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VTEVAVALSGGADSLALAAAAVARAWSVTALIVDHGLQQDSAQVAARARSQALALGCSDAVVLSVTVDGV GGLEAAARSARYAALEQARDGRPVLLAHTLDDQAETVLLGLGRGSGARSIAGMRPWDDPWGRPFLDRRRT ETRSYCDELAITAWEDPHNVDSRFVRVRLRHEVLPLLEEVLGGGVAEALARTALSLQDDGDALDAQARAA FPGAQGLAISDLRGLTPAVRRRVIRLWLLAGGAQDLNDNQIRAVDALVTQWRGQGGVAVGADLRYQRLVA SRSGEQLVLSVHDVAR
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_0521 | - | - | 100% (296) | putative tRNA(Ile)-lysidine synthase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3649c | mesJ | 3e-99 | 68.15% (292) | cell cycle protein MESJ |
M. gilvum PYR-GCK | Mflv_1411 | - | 2e-92 | 63.01% (292) | tRNA(Ile)-lysidine synthetase |
M. tuberculosis H37Rv | Rv3625c | mesJ | 3e-99 | 68.15% (292) | cell cycle protein MESJ |
M. leprae Br4923 | MLBr_00213 | mesJ | 7e-92 | 64.60% (291) | hypothetical protein MLBr_00213 |
M. marinum M | MMAR_5125 | mesJ | 5e-92 | 66.10% (292) | cell cycle protein MesJ |
M. avium 104 | MAV_0531 | tilS | 3e-96 | 67.25% (287) | tRNA(Ile)-lysidine synthetase |
M. smegmatis MC2 155 | MSMEG_6111 | tilS | 6e-90 | 61.49% (296) | tRNA(Ile)-lysidine synthetase |
M. thermoresistible (build 8) | TH_1410 | mesJ | 9e-87 | 62.54% (291) | POSSIBLE CELL CYCLE PROTEIN MESJ |
M. ulcerans Agy99 | MUL_4201 | mesJ | 2e-91 | 65.75% (292) | cell cycle protein MesJ |
M. vanbaalenii PYR-1 | Mvan_5378 | - | 3e-92 | 66.44% (292) | tRNA(Ile)-lysidine synthetase |
CLUSTAL 2.0.9 multiple sequence alignment Mb3649c|M.bovis_AF2122/97 MDRQSAVAQLRAAAEQFARVHLDACDRWSVGLSGGPDSLALTAVAAR-LW Rv3625c|M.tuberculosis_H37Rv MDRQSAVAQLRAAAEQFARVHLDACDRWSVGLSGGPDSLALTAVAAR-LW MMAR_5125|M.marinum_M MDRQGAVAQLRRAVEKFASTHLDATDRWSIGLSGGPDSLALTAVAAR-LR MUL_4201|M.ulcerans_Agy99 MDRQGAVAQLRRAVENFASTHLDATDRWSIGLSGGPDSLALTAVAAR-LR MLBr_00213|M.leprae_Br4923 MDRQGAVGQLRRTVEEFAGTYCDIDDQWCVALSGGSDSLALTAVAAQ-LR MAV_0531|M.avium_104 MDRPGALDRLRTAVEAFSTAHLGAVERWCVALSGGPDSLALTAVAAR-LR MSMEG_6111|M.smegmatis_MC2_155 MDRSRAVATLRRTVADFA-AQVDG-ERWCVALSGGPDSLALTAVAAA-ER Mflv_1411|M.gilvum_PYR-GCK MDRSGPVVELRTALVDFARTHRFPP-PWCVALSGGPDSLALTAVAAT-LH Mvan_5378|M.vanbaalenii_PYR-1 MDRPGAVAELRTAVAGFVRDHAAASGPWCVALSGGADSLALTAVAAA-LR TH_1410|M.thermoresistible__bu MDRPGAVAALRSALAAFERAWAGADDRWCVALSGGADSLALTAVAAE-LK MAB_0521|M.abscessus_ATCC_1997 ------------------------MTEVAVALSGGADSLALAAAAVARAW .:.****.*****:*.