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YLVTCFAFFMVGGLMALLIRAELTTPGLAFLSNEQYNQLFTMHGTAMLLFYATPIVFGFANVVLPLQIGA PDVAFPRLNALSFWLFLFGALIALAGFITPGGAADFGWTAYTPLSDAIHSPGAGGDLWILGVAVGGLGTI LGAVNMITTIVCMRAPGMVMFRMPIFTWNILVVSVLVLLVFPLLAAAAIGLEADRRLGAHLYDPANGGVL LWQHLFWFFGHPEVYVLALPFFGVVSEIFPVFSRKPIFGYTTLVFATLGIGALSIAVWAHHMYATGAVLL PFFSFMTFLIAVPTGIKFFNWIGTMWKGQLTFETPMLFSIGFLVTFLFGGLTGVLLAAPPIDFHVTDSYF VVAHFHYTLFGTIVFASFAGVYFWFPKMTGRLLDERLGKFHFWLTFIGFHATFLVQHWLGNEGMPRRYAD YLPTDGFTALNIVSTVGAFILGSSMLPFVWNVFKSYRYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTEL PRIRSERPAFELHYPHMVERMRAEAHVGH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1042c | - | - | 100% (520) | cytochrome c oxidase polypeptide I |
| M. abscessus ATCC 19977 | MAB_3389c | - | 0.0 | 89.79% (519) | cytochrome c oxidase polypeptide I |
| M. abscessus ATCC 19977 | MAB_2617c | - | 0.0 | 87.84% (518) | cytochrome c oxidase subunit I |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3069c | ctaD | 0.0 | 86.90% (519) | cytochrome C oxidase polypeptide I |
| M. gilvum PYR-GCK | Mflv_4277 | - | 0.0 | 87.48% (519) | cytochrome-c oxidase |
| M. tuberculosis H37Rv | Rv3043c | ctaD | 0.0 | 86.90% (519) | cytochrome C oxidase polypeptide I |
| M. leprae Br4923 | MLBr_01728 | - | 0.0 | 86.13% (519) | cytochrome C oxidase, polypeptide I |
| M. marinum M | MMAR_1651 | ctaD | 0.0 | 88.25% (519) | cytochrome C oxidase polypeptide I CtaD |
| M. avium 104 | MAV_3908 | ctaD | 0.0 | 85.36% (519) | cytochrome c oxidase, subunit I |
| M. smegmatis MC2 155 | MSMEG_4437 | ctaD | 0.0 | 85.55% (519) | cytochrome c oxidase, subunit I |
| M. thermoresistible (build 8) | TH_1815 | ctaD | 1e-162 | 84.62% (299) | PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME |
| M. ulcerans Agy99 | MUL_1887 | ctaD | 0.0 | 87.86% (519) | cytochrome C oxidase polypeptide I CtaD |
| M. vanbaalenii PYR-1 | Mvan_2082 | - | 0.0 | 88.63% (519) | cytochrome-c oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3069c|M.bovis_AF2122/97 MTAEAPPLGELEAIRPYPARTGPKGSLVYKLITTTDHKMIGIMYCVACIS
Rv3043c|M.tuberculosis_H37Rv MTAEAPPLGELEAIRPYPARTGPKGSLVYKLITTTDHKMIGIMYCVACIS
MLBr_01728|M.leprae_Br4923 MTAEALSSGELKAIRPYPARTGPKGNLVYKLITTTDHKMIGIMYCVACFI
MMAR_1651|M.marinum_M MTAEAPPLGELEAIRPYPARTGPKGNLVYKLLTTTDHKLIGIMYVVTCFI
MUL_1887|M.ulcerans_Agy99 MTAEAPPLGELEAIRPYPARTGPKGNLVYKLLTTTDHKLIGIMYVVTCFI
Mflv_4277|M.gilvum_PYR-GCK MVAEAPPIGELEARRPFPERIGPKGNLIYKLITTTDHKLIGIMYCVACFA
Mvan_2082|M.vanbaalenii_PYR-1 MVAEAPPIGELEIRRPYPERLGPKGNLIYKLITTTDHKLIGIMYCVVCFA
MAB_1042c|M.abscessus_ATCC_199 ------------------------------------------MYLVTCFA
