGFPDSHVL
MAV_2275|M.avium_104 MPAPQ---HSPQHFVHSADGTRIAVYDEG--NPEGPTVVLVHGFPDSHVL
TH_4323|M.thermoresistible__bu --------MATEHFIDSSGGVRIAAYEEG--NPDGPTVVLVHGWPDSHVV
Mflv_2937|M.gilvum_PYR-GCK --------MSSQRFVVSRDGVRIAVYEEG--AADGPTVVLVHGHADTHEA
Mvan_3576|M.vanbaalenii_PYR-1 --------MSTQRFVESSDGVRIAVSEQG--NPDGPTLVLVHGLRDTHRV
MSMEG_4280|M.smegmatis_MC2_155 ----------MYTFVTSQDGTRIAVYQQG--DPERPTLVMAHGWPDSHVL
MAB_1382|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1932|M.marinum_M ------MNTASRTGITASDGATLAVYHYTPLDPQRPTILAIHGWPDNHHL
Mb2237c|M.bovis_AF2122/97 WDGVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGEL
Rv2214c|M.tuberculosis_H37Rv WDGVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGEL
MUL_3574|M.ulcerans_Agy99 WDGVVPRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEAL
MLBr_00862|M.leprae_Br4923 WDGVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDEL
MAV_2275|M.avium_104 WDGVVPLLAERFRILRYDNRGVGASSAPKPVSAYRMDRFADDFAAVIGEL
TH_4323|M.thermoresistible__bu WDSVAPLLADRFRIIRYDNRGVGRTTAPRRVADHTMARYADDFGAVIDAL
Mflv_2937|M.gilvum_PYR-GCK WDAVVALLAARFRIVRYDTRGAGRSAAPQRTSGFRLERYADDLAAVLDAV
Mvan_3576|M.vanbaalenii_PYR-1 WDPVVALLADRFRIVAYDTRGAGNSGAPKQTSAYTVDRFADDFAAVAAAV
MSMEG_4280|M.smegmatis_MC2_155 WDGVVGELGDRYRIVRYDNRGAGASDVPKATSAYTMERFADDFSAVIDAV
MAB_1382|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1932|M.marinum_M WDPVAELLGDRYNVVAYDVRGSGESSCPASRSGYRLEQLVSDTGAVIDSL
Mb2237c|M.bovis_AF2122/97 SPGEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVY
Rv2214c|M.tuberculosis_H37Rv SPGEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVY
MUL_3574|M.ulcerans_Agy99 SPGQPVHVLGHDWGSVAIWDYLTRSGAADRVASFTSVSGPSQDQLVNYIF
MLBr_00862|M.leprae_Br4923 SPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYIL
MAV_2275|M.avium_104 SPGGPVHVLAHDWGSVGVWHYLKRPGANDRVATFTSVSGPSQDQLVDYIF
TH_4323|M.thermoresistible__bu APGQRVHVLAHDWGSAGVWEYLARPEAEDRIASFTSVSGPSGDHLARYVL
Mflv_2937|M.gilvum_PYR-GCK SAEAPVHVLAHDRGSAGVWRYLARPESRGRLASFTSVSGPAPEHVARYLR
Mvan_3576|M.vanbaalenii_PYR-1 GGDTPVHVLAHGWGAAGVWQYLKRADAPERVASLTSVSGPSPEHVAGYVR
MSMEG_4280|M.smegmatis_MC2_155 SPDAPVHVLAHDWGSVGIWEYLSRQGSAARMVSFTSVSGPSTDHYGAYVR
MAB_1382|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1932|M.marinum_M GVDR-VHLLAHDWGSIQGWAAVTADSVMEKVASFTSISGPHLQYAGAFLR
Mb2237c|M.bovis_AF2122/97 GGLRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVR--
Rv2214c|M.tuberculosis_H37Rv GGLRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVR--
MUL_3574|M.ulcerans_Agy99 GGLRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRASVR--
MLBr_00862|M.leprae_Br4923 SGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIR--
MAV_2275|M.avium_104 SGLRAPWRPRAFARALGQALRLSYMILLSIPVLAPLALRLTLSIPALR--
TH_4323|M.thermoresistible__bu DGLAAPYRPRRFLRSLTQLLRLSYMGFFSIPVLAPLLVRGVLSKALRRS-
