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MNSFLATDTTAYPDALYLTCSDWPVGPPADGCAPLYTVRNAGNLVPTDPAEGSVDAALDFALNHLHVRSV VVCGHSGCGAMGALLSEPIDAPTSAVGRWLDNARDTLAAYHEHHLARVGAAASGFNQVDQLAVVNVAIQS QRLVRHPLLAAAAHSGRLRVAGTFYSLGAQLLYEVTATGLPAPGAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0468 | - | - | 100% (186) | transmembrane carbonic anhydrase |
| M. abscessus ATCC 19977 | MAB_3098 | - | 4e-57 | 62.57% (171) | transmembrane carbonic anhydrase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3301 | - | 4e-44 | 50.57% (174) | transmembrane carbonic anhydrase |
| M. gilvum PYR-GCK | Mflv_1439 | - | 1e-06 | 25.79% (159) | carbonic anhydrase |
| M. tuberculosis H37Rv | Rv3273 | - | 4e-44 | 50.57% (174) | transmembrane carbonic anhydrase |
| M. leprae Br4923 | MLBr_01919 | - | 7e-05 | 23.95% (167) | putative carbonic anhydrase |
| M. marinum M | MMAR_1266 | sulP_2 | 8e-40 | 48.00% (175) | transmembrane carbonic anhydrase, SulP_2 |
| M. avium 104 | MAV_0565 | - | 2e-05 | 26.42% (159) | carbonic anhydrase |
| M. smegmatis MC2 155 | MSMEG_6082 | - | 3e-05 | 23.60% (161) | carbonic anhydrase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4164 | - | 3e-05 | 23.27% (159) | carbonic anhydrase |
| M. vanbaalenii PYR-1 | Mvan_5345 | - | 2e-08 | 24.84% (161) | carbonic anhydrase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01919|M.leprae_Br4923 --------------------------------------------------
MUL_4164|M.ulcerans_Agy99 --------------------------------------------------
MAV_0565|M.avium_104 --------------------------------------------------
MSMEG_6082|M.smegmatis_MC2_155 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLVALPLSL
Rv3273|M.tuberculosis_H37Rv MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLVALPLSL
MMAR_1266|M.marinum_M --------MSTAVKNSAEAPESRSQWMRANLRHDFPASLVVFLVALPLSL
MAB_0468|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01919|M.leprae_Br4923 --------------------------------------------------
MUL_4164|M.ulcerans_Agy99 --------------------------------------------------
MAV_0565|M.avium_104 --------------------------------------------------
MSMEG_6082|M.smegmatis_MC2_155 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 GIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAAGLTVVVAELID
Rv3273|M.tuberculosis_H37Rv GIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAAGLTVVVAELID
MMAR_1266|M.marinum_M GIAIASGAPLMAGLIAAVVGGIVAGLLGGSSVQVSGPAAGLTVVVAGLIE
MAB_0468|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01919|M.leprae_Br4923 --------------------------------------------------
MUL_4164|M.ulcerans_Agy99 --------------------------------------------------
MAV_0565|M.avium_104 --------------------------------------------------
MSMEG_6082|M.smegmatis_MC2_155 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 ELGWPMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVHAMLAGIGITIA
Rv3273|M.tuberculosis_H37Rv ELGWPMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVHAMLAGIGITIA
MMAR_1266|M.marinum_M QVGWQMLCLMTLGAGVLQIIFGLSRMARAALAIAPVVVHAMLAGIGVTIV
MAB_0468|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01919|M.leprae_Br4923 --------------------------------------------------
MUL_4164|M.ulcerans_Agy99 --------------------------------------------------
MAV_0565|M.avium_104 --------------------------------------------------
MSMEG_6082|M.smegmatis_MC2_155 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 LQQIHVLLGGTSHSSAWRNIVALPDGILHHELHEVIVGGTVIAILLMWSK
Rv3273|M.tuberculosis_H37Rv LQQIHVLLGGTSHSSAWRNIVALPDGILHHELHEVIVGGTVIAILLMWSK
MMAR_1266|M.marinum_M LQQIHVLMGGSAHSSAWRNIAALPNGILHHELHEVIVGGTVIAILLVWSR
MAB_0468|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01919|M.leprae_Br4923 --------------------------------------------------
MUL_4164|M.ulcerans_Agy99 --------------------------------------------------
MAV_0565|M.avium_104 --------------------------------------------------
MSMEG_6082|M.smegmatis_MC2_155 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 LPAKVRIIPGPLVAIAGATVLALLPVLQTERIDLQGNFFDAIGLPKLAEM
Rv3273|M.tuberculosis_H37Rv LPAKVRIIPGPLVAIAGATVLALLPVLQTERIDLQGNFFDAIGLPKLAEM
MMAR_1266|M.marinum_M LPAMVRMVPGPLVAIAGATALSLMVNLDVERINLSGNFFEAISLPRLPEL
MAB_0468|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01919|M.leprae_Br4923 --------------------------------------------------
MUL_4164|M.ulcerans_Agy99 --------------------------------------------------
MAV_0565|M.avium_104 --------------------------------------------------
MSMEG_6082|M.smegmatis_MC2_155 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 SPGGQPWSHEISAIALGVLTIALIASVESLLSAVGVDKLHHGPRTDFNRE
Rv3273|M.tuberculosis_H37Rv SPGGQPWSHEISAIALGVLTIALIASVESLLSAVGVDKLHHGPRTDFNRE
MMAR_1266|M.marinum_M TPDGQPWSNDISIIAVGVLTIALIASVESLLCAVGVDKLHHGPRTNFNRE
MAB_0468|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01919|M.leprae_Br4923 --------------------------------------------------
MUL_4164|M.ulcerans_Agy99 --------------------------------------------------
MAV_0565|M.avium_104 --------------------------------------------------
MSMEG_6082|M.smegmatis_MC2_155 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 MVGQGSANVVSGLLGGLPITGVIVRSSANVAAGARTRMSTILHGVWILLF
Rv3273|M.tuberculosis_H37Rv MVGQGSANVVSGLLGGLPITGVIVRSSANVAAGARTRMSTILHGVWILLF
MMAR_1266|M.marinum_M MLGQGSANVLSGLLGGLPVTGVIVRSSANVAAGARTRTSAVLHGVWILLF
MAB_0468|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01919|M.leprae_Br4923 --------------------------------------------------
MUL_4164|M.ulcerans_Agy99 --------------------------------------------------
MAV_0565|M.avium_104 --------------------------------------------------
MSMEG_6082|M.smegmatis_MC2_155 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 ASLFTNLVELIPKAALAGLLIVIGAQLVKLAHIKLAWRTGNFVIYAITIV
Rv3273|M.tuberculosis_H37Rv ASLFTNLVELIPKAALAGLLIVIGAQLVKLAHIKLAWRTGNFVIYAITIV
MMAR_1266|M.marinum_M ASLFTGLVELIPKAALAGLLIVVGAQLIQLAHIQIAWRTGNFAIYVITIL
MAB_0468|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01919|M.leprae_Br4923 --------------------------------------------------
MUL_4164|M.ulcerans_Agy99 --------------------------------------------------
MAV_0565|M.avium_104 --------------------------------------------------
MSMEG_6082|M.smegmatis_MC2_155 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 CVVFLNLLEGVAIGLVVAIVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDG
Rv3273|M.tuberculosis_H37Rv CVVFLNLLEGVAIGLVVAIVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDG
MMAR_1266|M.marinum_M GVIFLNLLEGVVIGLGVAIAFLLIRVIRAPIEARLVS-EEAKRWRVDIDG
MAB_0468|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1439|M.gilvum_PYR-GCK ---------------------------------MPNTNPLTAWKALREGN
Mvan_5345|M.vanbaalenii_PYR-1 ---------------------------------MPNTNPLTAWKALKEGN
MLBr_01919|M.leprae_Br4923 ---------------------------------MFNTNPIAAWKALKEGN
MUL_4164|M.ulcerans_Agy99 ---------------------------------MPNTNPITAWKALSEGN
MAV_0565|M.avium_104 ---------------------------------MPNTSPVTAWKSLKEGN
MSMEG_6082|M.smegmatis_MC2_155 ---------------------------------MPNSNPVAAWKALKDGN
Mb3301|M.bovis_AF2122/97 TLSFLLLPRLTTVLSKLPEGSEVTLNLNADYIDDSVSEAISDWRRAHETR
Rv3273|M.tuberculosis_H37Rv TLSFLLLPRLTTVLSKLPEGSEVTLNLNADYIDDSVSEAISDWRRAHETR
MMAR_1266|M.marinum_M TLSFLLLPRLTNVLSELPEGSDITLNLNADYIDHSVSEAISDWKTAHEAT
MAB_0468|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1439|M.gilvum_PYR-GCK ERFVAGKPQHPS--------------------------------------
Mvan_5345|M.vanbaalenii_PYR-1 ERFVAGKPEHPS--------------------------------------
MLBr_01919|M.leprae_Br4923 ERFVAGQPAHPS--------------------------------------
MUL_4164|M.ulcerans_Agy99 ERFVAGKPLHPS--------------------------------------
MAV_0565|M.avium_104 ERFVAGKPQHPS--------------------------------------
MSMEG_6082|M.smegmatis_MC2_155 ARFVAGQPLHPS--------------------------------------
Mb3301|M.bovis_AF2122/97 GGVVAIVETSPAKLHHAHARPPKRHFASDPIGLVPWRSAR-GKDRGSASV
Rv3273|M.tuberculosis_H37Rv GGVVAIVETSPAKLHHAHARPPKRHFASDPIGLVPWRSAR-GKDRGSASV
MMAR_1266|M.marinum_M GGEVTIIETSPANLVSAHTSPPKRHFMSRAL-REPWTSRRDSHPDAEPSI
MAB_0468|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1439|M.gilvum_PYR-GCK -------------QSTDHRASLAAAQKPTAVVFGCGDSRVAAEILFDQGL
Mvan_5345|M.vanbaalenii_PYR-1 -------------QSIERRTSLAAAQKPTAVVFGCGDSRVAAEIIFDQGL
MLBr_01919|M.leprae_Br4923 -------------QSVEHRASLADTQKPLAVIFGCADSRVAAELVFDQGL
MUL_4164|M.ulcerans_Agy99 -------------QSVDHRASLASGQKPTAVIFGCADSRVAAEIIFDQGL
MAV_0565|M.avium_104 -------------QSVEHRASLAAGQSPTAVVFGCSDSRVAAELIFDQGL
MSMEG_6082|M.smegmatis_MC2_155 -------------QGIERRASLTQAQRPTAVVFGCGDSRVAAEILFDQGL
Mb3301|M.bovis_AF2122/97 LDRIDEYHRNGAAVLHPHIAGLTDSQDPYELFLTCADSRILPNVITASGP
Rv3273|M.tuberculosis_H37Rv LDRIDEYHRNGAAVLHPHIAGLTDSQDPYELFLTCADSRILPNVITASGP
MMAR_1266|M.marinum_M RHGVEEYHRNGIGTLHHHVRELMDPANPDTVFLTCADSRILPDVITASKP
MAB_0468|M.abscessus_ATCC_1997 --------------MNSFLATDT-TAYPDALYLTCSDWPVGP---PADGC
* : : *.* : . .
Mflv_1439|M.gilvum_PYR-GCK GDMFVVRTAGHVIDS-----AVLGSIEYAVSVLEVPLVVVLGHDSCGAVK
Mvan_5345|M.vanbaalenii_PYR-1 GDMFVVRTAGHVIDG-----AVLGSIEYAVSVLHVPLIVVLGHDSCGAVG
MLBr_01919|M.leprae_Br4923 GDMFVVRTVGHVIDS-----AVLGSIEYAVTVLDVPLVVVLGHDSCGAVT
MUL_4164|M.ulcerans_Agy99 GDMFVVRTAGHVIDS-----AVLGSIEYAVTVLNVPLVVVLGHDSCGAVN
MAV_0565|M.avium_104 GDMFVVRTAGQAIDT-----AVLGSIEFAVSVLNVPLIVVLGHDSCGAVK
MSMEG_6082|M.smegmatis_MC2_155 GDMFVVRTAGHVIDN-----AVLGSIEYAVTVLKVPLIVVLGHDSCGAVK
Mb3301|M.bovis_AF2122/97 GDLYTVRNLGNLVPTDPDDRSVDAALDFAVNQLGVSSVVVCGHSSCAAMT
Rv3273|M.tuberculosis_H37Rv GDLYTVRNLGNLVPTDPDDRSVDAALDFAVNQLGVSSVVVCGHSSCAAMT
MMAR_1266|M.marinum_M GDLYIVRNVGNLVPIDPTERSVDAALDFAVNQLGVSSVVVCGHSSCRSMQ
MAB_0468|M.abscessus_ATCC_1997 APLYTVRNAGNLVPTDPAEGSVDAALDFALNHLHVRSVVVCGHSGCGAMG
. :: **. *: : :* .::::*:. * * :** **..* ::
Mflv_1439|M.gilvum_PYR-GCK AALG--------ALDDGEVPGGYVRDVVERVMPSILVGRRDGLSRVDEFE
Mvan_5345|M.vanbaalenii_PYR-1 ATLA--------ALDEGEVPGGYIRDIVERVMPSILLGRRDGLTRVDEFE
MLBr_01919|M.leprae_Br4923 AALA--------AINEGNLPSGYVRDVVERVAPSVLLGRRDGLTRVDEFE
MUL_4164|M.ulcerans_Agy99 AALT--------AINEGSVPGGYVRDVVERVAPSILMGRREGLKRVDEFE
MAV_0565|M.avium_104 AALG--------AIEEGAIPGGFVRDVVERVAPSILMGRREGLSRVDEFE
MSMEG_6082|M.smegmatis_MC2_155 ATLS--------ALDEGEVPSGFVRDIVERVTPSILLGRKAGLSRVDEFE
Mb3301|M.bovis_AF2122/97 ALLEDDPANTTTPMMRWLENAHDSLVVFRNHHPARRSAESAGYPEADQLS
Rv3273|M.tuberculosis_H37Rv ALLEDDPANTTTPMMRWLENAHDSLVVFRNHHPARRSAESAGYPEADQLS
MMAR_1266|M.marinum_M ALLDNGASDVDRPMNHWLEHAHDSLAAFRDGHPARASAASVGFGELDQLA
MAB_0468|M.abscessus_ATCC_1997 ALLSEPIDAPTSAVGRWLDNARDTLAAYHEHHLARVGAAASGFNQVDQLA
* * .: . . : . * . *::
Mflv_1439|M.gilvum_PYR-GCK ARHVTETGKQLLSRSTAIAEAVNAGKLAIVGLTYHLADGKVDLRDHIGDI
Mvan_5345|M.vanbaalenii_PYR-1 ARHVTETGKQLLSRSTAIAEAVRDGKLAIVGLTYQLADGKAVLRDHIGDI
MLBr_01919|M.leprae_Br4923 ERHVHETVAQAMARSTAIAQRVAAGTLAIVGVTYHLADGRAVLRTHIGNL
MUL_4164|M.ulcerans_Agy99 QRHIQETVAQLMARSTAISNRVAAGTLAIVGVTYQLSDGQAVLRDHVGDI
MAV_0565|M.avium_104 ERHVRETVAQLVSRSTTIAERIGDGTVAVAGVTYHLADGRAALCDHVGDI
MSMEG_6082|M.smegmatis_MC2_155 AQHVNETVAQLQMRSTAIAQGLAAGTQAIVGTTYHLADGRVELRSHLGDI
Mb3301|M.bovis_AF2122/97 IVNVAVQVERLTR-HPILATAVAAADLQVIGIFFDISTARVYEVGPNGII
Rv3273|M.tuberculosis_H37Rv IVNVAVQVERLTR-HPILATAVAAADLQVIGIFFDISTARVYEVGPNGII
MMAR_1266|M.marinum_M VVNVAVQLERLAH-NQVLAPAIASGAIQIVGMFFDFSTVHVHEVDQLGIV
MAB_0468|M.abscessus_ATCC_1997 VVNVAIQSQRLVR-HPLLAAAAHSGRLRVAGTFYSLGAQLLYEVTATGLP
:: : :: . : * : :. *
Mflv_1439|M.gilvum_PYR-GCK GES-------------
Mvan_5345|M.vanbaalenii_PYR-1 GEA-------------
MLBr_01919|M.leprae_Br4923 GEEVQLSHCS------
MUL_4164|M.ulcerans_Agy99 GA--------------
MAV_0565|M.avium_104 GE--------------
MSMEG_6082|M.smegmatis_MC2_155 GEV-------------
Mb3301|M.bovis_AF2122/97 CPDEPADRPVDHESAQ
Rv3273|M.tuberculosis_H37Rv CPDEPADRPVDHESAQ
MMAR_1266|M.marinum_M ASNQPVGKP-------
MAB_0468|M.abscessus_ATCC_1997 APGAR-----------