MAV_3908|M.avium_104 --------------------------------------MIGIMYTVTCFA
MSMEG_4437|M.smegmatis_MC2_155 MTTHAPSAGELLARRPFPQRLGPRWTLLYKLVTTTDHKLIGMMYVVACFI
TH_1815|M.thermoresistible__bu --------------------------------------------------
Mb3069c|M.bovis_AF2122/97 FFFIGGLLALLMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLFYATPIVF
Rv3043c|M.tuberculosis_H37Rv FFFIGGLLALLMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLFYATPIVF
MLBr_01728|M.leprae_Br4923 FFFVGGLLALLMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLFYATPIVF
MMAR_1651|M.marinum_M FFLIGGLLALLMRTELATPGLQFLSNEQFNQLFTMHGTVMLLFYATPIVF
MUL_1887|M.ulcerans_Agy99 FFLIGGLLALLMRTELATPGLQFLSNEQFNQLFTMHGTVMLLFYATPIVF
Mflv_4277|M.gilvum_PYR-GCK FFLIGGLMALFMRTELALPGLQFLSNEQFNQLFTMHGTVMLLFYATPIVF
Mvan_2082|M.vanbaalenii_PYR-1 FFLIGGLMALFMRTELATPGLQFLSNEQFNQLFTMHGTVMLLFYATPIVF
MAB_1042c|M.abscessus_ATCC_199 FFMVGGLMALLIRAELTTPGLAFLSNEQYNQLFTMHGTAMLLFYATPIVF
MAV_3908|M.avium_104 FFFIGGLMALLMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLLYATPVVF
MSMEG_4437|M.smegmatis_MC2_155 FFFIGGLMALLLRTELAVPGLQFLSNEQYNQLFTMHGTVMLLFYATPIVF
TH_1815|M.thermoresistible__bu --------------------------------------------------
Mb3069c|M.bovis_AF2122/97 GFANLVLPLQIGAPDVAFPRLNAFSFWLFVFGATIGAAGFITPGGAADFG
Rv3043c|M.tuberculosis_H37Rv GFANLVLPLQIGAPDVAFPRLNAFSFWLFVFGATIGAAGFITPGGAADFG
MLBr_01728|M.leprae_Br4923 GFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGAAIGMAGFITPGGAADFG
MMAR_1651|M.marinum_M GFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGATLGMAGFITPGGAADFG
MUL_1887|M.ulcerans_Agy99 GFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGATLGMAGFITPGGAADFG
Mflv_4277|M.gilvum_PYR-GCK GFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGALIATAGFITPGGAADFG
Mvan_2082|M.vanbaalenii_PYR-1 GFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGALIATAGFITPGGAADFG
MAB_1042c|M.abscessus_ATCC_199 GFANVVLPLQIGAPDVAFPRLNALSFWLFLFGALIALAGFITPGGAADFG
MAV_3908|M.avium_104 GFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGGLIAASGFIVPGGAADFG
MSMEG_4437|M.smegmatis_MC2_155 GFANLVVPLQIGAPDVAFPRLNALSFWLFLFGASIALGGFLAPGGPADFG
TH_1815|M.thermoresistible__bu -------------------------------------VGRIR----ADLC
* : **:
Mb3069c|M.bovis_AF2122/97 WTAYTPLTDAIHSPGAGGDLWIMGLIVAGLGTILGAVNMITTVVCMRAPG
Rv3043c|M.tuberculosis_H37Rv WTAYTPLTDAIHSPGAGGDLWIMGLIVAGLGTILGAVNMITTVVCMRAPG
MLBr_01728|M.leprae_Br4923 WTAYTPLTDAIHSPGVGGDLWIMGLIVAGLGTILGAVNMITTVVCLRAPG
MMAR_1651|M.marinum_M WTAYTPLTDAIHSPGVGGDLWIMGIAVGGLGTILGAVNMITTVVCMRAPG
MUL_1887|M.ulcerans_Agy99 WTAYTPLTDAIHSPGVGGDLWIMGIAVGGLGTILGAVNMITTVVCMRAPG