*. Mb3649c|M.bovis_AF2122/97 PTTALIVDHGLQPGSATVAETARIQAISLGCVDARVLCVQVG----AAGG Rv3625c|M.tuberculosis_H37Rv PTTALIVDHGLQPGSATVAETARIQAISLGCVDARVLCVQVG----AAGG MMAR_5125|M.marinum_M PTTALIVDHGLQPDSAAVSETARAQAVSLGCVAARVLRVQVGNPAGAGGG MUL_4201|M.ulcerans_Agy99 PTTALIVDHGLQPDSAAVSETARAQAVSLGCVTARVLRVQVGNPAGAGGG MLBr_00213|M.leprae_Br4923 STTAFIVDHGLQSDSAAVAETARKQAISLGCVDAQVLCVQIDPPFGPKGG MAV_0531|M.avium_104 PTTAVIVDHGLQPDSAAVAQTARAQAIALGCVAAQVISVHVD----GEGG MSMEG_6111|M.smegmatis_MC2_155 PTTALIVDHGLQTGSRAVAETARAQALSVGCVGAEIIPVVVG----RSGG Mflv_1411|M.gilvum_PYR-GCK PTTALIVDHRLQPGSADVAAAAREQALALGCVAAQVLPVDVG----SPGG Mvan_5378|M.vanbaalenii_PYR-1 PTTALIVDHGLQPGSARVAATARDQAMALGCVGAQVLCVEVG----VGGG TH_1410|M.thermoresistible__bu PTTALIVDHQLQPGSAEVAQTARRQALQLGCVAARILRVQVG----TAGG MAB_0521|M.abscessus_ATCC_1997 SVTALIVDHGLQQDSAQVAARARSQALALGCSDAVVLSVTVD----GVGG ..**.**** ** .* *: ** **: :** * :: * :. ** Mb3649c|M.bovis_AF2122/97 REAAARSARYSALEEHRDG-PVLLAHTLDDQAETVLLGLGRGSGARSIAG Rv3625c|M.tuberculosis_H37Rv REAAARSARYSALEEHRDG-PVLLAHTLDDQAETVLLGLGRGSGARSIAG MMAR_5125|M.marinum_M LEAAARTARYGALDAHRDG-PVLLAHTLDDQAETVLLGLGRGSGARSIAG MUL_4201|M.ulcerans_Agy99 LEAAARTARYGALDAHRDG-PVLLAHTLDDQAETVLLGLGRGSGARSIAG MLBr_00213|M.leprae_Br4923 LEAAARAARYAVLGANRNG-PVLLAHTLDDQAETVLLGLGRGSGARSIAG MAV_0531|M.avium_104 PEAAARRARYAALAAHRDG-PVLLGHTLDDQAETVLLGLGRGSGVRSIAG MSMEG_6111|M.smegmatis_MC2_155 PEAAARKARYTALQAARDGAPVLLGHTLDDQAETVLLGLARGSGPRSIAG Mflv_1411|M.gilvum_PYR-GCK PEAAARTARYRALDDARDGKPVLLGHTLDDQAETVLLGLGRGSGPRSIAG Mvan_5378|M.vanbaalenii_PYR-1 PEAAARAARYRALEEARRGAPVLLAHTLDDQAETVLLGLGRGSGARSIAG TH_1410|M.thermoresistible__bu PEAAARTARYEALSTARGEAPVLLGHTLDDQAETVLLGLGRGSGPRSIAG MAB_0521|M.abscessus_ATCC_1997 LEAAARSARYAALEQARDGRPVLLAHTLDDQAETVLLGLGRGSGARSIAG ***** *** .* * ****.**************.**** ***** Mb3649c|M.bovis_AF2122/97 MRPYDPPWCRPLLGVRRSVTHAACRELGLTAWQDPHNTDRRFTRTRLRTE Rv3625c|M.tuberculosis_H37Rv MRPYDPPWCRPLLGVRRSVTHAACRELGLTAWQDPHNTDRRFTRTRLRTE MMAR_5125|M.marinum_M MRPHDPPWCRPLLGVRRGVTHDACRELGLTAWQDPHNSDRRFTRTRLRAE MUL_4201|M.ulcerans_Agy99 MRPHDPPWCRPLLGVRRGVTHDACRELGLTAWQDPHNSDRRFTRTRLRAE MLBr_00213|M.leprae_Br4923 MRPHDPPWCRPLLGVRRSVPRAACHELGLNAWQDPHNTDCRYTRTRLRLE MAV_0531|M.avium_104 MRPHDPPWCRPLLGQRRAVTHAACAELGLTAWQDPHNSDRRFTRARLRAE MSMEG_6111|M.smegmatis_MC2_155 MRPHDPPWHRPLLGIRRTVTHAACEELGLKPWHDPHNFEPRFTRTRLRLD Mflv_1411|M.gilvum_PYR-GCK MRPYDLPWGRPLLGVRRDTTHRACAELGLNPWQDPHNLDPRYTRVRLRTE Mvan_5378|M.vanbaalenii_PYR-1 MRPSDPPWCRPLLGVRRAVTRLACAELGLTPWQDPHNTDRRFTRVRLRTE TH_1410|M.thermoresistible__bu MRPHDPPWYRPLLGVRRSVTVAACAELGLTPWQDPHNADPRFTRSRLRTE MAB_0521|M.abscessus_ATCC_1997 MRPWDDPWGRPFLDRRRTETRSYCDELAITAWEDPHNVDSRFVRVRLRHE *** * ** **:*. ** . * **.:..*.**** : *:.