Mflv_2937|M.gilvum_PYR-GCK DTLARPQHPARFAGGLGHLAR--------------------LAAAAPR--
Mvan_3576|M.vanbaalenii_PYR-1 AALTSPR---RFVRGAGQLVR--------------------LAAAAPR--
MSMEG_4280|M.smegmatis_MC2_155 RGLARPYRPVQFARAVNLASRFSYWIPFSIPVLAPALMR---RGAARR--
MAB_1382|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1932|M.marinum_M SGR----TPRSVAQVARQLASSGYIGFFLCPVVPELFFRSGIGVKLVGAF
Mb2237c|M.bovis_AF2122/97 RNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVD
Rv2214c|M.tuberculosis_H37Rv RNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVD
MUL_3574|M.ulcerans_Agy99 RNMVDNLPLDQIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGVPVID
MLBr_00862|M.leprae_Br4923 RTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVN
MAV_2275|M.avium_104 RNAVDNIPIEQIHHSDRLAADAARSVKTYPANYFRSFAIRK--QGVAVID
TH_4323|M.thermoresistible__bu LRLRDGVPADRLHHSDTFAADAARSIKVYGANFLRTLRHAR---TDHFVR
Mflv_2937|M.gilvum_PYR-GCK ----------------------AVTDKTLRANLFPVSSGGD----AHDVD
Mvan_3576|M.vanbaalenii_PYR-1 ----------------------AATAKPYRANLRPAAPAG------VPVD
MSMEG_4280|M.smegmatis_MC2_155 --LQAIDTPGPKFQSENLDIDAANSLKIYRANAIRSFTHVR---RDHYVQ
MAB_1382|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1932|M.marinum_M ERIGQSSTRSQRGQTPRSIGDYVNALNLYRANMPAGFVTDG--SSLPQTS
Mb2237c|M.bovis_AF2122/97 VPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAA
Rv2214c|M.tuberculosis_H37Rv VPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAA
MUL_3574|M.ulcerans_Agy99 VPVQLIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQVMAA
MLBr_00862|M.leprae_Br4923 VPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAA
MAV_2275|M.avium_104 VPVQLIVNTEDRYVRPYGYDHTPRFVPRLWRRDIRAGHFSPMSHPQVMAA
TH_4323|M.thermoresistible__bu VPVQLIVNTRDPYVRPHVYDETDRWVSRLWRRDIKAGHWSPMSHPQVLAT
Mflv_2937|M.gilvum_PYR-GCK IPVQLIVGSADPYPDPHLFEDRAGRPARLWRRDVKAGHVTPTSHPGILAR
Mvan_3576|M.vanbaalenii_PYR-1 VPVQLIVPDHDPHVGPHVYDGMSASVSRLWRRDIKTGDLSPGSHPQVLAR
MSMEG_4280|M.smegmatis_MC2_155 VPVQLICNRKDPVVRGEGYRDESKWVPLLWRRDLDAGHWAPFSHPRAIAQ
MAB_1382|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1932|M.marinum_M VPVQVLVPRKDMFVTPALQRFTGAIPGGGRVVPIEGGHWVVTSRPDVVAR
Mb2237c|M.bovis_AF2122/97 AVHDFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETAL
Rv2214c|M.tuberculosis_H37Rv AVHDFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETAL
MUL_3574|M.ulcerans_Agy99 AVHDFADLVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGRETAL
MLBr_00862|M.leprae_Br4923 AVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETAL
MAV_2275|M.avium_104 AVHDFADMAEGKPASRALLRAQVGRPRKAFGDTLVSVTGAGSGIGRATAF
TH_4323|M.thermoresistible__bu AVTELADHLAGAPAGRALLRAQVGRPREYFGDMLVAITGAGGGIGRETAL
Mflv_2937|M.gilvum_PYR-GCK ALTQLVDHLDGAPAARELLRAQVGRPRKAFGDTLVAVTGAASGIGRATAL
Mvan_3576|M.vanbaalenii_PYR-1 AVDQLVDHLGGAPAPRELLRAQVGRARKVFGDTLVSVTGAASGIGRETAL
MSMEG_4280|M.smegmatis_MC2_155 AVGEFVDHMEGAPPARALRRAEVARPRKAFSDMLVSVTGAASGIGRATAL
MAB_1382|M.abscessus_ATCC_1997 -------MAQGE--------DQVKRS----DIKLVVVTGAGSGIGRAAAE
MMAR_1932|M.marinum_M LTADWVDRVVAGTGDAAATVVRAGPGE--VRGQLALVTGAGAGIGRATAV
. .. *. :***..**** :*
Mb2237c|M.bovis_AF2122/97 AFAREGA-EIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAF
Rv2214c|M.tuberculosis_H37Rv AFAREGA-EIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAF
MUL_3574|M.ulcerans_Agy99 AFAREGA-EVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEAVEAF
MLBr_00862|M.leprae_Br4923 ALARRGA-EVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAF
MAV_2275|M.avium_104 AFAREGA-ELIVSDIDEAAVKATAAEIAGRGGVAHAYVLDVSDAQAVEEF
TH_4323|M.thermoresistible__bu AFAREGA-EVIVSDIDEATAKDTAAEIAARGGVAHAYQLDVSDAAAVDRF
Mflv_2937|M.gilvum_PYR-GCK AFAHHGA-DVVISDVNAAGLDETARLVTSAGVHAYPYTVDVADAAAVEAF
Mvan_3576|M.vanbaalenii_PYR-1 AFARAGA-DVVISDVDEAGLEQTARLVTAAGAAAHSYTVDVADAAAVEAM
MSMEG_4280|M.smegmatis_MC2_155 EFARLGA-EIVVSDIDEAGAKATATAIDEAGGVAHAYGLDVADPDAVQRF
MAB_1382|M.abscessus_ATCC_1997 RFAQLGA-RVIVSDINEVAAEATVAAIRDAGGDSCARRLDVTDVNEFEDF
MMAR_1932|M.marinum_M ELARQGARMVIIADRDLAAANESATQVRAAGAAAAVYQVDVSDETAMNDL
:*: ** ::::* : . . :. : * : :**:* .: :
Mb2237c|M.bovis_AF2122/97 AERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCR
Rv2214c|M.tuberculosis_H37Rv AERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCR
MUL_3574|M.ulcerans_Agy99 ADQVSATHGLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNLGGVVNGCR
MLBr_00862|M.leprae_Br4923 AEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCR
MAV_2275|M.avium_104 AERVSAAHGVPDIVVNNAGIGQAGGFLDTPAEEFDRVLAVNLGGVVNGCR
TH_4323|M.thermoresistible__bu ADEVCARHGVPDIVVNNAGIGHAGRFLDTPRDQWDRVLEVNLGGVVNGCR
Mflv_2937|M.gilvum_PYR-GCK AEQVCAEHGVPDVVVNNAGVGHAGFFLDTPAEEFDRVLDINFGGVVNGCR
Mvan_3576|M.vanbaalenii_PYR-1 AELVCAAHGVPDIVVNNAGVGHAGFFLDTPAEEFDRVLGINFGGVVNGCR
MSMEG_4280|M.smegmatis_MC2_155 VDDVCATHGVPDIVVNNAGIGHAGNFLDTPADQYERVLEVNFGGVVNCCR
MAB_1382|M.abscessus_ATCC_1997 ARWVQSEHGVCDVVVNNAGIGILGEVIDTTESDWDRIVGINLLGMVHGAR
MMAR_1932|M.marinum_M AAQVLDEHGVVDILVNNAGIGMAGRFLETTPQHWDAILGINVGGVISGSR
. * **: *::*****:* * .::*. ..:: :: :*. *:: .*
Mb2237c|M.bovis_AF2122/97 AFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAE
Rv2214c|M.tuberculosis_H37Rv AFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAE
MUL_3574|M.ulcerans_Agy99 AFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAE
MLBr_00862|M.leprae_Br4923 AFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAE
MAV_2275|M.avium_104 SFARRMVQRGTGGHLVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAE
TH_4323|M.thermoresistible__bu AFAPRLVERGTGGHIVNIASMASYAPLQSLNAYCTSKAAVYMFSDCLRAE
Mflv_2937|M.gilvum_PYR-GCK SFGKRLADRGVGGHIVNVASMASYTPVNVMNAYCTSKAAVFMFSDCLRAE
Mvan_3576|M.vanbaalenii_PYR-1 SWGRRLVDRGTGGHIVNVASMASYTPVNVMNAYCTSKAAVFMFSDCLRAE
MSMEG_4280|M.smegmatis_MC2_155 AFGRRLVEQGTGGHIVNVASMAAYSPAGSMNAYATSKAAVFMFSDCLRAE
MAB_1382|M.abscessus_ATCC_1997 LFAQQMVDANKPGHIVNVASAAAFLPMPNLASYSATKYAVKMFTDCIRGE
MMAR_1932|M.marinum_M AFGAQMVERGQGGTIINIASAAAYLPSKSMVAYSTTKAAVLGFSEALRAD
:. ::.: . * ::*::* *:: * : :*.::* *. *::.:*.:
Mb2237c|M.bovis_AF2122/97 LDAAGVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQIDKMFAL
Rv2214c|M.tuberculosis_H37Rv LDAAGVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQIDKMFAL
MUL_3574|M.ulcerans_Agy99 LDAADVGLTTICPGVINTNIVNTTRFDAPPGKGGDQLDGRRGQIDKMFAL
MLBr_00862|M.leprae_Br4923 LDAVGVGLTTICPGVIDTNIIQSTRIDTP-TAKQERVRDRRGQLDMMFRL
MAV_2275|M.avium_104 LDAAGVGLTTICPGLIDTNIINTTRFDAPAGARAERVDDRRGQLGKMFAL
TH_4323|M.thermoresistible__bu LDSAGIMLTTICPSTVNTNIIGSTRFNAP-DGLDDVVDTRREQLQKLFAL
Mflv_2937|M.gilvum_PYR-GCK LDSFGIGLTTICPGFISTNIVDTTRFSLA-QGRDDDVDVLRGRAQKGFSA
Mvan_3576|M.vanbaalenii_PYR-1 LDSAGIGVTTICPGVIGTNIVDTTRFSLP-EARRDDAESIRRRARQGFAV
MSMEG_4280|M.smegmatis_MC2_155 LAHAGIGVTTLCPGMIDTGIVDTTRFDVP-AHKAGQVEARRAQVKKTFQA
MAB_1382|M.abscessus_ATCC_1997 LAPNHIGASVICPGPIMTNIFSSATHTGADEQEQVQRSALTGAAFEKIRS
MMAR_1932|M.marinum_M LADEGISVTAVCPGFVNTNIAKSTVYAGM---STEQQERARQKADAAYRR
* : :.:**. : *.* ::
Mb2237c|M.bovis_AF2122/97 RS--YGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTA-
Rv2214c|M.tuberculosis_H37Rv RS--YGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTA-
MUL_3574|M.ulcerans_Agy99 RS--YGPDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPPALRSTA-
MLBr_00862|M.leprae_Br4923 RR--YGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTA-
MAV_2275|M.avium_104 RH--YGPDKVADAILSSVQKKKPIRPVAPEAYALYGLSRVMPQGLRNAA-
TH_4323|M.thermoresistible__bu RR--FGPDKAAKAIVSAVKQNKPIRPVMPEAYFVYGVSRVLPQALRSTA-
Mflv_2937|M.gilvum_PYR-GCK RK--YGPEKVADAIVDAVRTNKAIRPVAPEARFVYGVAHALPQVLRSTA-
Mvan_3576|M.vanbaalenii_PYR-1 RR--VGPDKVAKAIVAAVQKNKPVRPVTTEAYLVYGVAHALPQAMRSAA-
MSMEG_4280|M.smegmatis_MC2_155 RR--YGPEKVAKAVTSAVSRNQALRPVTPEAYVAYGVSRLFPAALRRAA-
MAB_1382|M.abscessus_ATCC_1997 WHLIPGPQNVARAIESAVVYNRKTVLVRPEAYLVYLLRRLSPTLLYAFSN
MMAR_1932|M.marinum_M RN--FTPEATARAIVKAIRSGPAVLPVAAESKVGYAMRRISPSMIRMFAR
*: .* :: :: * .*: * : : * : :
Mb2237c|M.bovis_AF2122/97 ---RLRVI------------------
Rv2214c|M.tuberculosis_H37Rv ---RLRVI------------------
MUL_3574|M.ulcerans_Agy99 ---RMRVI------------------
MLBr_00862|M.leprae_Br4923 ---RIRVI------------------
MAV_2275|M.avium_104 ---RLRVI------------------
TH_4323|M.thermoresistible__bu ---RGRVL------------------
Mflv_2937|M.gilvum_PYR-GCK ---RGGNFV-----------------
Mvan_3576|M.vanbaalenii_PYR-1 ---RGGNIM-----------------
MSMEG_4280|M.smegmatis_MC2_155 ---RSQVL------------------
MAB_1382|M.abscessus_ATCC_1997 LIFGSRTITFAYRLGKNPTVARLLGR
MMAR_1932|M.marinum_M LDIRQR--------------------