Mflv_4277|M.gilvum_PYR-GCK WTAYSPLTDAIHSPGAGADLWIMGLAVGGLGTILGGVNMITTVVCMRAPG
Mvan_2082|M.vanbaalenii_PYR-1 WTAYSPLTDAIHSPGAGGDLWIMGLAVGGLGTILGAVNMITTVVCMRAPG
MAB_1042c|M.abscessus_ATCC_199 WTAYTPLSDAIHSPGAGGDLWILGVAVGGLGTILGAVNMITTIVCMRAPG
MAV_3908|M.avium_104 WTAYTPLSDAVHSPGAGGDLWITGLIVAGLGTILGAVNMITTVVCMRAPG
MSMEG_4437|M.smegmatis_MC2_155 WTAYTPLSNAMHSPGAGGDLWIFGLIVGGLGTILGAVNMITTVVCMRAPG
TH_1815|M.thermoresistible__bu WDR------AMRSR---------------------YVPYATTPARLLAQ-
* *::* * ** . : *
Mb3069c|M.bovis_AF2122/97 MTMFRMPIFTWNIMVTSILILIAFPLLTAALFGLAADRHLGAHIYDAANG
Rv3043c|M.tuberculosis_H37Rv MTMFRMPIFTWNIMVTSILILIAFPLLTAALFGLAADRHLGAHIYDAANG
MLBr_01728|M.leprae_Br4923 MTMFRMPIFTWNILVTSILVLIAFPLLTAALFGLAADRHLGAHIYDAANG
MMAR_1651|M.marinum_M MTMFRMPIFTWNILVTSILVLIAFPLLTAALFGLAADRHLGAHIYDPANG
MUL_1887|M.ulcerans_Agy99 MTMFRMSIFTWNILVTSILVLIAFPLLTAALFGLAADRHLGAHIYDPANG
Mflv_4277|M.gilvum_PYR-GCK MTMFRMPIFTWNILVTSILVLLAFPILTAALFGLAADRHLGAHVYDPANG
Mvan_2082|M.vanbaalenii_PYR-1 MTMFRMPIFTWNILVTSILVLIAFPILTAALFGLAADRHLGAHVYDPANG
MAB_1042c|M.abscessus_ATCC_199 MVMFRMPIFTWNILVVSVLVLLVFPLLAAAAIGLEADRRLGAHLYDPANG
MAV_3908|M.avium_104 MTMFRMPIFTWNILVTSILILIAFPILTAALFGLAADRHLGAHVYDAANG
MSMEG_4437|M.smegmatis_MC2_155 MIMFRMPIFTWNILVTSVIVLVAFPLLTSALFGLAADRNLGAHVFDPANG
TH_1815|M.thermoresistible__bu -LLSDIVIALW----IAVWVLVGMAVHTAVST----IAEVGRNVHTGATG
: : * * :: :*: :.: ::. .:* ::. *.*
Mb3069c|M.bovis_AF2122/97 GVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYAT
Rv3043c|M.tuberculosis_H37Rv GVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYAT
MLBr_01728|M.leprae_Br4923 GVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYAT
MMAR_1651|M.marinum_M GVLLWQHLFWFFGHPEVYILALPFFGVVSEIFPVFSRKPIFGYTTLVYAT
MUL_1887|M.ulcerans_Agy99 GVLLWQHLFWFFGHPEVYILALPFFGVVSEIFPVFSRKPIFGYTTLVYAT
Mflv_4277|M.gilvum_PYR-GCK GVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLIYAT
Mvan_2082|M.vanbaalenii_PYR-1 GVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLIYAT
MAB_1042c|M.abscessus_ATCC_199 GVLLWQHLFWFFGHPEVYVLALPFFGVVSEIFPVFSRKPIFGYTTLVFAT
MAV_3908|M.avium_104 GVLLWQHLFWFFGHPEVYIIALPFFGIITEIIPVFARKPVFGYTTLVYAT
MSMEG_4437|M.smegmatis_MC2_155 GTMLWEHLFWFFGHPEVYIIALPFFGIVTEIFPVFSRKPVFGYTTLVYAT
TH_1815|M.thermoresistible__bu -------------VSEXXXVALPFFGIVTEIFPVFSRKPVFGYTALVYAT
.* :******:::**:***:***:****:*::**
Mb3069c|M.bovis_AF2122/97 LSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWIGTMWK
Rv3043c|M.tuberculosis_H37Rv LSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWIGTMWK
MLBr_01728|M.leprae_Br4923 LSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWVGTMWK
MMAR_1651|M.marinum_M LSIAALSVAVWAHHMFATGAVLLPFFSFMTFLIAVPTGIKFFNWVGTMWK
MUL_1887|M.ulcerans_Agy99 LSIAALSVAVWAHHMFATGAVLLPFFSFMTFLIAVPTGIKFFNWVGTMWK
Mflv_4277|M.gilvum_PYR-GCK LGIAALSVAVWAHHMYATGAVLLPFFSFMTFLIAVPTGIKFFNWIGTMWK
Mvan_2082|M.vanbaalenii_PYR-1 LGIAALSVAVWAHHMYATGAVLLPFFSFMTFLIAVPTGIKFFNWIGTMWK
MAB_1042c|M.abscessus_ATCC_199 LGIGALSIAVWAHHMYATGAVLLPFFSFMTFLIAVPTGIKFFNWIGTMWK
MAV_3908|M.avium_104 LSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWIGTMWK
MSMEG_4437|M.smegmatis_MC2_155 ISIGALSIAVWAHHLYATGAVLLPFFSFMTFMIAVPTGIKFVNWIGTMWK
TH_1815|M.thermoresistible__bu VGIGALSMAVWAHHMFATGAVLLPFFAFTTYLIAVPTGIKFFNWIGTMWK
:.*.***:******::**********:* *::*********.**:*****
Mb3069c|M.bovis_AF2122/97 GQLTFETPMLFSVGFMVTFLLGGLTGVLLASPPLDFHVTDSYFVVAHFHY
Rv3043c|M.tuberculosis_H37Rv GQLTFETPMLFSVGFMVTFLLGGLTGVLLASPPLDFHVTDSYFVVAHFHY
MLBr_01728|M.leprae_Br4923 GQLTFETPMLFSVGFAVTFLLGGLTGVLLASPPLDFHVTDSYFVVAHFHY
MMAR_1651|M.marinum_M GQLTFETPMLFSVGFAVTFLLGGLSGVLLASPPLDFHVTDSYFVVAHFHY
MUL_1887|M.ulcerans_Agy99 GQLTFETPMLFSVGFAVTFLLGGLSGVLLASPPLNFHVTDSYFVVAHFHY
Mflv_4277|M.gilvum_PYR-GCK GQLTFETPMLFSVGFILTFLLGGLSGVLLASPPLDFHVTDSYFVIAHFHY
Mvan_2082|M.vanbaalenii_PYR-1 GQLTFETPMLFSIGFIATFLLGGLSGVLLASPPLDFHVTDSYFVIAHFHY
MAB_1042c|M.abscessus_ATCC_199 GQLTFETPMLFSIGFLVTFLFGGLTGVLLAAPPIDFHVTDSYFVVAHFHY
MAV_3908|M.avium_104 GQLTFETPMLFCVGFLLTFLLGGLTGVMLASPPLDFHVTDTYFVVAHFHY
MSMEG_4437|M.smegmatis_MC2_155 GQLTFETPMLFSVGFLVTFLLGGLTGVILASPPLDFHVTDSYFVVAHFHY
TH_1815|M.thermoresistible__bu GQLTFESPMLFSVGFILTFLIGGLSGVMLASPPLDFHVTDTYFLVAHFHY
******:****.:** ***:***:**:**:**::*****:**::*****
Mb3069c|M.bovis_AF2122/97 VLFGTIVFATFAGIYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQH
Rv3043c|M.tuberculosis_H37Rv VLFGTIVFATFAGIYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQH
MLBr_01728|M.leprae_Br4923 VLFGTIVFSTFAGIYFWFPKMTGRLLDEQLGKLHFWLTFIGFHTTFLVQH
MMAR_1651|M.marinum_M VLFGTIVFSTFAGIYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQH
MUL_1887|M.ulcerans_Agy99 VLFGTIVFSTFAGIYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQH
Mflv_4277|M.gilvum_PYR-GCK VLFGTIVFATYAGIYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQH
Mvan_2082|M.vanbaalenii_PYR-1 VLFGTIVFATYAGIYFWFPKMTGRLLDERLGKVHFWLTFIGFHATFLVQH
MAB_1042c|M.abscessus_ATCC_199 TLFGTIVFASFAGVYFWFPKMTGRLLDERLGKFHFWLTFIGFHATFLVQH
MAV_3908|M.avium_104 VLFGTIVFATFAGVYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQH
MSMEG_4437|M.smegmatis_MC2_155 VLFGTIVFATYAGVYFWFPKMTGRLLDDRLGKLHFWLTLIGFHTTFLVHH
TH_1815|M.thermoresistible__bu VLFGTIVFATFAGVYFWFPKMTGRMLDERLAKLHFWLTFIGFHTTFLVQH
.*******:::**:**********:**::*.*.*****:****:****:*