* *** : Mb3649c|M.bovis_AF2122/97 VLPLLEDVLGGGVAEALARTATALREDTDLIDTIAAQALPGAAVAGSRG- Rv3625c|M.tuberculosis_H37Rv VLPLLEDVLGGGVAEALARTATALREDTDLIDTIAAQALPGAAVAGSRG- MMAR_5125|M.marinum_M VLPLLEEVLGGGVAAALARTATALRADTELLDAIAAEALPTAVVDSG--- MUL_4201|M.ulcerans_Agy99 VLPLLEEVLGGGVAAALARTATALRADTELLDAIAAEALPTAVVDFG--- MLBr_00213|M.leprae_Br4923 VLPLLEDVLGGGVVEALARTATALREDTELIDTFAAQALPNICAGSG--- MAV_0531|M.avium_104 VLPLLEEVLGGGVAEALARTATALREDNEVLDALAERALPAAQAGAG--- MSMEG_6111|M.smegmatis_MC2_155 VMPLLEEVLGGGVAEALARTATALREDTETLDEIARQALETSQTSARTP- Mflv_1411|M.gilvum_PYR-GCK VLPLLEDVLGGGVAEALARTAAALREDTDVLDALAA---EAVAPGDAD-- Mvan_5378|M.vanbaalenii_PYR-1 VLPLLEDVLGGGVAEALARTATALREDTDALDGIAA---RIVTVPGAD-- TH_1410|M.thermoresistible__bu VMPLLEEVLGGGVAEALARTAAALREDTDALDELAARELRRVVVGGEEGG MAB_0521|M.abscessus_ATCC_1997 VLPLLEEVLGGGVAEALARTALSLQDDGDALDAQARAAFPGAQG------ *:****:******. ****** :*: * : :* * Mb3649c|M.bovis_AF2122/97 -----QELSTSALTALPDAVRRRVIRGWLLAGGATGLTDRQIRGVDRLVT Rv3625c|M.tuberculosis_H37Rv -----QELSTSALTALPDAVRRRVIRGWLLAGGATGLTDRQIRGVDRLVT MMAR_5125|M.marinum_M -------LDTSVLATLPDPVRRRVIRSWLLAGGAIGLTDKQIRGVDALVT MUL_4201|M.ulcerans_Agy99 -------LDTSVLATLPDPVRRRVIRSWLLAGGAIGLTDKQIRGVDALVT MLBr_00213|M.leprae_Br4923 -------LHARALAALPDAVRRRVIRGWLLNGGATGLTDKQIRGVDTLVT MAV_0531|M.avium_104 -------LQVAALAGLDAPVRRRVIRAWLLAGGATGLTDKQIRGVDNLIT MSMEG_6111|M.smegmatis_MC2_155 -----PGLDTEVLAGLPGAVRRRVIRAWLLTNGGTDLTDVQIRGVDRLVT Mflv_1411|M.gilvum_PYR-GCK -------LDVTALADLPTALRRRAVRGWLLAAGARDLTDKHLRAVDALIT Mvan_5378|M.vanbaalenii_PYR-1 -------LDTAVLTPLPAAVRRRVIRGWLLGGGANGLTDKQIRAVDDLVV TH_1410|M.thermoresistible__bu ETGAATGLDARALERLPTAIRRRVIRVWLLDGGAANLSDHQIRAVDTLVT MAB_0521|M.abscessus_ATCC_1997 -------LAISDLRGLTPAVRRRVIRLWLLAGGAQDLNDNQIRAVDALVT * * * .:***.:* *** *. .*.* ::*.** *:. Mb3649c|M.bovis_AF2122/97 AWRGQGGVAVGSTLRGQRLVAGRRDGVLVLRREPV--------------- Rv3625c|M.tuberculosis_H37Rv AWRGQGGVAVGSTLRGQRLVAGRRDGVLVLRREPV--------------- MMAR_5125|M.marinum_M AWRGQGGVAVGSNLKARRLVAGRGGGLLTLRSEPI--------------- MUL_4201|M.ulcerans_Agy99 AWRGQGGVAFGSNLKARRLVAGRGGGLLTLRSEPI--------------- MLBr_00213|M.leprae_Br4923 AWRGQGGVAVGSTLRGQRLIASRYDGVLTLHCAPV--------------- MAV_0531|M.avium_104 AWRGQGGVAVGSSQPGERLFAGRRDGVLTLWREPVR-------------- MSMEG_6111|M.smegmatis_MC2_155 DWRGQGGVAVGSNLSRQRLFVGRRHGELVLYTEPV--------------- Mflv_1411|M.gilvum_PYR-GCK DWHGQGGVAVPGGLTRERLFVARNRNRLGMYREPVAQ--------RQG-- Mvan_5378|M.vanbaalenii_PYR-1 DWHGQGGVAVPGGLARERLFAGRRKDVLTLYREPVAE--------RQR-- TH_1410|M.thermoresistible__bu GWRGQGGVAVGSPLRGXXXATARACGVSRSGTPALTSGTCRRCRLRRGVS MAB_0521|M.abscessus_ATCC_1997 QWRGQGGVAVGADLRYQRLVASRSGEQLVLSVHDVAR------------- *:******. . ..* : Mb3649c|M.bovis_AF2122/97 - Rv3625c|M.tuberculosis_H37Rv - MMAR_5125|M.marinum_M - MUL_4201|M.ulcerans_Agy99 - MLBr_00213|M.leprae_Br4923 - MAV_0531|M.avium_104 - MSMEG_6111|M.smegmatis_MC2_155 - Mflv_1411|M.gilvum_PYR-GCK - Mvan_5378|M.vanbaalenii_PYR-1 - TH_1410|M.thermoresistible__bu G MAB_0521|M.abscessus_ATCC_1997 -