Mb3069c|M.bovis_AF2122/97 WLGDEGMPRRYADYLPTDGFQGLNVVSTIGAFILGASMFPFVWNVFKSWR
Rv3043c|M.tuberculosis_H37Rv WLGDEGMPRRYADYLPTDGFQGLNVVSTIGAFILGASMFPFVWNVFKSWR
MLBr_01728|M.leprae_Br4923 WLGDMGMPRRYADYLPTDGFQGLNVVSTIGSFILGASMFPFVWNVFKSWR
MMAR_1651|M.marinum_M WLGDEGMPRRYADYLPTDGFQGLNIVSTIGAFILGVAMIPFVWNVFKSWR
MUL_1887|M.ulcerans_Agy99 WLGDEGMPRRYADYLPTDGFQGLNIVSTIGAFILGVAMFPFVWNVFKSWR
Mflv_4277|M.gilvum_PYR-GCK WLGDEGMPRRYADYLPSDGFTTLNIVSTIGAFILGLSTLPFLWNVFKSWR
Mvan_2082|M.vanbaalenii_PYR-1 WLGDEGMPRRYADYLPTDGFTTLNVVSTIGAFILGASTLPFLWNVFKSWR
MAB_1042c|M.abscessus_ATCC_199 WLGNEGMPRRYADYLPTDGFTALNIVSTVGAFILGSSMLPFVWNVFKSYR
MAV_3908|M.avium_104 WLGDLGMPRRYADYLPSDGFQPYNVASTVGAFILGASMFPFVWNVFKSWR
MSMEG_4437|M.smegmatis_MC2_155 WLGAEGMPRRYADYLPTDGFTTLNIVSTIGSFILGVSMLPFVWNVFKSWR
TH_1815|M.thermoresistible__bu WLGNEGMPRRYADYLPTDGFTELNIVSSVGAFILGASMLPFIWNVFKSWR
*** ***********:*** *:.*::*:**** : :**:******:*
Mb3069c|M.bovis_AF2122/97 YGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHM
Rv3043c|M.tuberculosis_H37Rv YGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHM
MLBr_01728|M.leprae_Br4923 YGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHM
MMAR_1651|M.marinum_M YGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHM
MUL_1887|M.ulcerans_Agy99 YGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHM
Mflv_4277|M.gilvum_PYR-GCK YGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHM
Mvan_2082|M.vanbaalenii_PYR-1 YGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHM
MAB_1042c|M.abscessus_ATCC_199 YGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHM
MAV_3908|M.avium_104 YGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHM
MSMEG_4437|M.smegmatis_MC2_155 YGEPVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHM
TH_1815|M.thermoresistible__bu YGDPVTVDDPWGYGNSLEWATTCPPPRHNFYELPRIRSERPAFELHYPHM
**: *****************:******** *******************
Mb3069c|M.bovis_AF2122/97 VERLRAEAHVGRHHDEPAMVTSS----------
Rv3043c|M.tuberculosis_H37Rv VERLRAEAHVGRHHDEPAMVTSS----------
MLBr_01728|M.leprae_Br4923 VERLRDEAYVGRRHAEELVEVSLH---------
MMAR_1651|M.marinum_M VERLRAEAHVGRHHDELAKATSS----------
MUL_1887|M.ulcerans_Agy99 VERLRAEAHVGRHHDELAKATSS----------
Mflv_4277|M.gilvum_PYR-GCK IDRMRREAHVGRAHGPEDGDVTR-NEENVRT--
Mvan_2082|M.vanbaalenii_PYR-1 VERMRTEAHVGRAHGPEDGDVTRLDDENVRT--
MAB_1042c|M.abscessus_ATCC_199 VERMRAEAHVGH---------------------
MAV_3908|M.avium_104 VERLRAEAHVGRAHGPADKDVTRLDDVQVRS--
MSMEG_4437|M.smegmatis_MC2_155 IERLRAESHPGRTQGGPGAVTLPQPQARSHPVE
TH_1815|M.thermoresistible__bu IERMRAESHIGRSHGPADGDVTRMEDTNVRT--
::*:* *:: *: